Abstracts tagged "spondyloarthritis"

Abstract Number: 1707 • ACR Convergence 2024
TRBV9-Targeted Bispecific T Cell-Engaging Antibodies to Reset the Autoreactive T Cell Compartment in Spondyloarthritis and HLA-DQ8 Celiac Disease
Stephanie Glavaris, Alexander Pearlman, Jin Liu, Jiaxin Ge, Yuanxuan Xia, Kyle J. Kaeo, Tolulope Awosika, Colin Gliech, Tushar Nichakawade, Nikita Marcou, Chetan Bettegowda, Drew Pardoll, Kenneth W. Kinzler, Shibin Zhou, Bert Vogelstein, Suman Paul and Maximilian F. Konig, The Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Therapies that indiscriminately deplete all T cells carry a high risk of opportunistic infection, precluding their widespread use in T cell-mediated autoimmune diseases. Targeting…
Abstract Number: 2313 • ACR Convergence 2024
Race and Ethnicity as Predictors of Diagnostic Delay in Psoriatic Arthritis and Axial Spondyloarthritis
Christine Loftis¹, Liron Caplan², Joanna Padilla Zepeda³, Nicole Mukooba³, Mayan Caplan³, Meika Fang⁴, Liya Stolyar⁵, Jessica Walsh⁶, Gail Kerr⁷, Siba Raychaudhuri⁸, Andreas Reimold⁹ and Maida Wong¹⁰, ¹University of Colorado Anschutz School of Medicine, Aurora, CO, ²Univ of Colorado School of Medicine/Rocky Mtn Regional Veterans Affairs Medical Center, Aurora, CO, ³University of Colorado, Aurora, CO, ⁴Veterans Affairs, Los Angeles, ⁵Veterans Affairs, Palo Alto, ⁶Veterans Affairs, Salt Lake City, UT, ⁷Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, ⁸Veterans Affairs, Sacramento, ⁹University of Texas Southwestern Medical School, Dallas, ¹⁰Veterans Affairs, Long Beach
Background/Purpose: Studies have suggested a delay between symptom onset and diagnosis for Psoriatic Arthritis (PsA) and axial spondyloarthritis (axSpA). Factors that influence this delay have…
Abstract Number: 0352 • ACR Convergence 2024
Fast-tracking Axial Spondyloarthritis Diagnosis: A Novel Approach to Public Health Advocacy and Awareness
Joe Eddison, National Axial Spondyloarthritis Society, London, United Kingdom
Background/Purpose: The Act on Axial SpA campaign is dedicated to minimising the lengthy 8.5-year delay in diagnosing axial spondyloarthritis (axial SpA) by implementing a pioneering…
Abstract Number: 0551 • ACR Convergence 2024
Evaluation of Instruments Assessing Peripheral Arthritis in Spondyloarthritis: An Analysis of the ASAS-perSpA Study
Dafne Capelusnik¹, Anna Molto², Clementina López Medina³, Desiree van der Heijde⁴, Robert Landewé⁵, Maxime Dougados⁶, Joachim Sieper⁷ and Sofia Ramiro⁸, ¹Tel Aviv Sourasky Medical Center, Ramat Gan, Israel, ²Groupe Hospitalier Cochin, AP-HP, Paris, France, ³Reina Sofia University Hospital, Cordoba, Spain, ⁴Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, ⁵Amsterdam University Medical Center, Meerssen, Netherlands, ⁶Rheumatology Department, Cochin Hospital and Clinical Epidemiology and Biostatistics, University of Paris, INSERM (U1153), Paris, France, ⁷Charité University Medicine Berlin, Berlin, Germany, ⁸Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: The optimal instrument to assess peripheral arthritis and related disease activity in SpA has not yet been identified. In the recent update of the…
Abstract Number: 0569 • ACR Convergence 2024
The Longitudinal Association Between Disease Activity, Function and Health-Related Quality of Life in Axial Spondyloarthritis: Results from the DESIR Cohort
Augusta Ortolan¹, Desiree van der Heijde², Laure Gossec³ and Sofia Ramiro⁴, ¹Policlinico Universitario Agostino Gemelli IRCSS, Rome, Lazio, Italy, ²Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, ³Sorbonne Université, Paris, France, ⁴Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: Health-related quality of life (HRQoL) in axSpA is considered an overarching outcome, with other disease outcomes contributing to it [1]. To validate a previously…
Abstract Number: 0821 • ACR Convergence 2024
Validation of ASAS Preliminary Data-Driven MRI Lesion Cut-offs for a Positive MRI of the Sacroiliac Joints in Patients with Axial Spondyloarthritis and Subgroups with Psoriasis, Iritis, and Colitis
Susanne Pedersen¹, Ulrich Weber², Ozun Bayindir Tsechelidis³, Robert Lambert⁴, Joel Paschke⁵, Stephanie Wichuk⁴ and Walter Maksymowych⁴, ¹Rigshospitalet, København, Denmark, ²Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, ³Ottawa University, Ottawa, ON, Canada, ⁴University of Alberta, Edmonton, AB, Canada, ⁵CARE Arthritis, Edmonton, AB, Canada
Background/Purpose: Recent analysis of MRI scans from the 2009 ASAS classification cohort has led to a new proposal for the application of more stringent MRI…
Abstract Number: 1441 • ACR Convergence 2024
Factors Associated with the Evolution of Degenerative Spinal Lesions in Axial Spondyloarthritis: 10-Year Follow-up of the DESIR Cohort
Laura Pina Vegas¹, Sofia Ramiro², Miranda van Lunteren³, Damien Loeuille⁴, Esther Newsum⁵, Caroline Morizot⁶, Floris van Gaalen⁷, Alain SARAUX⁸, Pascal Claudepierre⁹, Antoine Feydy¹⁰, Desiree van der Heijde¹¹ and Monique Reijnierse¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Bunde, Netherlands, ³Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ⁴Phd, Nancy Vandoeuvre, Lorraine, France, ⁵Nij Smellinghe, Drachten, Netherlands, ⁶Nancy University hospital, Nancy, France, ⁷LUMC, Leiden, Zuid-Holland, Netherlands, ⁸CHU Brest, Brest, France, ⁹CHU Henri Mondor, AP-HP/EpiDermE, UPEC, Créteil, France, ¹⁰CHU Cochin, AP-HP, Paris, France, ¹¹Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands
Background/Purpose: Radiographs and MRI are both used to diagnose axial spondyloarthritis (axSpA) but they also provide information about morphological and even biomechanical changes in the…
Abstract Number: 1708 • ACR Convergence 2024
Unveiling the Uterine-Joint Axis: Dysbiosis and Subclinical Uterine Inflammation in Female Axial Spondyloarthritis Pathogenesis
Daniele Mauro¹, Matteo Vecellio², Anne-Sophie Bergot³, Eva Schmid⁴, Giulio Forte⁵, Alessia Stingo⁶, Alessia Salzillo⁵, Aldo Pastore⁷, Paolo Aretini⁷, Francesca Di Lorenzo⁷, Antonio ciancio⁵, Ilenia Pantano⁵, Gabriele Saccone⁸, Fulvio Zullo⁹, carlo Maurizio Montecucco¹⁰, Aroldo Rizzo¹¹, Georg Schett¹², Ranjeny Thomas¹³, Mario Zaiss¹⁴ and Francesco Ciccia¹⁵, ¹University of Campania, Italy, Naples, Naples, Italy, ²Fondazione Pisana per la Scienza ONLUS, Pisa, Italy, ³Frazer Institute, University of Queensland, Brisbane, Australia, ⁴Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Rheumatology and Immunology, Erlangen, Erlangen, Germany, ⁵University of Campania L. Vanvitelli, Naples, Italy, ⁶University of Campania L. Vanvitelli, Nasples, Italy, ⁷Fondazione Pisana per la Scienza ONLUS, Giuliano Terme, Italy, ⁸University Federico II of Naples, Naples, Italy, ⁹University of Catanzaro, Catanzaro, Italy, ¹⁰Unit of Rheumatology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy, ¹¹Azienda Ospedaliera Ospedali riuniti Villa Sofia Cervello,, Palermo, Italy, ¹²Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ¹³University of Queensland, Brisbane, Australia, ¹⁴Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universittsklinikum Erlangen, Erlangen, Germany; 2 Deutsches Zentrum für Immuntherapie (DZI), Erlangen, Germany, ¹⁵Università degli studi della Campania Luigi Vanvitelli, Naples, Italy
Background/Purpose: Numerous studies exploring gender differences in axial spondyloarthritis (AxSpA) have noted that women exhibit distinct disease manifestations. Yet, a definitive pathophysiological distinction of these diverse…
Abstract Number: 2334 • ACR Convergence 2024
Characteristics of Patients with Psoriatic Arthritis Presenting with Axial Involvement: Results of a Prospective International Multicenter Study (AXIS)
Murat Torgutalp¹, Valderilio Azevedo², Xenofon Baraliakos³, Filip Van den Bosch⁴, Jürgen Braun⁵, Alberto Cauli⁶, Laura Coates⁷, Vinod Chandran⁸, Torsten Diekhoff⁹, Floris van Gaalen¹⁰, Rodrigo Garcia Salinas¹¹, Lianne S Gensler¹², Niti Goel¹³, Alice Gottlieb¹⁴, Desiree van der Heijde¹⁵, Philip Helliwell¹⁶, Kay Geert Hermann¹⁷, Umut Kalyoncu¹⁸, Uta Kiltz¹⁹, Robert Lambert²⁰, Ying Ying Leung²¹, Maria Llop²², Alejandra Lopez²³, Miranda van Lunteren²⁴, Ajesh Maharaj²⁵, Walter Maksymowych²⁶, Helena Marzo-Ortega²⁷, Ashish J Mathew²⁸, Philip Mease²⁹, Peter Nash³⁰, Mikkel Ostergaard³¹, Fabian Proft³², Mikhail Protopopov³³, Sherry Rohekar³⁴, RUXANDRA ELENA SCHIOTIS³⁵, Joachim Sieper³⁶, Enrique R. Soriano³⁷, Lai-shan Tam³⁸, James Wei³⁹, Nelly Ziade⁴⁰, Dafna Gladman⁴¹ and Denis Poddubnyy⁴², and AXIS Cohort Investigators, ¹Charite Universitatsmedizin - Berlin, Berlin, Germany, ²Department of Internal Medicine, Universidade Federal of Paraná, Curitiba, Brazil, Curitiba, Brazil, ³Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁴Ghent University Hospital, Ghent, Belgium, ⁵Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany., Herne, Germany, ⁶University of Cagliari, Cagliari, Italy, ⁷University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, ⁸University of Toronto, Toronto, ON, Canada, ⁹Charite Universitatsmedizin Berlin, Berlin, Germany, ¹⁰LUMC, Leiden, Zuid-Holland, Netherlands, ¹¹Hospital Italiano La Plata, La Plata, Argentina, ¹²Department of Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ¹³Caduceus Biomedical Consulting, Duke University, Durham, NC, ¹⁴Department of Dermatology, Icahn School of Medicine, New York, NY, USA., New York, NY, ¹⁵Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, ¹⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK., Leeds, United Kingdom, ¹⁷Charite Medical School, Berlin, Germany, ¹⁸Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ¹⁹Rheumazentrum Ruhrgebiet Herne, Ruhr-University, D-44649 Herne, Germany, ²⁰University of Alberta, Edmonton, AB, Canada, ²¹Singapore General Hospital, Singapore, Singapore, ²²Hospital Parc Tauli, Sabadell, Spain, ²³Centro Dermatológico del Country, Guadalajara, Jalisco, Mexico, Guadalajara, Mexico, ²⁴Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ²⁵Department of Internal Medicine & Therapeutics, Faculty of Health Sciences. Walter Sisulu University, Eastern Cape, South Africa, Eastern Cape, South Africa, ²⁶Department of Medicine, University of Alberta, Edmonton, AB, Canada; CARE Arthritis, Edmonton, AB, Canada, Edmonton, Canada, ²⁷NIHR Leeds BRC, Leeds Teaching Hospitals Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK., Leeds, United Kingdom, ²⁸Christian Medical College, Vellore, Tamil Nadu, India, ²⁹Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, ³⁰School of Medicine, Griffith University, Sunshine Coast, Queensland, Australia, ³¹Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark, ³²Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ³³Charite – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ³⁴Western University, London, Ontario, Canada, London, Canada, ³⁵SPITAL CLINIC DE BOLI INFECTIOASE CLUJ NAPOCA, Cluj-Napoca, Romania, ³⁶Charité University Medicine Berlin, Berlin, Germany, ³⁷Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ³⁸The Chinese University of Hong Kong, New Territories, Hong Kong, ³⁹Chung Shan Medical University Hospital; China Medical University, Taichung, Taiwan (Republic of China), ⁴⁰Saint-Joseph University, Beirut, Lebanon, ⁴¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴²Charite-Universitatsmedizin Berlin, Berlin, Germany
Background/Purpose: Axial involvement, affecting the sacroiliac joints (SIJ) and/or spine, is a clinically relevant manifestation of psoriatic arthritis (PsA) that can influence management strategies. Previous…
Abstract Number: 0359 • ACR Convergence 2024
SpA Disk©: A New Tool to Monitor the QoL of Spondyloarthritis Patients
Roba Ghossan¹, OLIVIER FOGEL², Cécile Gaujoux-Viala³, anthony SABER⁴, Cedric Lukas⁵ and Corinne MICELI⁶, and SpA Disk Group, ¹COCHIN HOSPITAL, PARIS, France, ²AP-HP, Paris, France, ³CHU Nîmes, Nïmes, Languedoc-Roussillon, France, ⁴Sorbonne Paris Nord Université, Paris, France, ⁵Rheumatology department, CHU Montpellier, Montpellier, France, ⁶Université de Paris Cité, APHP, Paris, France
Background/Purpose: Spondyloarthritis (SpA) significantly affects patients' quality of life (QoL). Current tools in routine medical practice primarily focus on assessing disease activity, neglecting the broader…
Abstract Number: 0552 • ACR Convergence 2024
Presence of MAIT Cells in Synovial Tissue of Patients with Axial Spondyloarthritis: A Comparative Study
Andre Ramon¹, Philippe Saas², Charline Vauchy³, Maxime Samson² and ERIC TOUSSIROT⁴, ¹Dijon University Hospital, Besançon, France, ²Franche-Comté University, EFS, INSERM, UMR RIGHT, Besançon, France, Besançon, France, ³INSERM CIC-1431, CHU de Besançon, Besancon, France, Besançon, France, ⁴university hospital of BESANCON, besancon, France
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate immune T cells that are located at the mucosal barriers. They play a role in mucosal defense,…
Abstract Number: 0571 • ACR Convergence 2024
Gender-specific Performance of Disease Activity Assessment Tools in Axial Spondyloarthritis: Ancillary Analysis of the PREDICT-SpA Study
Sabrina Hamroun¹, Laure Gossec², Serge Perrot³, Maxime Dougados⁴ and Anna Molto⁵, ¹Cochin University Hospital, Paris, Ile-de-France, France, ²Sorbonne Université, Paris, France, ³Paris Dauphine University, Paris, France, ⁴Rheumatology Department, Cochin Hospital and Clinical Epidemiology and Biostatistics, University of Paris, INSERM (U1153), Paris, France, ⁵Groupe Hospitalier Cochin, AP-HP, Paris, France
Background/Purpose: There are several tools for assessing disease activity in spondyloarthritis (SpA). The literature reveals gender differences, with unfavorable Patient Reported Outcomes in women compared…
Abstract Number: 0822 • ACR Convergence 2024
Investigating the Association Between Alcohol Consumption and Spinal Radiographic Progression in Axial Spondyloarthritis: A Longitudinal Cohort Analysis over a Period of 6 Years
Evelyne Gendron¹, Sinead Maguire², Yangqing Deng³, Nigil Haroon⁴ and Robert Inman⁵, ¹University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Rheumatology, Quebec City, QC, Canada, ²University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Rheumatology, Toronto, Canada, ³Department of Biostatistics, University Health Network, Toronto, Canada, ⁴Department of Medicine/Rheumatology, University Health Network, Schroeder Arthritis Institute, University of Toronto, Toronto, ON, Canada, ⁵University Health Network, Toronto, ON, Canada
Background/Purpose: We assessed whether alcohol consumption (AC) is associated with spinal radiographic progression in axSpA as measured by the modified Stoke Ankylosing Spondylitis Spinal Score…
Abstract Number: 1442 • ACR Convergence 2024
Relationship Between Degenerative Lesions over Time in Axial Spondyloarthritis: 10-year Follow-up of the DESIR Cohort
Laura Pina Vegas¹, Floris van Gaalen², Miranda van Lunteren³, Damien Loeuille⁴, Caroline Morizot⁵, Esther Newsum⁶, Pascal Claudepierre⁷, Alain SARAUX⁸, Antoine Feydy⁹, Monique Reijnierse¹, Desiree van der Heijde¹⁰ and Sofia Ramiro¹¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²LUMC, Leiden, Zuid-Holland, Netherlands, ³Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ⁴Phd, Nancy Vandoeuvre, Lorraine, France, ⁵Nancy University hospital, Nancy, France, ⁶Nij Smellinghe, Drachten, Netherlands, ⁷CHU Henri Mondor, AP-HP/EpiDermE, UPEC, Créteil, France, ⁸CHU Brest, Brest, France, ⁹CHU Cochin, AP-HP, Paris, France, ¹⁰Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, ¹¹Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: Spinal degenerative lesions (DLs) are commonly seen/reported in radiographs and MRI in axSpA. However, the relationship between the different DLs over time has not…
Abstract Number: 1755 • ACR Convergence 2024
Single Cell TCR Sequencing Suggests Potential Limitations of TRBV9-depleting Therapies in Axial Spondyloarthritis
Michael Paley¹, Xinbo Yang², Lynn Hassman¹, Grace Paley¹, Nicole Linskey¹, Ryan Agnew¹, Paulo Arantes de Faria¹, Annie Feng¹, Sophia Li¹, Elisha Roberson¹, Philip Ruzycki¹, Ekaterina Esaulova¹, Jennifer Laurent¹, Lacey Feigl¹, Luke Springer¹, Chang Liu¹, K. Chris Garcia³ and Wayne Yokoyama⁴, ¹Washington University in St. Louis, Saint Louis, MO, ²Sloan Kettering Institute, New York, NY, ³Stanford, Stanford, CA, ⁴Washington University School of Medicine, St Louis, MO
Background/Purpose: TRBV9 depletion is a novel strategy for the treatment of HLA-B27+ axial spondyloarthritis (axSpA) and has achieved clinical remission in at least one patient.…

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