Abstracts tagged "Spondyloarthropathies"

Abstract Number: 2257 • ACR Convergence 2022
MRI Spinal Lesions in Patients Without MRI or Radiographic Lesions in the Sacroiliac Joints Typical of Axial Spondyloarthritis
Walter P Maksymowych¹, Mikkel Østergaard², Xenofon Baraliakos³, Pedro Machado⁴, Susanne J. Pedersen⁵, Ulrich Weber⁶, Iris Eshed⁷, Manouk de Hooge⁸, Joachim Sieper⁹, Denis Poddubnyy¹⁰, Martin Rudwaleit¹¹, Désirée van der Heijde¹², Robert Landewé¹³ and Robert G Lambert¹⁴, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rigshospitalet, University of Copenhagen, Glostrup, Denmark, ³Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁴University College London, London, United Kingdom, ⁵Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ⁶Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, ⁷Sheba Medical Center, Tel Aviv, Israel, ⁸Ghent University Hospital, Luxembourg, Luxembourg, ⁹Charité - Universitätsmedizin, Berlin, Berlin, Germany, ¹⁰Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ¹¹University of Bielefeld, Klinikum Bielefeld, Bielefeld; Germany Klinikum Bielefeld and Charité Berlin, Germany, and Gent University, Gent, Belgium, ¹²Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ¹³Amsterdam University Medical Center, Meerssen, Netherlands, ¹⁴University of Alberta, Edmonton, AB, Canada
Background/Purpose: There is limited data as to the frequency of spinal lesions on MRI in patients without MRI or radiographic features typical of sacroiliac joint…
Abstract Number: 0405 • ACR Convergence 2022
Efficacy and Safety of Tofacitinib in Patients with Ankylosing Spondylitis by Baseline BMI: A Post Hoc Analysis of Phase 2 and Phase 3 Trials
Hillary Norton¹, Paula Sliwinska-Stanczyk², Tomas Hala³, Bassel Elzorkany⁴, Lori Stockert⁵, Harry Shi⁵, Cunshan Wang⁶, Jerome Paulissen⁷ and Christopher Ritchlin⁸, ¹Sante Fe Rheumatology, Santa Fe, NM, ²Reumatika Centrum Reumatologii, Warsaw, Poland, ³Center for Clinical and Basic Research, Pardubice, Czech Republic, ⁴Department of Rheumatology, Cairo University, Cairo, Egypt, ⁵Pfizer, Inc, Collegeville, PA, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc, New York, NY, ⁸Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY
Background/Purpose: Higher BMI is associated with reduced response to TNF inhibitors (TNFi) in patients (pts) with AS.1 Tofacitinib is an oral Janus kinase inhibitor for…
Abstract Number: 1031 • ACR Convergence 2022
Foot Involvement in Psoriatic Arthritis- a Retrospective Study
Sofia Ferreira Azevedo¹, Carolina Mazeda², Susana P. Silva³, Claudia P. Oliveira¹ and Anabela Barcelos³, ¹Rheumatology Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal, ²Centro Hospitalar Baixo Vouga, Ovar, Portugal, ³Centro Hospitalar Baixo Vouga, Aveiro, Portugal
Background/Purpose: Foot involvement is well recognized in many inflammatory rheumatic diseases, namely in Spondylarthritis (SpA), where its early recognition is of utmost importance. Psoriatic arthritis…
Abstract Number: 1516 • ACR Convergence 2022
How Disease Activity Can Affect Workability in Spondyloarthropaties: A Monocentric Cohort Analysis
Federico Fattorini¹, Cosimo Cigolini², Gabriele Marchetti³, Andrea Delle Sedie⁴, Linda Carli⁵ and Marta Mosca⁵, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, ³University of Pisa, Pisa, Toscana, Italy, ⁴University of Pisa, Pisa, Pisa, Italy, ⁵Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, PISA, Italy
Background/Purpose: Spondyloarthropathies (SpA) may compromise the working ability (WA) of patients, often affected by the disease during their productive life. The Work Productivity and Activity…
Abstract Number: 2258 • ACR Convergence 2022
Relative Frequencies of the Spectrum of MRI Lesions in the Sacroiliac Joints of Healthy Individuals and Patients with Non-Specific Back Pain: What Is the Impact of Increasing Age?
Ulrich Weber¹, Susanne Pedersen², Mikkel Østergaard³, Pedro Machado⁴, Xenofon Baraliakos⁵, Robert G Lambert⁶ and Walter P Maksymowych⁷, ¹Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, ²Rigshospitalet, København, Denmark, ³Rigshospitalet, University of Copenhagen, Glostrup, Denmark, ⁴University College London, London, United Kingdom, ⁵Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁶University of Alberta, Edmonton, AB, Canada, ⁷Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Previous studies of patients with axial spondyloarthritis (axSpA) have demonstrated that certain MRI structural lesions in the sacroiliac joints (SIJ), notably erosions, has high…
Abstract Number: 0406 • ACR Convergence 2022
Are the BASDAI & BASFI Capturing the Full Impact of Disease Activity on Quality of Life in Women with Axial Spondyloarthritis?
Sinead Maguire¹, Fiona Wilson², Phil Gallagher³ and Finbar (Barry) O'Shea¹, ¹St James' Hospital, Dublin, Ireland, ²Trinity College Dublin, Dublin, Ireland, ³St Vincent's University Hospital, Dublin, Ireland
Background/Purpose: The tools to assess disease activity and quality of life in axial spondyloarthritis (axSpA) were developed in ankylosing spondylitis cohorts biased towards inclusion of…
Abstract Number: 1032 • ACR Convergence 2022
Anti-arthritogenic Effect of Smoking in Curdlan-Administered SKG Mice
YoungEun Kim¹, Eun-Ju Lee¹, Jae-Hyun Lee¹, Soo Min Ahn¹, Ji Seon Oh², Seokchan Hong¹, Chang Keun Lee¹, Bin Yoo¹ and Yong Gil Kim¹, ¹Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, Seoul, Republic of Korea, ²Department of Information Medicine, Big Data Research Center, Asan Medical Center, Seoul, Republic of Korea
Background/Purpose: Alpha7 nicotinic acetylcholine receptor (α7nAChR), a member of AChR expressed in various immune cells and synoviocytes, has an important role in the anti-inflammatory pathway…
Abstract Number: 1601 • ACR Convergence 2022
Female Psoriatic Arthritis Patients Show Differences in Treatment Response to IL12/23 Inhibition in Combination with or Without MTX Compared to Male – Results from a Multicenter Investigator-initiated Randomized Placebo-controlled Clinical Trial
Michaela Koehm¹, Ann Christina Foldenauer², Tanja Rossmanith³, Herbert Kellner⁴, Uta Kiltz⁵, Juergen Rech⁶, Gerd Burmester⁷, David Kofler⁸, Jan Brandt-Juergens⁹, Stephanie Finzel¹⁰, Raoul Bergner¹¹, Maren Sieburg¹² and Frank Behrens¹³, ¹Rheumatology Goethe-University Frankfurt, Frankfurt Am Main, Germany, ²Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, ³Fraunhofer Institute for Translational Medicine & Pharmacology ITMP, Frankfurt, Germany, ⁴Schwerpunktpraxis für Rheumatologie und Gastroenterologie, Munich, Germany, ⁵Rheumazentrum Ruhrgebiet, Herne, Germany, ⁶University Clinic Erlangen, Erlangen, Germany, ⁷Charité University Medicine Berlin, Berlin, Germany, ⁸University of Cologne, Cologne, Germany, ⁹Rheumatologische Schwerpunktpraxis, Berlin, Germany, ¹⁰University of Freiburg, Freiburg, Germany, ¹¹Klinikum Ludwigshafen, Ludwigshafen, Germany, ¹²Rheumatologische Facharztpraxis, Magdeburg, Germany, ¹³Rheumatology University Hospital & Fraunhofer Institute Translational Medicine and Pharmacology, Goethe-University Frankfurt, Frankfurt Am Main, Germany
Background/Purpose: Subgroup analysis from different clinical trials and real-world data suggest, that there are differences in baseline characteristics, clinical phenotypes, and treatment responses in female…
Abstract Number: 0413 • ACR Convergence 2022
Efficacy and Safety of Non-Pharmacological and Non-Biological Therapy: A Systematic Literature Review Informing the 2022 Update of the ASAS-EULAR Recommendations for the Management of Axial Spondyloarthritis
Augusta Ortolan¹, Casper Webers², Alexandre Sepriano³, Louise Falzon⁴, Xenofon Baraliakos⁵, Robert Landewé⁶, Sofia Ramiro⁷, Désirée van der Heijde⁸ and Elena Nikiphorou⁹, ¹University of Padova/Leiden University Medical Center, Padova, Italy, ²Maastricht University Medical Centre, Maastricht, Netherlands, ³Leiden University Medical Centre, Portela Loures, Portugal, ⁴Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom, ⁵Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁶Amsterdam University Medical Center, Meerssen, Netherlands, ⁷Leiden University Medical Center, Leiden, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ⁹Leiden University Medical Center & King's College London, London, United Kingdom
Background/Purpose: Since the 2016 recommendations for axial spondyloarthritis (axSpA) management, new evidence emerged regarding axSpA treatment. The aim of this work was to update the…
Abstract Number: 1033 • ACR Convergence 2022
Risk of Mood Disorders in SpA Patients and Correlations with Disease Activity, Quality of Life and Working Ability: Analysis of a Monocentric Cohort
Cosimo Cigolini¹, Federico Fattorini¹, Linda Carli², Andrea Delle Sedie³, Marta Mosca² and Gabriele Marchetti⁴, ¹Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, ²Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, PISA, Italy, ³University of Pisa, Pisa, Pisa, Italy, ⁴University of Pisa, Pisa, Toscana, Italy
Background/Purpose: Spondyloarthropathies (SpA) are chronic inflammatory arthritides, characterized by both peripheral and axial skeletal involvement and some typical extra-articular marks; they tend to associate with…
Abstract Number: 1612 • ACR Convergence 2022
Prediction of Psoriatic Arthritis Tool (PRESTO): Development and Performance of a New Scoring System for Psoriatic Arthritis Risk
Lihi Eder¹, Ker-Ai Lee², Vinod Chandran³, Jessica Widdifield⁴, Aaron Drucker⁴, Christopher Ritchlin⁵, Cheryl F Rosen⁴, Richard Cook² and Dafna Gladman⁶, ¹Women’s College Research Institute, Department of Medicine, University of Toronto, Toronto, ON, Canada, ²University of Waterloo, Waterloo, ON, Canada, ³Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, ⁶Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada
Background/Purpose: A simple, scalable tool that identifies psoriasis patients at high risk for developing PsA could improve early detection and facilitate early intervention. Our overall…
Abstract Number: 0416 • ACR Convergence 2022
Efficacy and Safety of Biological DMARDs: A Systematic Literature Review Informing the 2022 Update of the ASAS-EULAR Recommendations for the Management of Axial Spondyloarthritis
Casper Webers¹, Augusta Ortolan², Alexandre Sepriano³, Louise Falzon⁴, Xenofon Baraliakos⁵, Robert Landewé⁶, Sofia Ramiro⁷, Désirée van der Heijde⁸ and Elena Nikiphorou⁹, ¹Maastricht University Medical Centre, Maastricht, Netherlands, ²University of Padova/Leiden University Medical Center, Padova, Italy, ³Leiden University Medical Centre, Portela Loures, Portugal, ⁴Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom, ⁵Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁶Amsterdam University Medical Center, Meerssen, Netherlands, ⁷Leiden University Medical Center, Leiden, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ⁹Leiden University Medical Center & King's College London, London, United Kingdom
Background/Purpose: Since the 2016 update of the management recommendations for axial spondyloarthritis (axSpA), new evidence has emerged on the efficacy and safety of biological disease-modifying…
Abstract Number: 1035 • ACR Convergence 2022
Efficacy of Guselkumab in Three Cohorts of Biologic-Naïve PsA Patients with Axial Involvement Defined Based on Imaging and Machine-Learning Criteria: Pooled Analysis of Two Phase 3 Studies
Philip J Mease¹, William Tillett², Sarah Ohrndorf³, Michelle Perate⁴, Mary Medysky⁵, Miriam Zimmermann⁶, May Shawi⁷, Emmanouil Rampakakis⁸, Paul Bird⁹, Alen Zabotti¹⁰, Atul Deodhar¹¹ and Dafna Gladman¹², ¹Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, ²Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴Janssen Scientific Affairs, LLC, Horsham, PA, ⁵Janssen Scientific Affairs, LLC, Seattle, WA, ⁶Immunology, Janssen Scientific Affairs, LLC, Zug, Switzerland, ⁷Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, ⁸McGill University, Department of Pediatrics and JSS Medical Research, Montréal, QC, Canada, ⁹University of New South Wales, Sydney, Australia, ¹⁰Department of Medical and Biological Sciences, Rheumatology Unit, University of Udine, Udine, Italy, ¹¹Oregon Health & Science University, Portland, OR, USA, Portland, OR, ¹²Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada
Background/Purpose: Evidence on the efficacy of advanced therapies for axial involvement in PsA (axPsA) is scarce, largely due to the lack of a widely accepted…
Abstract Number: 1768 • ACR Convergence 2022
Sex-Related Differences in Healthcare Utilization in Patients with Inflammatory Arthritis: A Population-based Study
Sanjana Tarannum¹, Jessica Widdifield¹, C. Fangyun Wang², Sindhu R. Johnson³, Paula Rochon¹ and Lihi Eder⁴, ¹University of Toronto, Toronto, ON, Canada, ²Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ³Division of Rheumatology, Department of Medicine, Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western and Mount Sinai Hospitals; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ⁴Women’s College Research Institute, Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Delayed diagnosis of inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), is associated with joint damage and disability.…
Abstract Number: 0796 • ACR Convergence 2022
SARS-CoV-2 Vaccine in Axial Spondyloarthritis and Psoriatic Arthritis: Does Sulfasalazine Counterbalance TNFI Impaired Immunogenicity?
Carla Goncalves Schahin Saad¹, Matheus SR Silva², PERCIVAL SAMPAIO-BARROS¹, Julio Moraes³, Claudia G Schainberg², Celio Roberto goncalves¹, Andrea Shimabuco¹, Nadia Aikawa¹, Emily Figueiredo Neves Yuki¹, Sandra Gofinet Pasoto⁴, Leonard VK Kupa², Renato K Aoyama², Carlo Araujo¹, Clovis A. Silva⁵, ana Medeiros⁶ and Eloisa Silva Dutra de Oliveira Bonfa⁴, ¹Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Faculdade de Medicina da Universidade de São Paulo, São Paulo, ³Faculdade de Medicina da Universidade de Sao Paulo, Jundiai, Brazil, ⁴Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁵Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil, ⁶Faculdade de Medicina da Universidade de São Paulo, São Jose Dos Campos, Brazil
Background/Purpose: Spondyloarthritis(SpA) patients are exposed to a variety of immunosuppressors capable of reduce humoral responses to vaccination. In context of the SARS-CoV-2 pandemic, assessment of…

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