Abstracts tagged "spondyloarthritis"

Abstract Number: 1757 • ACR Convergence 2024
Bimekizumab Treatment Resulted in Improvements in MRI Inflammatory and Structural Lesions in the Sacroiliac Joints of Patients with Axial Spondyloarthritis: 52-Week Results and Post Hoc Analyses from Two Phase 3 Studies
Walter Maksymowych¹, Sofia Ramiro², Denis Poddubnyy³, Xenofon Baraliakos⁴, Robert Lambert¹, Ute Massow⁵, Thomas Vaux⁶, Chetan Prajapati⁶, Alexander Marten⁵, Natasha de Peyrecave⁷ and Mikkel Ostergaard⁸, ¹University of Alberta, Edmonton, AB, Canada, ²Leiden University Medical Center, Bunde, Netherlands, ³Charite-Universitatsmedizin Berlin, Berlin, Germany, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁵UCB Pharma, Monheim am Rhein, Germany, ⁶UCB Pharma, Slough, United Kingdom, ⁷UCB Pharma, Brussels, Belgium, ⁸Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark
Background/Purpose: The impact of bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)‑17F in addition to IL-17A, on structural lesions in patients (pts)…
Abstract Number: 2346 • ACR Convergence 2024
Treatment Effect on Predictors of Ankylosis in Axial Spondyloarthritis
Pauline KRUG¹, Anthony Lichaa¹ and Adrien Nzeusseu Toukap², ¹Cliniques universitaires St-Luc, Brussel, Belgium, ²Cliniques universitaires Saint-Luc,, St.-Lambrechts-Woluwe, Belgium
Background/Purpose: Axial spondyloarthritis (axSpA) is a progressive chronic inflammatory disease. In its early stages, symptoms appear without radiographic evidence. Later, structural lesions are observed on…
Abstract Number: 0411 • ACR Convergence 2024
Axial Radiographic Structural Damage in Enthesitis-Related Arthritis in Children and Young Adult Patients
Annelyse de Araújo Pereira¹, Marcelo Pinheiro², Jade Dib Fernandez¹, Ana Sakamoto³, Adham do Amaral e Castro¹ and Maria Teresa Terreri⁴, ¹UNIFESP-EPM, São Paulo, SP, Brazil, ²UNIFESP/ EPM, São Paulo, SP, Brazil, ³Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil, ⁴UNIFESP, São Paulo, SP, Brazil
Background/Purpose: Enthesitis-related arthritis (ERA), a distinct subtype of juvenile idiopathic arthritis (JIA) related to HLA-B27 status and peripheral and axial involvement, presents with insidious onset…
Abstract Number: 0555 • ACR Convergence 2024
The Effect of Alcohol Consumption on Clinical Outcomes and Structural Damage in Patients with Axial Spondyloarthritis: A Systematic Literature Review and Meta-Analysis
Sinead Maguire¹, Nigil Haroon², Robert Inman³, Melanie Anderson⁴, Evelyne Gendron⁵ and Sindhu R. Johnson⁶, ¹University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Rheumatology, Toronto, Canada, ²Department of Medicine/Rheumatology, University Health Network, Schroeder Arthritis Institute, University of Toronto, Toronto, ON, Canada, ³University Health Network, Toronto, ON, Canada, ⁴The Institute for Education Research, Library and Information Services, University Health Network, Toronto, ON, Canada, ⁵University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Rheumatology, Quebec City, QC, Canada, ⁶University of Toronto, Toronto, Canada
Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic progressive inflammatory disease characterized by the involvement of the axial skeleton. Alcohol consumption (AC) is a modifiable lifestyle…
Abstract Number: 0577 • ACR Convergence 2024
AMH Titers in Women with Axial Spondyloarthritis Are Significantly Lower Compared to the General Population: An Analysis of the 10-year Follow-up of the DESIR Cohort
Madeleine FRANC¹, Jean Guibourdenche², Anne Tournadre³ and Anna Molto⁴, ¹Groupe Hospitalier Cochin, APHP, Paris, France, ²Groupe Hospitalier Cochin, APHP, Paris, ³Service de Rhumatologie, centre hospitalier universitaire de Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France, ⁴Groupe Hospitalier Cochin, AP-HP, Paris, France
Background/Purpose: Data on fertility in women with spondyloarthritis (SpA) is sparse but seems to be impaired compared to the general population. Divergent results have been…
Abstract Number: 1011 • ACR Convergence 2024
Use of the Shingrix Vaccine Among Patients with Inflammatory Arthritis and Risk of Cardiovascular Events Following Herpes Zoster
Jeffrey Curtis¹, Danielle M Conrad², Whitney S Krueger², Andrew P Gara² and Kevin Winthrop³, ¹FASTER Medicine, Hoover, AL, ²AbbVie, North Chicago, IL, ³School of Medicine, Oregon Health and Science University, Portland, OR
Background/Purpose: The risk of herpes zoster (HZ) is increased in patients with inflammatory arthritis (IA); although the Shingrix vaccine has been available since 2017, its…
Abstract Number: 1445 • ACR Convergence 2024
Systematic Characterization of MRI Lesions Per ASAS Definitions in the Sacroiliac Joints of Patients with Axial Spondyloarthritis and Comparisons Among Subgroups with Psoriasis, Iritis, Colitis, AxSpA Alone, and Matched Back Pain Controls
Ulrich Weber¹, Susanne Pedersen², Ozun Bayindir Tsechelidis³, Robert Lambert⁴, Joel Paschke⁵, Stephanie Wichuk⁴ and Walter Maksymowych⁴, ¹Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, ²Rigshospitalet, København, Denmark, ³Ottawa University, Ottawa, ON, Canada, ⁴University of Alberta, Edmonton, AB, Canada, ⁵CARE Arthritis, Edmonton, AB, Canada
Background/Purpose: There is limited information on the frequency and topographical distribution of MRI lesions in the sacroiliac joints (SIJ) of patients with axSpA according to…
Abstract Number: 1758 • ACR Convergence 2024
Minimal Spinal Radiographic Progression in Patients with Radiographic Axial Spondyloarthritis over 2 Years of Bimekizumab Treatment: Results from a Phase 3 Open-Label Extension Study
Xenofon Baraliakos¹, Sofia Ramiro², Walter Maksymowych³, Mikkel Ostergaard⁴, Ute Massow⁵, Thomas Vaux⁶, Chetan Prajapati⁶, Alexander Marten⁵, Natasha de Peyrecave⁷ and Denis Poddubnyy⁸, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ²Leiden University Medical Center, Bunde, Netherlands, ³University of Alberta, Edmonton, AB, Canada, ⁴Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark, ⁵UCB Pharma, Monheim am Rhein, Germany, ⁶UCB Pharma, Slough, United Kingdom, ⁷UCB Pharma, Brussels, Belgium, ⁸Charite-Universitatsmedizin Berlin, Berlin, Germany
Background/Purpose: The effect of bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)‑17F in addition to IL-17A, on structural radiographic progression in the…
Abstract Number: 2347 • ACR Convergence 2024
Drug Survival in Spondyloarthritis: Anti-IL17 Outperforms Anti-TNF in First Biologic Treatment
Thao Pham¹, Raphaëlle Curmin², BENOIT FLACHAIRE³, Florence Tubach² and Corinne MICELI⁴, ¹Assistance Publique-Hôpitaux de Marseille, Marseille, France, ²Cephepi, Sorbonne Université, INSERM, APHP, Paris, Paris, France, ³Aix Marseille University, Marseille, France, ⁴Université de Paris Cité, APHP, Paris, France
Background/Purpose: Drug survival rates serve as key indicators for assessing both the efficacy and safety of treatments in real life setting. Our aim was to…
Abstract Number: 0422 • ACR Convergence 2024
Greater Use of Assisted Reproductive Techniques but Comparable Obstetric Morbidity in a Population of Women with Spondyloarthritis: A Matched Comparative Analysis of the GR2 Prospective Cohort and the French National Perinatal Surveys
Sabrina Hamroun¹, Grégoire Martin De Frémont², Nathalie Costedoat-chalumeau³, Marion couderc⁴, René-Marc Flipo⁵, Jérémie Sellam⁶, Christophe Richez⁷, Rakiba Belkhir⁸, Laure Gossec⁹, Hubert Marotte¹⁰, Emmanuelle Dernis¹¹, Aline Frazier¹², Elisabeth Gervais¹³, Cedric Lukas¹⁴, Valerie Devauchelle¹⁵, Alban Deroux¹⁶, Véronique Le Guern¹⁷, Gaëlle Guettrot-Imbert¹⁸, Nathalie Lelong¹⁹, Camille Le Ray¹⁹, Raphaele Seror²⁰ and Anna Molto²¹, and ENP 2021 and GR2 Study Groups, ¹Cochin University Hospital, Paris, Ile-de-France, France, ²Le Kremlin-Bicêtre University Hospital, Le Kremlin-Bicêtre, Guyana, ³University Paris Cité, Paris, France, ⁴CHU de Clermont-Ferrand, Clermont-Ferrand, ⁵CHU Lille, Lille, Nord-Pas-de-Calais, France, ⁶Saint-Antoine Hospital - AP-HP, Paris, Ile-de-France, France, ⁷Pellegrin Hospital, Rheumatology, Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases, Bordeaux, France, ⁸Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France, ⁹Sorbonne Université, Paris, France, ¹⁰Université Jean Monnet, CHU Saint-Etienne, Mines Saint-Etienne, INSERM SAINBIOSE 1059, Saint-Etienne, France, ¹¹CH LE MANS, LE MANS, Pays de la Loire, France, ¹²Lariboisière University Hospital, Paris, France, ¹³University hospital, Poitiers, France, ¹⁴Rheumatology department, CHU Montpellier, Montpellier, France, ¹⁵UBO, Brest, France, ¹⁶Clinique Universitaire de Médecine Interne, Department of Internal Medicine, Grenoble University Hospital, Grenoble, France, ¹⁷APHP, Hôpital Cochin, Paris, ¹⁸Cochin Hospital, Paris, France, ¹⁹University of Paris, INSERM Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Paris, France, ²⁰Service de Rhumatologie, Hôpital Bicêtre, AP-HP, le Kremlin Bicetre, Ile-de-France, France, ²¹Groupe Hospitalier Cochin, AP-HP, Paris, France
Background/Purpose: Spondyloarthritis (SpA) regularly affects women of childbearing age1. A higher obstetric morbidity in women with SpA is suggested in the literature in several countries,…
Abstract Number: 0556 • ACR Convergence 2024
Disease Duration, Age and Clinical Features Related to Aortic Valve Sclerosis in Patients with Spondyloarthritis
Asier García-Alija¹, Hye Sang Park¹, Patricia Moya¹, Ana Laiz¹, Carla Marco², Albert Casals¹, Concepcion Pitarch², Cesar Diaz-Torné¹, Berta Paula Magallares³, Ivan Castellvi Barranco¹, Susana Fernández-Sánchez¹, Andrea García-Guillen², Jose Luis Tandaipan¹, Helena Codes-Mendez¹, Guillem Verdaguer¹, Luis Sainz¹ and Hèctor Corominas¹, ¹Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ²Hospital Dos de Maig, Barcelona, Spain, ³Dept of Rheumatology, Hospital de la Santa Creu I Sant Pau, Barcelona, ES, Barcelona, Spain
Background/Purpose: Valve degeneration is prevalent in Spondylarthritis (SpA) patients according to descriptive studies, but it is also common in general population. Disease burden may be…
Abstract Number: 0578 • ACR Convergence 2024
Gender Differences in Disease Parameters, Adherence to Treat to Target Strategy and Outcomes in Axial Spondyloarthritis (axSpA) in Pakistani Cohort
Muhammad Saeed¹, HIna Ahmed² and Aziza Ahmed³, and Arthritis Carte Foundation Faculty, ¹Central Park Medical College, Arthritis Care Foundation, Lahore, Pakistan, ²Central Park Medical College, Lahore, Pakistan, ³Rashid Latif Medical College, Lahore, Pakistan
Background/Purpose: In patients with Axial Spondyloarthritis (axSpA) there has been wide variability in terms of gender regarding disease characteristics as well as outcomes across different…
Abstract Number: 1020 • ACR Convergence 2024
Health Inequalities Exist Between the United States and Europe for Patients with Axial Spondyloarthritis
Elena Nikiphorou¹, Alexis Ogdie², Dan Twigg³, Emily Quiñones⁴, You-Li Ling⁵, Karim Masri⁶, Joseph C. Cappelleri⁷, Lidia Sanchez-Riera⁸, Megan Hughes⁹ and NICOLA MASSEY⁹, ¹King's College London, London, United Kingdom, ²Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ³Adelphi Real World, Manchester, United Kingdom, ⁴Adelphi Real World, Macclesfield, United Kingdom, ⁵Pfizer Inc, New York, NY, ⁶Pfizer Inc, Collegeville, PA, ⁷Pfizer, Groton, ⁸Pfizer, Madrid, ⁹Adelphi Real World, Bollington, United Kingdom
Background/Purpose: Structural differences exist between the healthcare systems in the United States (US) and Europe. In real-world clinical settings, we investigated whether these differences create…
Abstract Number: 1447 • ACR Convergence 2024
The Frequency of Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Spondyloarthritis in Comparison to Age and Sex-matched Controls and Impact of SpA on Onset Age of DISH
Ummugulsum Gazel¹, Nicole Hryciw², Baljot Chahal³, Seyyid Bilal Acikgoz⁴, Gizem Ayan⁵, Zaid Jibri³, Marcos Loreto Sampaio³ and Sibel Aydin⁶, ¹University of Ottawa, Ottawa, ON, Canada, ²University of Ottawa, Ottawa, Canada, ³University of Ottawa, Radiology, Ottawa, Canada, ⁴University of Ottawa, Rheumatology, Ottawa, ON, Canada, ⁵University of Ottawa, Rheumatology, Ankara, Turkey, ⁶University of Ottawa - Ottawa, Ottawa, ON, Canada
Background/Purpose: Although diffuse idiopathic skeletal hyperostosis (DISH) is classically defined in the thoracic spine and the elderly population, there are case reports on the overlap…
Abstract Number: 1875 • ACR Convergence 2024
Assessing the PULSAR (Program to Understand the Longterm Outcomes in Spondyloarthritis) Registry for Environmental Determinants of Heath Research
Liya Stolyar¹, Diane Mar², Yuhan Liu³, Esther Velasquez⁴, orr Sharpe⁵, Michael Weisman⁶, Liron Caplan⁷ and suzanne Tamang⁸, ¹Palo Alto VA Medical Center/Stanford, Stanford, CA, ²Palo Alto VA Medical Center/Stanford University Medical Center, Palo Alto, CA, ³Stanford Medicine Quantitative Sciences Unit, Palo Alto, CA, ⁴Stanford Center for Population Health Sciences, Palo Alto, CA, ⁵Department of Immunology and Rheumatology, Stanford University, Stanford, CA, ⁶Stanford University, Los Angeles, CA, ⁷Univ of Colorado School of Medicine/Rocky Mtn Regional Veterans Affairs Medical Center, Aurora, CO, ⁸Stanford University, Atherton, CA
Background/Purpose: Acute exposure to air pollution has been associated with flares of psoriasis and chronic inflammatory arthritides in prior studies. However, the impact of air pollution,…

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