Abstracts tagged "syk and tissue remodeling"

Abstract Number: 1106 • 2016 ACR/ARHP Annual Meeting
Test of the Spleen Tyrosine Kinase Inhibitor Fostamatinib in a Translational Joint Tissue Model Show Significant Effect on Bone, but Not on Synovial Tissue
Cecilie F. Kjelgaard-Petersen^1,2, Anne C. Bay-Jensen³, Thorbjørn G. Christiansen⁴, Morten Asser Karsdal³, Per Hägglund² and Christian S. Thudium¹, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Rheumatology, Nordic Bioscience, Herlev, Denmark, ⁴Gentofte University Hospital, Orthopaedicsurgery unit, Gentofte, Denmark
Background/Purpose: The Spleen tyrosine kinase (Syk) inhibitor fostamatinib was not approved as treatment for rheumatoid arthritis (RA) due to insufficient effect on joint structure in…

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Abstracts tagged "syk and tissue remodeling"

Test of the Spleen Tyrosine Kinase Inhibitor Fostamatinib in a Translational Joint Tissue Model Show Significant Effect on Bone, but Not on Synovial Tissue