Abstracts tagged "ssc"

Abstract Number: 1048 • 2019 ACR/ARP Annual Meeting
Clonally Expanded CD4+ Cytotoxic T Cells, Endothelial Cell Apoptosis and the Pathogenesis of Early Systemic Sclerosis
Takashi Maehara ¹, Cory Perugino², Naoki Kaneko ¹, Hamid Mattoo ³, Jesper Kers ⁴, Hugues Allard-Chamard ⁵, Vinay Mahajan ⁵, Hang Liu ⁵, Samuel Murphy ⁵, Musie Ghebremichael ⁵, Yesim Tuncay ⁵, Emanuel Della Torre ⁶, Lloyd Liang ², Sydney Montesi ⁷, Zachary Wallace ², David Fox ⁸, Robert Lafyatis ⁹, John Stone ¹⁰, Dinesh Khanna ¹¹ and Shiv Pillai ¹², ¹Kyushu University, Fukuoka, Japan, ²Massachusetts General Hospital, Boston, ³Sanofi, Cambridge, ⁴University of Amsterdam, Amsterdam, Netherlands, ⁵Ragon Institute of MGH, MTI and Harvard, Cambridge, ⁶Hospital San Raffaele, milan, Italy, ⁷Massachusetts General Hospital, Boston, MA, ⁸University of Michigan, Ann Arbor, ⁹University of Pittsburgh, Pittsburgh, PA, ¹⁰Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ¹¹Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, ¹²Ragon Institude of MGH, MIT and Harvard, Charlestown, MA
Background/Purpose: The CD4+ T cell subset driving the pathogenesis of systemic sclerosis (SSc) remains poorly understood. Many different CD4+ T cell subsets have been implicated,…
Abstract Number: 1071 • 2019 ACR/ARP Annual Meeting
A Common Transcriptional Signature Is Present in Circulating Classical Monocytes and Skin Macrophages in Systemic Sclerosis
Hadijat Makinde¹, Salina Dominguez ², Gaurav Gadhvi ³, Kathleen Aren ⁴, Chang Zeng ³, Garrett Eickelberg ³, Dinesh Khanna ⁵, Shervin Assassi ⁶, Tracy Frech ⁷, Monique Hinchcliff ⁸, Carla Cuda ⁹, Deborah Winter ² and Harris Perlman ², ¹Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, ³Northwestern University, Chicago, ⁴Northwestern.edu, Chicago, ⁵Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, ⁶Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, ⁷Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT, ⁸Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT, ⁹Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL
Background/Purpose: The etiology and pathogenesis of systemic sclerosis (SSc) are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes…

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