ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "SYK and rheumatoid arthritis (RA)"

  • Abstract Number: 2518 • 2018 ACR/ARHP Annual Meeting

    GS-9876, a Novel, Highly Selective, SYK Inhibitor in Patients with Active Rheumatoid Arthritis: Safety, Tolerability and Efficacy Results of a Phase 2 Study

    Alan J. Kivitz1, Daksha P Mehta2, Franziska Matzkies3, Afsaneh Mozaffarian3, Rebecca Kunder3, Julie Di Paolo4, Neelufar Mozaffarian3, Sean Hsueh3, JiYun Kim5, Wendy Jiang3, Lin Liu3, John S. Sundy6 and Mark C. Genovese7, 1Altoona Center for Clinical Research, Duncansville, PA, 2Center for Arthritis and Osteoporosis, Elizabethtown, KY, 3Gilead Sciences, Inc., Foster City, CA, 4Immunology and Inflammation Biology, Gilead Sciences, Inc., Foster City, CA, 5Biomarkers, Gilead Sciences, Inc., Foster City, CA, 6Clinical Research, Inflammation and Respiratory, Gilead Sciences, Inc., Foster City, CA, 7Stanford University Medical Center, Palo Alto, CA

    Background/Purpose: Spleen tyrosine kinase (SYK) mediates immunoreceptor signaling and is essential in activation of cells including B lymphocytes, monocytes, macrophages, dendritic cells, and osteoclasts. SYK…
  • Abstract Number: 1621 • 2016 ACR/ARHP Annual Meeting

    A Phase I, Randomized, Double Blind, Placebo-Controlled, Dose Escalating Study of the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of Hmpl‑523 in Australian Male Healthy Subjects

    Jason Lickliter1, Yan Wu2, Ye Hua2, Irena Yuan2, Guangxiu Dai2, Xiong Li2, Jian Wang2, Yang Sai2, Zhongcui Sun2, Angela Pan2, Jing Li2 and Weiguo Su2, 1Nucleus Network, Melbourne, Australia, 2Hutchison MediPharma Limited, Shanghai, China

    Background/Purpose:   Spleen Tyrosine Kinase (SYK) plays a pivotal role in the regulation of downstream signals in immune receptors, including B cell receptors (BCRs), which…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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