Abstracts tagged "spondyloarthritis"

Abstract Number: 0059 • ACR Convergence 2021
Deep Immune Cell Profiling of Tissue Microenvironment Using Imaging Mass Cytometry in Psoriatic Disease
Lihi Eder¹, Stephane Caucheteux¹, Somi Afiuni², Adriana Krizova¹, James Limacher¹, Hartland Jackson¹ and Vincent Piguet¹, ¹University of Toronto, Toronto, ON, Canada, ²Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada
Background/Purpose: Cross talk between different cell types, such as T cell subsets and other immune cell populations, is important in psoriatic disease. Imaging Mass Cytometry…
Abstract Number: 0366 • ACR Convergence 2021
Why Is It so Difficult for AxSpA Patients to Find a Job? Results from the European Map of Axial Spondyloarthritis (EMAS)
Marco Garrido-Cumbrera¹, Victoria Navarro-Compán², Christine Bundy³, Souzi Makri⁴, Laura Christen⁵, José Correa-Fernández⁶, Sergio Sanz-Gomez⁶, Raj Mahapatra⁷, Carlos Jesús Delgado-Domínguez⁶ and Denis Poddubnyy⁸, ¹Health & Territory Research (HTR), University of Seville, Sevilla, Spain, ²Rheumatology service, Hospital Universitario La Paz-IdiPaz, Madrid, Spain, ³Cardiff University, Cardiff, Wales, United Kingdom, ⁴Cyprus League Against Rheumatism (CYPLAR), Limassol, Cyprus, ⁵Novartis Pharma AG, Basel, Switzerland, ⁶Health & Territory Research (HTR), Universidad de Sevilla, Seville, Spain, ⁷Axial Spondyloarthritis International Federation (ASIF), London, United Kingdom, ⁸Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany
Background/Purpose: AxSpA is associated with substantial negative consequences regarding work status and career prospects. The aim is to identify factors associated with barriers to job…
Abstract Number: 0384 • ACR Convergence 2021
A Tough Cell: The Argument for a Biomarker of Clinical and Imaging Outcomes in Spondyloarthritis: The Neutrophil Lymphocyte Ratio and the Platelet Lymphocyte Ratio
Rouhin Sen¹, Emmeline Kim², Elizabeth Cheng³, Kavya Ganuthula⁴, Meika Fang⁵, Gail Kerr⁶, Jessica Walsh⁷, Elizabeth Chang⁸, Siba Raychaudhuri⁹, Andreas Reimold¹⁰ and Liron Caplan¹¹, ¹University of Colorado School of Medicine/Rocky Mountain Regional Veterans Affairs Medical Center (VAMC), Denver, CO, ²University of Colorado School of Medicine, Aurora, CO, ³Rocky Mountain Regional VAMC, Aurora, CO, ⁴Rocky Mountain Regional VAMC/University of Colorado School of Medicine, Aurora, CO, ⁵David Geffen School of Medicine at UCLA/West Los Angeles Veterans Affairs Medical Center (VAMC), Los Angeles, CA, ⁶Washington D.C., Veterans Affairs Medical Center (VAMC)/Georgetown and Howard Universities, Washington, DC, ⁷Salt Lake City Veteran Affairs Medical Center (VAMC)/University of Utah Hospital, Salt Lake City, UT, ⁸Phoenix Veterans Affairs Medical Center (VAMC), Phoenix, AZ, ⁹Sacramento Veterans Affairs Medical Center (VAMC)/University of California-Davis Health, Davis, CA, ¹⁰University of Texas – Southwestern Medical Center/Dallas Veterans Affairs Medical Center (VAMC), Dallas, TX, ¹¹Rocky Mountain Regional Veterans Affairs Medical Center (VAMC)/University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Biomarkers of disease activity/severity and imaging outcomes in axial spondyloarthritis (axSpA) remain a challenge. The most common relevant biomarker is the C-Reactive Protein (CRP),…
Abstract Number: 0907 • ACR Convergence 2021
Radiographic Sacroiliitis Progression up to Six Years of Follow-Up in Patients with Non-Radiographic Axial Apondyloarthritis
Stan Kieskamp¹, Rick Wilbrink², Freke Wink³, Reinhard Bos⁴, Hendrika Bootsma¹, Suzanne Arends¹ and Anneke Spoorenberg¹, ¹University Medical Center Groningen, Groningen, Netherlands, ²University of Groningen, Leeuwarden, Netherlands, ³Medical Center Leeuwarden, Leeuwarden, Netherlands, ⁴Department of Rheumatology, Medical Centre Leeuwarden, Leeuwarden, Netherlands
Background/Purpose: In two years, approximately 10% of patients with non-radiographic axial spondyloarthritis (nr-axSpA) progresses to ankylosing spondylitis (AS). There are no data available of more…
Abstract Number: 0936 • ACR Convergence 2021
Factors Associated with the Development of Anti-drug Antibodies to Tumour Necrosis Factor Inhibitors in Patients with Axial Spondyloarthritis; A Two Year Follow-up Study
Elif Ediboglu¹, Dilek Solmaz², Gokhan Kabadayi³, Mustafa Ozmen⁴, Kübra Kaya⁵, Muhammet Çınar⁶, Gökhan Sargın⁷, Gülen Hatemi⁸, Ömer Karadağ⁹, Gülay Kınıklı¹⁰, Onay Gercik¹¹, Umut Kalyoncu⁹, Sedat Yılmaz⁶, Taskın Şentürk⁷, Gokhan Keser¹², Figen Yargucu¹², Ayse Cefle¹³, Didem Kozacı⁵, Bünyamin Kısacık¹⁴ and Servet Akar², ¹Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ²Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir, Turkey, ³Cigli Education and Research Hospital, İzmir, Turkey, ⁴katip çelebi university, izmir, Turkey, ⁵Yıldırım Beyazit University, Ankara, Turkey, ⁶Gülhane Education and Research Hospital, Ankara, Turkey, ⁷Adnan Menderes University, Aydın, Turkey, ⁸Istanbul University‒Cerrahpaşa, Cerrahpaşa Medical School and Behçet’s Disease Research Center, İstanbul, Turkey, ⁹Hacettepe University, Ankara, Turkey, ¹⁰Ankara University, Ankara, Turkey, ¹¹Izmir Katip Celebi University, Izmir, Turkey, ¹²Ege University, İzmir, Turkey, ¹³Kocaeli University, Kocaeli, Turkey, ¹⁴Gaziantep Medicalpark Hospital, Gaziantep, Turkey
Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease affecting sacroiliac joints and spine as well as peripheral joints and entheses. Tumour necrosis factor…
Abstract Number: 1316 • ACR Convergence 2021
Vitamin D Deficiency and Disease Activity in Patients with Spondyloarthritis
Maria Rato¹, Filipe Pinheiro¹, Salomé Garcia¹, Bruno Fernandes², Ana Martins¹, Daniela Oliveira¹, Frederico Martins³, Diogo Fonseca⁴, Alexandra Bernardo¹, Miguel Bernardes¹ and Lúcia Costa¹, ¹Rheumatology Department, Centro Hospitalar Universitário de São João EPE, Porto, Portugal, ²Rheumatology Department, Centro Hospitalar Universitário de São João EPE, Braga, Portugal, ³Rheumatology Department, Centro Hospitalar Universitário do Algarve EPE, Algarve, Portugal, ⁴Rheumatology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE, Gaia, Portugal
Background/Purpose: There are increasing data about vitamin D immunomodulatory potential in different rheumatologic disorders. Deficiency of vitamin D is frequent in patients with spondyloarthritis (SpA)…
Abstract Number: 1788 • ACR Convergence 2021
Improving Care and Capacity Through Capturing and Recording Patient Reported Outcomes with Digital Solutions in Spondyloarthritis
Antoni Chan¹, Kathryn Rigler¹ and Liz van Rossen², ¹Royal Berkshire NHS Foundation Trust, Reading, United Kingdom, ²East Kent NHS Foundation Trust, Kent, United Kingdom
Background/Purpose: Patient-reported outcomes (PROs) have always been at the forefront for the assessment of spondyloarthritis (SpA) which includes axial Spa (axSpA) and psoriatic arthritis (PsA).…
Abstract Number: 0062 • ACR Convergence 2021
Axial Spondyloarthritis and Its Related Immune-Mediated Diseases Share a Gut Microbiome Signature Besides Their Own Distinctive Profile
Valeria Rios Rodriguez¹, Morgan Essex², Judith Rademacher¹, Fabian Proft¹, Ulrike Löber², Lajos marko², Uwe Pleyer³, Britta Siegmund⁴, Denis Poddubnyy⁵ and Sofia Forslund⁶, ¹Charité University Medicine Berlin, Berlin, Germany, ²Experimental and Clinical Research Center of the MDC and Charité Berlin, Berlin, Germany, ³Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin; Department of Ophthalmology, Berlin, Germany, ⁴Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin. Department of Gastroenterology, Infectious Diseases and Rheumatology (including Nutrition Medicine), Berlin, Germany, ⁵Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, ⁶Experimental an dclinical Research Center of the MDC and Charité Berlin, Berlin, Germany
Background/Purpose: Deep profiling of gut microbiota may reveal new pathways of how SpA and its related diseases such as Crohn’s disease (CD) and acute anterior…
Abstract Number: 0367 • ACR Convergence 2021
Can Belonging to an AxSpA Patient Organization Be Associated with Benefits to Its Members? Results from the European Map of Axial Spondyloarthritis (EMAS)
Marco Garrido-Cumbrera¹, Souzi Makri², Denis Poddubnyy³, Christine Bundy⁴, Laura Christen⁵, Sergio Sanz-Gomez⁶, José Correa-Fernández⁶, Raj Mahapatra⁷, Carlos Jesús Delgado-Domínguez⁶ and Victoria Navarro-Compán⁸, ¹Health & Territory Research (HTR), University of Seville, Sevilla, Spain, ²Cyprus League Against Rheumatism (CYPLAR), Limassol, Cyprus, ³Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, ⁴Cardiff University, Cardiff, Wales, United Kingdom, ⁵Novartis Pharma AG, Basel, Switzerland, ⁶Health & Territory Research (HTR), Universidad de Sevilla, Seville, Spain, ⁷Axial Spondyloarthritis International Federation (ASIF), London, United Kingdom, ⁸Rheumatology service, Hospital Universitario La Paz-IdiPaz, Madrid, Spain
Background/Purpose: Patient organizations (POs) provide education and support services aimed to improve the quality of life of axSpA patients. This analysis aims to identify factors…
Abstract Number: 0450 • ACR Convergence 2021
Identifying Trajectories of Radiographic Spinal Disease in Ankylosing Spondylitis
Mark Hwang¹, Minjae Lee², Lianne Gensler³, Matthew Brown⁴, Amirali Tahanan⁵, Mohammad Rahbar⁶, Theresa Hunter⁷, Mingyan Shan⁸, Mariko Ishimori⁹, John Reveille¹⁰, Michael Weisman¹¹ and Thomas Learch¹², ¹McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ²UT Southwestern, Dallas, TX, ³Department of Rheumatology, University of California San Francisco, San Francisco, CA, ⁴King's College London, London, United Kingdom, ⁵McGovern Medical School, Houston, TX, ⁶Division of Clinical and Translational Sciences, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, ⁷Eli Lilly and Company, Indianapolis, IN, USA, Indianapolis, IN, ⁸Eli Lilly and Company, Indianapolis, IN, ⁹Cedars-Sinai Health System, Los Angeles, CA, ¹⁰Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, ¹¹Adjunct Professor of Medicine, Stanford University; Distinguished Professor of Medicine Emeritus, David Geffen School of Medicine at UCLA, Los Angeles, CA, ¹²Cedars-Sinai, Los Angeles, CA
Background/Purpose: Little is known about the natural history of spinal disease in Ankylosing Spondylitis (AS). Our objective was to identify distinct patterns of change in…
Abstract Number: 0910 • ACR Convergence 2021
The Association of TNF Inhibitor Use with Incident Hypertension in Ankylosing Spondylitis: Data from the PSOAS Cohort
Jean Liew¹, S. Reza Jafarzadeh², Maureen Dubreuil³, Susan Heckbert⁴, Stephen Mooney⁴, Matthew Brown⁵, Mariko Ishimori⁶, John Reveille⁷, Michael Ward⁸, Michael Weisman⁹ and Lianne Gensler¹⁰, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Boston University School of Medicine/ VA Boston, Boston, MA, ⁴University of Washington, Seattle, WA, ⁵King's College London, London, United Kingdom, ⁶Cedars-Sinai Health System, Los Angeles, CA, ⁷Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, ⁸Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States, Rockville, MD, ⁹Adjunct Professor of Medicine, Stanford University; Distinguished Professor of Medicine Emeritus, David Geffen School of Medicine at UCLA, Los Angeles, CA, ¹⁰Department of Rheumatology, University of California San Francisco, San Francisco, CA
Background/Purpose: Ankylosing spondylitis (AS) is associated with greater cardiovascular (CV) risk than in the general population. The impact of tumor necrosis factor inhibitors (TNFi) on…
Abstract Number: 0938 • ACR Convergence 2021
Comparative Effectiveness and Treatment Survival of Different TNF Inhibitors for Axial Spondyloarthritis in Real-World Clinical Practice
Javier Marrugo¹, Maude Bonin¹, Gilles Boire¹, Louis Bessette² and Ariel Masetto¹, ¹Universite de Sherbrooke, Sherbrooke, QC, Canada, ²Centre de l'Ostoporose et de Rhumatologie de Qubec, Québec City, QC, Canada
Background/Purpose: Tumor necrosis factor (TNF) inhibitors are the mainstay treatment for NSAID refractory axial spondyloarthritis (axSpA). However, few data exist on their use during routine…
Abstract Number: 1317 • ACR Convergence 2021
Impairment of Memory in Axial Spondyloarthritis?
Stefan Kleinert¹, Florian Schuch², Praxedis Rapp², Monika Ronneberger², Joerg Wendler², Patrizia Sternad³, Florian Popp³, Peter Bartz-Bazzanella⁴, Cay Von der Decken⁵, Kirsten Karberg⁶, Georg Gauler⁷, Patrick Wurth⁸, Susanna Späthling-Mestekemper⁹, Christoph Kuhn¹⁰, Mathias Englbrecht¹¹, Wolfgang Vorbrüggen¹², Georg Adler¹³ and Martin Welcker¹⁴, ¹Praxisgemeinschaft Rheumatologie - Nephrologie (PGRN), Erlangen, Germany, ²Praxisgemeinschaft Rheumatologie-Nephrologie, Erlangen, Germany, ³Medizinisches Versorgungszentrum für Rheumatologie Dr. M. Welcker GmbH, Planegg, Germany, ⁴Rhein-Maas Klinikum, Wuerselen, Germany, ⁵Klinik für Internistische Rheumatologie, Rhein-Maas-Klinikum, Würselen, Germany, ⁶Praxis für Rheumatologie und Innere Medizin, Berlin, Germany, Berlin, Germany, ⁷rheumapraxis, Osnabrck, Germany, ⁸Rheumatologische Schwerpunktpraxis, Osnabrück, Germany, ⁹Rheumapraxis München, München, Germany, ¹⁰Praxis für Rheumatologie, Karlsruhe, Germany, Karlsruhe, Germany, ¹¹Freelance Healthcare Data Scientist, Eckental, Germany., Eckental, Germany, ¹²Verein zur Förderung der Rheumatologie e.V., Würselen, Germany, ¹³Institut für Studien zur Psychischen Gesundheit (ISPG), Mannheim, Germany, ¹⁴MVZ für Rheumatologie, Planegg, Germany
Background/Purpose: There is certain evidence that neuropsychiatric changes occur in systemic lupus(1) and rheumatoid arthritis (2). However, there is little knowledge about possible cognitive changes…
Abstract Number: 1790 • ACR Convergence 2021
Regional Differences in Clinical Characteristics and Treatment of Psoriatic Arthritis with Axial Involvement: Results from the Cross Sectional International ASAS PerSpA Study
Haruki Sawada¹, Mitsumasa Kishimoto², Kurisu Tada¹, Gautam Deshpande³, Daiki Kobayashi⁴, Keisuke Ono⁵, Yoshinori Taniguchi⁶, Ayako Hirata⁷, Hideto Kameda⁷, Shigeyoshi Tsuji⁸, Yuko Kaneko⁹, Tadashi Okano¹⁰, Yoichiro Haji¹¹, Hiroaki Dobashi¹², Akimichi Morita¹³, Akihiko Asahina¹⁴, Masato Okada¹⁵, Tetsuya Tomita¹⁶, Diego Benavent¹⁷, Chamaida Plasencia-Rodríguez¹⁸, Victoria Navarro-Compán¹⁷, Clementina López Medina¹⁹, Anna Molto²⁰, Désirée van der Heijde²¹, Maxime Dougados²² and Naoto Tamura¹, ¹Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan, ²Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Yokohama, Japan, ³Department of General Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan, ⁴Department of Internal Medicine, St. Luke's International Hospital, Tokyo, Japan, ⁵Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, ⁶Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Nankoku, Japan, ⁷Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan, ⁸Department of Orthopedics and Rheumatology, National Hospital Organization Osaka Minami Medical Center, Osaka, Japan, ⁹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ¹⁰Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ¹¹Department of Rheumatology, Daido Hospital, Nagoya, Japan, ¹²Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan, ¹³Department of Geriatric and Environmental Dermatology, Nagoya City University, Nagoya, Japan, ¹⁴Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan, ¹⁵Immuno-Rheumatology Center, St. Luke’s International Hospital, Tokyo, Japan, ¹⁶Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, Suita Osaka, Japan, ¹⁷Rheumatology service, Hospital Universitario La Paz-IdiPaz, madrid, Spain, ¹⁸Immuno-Rheumatology Research Group, Hospital La Paz Institute for Health Research-IdiPAZ, Rheumatology, La Paz University Hospital, Madrid, Spain, ¹⁹Department of Rheumatology, Reina Sofia Hospital, IMIBIC, University of Cordoba, Cordoba, Spain/ Department of Rheumatology, University of Paris, Cochin Hospital, Paris, France, ²⁰Department of Rheumatology, University of Paris, Cochin Hospital, Paris, France, ²¹Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, ²²Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France
Background/Purpose: Psoriatic arthritis (PsA) shares genetic and clinical features with other forms of spondyloarthritis (SpA). However, no studies have evaluated regional differences regarding characteristics of…
Abstract Number: 0064 • ACR Convergence 2021
Prevalence, Incidence and Predictor Features of Uveitis in Spondyloarthritis in a Canadian Cohort
Vanessa Ocampo¹, Mitchell Sutton², Steve Ramkissoon¹, Alexander Kaplan³, Nigil Haroon⁴ and Dafna Gladman⁵, ¹University Health Network, Toronto, ON, Canada, ²University of Toronto, University Health Network, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Spondyloarthritis (SpA) encompasses Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA), Inflammatory bowel disease- associated spondyloarthritis (IBD-SpA), Reactive Arthritis (ReA), and undifferentiated spondyloarthritis. These conditions share…

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