ACR Meeting Abstracts

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Abstracts tagged "Structure"

  • Abstract Number: 0315 • ACR Convergence 2024

    Microvascular Abnormalities Are Present in Autonomic Dysfunction: Results of a Prospective Study

    Sehreen Mumtaz1, Karissa Arca2, Vikas Majithia3, David Hodge3, William Cheshire3 and Florentina Berianu4, 1Mayo Clinic, Florida, Jacksonville, FL, 2Mayo Clinic Arizona, Scottsdale, AZ, 3Mayo Clinic Florida, Jacksonville, FL, 4mayo clinic, Ponte Vedra Beach, FL

    Background/Purpose: Dysfunction of the autonomic system affects multiple target organs and is linked to microvascular impairment and abnormal vasoreactivity. Given its variable manifestations, diagnosis is…
  • Abstract Number: 0852 • ACR Convergence 2024

    3-dimensional Shape Changes of the Knee over 4 Years Are Linear and Progressive but Much More Rapid in Osteoarthritic Joints: Data from the Osteoarthritis Initiative

    Alan Brett1, Philip G Conaghan2 and Michael Bowes3, 1Imorphics, Austin, TX, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Imorphics, Manchester, United Kingdom

    Background/Purpose: The specific bony changes of osteophyte growth and “bone attrition” (broadening and flattening of the femoral condyles) associated with OA have been recognized in…
  • Abstract Number: 0917 • ACR Convergence 2024

    Role of Mutual Information Profile Shifts in Assessing the Pathogenicity of Mutations on Protein Functions: The Case of Pyrin Mutations in Familial Mediterranean Fever

    Aysima Hacisuleyman1, Ahmet Gul2 and Burak Erman3, 1Department of Computational Biology, University of Lausanne, Lausanne, Switzerland, 2Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, Istanbul, Turkey, 33Chemical and Biological Engineering, Koc University, Istanbul, Turkey

    Background/Purpose: Predicting the pathogenicity of amino acid substitutions is crucial for understanding the functional consequences of genetic variations. Several computational methods frequently used so far…
  • Abstract Number: 2593 • ACR Convergence 2024

    A Long-term Synovial Tissue 3D Model Incorporating Fibroblasts, Macrophages, Endothelial Cells, and Other Immune Cells Such as Innate Lymphoid Cells Enables Animal Model-Independent Rheumatoid Arthritis Research

    Miriam Bollmann1, Oskar Landberg2, Negar Ayoubzadeh2, Charlotte A. Jonsson2, Inger Gjertsson2 and Mattias Svensson2, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with multiple tissues contributing to its pathology, including the synovial membrane. The RA synovial membrane…
  • Abstract Number: 0798 • ACR Convergence 2023

    A Novel 3D Model of Rheumatoid Arthritis Synovial Tissue Incorporating Fibroblasts, Endothelial Cells and Macrophages

    Eva Philippon1, Lisanne van Rooijen1, Jan Piet van Hamburg1, Fatemeh Khodadust1, Conny Van der Laken2 and Sander Tas3, 1Amsterdam University Medical Centers, Amsterdam, Netherlands, 2Amsterdam UMC - location VUMC, Amsterdam, Netherlands, 3Amsterdam UMC, locatie AMC, Utrecht, Netherlands

    Background/Purpose: Rheumatoid Arthritis (RA) is a progressive and systemic autoimmune disorder associated with chronic and destructive inflammation of the joints. The hallmarks of RA are…
  • Abstract Number: 1992 • ACR Convergence 2023

    Association Between Knee Osteoarthritis Pain and Concomitant Drug Use: A Post-hoc Analysis of Two Phase 3 Clinical Trials

    Claire Miller1, Matthew Baker2, Peter Alexandersen3, Alejandro Mondragón1, Ida Sofie Adrian1, Morten Karsdal4, Jeppe Andersen5 and Asger Bihlet1, 1NBCD, Soeborg, Denmark, 2Stanford University, Menlo Park, CA, 3Sanos Clinics, Gandrup, Denmark, 4Nordic Bioscience, Herlev, Denmark, 5Sanos Group, Soeborg, Denmark

    Background/Purpose: Patients with knee osteoarthritis are often overweight and suffer from comorbidities, which are frequently treated pharmacologically. Our understanding of the potential disease-modifying and/or symptom-modifying…
  • Abstract Number: 0691 • ACR Convergence 2022

    Structural Differences Exist in Beta-2-Glycoprotein I from APS Patients Compared to Healthy Controls

    Hannah Britt1, Hannah Bradford1, Valentina Spiteri1, Anisur Rahman2, Ian Giles1, Mihaela Delcea3, Paul Dalby1, Kostas Thalassinos1 and Thomas McDonnell1, 1University College London, London, United Kingdom, 2Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 3University of Greifswald, Greifswald, Germany

    Background/Purpose: Beta-2-Glycoprotein I (B2GPI) is a serum protein of approximately 50kDa and is the main autoantigen of Antiphospholipid syndrome (APS). Antibodies to B2GPI (aB2GPI) are…
  • Abstract Number: 1498 • ACR Convergence 2022

    The Association Between Sonographic Enthesitis with Sonographic Synovitis and Tenosynovitis in Psoriatic Arthritis

    gavriel Balulu1, Victoria Furer1, Jonathan Wollman2, David Levartovsky1, Valerie Aloush1, Ofir Elalouf1, Hagit Sarbagil-Maman3, Liran Mendel2, Sara Borok1, Daphna Paran1, Ori Elkayam3 and Ari Polachek1, 1Tel Aviv Medical Center, Tel Aviv, Israel, 2Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel, 3Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

    Background/Purpose: Enthesitis is considered a hallmark of psoriatic arthritis (PsA). Ultrasound (US) is considered a more accurate tool for the assessment of enthesitis compared to…
  • Abstract Number: 1116 • ACR Convergence 2020

    Magnetic Resonance Imaging Structural Changes Correlated with Knee Extension: Data from the Osteoarthritis Initiative

    T Mark Campbell1, Guy Trudel2 and Dennis McGonagle3, 1Elisabeth Bruyère Hospital, Ottawa, ON, Canada, 2The Ottawa Hospital, Ottawa, ON, Canada, 3The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom

    Background/Purpose: Knee OA is often accompanied by loss of passive extension, termed a flexion contracture (FC), resulting in worse clinical outcomes. To our knowledge, MRI-based…
  • Abstract Number: 1541 • ACR Convergence 2020

    Ultrasound in Knee Osteoarthritis: Reader Performance, Sonographic Features, and Correlation with Radiographic Findings

    Ogonna Nwawka1, Susan Lee1, Bin Lin2, Said Ibrahim3, Collin Brantner4, Peter Sculco5, Michael Parks1, Mark Figgie6, Laura Donlin1, Dana Orange7, Serene Mirza2, Michael Cross1, Jose Rodriguez1, Thomas Sculco1, Miguel Otero2, William Robinson8, Susan Goodman6 and Bella Mehta5, 1Hospital for Special Surgery, Weill Cornell Medicine, New York, 2Hospital for Special Surgery, New York, 3Weill Cornell Medicine, Cleveland, OH, 4Hospital for Special Surgery, New York, NY, 5Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 6Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 7Rockefeller University, New York, 8Stanford University, Palo Alto, CA

    Background/Purpose: Radiography is the most widespread imaging technique used in the evaluation of knee osteoarthritis (KOA), and MRI is known to be specific in characterization…
  • Abstract Number: 2024 • ACR Convergence 2020

    Effects of Filgotinib on Spinal Lesions in Patients with Ankylosing Spondylitis: Magnetic Resonance Imaging Data from the Placebo-Controlled, Double‑Blind, Randomized TORTUGA Trial

    Walter Maksymowych1, Mikkel Østergaard2, Robert Landewé3, William Barchuk4, Ke Liu4, Chantal Tasset5, Leen Gilles5, Thijs Hendrikx6, Robin Besuyen6 and Xenofon Baraliakos7, 1University of Alberta, Edmonton, AB, Canada, 2Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 3Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, 4Gilead Sciences, Inc., Foster City, CA, 5Galapagos NV, Mechelen, Belgium, 6Galapagos BV, Leiden, Netherlands, 7Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany

    Background/Purpose: The oral, selective Janus kinase 1 inhibitor filgotinib (FIL) significantly improved Spondyloarthritis Research Consortium of Canada (SPARCC) MRI inflammation scores (bone marrow edema) in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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