Abstracts tagged "SYK and T cells"

Abstract Number: 3030 • ACR/ARHP Annual Meeting 2015
Increased Localization of Spleen Tyrosine Kinase (Syk) in Lipid Rafts of in Vitro TCR/CD3-CD28 Activated Lupus T Cells
Noymar Luque¹, Nursamaa Abdoel¹, Héctor Rojas², Martín Rodríguez¹, Gloria Vásquez³ and Ana Blasini¹, ¹Centro Nacional de Enfermedades Reumáticas. Hospital Universitario de Caracas, Caracas, Venezuela, ²Instituto de Inmunología, Escuela de Medicina, Universidad Central de Venezuela, Caracas, Venezuela, ³Grupo de Inmunología Celular e Inmunogenética. Universidad de Antioquia, Medellin, Colombia
Background/Purpose: Numerous alterations in signal transduction in SLE T cells have been previously reported. Diminished expression of the ζ chain of the TCR/CD3 complex has been…