Abstracts tagged "spondyloarthritis"

Abstract Number: 2560 • ACR Convergence 2025
Quality and Accuracy of TikTok Videos on Axial Spondyloarthritis: A Modified DISCERN Analysis
Mahiar Rabie and Susan Harwell, University of Tennessee- Nashville, Nashville, TN
Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the axial skeleton that can cause significant pain and disability. Its variable and often non-specific…
Abstract Number: 2331 • ACR Convergence 2025
Coping with Rheumatic Stressors in Axial Spondyloarthritis: Association with Patient Characteristics and Disease Phenotypes and Changes Over Time
Marc van Essen¹, Dafne capelusnik², Désirée Van Der Heijde³, Robert Landewé⁴, Wim van Lankveld⁵, Astrid Van Tubergen⁶, Sofia Ramiro⁷ and Annelies Boonen⁸, ¹Maastricht University, Zeist, Netherlands, ²Tel Aviv Sourasky Medical Center, Ramat Gan, Israel, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Amsterdam University Medical Center, Amsterdam, Netherlands; and Zuyderland Medical Center, Heerlen, Netherlands, ⁵HAN University of Applied Sciences, Arnhem, Netherlands, ⁶Maastricht university, Maastricht, Netherlands, ⁷Leiden University Medical Center, Bunde, Netherlands, ⁸Maastricht University Medical Centre+ & Maastricht University, Maastricht, Limburg, Netherlands
Background/Purpose: To identify patient characteristics and disease phenotypes associated with coping strategies in axial spondyloarthritis (axSpA), and assess whether coping strategies change over time.Methods: Data…
Abstract Number: 2036 • ACR Convergence 2025
JAK1 selective inhibitors versus pan-JAK inhibitors: comparative real-world study of drug retention in chronic inflammatory arthritis
LETICIA LEON¹, Pedro Pablo Bermejo², Leonor Laredo³, José Alberto Peña⁴, María Teresa Benítez⁵, DALIFER FREITES⁶, CLARA DE MIGUEL³ and lydia Abasolo Alcazar⁷, ¹Fundación Investigación Biomédica Hospital Clínico San Carlos, IdISSC; Universidad Camilo Jose Cela, MADRID, Madrid, Spain, ²Clinical Pharmacology Service, San Carlos Clinical Hospital, MADRID, Madrid, Spain, ³Hospital Clinico San Carlos, MADRID, Madrid, Spain, ⁴Pharmacy Service San Carlos Clinical Hospital, MADRID, Madrid, Spain, ⁵San Carlos Clinical Hospital, MADRID, Madrid, Spain, ⁶Rheumatology Service, San Carlos Clinical Hospital, Madrid, Madrid, Spain, ⁷IdISSC. HCSC, Madrid, Madrid, Spain
Background/Purpose: Janus kinase inhibitors (JAKis) are effective therapeutic agents against chronic inflammatory arthritis (CIA). Tofacitinib and baricitinib were defined as pan-JAK inhibitors, while upadacitinib and…
Abstract Number: 1446 • ACR Convergence 2025
Persistence of Second-line Treatment in Anti-TNF-experienced Axial Spondyloarthritis Patients: Comparing Cycling Anti–TNF vs Switching to a Different Mechanism of Action
José Miguel Senabre¹, Lucia Otero², Jerusalén Calvo³, Vega Jovaní⁴, Javier Manero-Ruiz⁵, Rabadán Elena⁶, Eugenia Enriquez⁷, Yanira Pérez⁸, Alicia Garcia⁹, Francisca Sivera¹⁰, Olga Martínez¹¹, María Colazo Burlato¹², Diana Sueiro¹³, Fernando Sánchez-Alonso¹⁴ and Isabel Castrejón Fernández¹⁵, ¹Hospital Marina Baixa, Villajoyosa/Vila Joiosa, La, Comunidad Valenciana, Spain, ²Spanish Society of Rheumatology, Madrid, Spain, ³IMIBIC / Reina Sofia Hospital / University of Cordoba, Córdoba, Spain, ⁴Hospital General Universitario de Alicante, Reumatología, Alicante, Alicante, Comunidad Valenciana, Spain, ⁵Hospital Miguel Servet, Zaragoza, Spain, ⁶Hospital Universitario Príncipe de Asturias, Alcala de Henares, Spain, ⁷Clínica Universidad de Navarra, Madrid, Spain, ⁸Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain, ⁹Rheumatologist, La Laguna, Spain, ¹⁰Hospital General Universitario Elda, Elda, Spain, ¹¹Hospital Universitario de Salamanca, Salamanca, Castilla y Leon, Spain, ¹²Hospital Universitario de Burgos, Burgos, Spain, ¹³Complexo Hospitalario Universitario de Ourense, Ourense, ¹⁴Sociedad Española de Reumatología, Madrid, Spain, ¹⁵MD, PhD, Madrid, Madrid, Spain
Background/Purpose: Failure of a first-line anti-TNF in axial spondyloarthritis (axSpA) is common, and when it occurs, there are no randomized clinical trials (RCTs) comparing the…
Abstract Number: 1406 • ACR Convergence 2025
A Combined Score of Facet Joint Ankylosis and Syndesmophyte Development Correlates Well with Spinal Mobility in Axial Spondyloarthritis
Ana Bento da Silva¹, Floris A. van Gaalen¹, Robert Landewé², Manouk de Hooge³, Mary Lucy Marques⁴, Miranda van Lunteren¹, Liese de Bruin¹, Gizem Ayan⁵, Xenofon Baraliakos⁶, Monique Reijnierse⁷, Jürgen Braun⁸, Désirée Van Der Heijde¹ and Sofia Ramiro⁹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Amsterdam University Medical Center, Amsterdam, Netherlands; and Zuyderland Medical Center, Heerlen, Netherlands, ³Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands; and Coimbra Local Health Unit, Coimbra, Portugal, ⁵Ankara Research and Training Hospital, Ankara, Turkey, ⁶Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁷Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁸Ruhr-University, Bochum, Germany; and Rheumatologische Versorgungszentrum (RVZ) Steglitz, Berlin, Germany, ⁹Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: In axial SpA (axSpA), the computed tomography (CT) syndesmophyte score (CTSS) has shown to capture more spinal structural damage progression and to better correlate…
Abstract Number: 0854 • ACR Convergence 2025
The Assessments in Spondyloarthritis International Society (ASAS) and Spondyloarthritis Research and Treatment Network (SPARTAN) Revised Classification Criteria for Axial Spondyloarthritis: Development and Validation in the Classification of Axial SpA Inception Cohort Study
Walter P. Maksymowych¹, Désirée van der Heijde², Liron Caplan³, Robert Landewé⁴, Lianne S. Gensler⁵, Pedro Machado⁶, Alexandre Sepriano⁷, Floris A. van Gaalen², Miranda van Lunteren², Ben Vandermeer⁸, Servet Akar⁹, Sibel Aydin¹⁰, Xenofon Barliakos¹¹, Wilson bautista molano¹², Stephanie Bernard¹³, RUBEN BURGOS-VARGAS¹⁴, John Carrino¹⁵, Alberto Cauli¹⁶, Jonathan Chan¹⁷, Abhijeet Danve¹⁸, Torsten Diekhoff¹⁹, Maxime Dougados²⁰, iris Eshed²¹, Warren Fong²², Rodrigo García Salinas²³, Hildrun Haibel²⁴, Nigil Haroon²⁵, Kay-Geert Hermann²⁶, Lennart Jans²⁷, Anne Jurik²⁸, Uta Kiltz²⁹, Tae-Jong Kim³⁰, Robert G. W. Lambert³¹, Clementina López Medina³², Ennio Lubrano³³, Marina Magrey³⁴, Vikas Majithia³⁵, Helena Marzo-Ortega³⁶, Philip J. Mease³⁷, Victoria Navarro-Compan³⁸, John O'Neill³⁹, Mikkel Ostergaard⁴⁰, Salih Ozgocmen⁴¹, Susanne Pedersen⁴², Fernando Pimentel-Santos⁴³, Denis Poddubnyy⁴⁴, Fabian Proft⁴⁵, Sofia Ramiro⁴⁶, Monique Reijnierse⁴⁷ and John Reveille⁴⁸, ¹Department of Medicine, University of Alberta, ⁵⁶⁸ Heritage Building, Edmonton, AB, Canada, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Medicine Service, Rocky Mountain Regional VAMC, Aurora, CO, ⁴Department of Rheumatology, Amsterdam University Medical Center, Amsterdam, Netherlands; and Zuyderland Medical Center, Heerlen, Netherlands, ⁵Department of Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁶Department of Rheumatology, University College London, and Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust, Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, ⁷Department of Rheumatology, Leiden University Medical Centre, Portela Loures, Portugal, ⁸Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁹Department of Medicine, Izmir Katip Çelebi University School of Medicine, Izmir, Turkey, ¹⁰Department of Medicine, University of Ottawa, The Ottawa Hospital Research Institute, Ottawa, ON, Canada, ¹¹Ruhr-University Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany, ¹²University Hospital Fundacion Santa Fe de Bogota, Bogota, Colombia, ¹³Department of Radiology, Brooke Army Medical Center, Fort Sam Houston, TX, ¹⁴Department of Rheumatology, Hospital General de Mexico, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, Ciudad de México, Mexico, ¹⁵Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY, ¹⁶Rheumatology Unit, Department of Medicine and Public Health, AOU and University of Cagliari, Cagliari, Italy, ¹⁷Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ¹⁸Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT, ¹⁹Department of Radiology, Immanuel Clinic Ruedersdorf, Brandenburg Medical School, Ruedersdorf, Germany, ²⁰Department of Medicine, Hopital Cochin, Universite de Paris, Paris, France, ²¹Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer affiliated with School of Medicine, Tel Aviv University, Tel Aviv, Israel, ²²Department of Medicine, Singapore General Hospital, Singapore, Singapore, ²³Hospital Italiano La Plata, La Plata, Argentina, ²⁴Charite- University Medicine Berlin Campus Benjamin Franklin, Berlin, Germany, ²⁵Department of Medicine/Rheumatology, University Health Network, Schroeder Arthritis Institute, University of Toronto, Toronto, ON, Canada, ²⁶Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²⁷Department of Radiology, Ghent University Hospital, Ghent, Belgium, ²⁸Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, ²⁹Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ³⁰Department of Medicine, Chonnam National University Hospital, Seoul, Republic of Korea, ³¹University of Alberta, Department of Radiology & Diagnostic Imaging, Edmonton, AB, Canada, ³²Department of Medicine, Hospital Universitario Reina Sofia, University of Cordoba, IMIBIC, Cordoba, Spain, ³³Department of Medicine, Università deglia Studi del Molise, CAMPOBASSO, Italy, ³⁴Case Western Reserve University School of Medicine/University Hospitals Cleveland, Richfield, OH, ³⁵Mayo Clinic Hospital, Jacksonville, FL, ³⁶NIHR Leeds Biomedical Research Centre, The Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom, ³⁷Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, ³⁸Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ³⁹Department of Radiology, McMaster University, Hamilton, ON, Canada, ⁴⁰Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, and Copenhagen Center for Arthritis Research, Center for Rheumatology, Rigshospitalet, Glostrup, Denmark, ⁴¹Department of Rheumatology, Istinye University/Faculty of Medicine, Istanbul, Turkey, ⁴²Department of Medicine, Rigshopital, University of Copenhagen, Copenhagen, Denmark, ⁴³NOVA Medical School, Universidade NOVA e Lisboa, Lisboa, Portugal, ⁴⁴Division of Rheumatology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada, and Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Department of Epidemiology, German Rheumatism Research Centre, Berlin, Germany, ⁴⁵Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ⁴⁶Leiden University Medical Center, Bunde, Netherlands, ⁴⁷Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴⁸Department of Medicine, University of Texas Medical Center, Houston, TX
Background/Purpose: The 2009 ASAS classification criteria had sensitivity (Sn) of 83% and specificity (Sp) of 84% for a rheumatologist diagnosis of axial spondyloarthritis (axSpA). Given…
Abstract Number: 0529 • ACR Convergence 2025
Anti-PeptidylArginine Deiminase-2 (anti-PAD2) Autoantibodies in Psoriatic Arthritis
Ana-Maria Orbai¹, Hong Wang², Maria Grecu³, Ning Meng⁴, Ji Soo Kim⁵, Clifton Bingham⁴, Uzma Haque², John Miller⁴, Felipe Andrade², Erika Darrah⁶ and Eleni Tiniakou⁷, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³River Hill High School, Clarksville, MD, ⁴Johns Hopkins University, Baltimore, MD, ⁵Johns Hopkins, Baltimore, MD, ⁶Astra Zeneca, Gaithersburg, MD, ⁷UT Health Science Houston, Houston, TX
Background/Purpose: Citrullinated cathelicidin (LL37), a human-derived antimicrobial peptide, is an autoantigen in psoriatic arthritis (PsA).1 LL37 citrullination by peptidylarginine deiminase (PAD) enzymes attenuates immune activation…
Abstract Number: 0101 • ACR Convergence 2025
Enrichment of putative bacteria-reactive gut-derived IL-17+ tissue resident memory helper T cells in arthritic ankles in the SKG mouse model of spondyloarthritis
Benjamin Cai¹, Megan Soon², Zewen Kelvin Tuong², Mark Morrison², Anne-Sophie Bergot³ and Ranjeny Thomas⁴, ¹Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia, ²Frazer Institute, The University of Queensland, Brisbane, Australia, ³Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia, ⁴Frazer Institute, University of Queensland, Brisbane, Queensland, Australia
Background/Purpose: In spondyloarthropathy (SpA), arthritis is often associated with gut inflammation. The strong genetic association with HLA-B27 implicates involvement of T cells, but how gut…
Abstract Number: 2367 • ACR Convergence 2025
Real-World Effectiveness of Risankizumab on Axial Symptoms in Biologic-Naïve Patients With Psoriatic Arthritis in the United States and Europe
Philip J. Mease¹, Andrew Ostor², Christopher Saffore³, Xiaolan Ye⁴, Manish Patel⁵, Ana Biljan⁶, Ralph Lippe⁵, Molly Edwards⁷, Iwan Armstrong⁷ and Xenofon Baraliakos⁸, ¹Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, ²Australian National University, Canberra, Australia, ³AbbVie Inc., waukegan, IL, ⁴AbbVie Inc., Mettawa, IL, ⁵AbbVie Inc., North Chicago, IL, ⁶AbbVie Inc., Buffalo Grove, IL, ⁷Adelphi Real World, Bollington, United Kingdom, ⁸Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany
Background/Purpose: Axial involvement is a clinically relevant manifestation of psoriatic arthritis (PsA) that can influence management strategies. Evidence on the real-world effectiveness of advanced therapies,…
Abstract Number: 2332 • ACR Convergence 2025
Development and validation of a Disease Activity index for PSoriatic Arthritis based on 44 joints: DAPSA44
Dafne capelusnik¹, Clementina López Medina², Désirée Van Der Heijde³, Daniel Aletaha⁴, Josef Smolen⁵, Anna Molto⁶ and Sofia Ramiro⁷, ¹Tel Aviv Sourasky Medical Center, Ramat Gan, Israel, ²Department of Medicine, Hospital Universitario Reina Sofia, University of Cordoba, IMIBIC, Cordoba, Spain, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Medical University Vienna, Wien, Austria, ⁵Division of Rheumatology, Department of Medicine ³, Medical University of Vienna, Vienna, Austria, Vienna, Austria, ⁶Assistance Publique Hôpitauxde Paris, Paris, France, ⁷Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: Recent studies have highlighted the potential of composite scores such as the DAPSA for assessing peripheral arthritis in axSpA and pSpA. However, the swollen…
Abstract Number: 1984 • ACR Convergence 2025
Improving Lipid Screening Rates in Rheumatic Disease Patients: An Academic Fellowship Quality Improvement Project
Mahnoor Javed¹, Deepak Jagannath², Lilly Morgan¹, Rishi Patel¹, Eleonora Avenatti¹, Kanika Monga¹ and Kenneth Williams¹, ¹Houston Methodist, Houston, ²Houston Methodist Hospital, Sugar Land, TX
Background/Purpose: Autoimmune diseases, including rheumatoid arthritis (RA) and spondyloarthritis (SpA)—which encompasses ankylosing spondylitis (AS) and psoriatic arthritis (PsA)—are associated with chronic inflammation and increased cardiovascular…
Abstract Number: 1445 • ACR Convergence 2025
Patient Characteristics, and Physician-Reported Treatment Effectiveness and Treatment Satisfaction with Bimekizumab for Axial Spondyloarthritis in the United States: Interim Analysis from a Real-World Study
Jessica A. Walsh¹, Abhijeet Danve², Isabel Truman³, Dan Twigg³, Hervé Besson⁴ and Helena Roque⁵, ¹Division of Rheumatology, Salt Lake City Veterans Affairs Health and University of Utah Health, Salt Lake City, UT, ²Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT, ³Adelphi Real World, Bollington, United Kingdom, ⁴UCB, Breda, Netherlands, ⁵UCB, Brussels, Belgium
Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic inflammatory condition affecting the sacroiliac joints and spine.1 Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits…
Abstract Number: 1405 • ACR Convergence 2025
A Combined Score of Syndesmophytes and Facet Joint Ankylosis Improves Sensitivity to Spinal Structural Damage Progression in Axial Spondyloarthritis
Ana Bento da Silva¹, Floris A. van Gaalen¹, Robert Landewé², Manouk de Hooge³, Mary Lucy Marques⁴, Miranda van Lunteren¹, Liese de Bruin¹, Gizem Ayan⁵, Xenofon Baraliakos⁶, Monique Reijnierse⁷, Jürgen Braun⁸, Désirée Van Der Heijde¹ and Sofia Ramiro⁹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Amsterdam University Medical Center, Amsterdam, Netherlands; and Zuyderland Medical Center, Heerlen, Netherlands, ³Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands; and Coimbra Local Health Unit, Coimbra, Portugal, ⁵Ankara Research and Training Hospital, Ankara, Turkey, ⁶Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁷Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁸Ruhr-University, Bochum, Germany; and Rheumatologische Versorgungszentrum (RVZ) Steglitz, Berlin, Germany, ⁹Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: The computed tomography (CT) syndesmophyte score (CTSS) has shown to be more sensitive in capturing spinal structural damage progression in axial SpA (axSpA), compared…
Abstract Number: 0550 • ACR Convergence 2025
Clinical and Genetic Factors Associated with Anti-TNF Therapy Initiation in Radiographic Axial Spondyloarthritis: A 15-Year Observational Study
Tae-jong Kim¹, Bora Nam², So-Young Bang³, Youngho Park⁴, Ji Hui Shin⁵, Sungsin Jo⁶ and Tae-Hwan Kim⁷, ¹Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwang-Ju, South Korea, ²Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Hanyang University, Seoul, Republic of Korea, ⁴Department of Big Data Application College of Smart Convergence, Hannam University, Daejeon, Republic of Korea, ⁵Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁶Department of Biology, Soonchunhyang University, Asan,, Republic of Korea, ⁷Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea
Background/Purpose: To identify clinical and genetic factors associated with the initiation of anti-TNF (tumor necrosis factor) therapy in patients with radiographic axial spondyloarthritis (r-axSpA) who…
Abstract Number: 0524 • ACR Convergence 2025
Radiographic progression in sacroiliac joints in five years follow up in non-radiographic axial spondyloarthritis patients and the predictive factors
Esra Erpek¹, Hasan Kocaayan², Elif Ediboğlu³, Ayberk Sinci⁴, Özgür Tosun⁴, Dilek Solmaz³ and Servet Akar⁵, ¹İzmir Katip Çelebi Üniversitesi, Romatoloji Bilim Dalı, İzmir, Izmir, Turkey, ²Izmir Katip Çelebi University School of Medicine, Rheumatology, Turkey, İzmir, Turkey, ³Izmir Katip Çelebi University School of Medicine, Rheumatology, Turkey, İzmir, Izmir, Turkey, ⁴İzmir Katip Çelebi Üniversitesi, Radyoloji Bilim Dalı, İzmir, Izmir, Turkey, ⁵Department of Medicine, Izmir Katip Çelebi University School of Medicine, Izmir, Turkey
Background/Purpose: This study aimed to assess the rate of progression in sacroiliac joints in non-radiographic axial spondyloarthritis (nr-axSpA) and to identify the predictive factors for…

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