ACR Meeting Abstracts

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Abstracts tagged "spondyloarthritis"

  • Abstract Number: 0395 • ACR Convergence 2024

    Assessment of Enthesitis by Pediatric Rheumatology Providers

    Erin Treemarcki1, Shirley Tse2, Marisa Klein-Gitelman3, Adam Mayer4, Hemalatha Srinivasalu5, Heather Walters6 and Melissa Oliver7, and the CARRA Juvenile Spondyloarthritis Workgroup and the CARRA investigators, 1University of Utah, Salt Lake City, UT, 2SickKids, Toronto, ON, Canada, 3Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 4University of Pennsylvania/Children's Hospital of Philadelphia, Philadelphia, PA, 5Children's National Hospital, Washington, DC, 6Northwell Health, New Hyde Park, NY, 7Indiana University, Indianapolis, IN

    Background/Purpose: Enthesitis is a characteristic feature of enthesitis related arthritis (ERA) but can be found in other juvenile idiopathic arthritis (JIA) subtypes. It occurs with…
  • Abstract Number: 0553 • ACR Convergence 2024

    Analyzing the Utilization of HLA-B27 Testing in a Large Rural Health System: Implications for Diagnostic Appropriateness

    Sanjeev Shrestha1, Angela Bobak2, Idorenyin Udoeyo3, Pradeep Puri4, Jordan Law5 and David Bulbin6, 1Geisinger Medical Center, Bloomsburg, PA, 2Geisinger Medical Center Internal Medicine Residency, Danville, PA, 3Geisinger Medical Center, Danville, PA, 4Geisinger Medical Center, Danville, 5Geisinger Health System, Danville, 6Geisinger Health System, Danville, PA

    Background/Purpose: Human leukocyte antigen (HLA)-B27 is linked to spondyloarthropathies (SpA), uveitis, and inflammatory bowel disease (IBD). By analyzing ordering diagnoses and final diagnoses during patient…
  • Abstract Number: 0575 • ACR Convergence 2024

    Combined Testing of anti-CD74 IgA and Anti-UH-axSpA Antibodies Increases the Diagnostic Potential for axSpA

    Kurt de Vlam1, Pieter Ruytinx2, Elien luyten2, Anouk Agten2, Frank Vandenabeele2 and Veerle somers2, 1Department of Rheumatology, UZ Leuven, and Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, 2Universiteit Hasselt, Hasselt, Belgium

    Background/Purpose: Diagnosis of axial spondyloarthritis (axSpA) is challenging and a specific laboratory diagnostic test is lacking. Previously, we identified novel immunoglobulin G (IgG) and IgA…
  • Abstract Number: 0925 • ACR Convergence 2024

    Macrophages Produce Bone Anabolic Factors in Settings of Inflammation-Induced Bone Formation

    Jia (Sijia) Chen1, Megan Hanlon2, Catherine Manning3, Susan MacLauchlan1, Paul Hoover4, Christian Jacome-Galarza5 and Ellen Gravallese6, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women’s Hospital, Boston, MA, 3Brigham and Women's Hospital, Dedham, MA, 4Brigham and Women's Hospital, SWAMPSCOTT, MA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Understanding the pathogenesis of inflammation-induced pathologic bone formation remains a significant challenge in spondyloarthritis patients. We thought to uncover the pivotal events driving the…
  • Abstract Number: 1443 • ACR Convergence 2024

    Natural Course of Degenerative Lesions of the Spine on Radiographs and MRI in Axial SpondyloarthritisFollowed 10 Years in the DESIR Cohort

    Laura PINA VEGAS1, Miranda van Lunteren2, Damien Loeuille3, Caroline Morizot4, Esther Newsum5, Sofia Ramiro6, Floris van Gaalen7, Alain SARAUX8, Pascal Claudepierre9, Antoine Feydy10, Desiree van der Heijde11 and Monique Reijnierse1, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, 3Phd, Nancy Vandoeuvre, Lorraine, France, 4Nancy University hospital, Nancy, France, 5Nij Smellinghe, Drachten, Netherlands, 6Leiden University Medical Center, Bunde, Netherlands, 7LUMC, Leiden, Zuid-Holland, Netherlands, 8CHU Brest, Brest, France, 9CHU Henri Mondor, AP-HP/EpiDermE, UPEC, Créteil, France, 10CHU Cochin, AP-HP, Paris, France, 11Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands

    Background/Purpose: Radiographs and MRI are the two imaging techniques often used to assess structural lesions in axial spondyloarthritis (axSpA). A high prevalence of degenerative lesions…
  • Abstract Number: 1756 • ACR Convergence 2024

    What Is the Impact of Prior TNF Inhibitor Treatment on the Time to Achieve Low Disease Activity and the Durability of Low Disease Activity? Real-world Results Based on 17 858 European Patients with Axial Spondyloarthritis Initiating a TNF Inhibitor or an IL-17A Inhibitor

    Jette Heberg1, Stylianos Georgiadis2, Marion Pons3, Anne Gitte Loft4, Brigitte Michelsen5, Louise Linde3, Daniela DiGuiseppe6, Simon Horskjær Rasmussen3, Mehrdad Kazemi3, Gary Macfarlane7, Gareth Jones7, Karin Laas8, Sigrid Vorobjov9, Isabel Castrejon10, Ziga Rotar11, Katja Perdan-Pikmajer11, Ladislav Šenolt12, Jana Baranová13, Bente Glintborg14, Adrian Ciurea15, Miguel Bernardes16, Paula Valente17, Bjorn Gudbjornsson18, Gerdur Gröndal18, Gunnstein Bakland19, Catalin Codreanu20, Corina Mogosan20, Florenzo Iannone21, Roberto Caporali22, Johan Karlsson Wallman23, Vappu Rantalaiho24, Ritva Peltomaa25, Karel Pavelka26, Pavel Horak27, Diogo Esperança Almeida28, Sara Dias Rodrigues29, Lykke Oernbjerg2, Mikkel Ostergaard30 and Merete Hetland31, 1Rigshospitalet Glostrup, København V, Denmark, 2Rigshospitalet Glostrup, Glostrup, Hovedstaden, Denmark, 3Rigshospitalet Glostrup, Glostrup, Denmark, 4Aarhus University Hospital and Aarhus University, Horsens, Denmark, 5Rigshospitalet Glostrup, Diakonhjemmet Hospital and Sørlandet Hospital, Copenhagen, Denmark, 6Karolinska Institutet, Stockholm, 7University of Aberdeen, Aberdeen, United Kingdom, 8East-Tallinn Central Hospital, Tallinn, Estonia, 9National Institute for Health Development, Tallinn, Estonia, 10Hospital General Universitario Gregorio Marañón and Complutense University of Madrid, Madrid, Spain, 11University Medical Centre Ljubljana and University of Ljubljana, Ljubljana, Slovenia, 12Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 13Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic, 14DANBIO, Rigshospitalet Glostrup and University of Copenhagen, Virum, Denmark, 15University Hospital Zurich, Zürich, Switzerland, 16São João Hospital Center and FMUP, Lisboa, Portugal, 17Rheumatology Department, Hospital de São Sebastião, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal, 18Landspitali University Hospital and University of Iceland, Reykjavik, Iceland, 19Department of Rheumatology, University Hospital North Norway, Tromsø, Norway, 20University of Medicine and Pharmacy, Bucharest, Romania, 21Rheumatology Unit- University of Bari "Aldo Moro", IT, Bari, Italy, 22Department of Clinical Sciences and Community Health, University of Milan, and Department of Rheumatology and Medical Sciences, ASST Gaetano Pini-CTO, Milan, Italy, 23Lund University, Department of Clinical Sciences Lund, Section of Rheumatology and Skåne University Hospital, Lund, Sweden, Lund, Skane Lan, Sweden, 24Tampere University Hospital, Tampere University and Kanta-Häme Central Hospital, Tampere, Finland, 25Helsinki University Hospital and University of Helsinki, Helsinki, Finland, 26Institute of Rheumatology and Charles University, Praha, Czech Republic, 273rd Department of Internal Medicine - Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc & Palacky University Olomouc, Faculty of Medicine and Dentistry, Olomouc, Olomoucky kraj, Czech Republic, 28Hospital de Braga, Braga, Portugal, 29Serviço de Reumatologia, Hospital Egas Moniz, Unidade Local de Saúde Lisboa Ocidental, Lisboa, Portugal, 30Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark, 31Rigshospitalet Glostrup and University of Copenhagen, Glostrup, Denmark

    Background/Purpose: Tumour necrosis factor inhibitors (TNFi) and Interleukin-17Ai inhibitors (IL-17Ai) have shown effectiveness in achieving low disease activity (LDA) in patients with axial spondyloarthritis (axSpA).…
  • Abstract Number: 2345 • ACR Convergence 2024

    Combination of Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drugs in Psoriatic Arthritis

    Andre Lucas Ribeiro1, Virginia Carrizo Abarza2, Dafna Gladman3, Vinod Chandran4 and Lihi Eder5, 1Women's College Hospital & University of Toronto, Porto Alegre, Rio Grande do Sul, Brazil, 2Toronto Western Hospital - University of Toronto, Toronto, ON, Canada, 3University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4University of Toronto, Toronto, ON, Canada, 5University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is a complex inflammatory disease where achieving remission remains challenging despite multiple approved biologic DMARDs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs).…
  • Abstract Number: 0401 • ACR Convergence 2024

    Biologic Abatement and Capturing Kids Outcomes and Flare Frequency in Juvenile Spondyloarthritis: Baseline Characteristics and Enrollment

    Cora Sears1, Cassandra Muir1, Timothy Brandon1, Polly Ferguson2, Colleen Correll3, Margalit Rosenkranz4, Kevin Baszis5, Tzielan Lee6, Edward Oberle7, Matthew Stoll8, Kathryn Cook9, Eyal Muscal10, Hemalatha Srinivasalu11, Daniel Lovell12, Sampath Prahalad13, Michal Cidon14, Evan Mulvihill15, Marisa Klein-Gitelman16, Daniel Kingsbury17, Jennifer Cooper18, Natalie Rosenwasser19, Erin Treemarcki20, Joyce Chang21, Stacey Tarvin22, Heather Walters23, Michael Shishov24, Lisa Buckley25, Mary Toth26, Ashley Cooper27, Rui Xiao28, Emily Neu29, Melanie Kohlheim30, Jenny Leal31, Kweli Archie32, English Holland33, Miles Holland34, Aamena Hameed35, Asad Khan36, Lynn Murphy37, Sean Murphy38, Justin Neu29, Rachel Richmond39, Dylan Suplee40, Theresa Suplee41, Dawn Wiley42 and Pamela Weiss43, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2University of Iowa Carver College of Medicine, Iowa City, IA, 3University of Minnesota, Minneapolis, MN, 4UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 5Washington Univ in St. Louis School of Medicine, St Louis, MO, 6Stanford University School of Medicine, Palo Alto, CA, 7Nationwide Children's Hospital, Columbus, OH, 8University of Alabama at Birmingham, Birmingham, AL, 9Akron Children's Hospital, Akron, OH, 10Baylor College of Medicine, Houston, TX, 11Children's National Hospital, Washington, DC, 12Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 13Emory + Children's Pediatric Institute, Atlanta, GA, 14Children's Hospital of Los Angeles, Los Angeles, CA, 15Nemours/A.I.duPont Hospital for Children, Wilmington, DE, 16Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 17Legacy Health, Portland, OR, 18University of Colorado/Children's Hospital Colorado, Aurora, CO, 19Seattle Children's Hospital, Seattle, WA, 20University of Utah, Salt Lake City, UT, 21Boston Children's Hospital, Boston, MA, 22Indiana University School of Medicine, Indianapolis, IN, 23Northwell Health, New Hyde Park, NY, 24Phoenix Children's Hospital, Phoenix, AZ, 25Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, 26Nemours Foundation, Orlando, FL, 27Children's Mercy Kansas City, Kansas City, MO, 28University of Pennsylvania, Philadelphia, PA, 29Parent Partner, Sidney, OH, 30Parent Partner, Granville, OH, 31Parent Partner, Columbus, OH, 32Parent Partner, Philadelphia, PA, 33Parent Partner, Williamsburg, VA, 34Patient Partner, Williamsburg, VA, 35Parent Partner, Franklin Park, NJ, 36Patient Partner, Franklin Park, NJ, 37Parent Partner, Haddon Heights, NJ, 38Patient Partner, Haddon Heights, NJ, 39Parent Partner, Albuquerque, NM, 40Patient Partner, Maple Shade, NJ, 41Parent Partner, Maple Shade, NJ, 42Parent Partner, Downingtown, PA, 43Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Inactive disease is the goal for youth with spondyloarthritis (SpA).  Many patients are interested in stopping medications after inactive disease is achieved. The risk…
  • Abstract Number: 0554 • ACR Convergence 2024

    Different Prevalence of Intestinal Inflammation in Radiographic and Non-radiographic Axial Spondyloarthritis. Data from EISER Study

    Carolina Merino1, Zulema Plaza2, Jordi Gratacos Masmitja3, Iago Rodríguez-Lago4, Elisa Trujillo5, Ignacio Marin-Jimenez6, Eva Perez Pampin7, Manuel Barreiro8, Vanesa Hernández-Hernández9, Marta Carrillo-Palau10, Maria Luz Garcia Vivar11, Maria Carmen Muñoz12, María Lourdes Ladehesa-Pineda13, Eva Iglesias Flores14, Yago González-Lama15, Marta Arevalo Salaet16, Xabier Calvet17, Ana Gutierrez-Casbas18 and JESUS SANZ SANZ19, and EISER group, 1Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda (Madrid), Spain, 2Fundacion Española de Reumatología, Madrid, Spain, 3University Hospital Parc Taulí, Sabadell, Spain, 4Gastroenterology department. Hospital Universitario Galdakao-Usansolo, Instituto de Investigación Sanitaria Biobizkaia, Galdakao, Bizkaia, Spain, Galdakao, Spain, 5Rheumatology department. Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, 6Gastroenterology department. Hospital Universitario Gregorio Marañón, Madrid, Spain, 7Rheumatology department. Instituto de Investigación Sanitaria de Santiago (IDIS), Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Santiago de Compostela, Spain, 8Gastroenterology department. Hospital Clínico Universitario de Santiago de Compostela Santiago de Compostela, Spain, Santiago de Compostela, Spain, 9Hospital Universitario de Canarias, San Cristobal de La Laguna, Canarias, Spain, 10Gastroenterology department. Hospital Universitario Canarias, La Laguna, Spain., Santa Cruz de Tenerife, Spain, 11Basurto Hospital, Bilbao, Spain, 12Gastroenterology department. Hospital Universitario Basurto Hospital Universitario Basurto. Bilbao. Spain., Bilbao., Spain, 13IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Andalucia, Spain, 14Gastroenterology department. Hospital Reina Sofia, Córdoba, Spain, Cordoba, Spain, 15Servicio de Gastroenterología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Majadahonda, Spain, 16Parc Tauli Hospital Universitari I3PT, Rheumatology, Medicine Department, UAB, Sabadell, Spain, 17Gastroenterology department. Parc Taulí, Hospital Universitari. Institut d’Investigació i Innovació Parc Taulí. Universitat Autònoma de Barcelona. Sabadell, Spain, Sabadell, Spain, 18Gastroenterology department. Hospital General Universitario de Dr. Balmis de Alicante. ISABIAL y CIBERehd, Alicante, Spain, Alicante, Spain, 19Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda, Spain

    Background/Purpose: Axial spondyloarthritis (AxSpA) encompasses both non-radiographic axial spondyloarthritis (nr-AxSpA) and radiographic axial spondyloarthritis (r-AxSpA), also known as ankylosing spondylitis (AS). Although nr-AxSpA is often…
  • Abstract Number: 0576 • ACR Convergence 2024

    Less Than 15% Unfavourable Pregnancy Outcomes in Patients with Recent-onset Axial Spondyloarthritis: The Analysis of the 10 Years DESIR Cohort Follow-up

    Madeleine FRANC1, Anne Tournadre2 and Anna Molto3, 1Groupe Hospitalier Cochin, APHP, Paris, France, 2Service de Rhumatologie, centre hospitalier universitaire de Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France, 3Groupe Hospitalier Cochin, AP-HP, Paris, France

    Background/Purpose: Only scarce data is available regarding pregnancy outcomes in early axSpA. The objective of this study was to determine (a) the factors associated with…
  • Abstract Number: 1010 • ACR Convergence 2024

    Total Cost Risk Scores and Barrier Categories in Patients with Axial Spondyloarthritis and Associated Factors

    Marina Magrey1, Yashashvi Raghuwanshi2, Tyler Barnett2, lindsay Frumker3 and Omer Pamuk4, 1Case Western Reserve University School of Medicine/University Hospitals, Richfield, OH, 2University hospitals, Cleveland, OH, 3University Hospitals Cleveland, cleveland, OH, 4University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH

    Background/Purpose: Axial spondyloarthritis (axSpA) is associated with an increased risk of morbidity and mortality. Patients with axSpA suffer from chronic back pain, and epidemiological studies…
  • Abstract Number: 1444 • ACR Convergence 2024

    Characterization and Comparison of MRI Findings in Axial Spondyloarthritis, Axial Psoriatic and Chronic Non-inflammatory Back Pain

    Mauricio Parada1, maría Luisa Molina1, Daniel Ríos1, Daniela Suarez1, Natalie Hitchin2, Cristóbal Bravo2, Nicolás Guzmán2 and Annelise Goecke1, 1Hospital Clínico Universidad de Chile, santiago, Chile, 2Universidad de Chile, Santiago, Chile

    Background/Purpose: MRI of the sacroiliac joints (SIJ) is part of the evaluation of patients with suspected axial spondyloarthritis (axSpA). However, sacroiliitis (SI) could be a…
  • Abstract Number: 1757 • ACR Convergence 2024

    Bimekizumab Treatment Resulted in Improvements in MRI Inflammatory and Structural Lesions in the Sacroiliac Joints of Patients with Axial Spondyloarthritis: 52-Week Results and Post Hoc Analyses from Two Phase 3 Studies

    Walter Maksymowych1, Sofia Ramiro2, Denis Poddubnyy3, Xenofon Baraliakos4, Robert Lambert1, Ute Massow5, Thomas Vaux6, Chetan Prajapati6, Alexander Marten5, Natasha de Peyrecave7 and Mikkel Ostergaard8, 1University of Alberta, Edmonton, AB, Canada, 2Leiden University Medical Center, Bunde, Netherlands, 3Charite-Universitatsmedizin Berlin, Berlin, Germany, 4Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 5UCB Pharma, Monheim am Rhein, Germany, 6UCB Pharma, Slough, United Kingdom, 7UCB Pharma, Brussels, Belgium, 8Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark

    Background/Purpose: The impact of bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)‑17F in addition to IL-17A, on structural lesions in patients (pts)…
  • Abstract Number: 2346 • ACR Convergence 2024

    Treatment Effect on Predictors of Ankylosis in Axial Spondyloarthritis

    Pauline KRUG1, Anthony Lichaa1 and Adrien Nzeusseu Toukap2, 1Cliniques universitaires St-Luc, Brussel, Belgium, 2Cliniques universitaires Saint-Luc,, St.-Lambrechts-Woluwe, Belgium

    Background/Purpose: Axial spondyloarthritis (axSpA) is a progressive chronic inflammatory disease. In its early stages, symptoms appear without radiographic evidence. Later, structural lesions are observed on…
  • Abstract Number: 0411 • ACR Convergence 2024

    Axial Radiographic Structural Damage in Enthesitis-Related Arthritis in Children and Young Adult Patients

    Annelyse de Araújo Pereira1, Marcelo Pinheiro2, Jade Dib Fernandez1, Ana Sakamoto3, Adham do Amaral e Castro1 and Maria Teresa Terreri4, 1UNIFESP-EPM, São Paulo, SP, Brazil, 2UNIFESP/ EPM, São Paulo, SP, Brazil, 3Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil, 4UNIFESP, São Paulo, SP, Brazil

    Background/Purpose: Enthesitis-related arthritis (ERA), a distinct subtype of juvenile idiopathic arthritis (JIA) related to HLA-B27 status and peripheral and axial involvement, presents with insidious onset…
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