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Abstracts tagged "synovial fluid"

  • Abstract Number: 1127 • ACR Convergence 2021

    Synovial Fluid Cytokines, Chemokines, and MMPs in Osteoarthritis Patients with Knee Pain Compared to RA Patients and Normal Knees

    Richard Meehan1, Elizabeth Regan1, Eric Hoffman1, Molly Wolff1, Mary Gill1, James Crooks2, Presant Parmar3, Richard Scheuring4, John Hill5, karin Pacheco6 and Vijaya Knight7, 1National Jewish Health, Denver, CO, 2National Jewsih Health and Colorado School of Public Health, Denver, CO, 3St Joeseph hospital/NJH, Denver, CO, 4NASA/JSC, Houston, TX, 5University of Colorado Sports Medicine, Denver, CO, 6Nationals Jewish Health, Denver, CO, 7Children's Hospital Department of Immunology, Denver, CO

    Background/Purpose: A major limitation of synovial fluid (SF) biomarker studies in osteoarthritis (OA) has been difficulty in obtaining SF (SF) in patients with small effusions.…
  • Abstract Number: 1131 • ACR Convergence 2021

    Interleukin 6 Concentration in Synovial Fluid and Its Clinical Significance

    Ivars Veckalns and Anna Mihailova, Riga Stradins University, Riga, Latvia

    Background/Purpose: Inflammatory arthritis (IA) treated with disease modifying antirheumatic drugs lead to secondary osteoarthritis (OA) due to inflammation, aging, and other factors. Inflammatory arthritis can…
  • Abstract Number: 1 • 2019 ACR/ARP Annual Meeting

    Interleukin-6 Promotes Osteoclast-like Phenotype in Human Rheumatoid Arthritis Synovial Fibroblasts

    Anil Singh1, Mahamudul Haque 1, Bhanupriya Madarampalli 2 and Salahuddin Ahmed 3, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, Spokane, WA, 2University of Washington, Seattle, WA, 3Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA. Division of Rheumatology, University of Washington School of Medicine, Seattle, WA, Spokane, WA

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation and joint destruction caused by pro-inflammatory cytokines. Progressive joint damage is also an…
  • Abstract Number: 12 • 2019 ACR/ARP Annual Meeting

    Intraarticular and Circulatory Cytokine Responses to Chlamydia Trachomatis: A Clinical Study in Reactive Arthritis/ Undifferentiated Spondyloarthropathy Patients

    Sangita Rastogi1, Praveen Kumar 2, Darshan Bhakuni 3 and Geetika Khanna 4, 1ICMR- National Institute of Pathology, Safdarjung hospital campus, New Delhi- 110 029, India, New Delhi, Delhi, India, 2ICMR- National Institute of Pathology, Safdarjung hospital campus, New Delhi- 110 029, India, Kota, Rajasthan, India, 3Department of Rheumatology and Clinical Immunology, Army Hospital (Research & Referral), Dhaula Kuan, New Delhi- 110 010, India, New Delhi, Delhi, India, 4Central Institute of Orthopedics (CIO), Vardhaman Mahavir Medical College (VMMC) & Safdarjung hospital, New Delhi-110029, India, New Delhi, Delhi, India

    Background/Purpose: Chlamydia trachomatis-induced reactive arthritis (ReA)/ undifferentiated spondyloarthropathy (uSpA) is an immune-mediated situation where development of disease and maintenance of this pathogen remains elusive. The…
  • Abstract Number: 819 • 2019 ACR/ARP Annual Meeting

    The Long Noncoding RNA HOTTIP Regulates Cell Cycle and Inflammatory Response in Hand Synovial Fibroblasts

    Mojca Frank-Bertoncelj 1, Tadeja Kuret2, Ana Županič 3, Snezna Sodin-Semrl 4, Oliver Distler 5 and Caroline Ospelt 1, 1University Hospital Zürich, Zürich, Switzerland, 2University Hospital Zürich, Zurich, Tajikistan, 3University Hospital Zürich, Zurich, Switzerland, 4University Medical Center Ljubljana, Ljubljana, Slovenia, 5Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Previously we showed that the long noncoding RNA (lncRNA) HOTTIP is exclusively expressed in synovial fibroblasts (SF) from distal joints, such as small joints…
  • Abstract Number: 1305 • 2019 ACR/ARP Annual Meeting

    Quality Improvement in Diagnostic and Therapeutic Arthrocentesis in the Flexed Knee Using Pneumatic Compression of the Suprapatellar Bursa

    Fatemeh Jafari Farshami1, Jaren Trost 2, Wilmer Sibbitt 2, Maheswari Muruganandam 2, Philip Band 3, Monthida Fangtham 1, Nicole Emil 1, William Hayward 4, Luke Haseler 5 and Arthur Bankhurst 1, 1Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 2Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, 3Department of Orthopaedic Surgery, Biochemistry & Molecular Pharmacology NYU School of Medicine, New York City, New York City, NY, 4The Department of Exercise and Sport Sciences, New Mexico Highlands University, Las Vegas, NM, 5Faculty of Health Sciences, School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia

    Background/Purpose: Arthrocentesis is an essential procedure in diagnosing inflammatory and septic arthritis and is a basic procedure for intra-articular therapy, including therapeutic arthrocentesis and intra-articular…
  • Abstract Number: 1982 • 2019 ACR/ARP Annual Meeting

    Senescent Synoviocytes in Knee Osteoarthritis Correlate with Disease Biomarkers, Synovitis, and Knee Pain

    Christopher Yohn 1, Robert O'Brien 1, Stephanie Lussier 1, Casey Berridge 1, Rathi Ryan 1, Ali Guermazi 2, Mahru An 1, Remi-Martin Laberge 1, Benjamin Hsu1, Carl Millward 1, Kate Doherty 1 and Jamie Dananberg 1, 1Unity Biotechnology, Brisbane, CA, 2Boston Medical Center, Boston

    Background/Purpose: Background/Purpose:  Cellular senescence is a natural state in which a cell permanently halts division through upregulation of a set of intracellular proteins including p16INK4A…
  • Abstract Number: 1985 • 2019 ACR/ARP Annual Meeting

    Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis

    Ricardo Grieshaber-Bouyer1, Till Kämmerer 2, Nils Rosshirt 2, Philipp Koniezke 2, Sebastien Hagmann 2, Elena Tripel 2, Johannes Kirsch 2, Tobias Gotterbarm 2 and Babak Moradi 2, 1Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Boston, MA, 2Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Germany

    Background/Purpose: Osteoarthritis (OA) is a progressive joint disease driven by a blend of inflammatory and biomechanical processes. Studies using human samples to understand inflammatory mechanisms…
  • Abstract Number: 2816 • 2019 ACR/ARP Annual Meeting

    An Expanded Granzyme K+ CD8 T Cell Population Induces Inflammatory Responses in Rheumatoid Arthritis Synovium

    Anna Helena Jonsson1, Fan Zhang 2, Gerald Watts 2, Kevin Wei 1, Deepak Rao 2, Soumya Raychaudhuri 2 and Michael Brenner 3, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Brigham and Women’s Hospital:, Boston

    Background/Purpose: CD8 T cells represent nearly half of T cells in inflamed synovium from patients with rheumatoid arthritis (RA). Research to date has focused on…
  • Abstract Number: 2025 • 2018 ACR/ARHP Annual Meeting

    Fibroblast-like Synoviocytes from Juvenile Idiopathic Arthritis and Controls Influence Expression of Bone Morphogenetic Protein Antagonists in Chondrocytes

    Megan Simonds1, Amanda R. Schlefman2, Suzanne M. McCahan3, Kathleen E. Sullivan4, Carlos D. Rosé5 and AnneMarie C. Brescia5, 1Nemours, Nemours Biomedical Research, Wilmington, DE, 2Pediatric Rheumatology, Nemours/Thomas Jefferson University, Wilmington, DE, 3Nemours Biomedical Research, Wilmington, DE, 4Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, 5Nemours/Thomas Jefferson University, Wilmington, DE

    Background/Purpose: Fibroblast-like synoviocytes (FLS) may play a role in the pathogenesis of Juvenile idiopathic arthritis (JIA) and have chondrogenic potential. Bone morphogenetic proteins (BMP) are…
  • Abstract Number: 2459 • 2018 ACR/ARHP Annual Meeting

    Nivolumab-Induced Synovial Tissue T Cell Infiltration, Sustained PD1 Occupancy and Resolution of Severe Synovitis with Infliximab Therapy

    William Murray-Brown1, Helen Weedon1, Tom Wilsdon2, Susanna Proudman3, Jenny Walker1, Malcolm D. Smith4 and Mihir D Wechalekar1,5, 1Rheumatology, Flinders University, Adelaide, Australia, 2Rheumatology, Flinders Medical Centre, Adelaide, Australia, 3Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia, 4Rheumotology, Flinders University, Adelaide, Australia, 5Royal Adelaide Hospital, Adelaide, Australia

    Background/Purpose: Checkpoint inhibitors (CI) for cancer therapy are associated with inflammation that can recapitulate features of autoimmunity, including synovitis resembling rheumatoid arthritis (RA). No reports…
  • Abstract Number: 2801 • 2018 ACR/ARHP Annual Meeting

    A Novel B-Cell-Helper IL-21-Producing CD8+ T Cell Subset Involved in the Pathogenesis of Rheumatoid Arthritis

    Kazuhiko Higashioka1, Masahiro Ayano1, Yasutaka Kimoto2, Hiroki Mitoma1, Mitsuteru Akahoshi1, Yojiro Arinobu1, Koichi Akashi1, Takahiko Horiuchi3 and Hiroaki Niro4, 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, 3Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 4Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    Background/Purpose: A plethora of evidence from genome-wide association studies and relevant animal models implicates a pivotal role of T cells in the pathogenesis of rheumatoid…
  • Abstract Number: 53 • 2018 ACR/ARHP Annual Meeting

    Cyclin-Dependent Kinase 4/6 Inhibitor: A Promising Development Candidate Targeting Synovial Hypertrophy for Rheumatoid Arthritis Treatment

    Shunsuke Tsujimoto, Kyohei Horie, Toshiya Mashiko, Johji Nomura and Tsunefumi Kobayashi, Teijin Institute for Bio-medical Research, TEIJIN PHARMA LIMITED, Tokyo, Japan

    Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is characterized by the infiltration of immune cells into the synovial tissues and the hypertrophy of synovial fibroblasts,…
  • Abstract Number: 59 • 2018 ACR/ARHP Annual Meeting

    Elucidating the Expression and Role of Heparan Sulfate Proteoglycan Editing Sulfatases in Human Rheumatoid Arthritis Synovium and a Rat Adjuvant-Induced Arthritis Model

    Ruby J. Siegel1, Solomon A. Agere1, Anil K. Singh1 and Salahuddin Ahmed2,3, 1Washington State University, Department of Pharmaceutical Sciences, College of Pharmacy, Spokane, WA, 2Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 3Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA

    Background/Purpose: Syndecans are cell-surface heparan sulfate proteoglycans (HSPGs) that modulate the receptor/ligand binding of chemokines, cytokines, and growth factors in order to facilitate cellular signaling.…
  • Abstract Number: 155 • 2018 ACR/ARHP Annual Meeting

    Polyfunctional Synovial T-Cell Responses and Synovial Invasiveness Repressed By Blockade of Phosphodiesterase 4

    Sarah M. Wade1, Mary Canavan1, Trudy McGarry1, Siobhan C. Wade1, Ronan Mullan2, Douglas J. Veale3 and Ursula Fearon1, 1Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 2Department of Rheumatology,, Tallaght Hospital, Dublin, Ireland, 3Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland

    Background/Purpose: Genetic and functional studies strongly support the role of T-cells in PsA pathophysiology. Effective targeting of T-cells requires a detailed understanding of their phenotypic…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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