ACR Meeting Abstracts

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Abstracts tagged "spondyloarthritis"

  • Abstract Number: 1776 • ACR Convergence 2023

    Macrophage Migration Inhibitory Factor May Help Maintain Tight Junctions in the Gut by Enhancing Occludin Expression

    Shaghayegh Foroozan1 and Nigil Haroon2, 1University Health Network/University of Toronto, Toronto, ON, Canada, 2University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Medicine/Rheumatology, Toronto, ON, Canada

    Background/Purpose: Axial Spondyloarthritis (AxSpA) is a chronic inflammatory disease with multifactorial origins, primarily affecting the musculoskeletal system. Gut inflammation is seen in the majority of…
  • Abstract Number: 1892 • ACR Convergence 2023

    Sacroiliac Bone Marrow Oedema on Postpartum MRI Does Not Result in Significant SpA-like Structural Lesions: Results of a 5-year Follow-up Study

    De Meester Liesbet1, Gaelle Varkas2, Manouk de Hooge3, Ann-Sophie De Craemer4, Nele Herregods5, Lennart Jans5, Philippe Carron6, Dirk Elewaut7 and Filip Van den Bosch8, 1Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, 2Dept. of Rheumatology, Ghent University Hospital, Ghent, Belgium, 3Ghent University Hospital, Hesperange, Luxembourg, 4Ghent University Hospital, Gent, Belgium, 5Department of Radiology, Ghent University Hospital, Ghent, Belgium, 6UZ Gent, Gent, Belgium, 7Ghent University and VIB Center for Inflammation Research, Ghent, Belgium, 8Department of Internal Medicine and Pediatrics, Ghent University and VIB Center for Inflammation Research, Ghent, Belgium

    Background/Purpose: Sacroiliac bone marrow oedema (BMO) on MRI, immediately after childbirth, has been observed in a large proportion of postpartum women and appears to be…
  • Abstract Number: 2208 • ACR Convergence 2023

    Awareness and Attitudes Regarding Axial Spondyloarthritis Among Non-Rheumatology Physicians in the United States

    William Odell1, Swetha Ann Alexander2, Nicolas Page3, Narinder Maheshwari4 and Abhijeet Danve5, 1Yale University, Wethersfield, CT, 2University of Utah Health, Salt Lake City, UT, 3Yale University, New Haven, CT, 4UCONN Health, Farmington, CT, 5Yale University School of Medicine, Glastonbury, CT

    Background/Purpose: Average diagnostic delay for axial spondyloarthritis (axSpA) is 7 to 10 years. Lack of timely referral of inflammatory back pain (IBP) patients by non-rheumatology…
  • Abstract Number: 2230 • ACR Convergence 2023

    Bimekizumab Treatment in Patients with Active PsA and Prior Inadequate Response to TNF Inhibitors: Sustained Efficacy and Safety Results from a Phase 3 Study and Its Open-Label Extension up to 1 Year

    Laura Coates1, Robert BM Landewé2, Iain McInnes3, Philip J. Mease4, Christopher T Ritchlin5, Yoshiya Tanaka6, Akihiko Asahina7, Frank Behrens8, Dafna Gladman9, Laure Gossec10, Alice B. Gottlieb11, Richard B. Warren12, Barbara Ink13, Rajan Bajracharya13, Jason Coarse14 and Joseph Merola15, 1University of Oxford, Oxford, United Kingdom, 2Amsterdam Rheumatology & Clinical Immunology Center, Amsterdam and Zuyderland MC, Herleen, Netherlands, 3University of Glasgow, Glasgow, United Kingdom, 4Swedish Medical Center/Providence St. Joseph Health and University of Washington School of Medicine, Seattle, WA, 5University of Rochester Medical School, Allergy, Immunology & Rheumatology Division, Canandaigua, NY, 6University of Occupational and Environmental Health, Kitakyushu, Japan, 7The Jikei University School of Medicine, Department of Dermatology, Tokyo, Japan, 8Goethe University, Division of Rheumatology, University Hospital and Fraunhofer Institute for Translational Medicine & Pharmacology, Frankfurt, Germany, 9Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, 10Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France, 11Icahn School of Medicine at Mount Sinai, New York, NY, 12Dermatology Centre, Northern Care Alliance NHS Foundation Trust; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 13UCB Pharma, Slough, United Kingdom, 14UCB Pharma, Morrisville, NC, 15Harvard Medical School, Brigham and Women's Hospital, Newton, MA

    Background/Purpose: Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A, has shown superior efficacy to 16 weeks (wks) vs placebo…
  • Abstract Number: 0409 • ACR Convergence 2023

    Prevalence of Pulmonary Manifestations in Patients with Newly Diagnosed Rheumatoid Arthritis, Psoriatic Arthritis, and Peripheral Spondyloarthritis

    Lone Winter1, Dirk Skowasch1, Marcel Weber1, Daniel Kütting1, Charlotte Behning2, Peter Brossart3, Simon Petzinna4 and Valentin Sebastian Schäfer3, 1University Hospital Bonn, Bonn, Germany, 2Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany, 3Clinic of Internal Medicine III, Department of Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital of Bonn, Bonn, Germany, 4Clinic of Internal Medicine III, Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital Bonn, Bonn, Germany

    Background/Purpose: Pulmonary impairment is a common, yet poorly understood, extraarticular manifestation in rheumatic diseases, which is often inadequately screened and managed. This can result in…
  • Abstract Number: 0525 • ACR Convergence 2023

    Bimekizumab Achieved Sustained Improvements in Efficacy Outcomes in Patients with Axial Spondyloarthritis, Regardless of Prior TNF Inhibitor Treatment: Week 52 Pooled Results from Two Phase 3 Studies

    Marina Nighat Magrey1, Marleen van de Sande2, Maxime Breban3, Filip Van den Bosch4, Carmen Fleurinck5, Ute Massow6, Natasha De Peyrecave7, Thomas Vaux8, Xenofon Baraliakos9 and Helena Marzo-Ortega10, 1Case Western Reserve University, University Hospitals, Cleveland, OH, 2Amsterdam UMC, University of Amsterdam, Department of Rheumatology & Clinical Immunology and Department of Experimental Immunology, Amsterdam Infection & Immunity Institute; Amsterdam Rheumatology & Immunology Center (ARC), Academic Medical Center, Amsterdam, Netherlands, 3CHU Ambroise-Paré, Boulogne-Billancourt, Paris, France, 4Department of Internal Medicine and Pediatrics, Ghent University and VIB Center for Inflammation Research, Ghent, Belgium, 5UCB Pharma, Oosterzele, Belgium, 6UCB Pharma, Monheim am Rhein, Germany, 7UCB Pharma, Brussels, Belgium, 8UCB Pharma, Slough, United Kingdom, 9Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 10NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: In patients (pts) with axial spondyloarthritis (axSpA), tumor necrosis factor inhibitors (TNFi) are the usual first line biologic treatment, yet many pts may experience…
  • Abstract Number: 0843 • ACR Convergence 2023

    Predictive Validity of Data-driven Definitions for Active and Structural Lesions in the SI Joints Typical for Axial SpA: A 2-year Follow-up in the SPondyloArthritis Caught Early Cohort

    Liese de Bruin1, Mary Lucy marques2, Miranda Van Lunteren3, Manouk de Hooge4, Sofia Exarchou5, Floris Van Gaalen3, Désirée van der Heijde6 and Sofia Ramiro6, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center; Centro Hospitalar e Universitário de Coimbra (Department of Rheumatology), Coimbra, Portugal, 3Leiden University Medical Center, Department of Rheumatology, Leiden, Netherlands, 4Ghent University Hospital, Hesperange, Luxembourg, 5Lund University, Åkarp, Sweden, 6Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The Assessment of Spondyloarthritis international Society MRI (ASAS MRI) group has proposed definitions for active and structural lesions typical for axial SpA (axSpA) on…
  • Abstract Number: 1393 • ACR Convergence 2023

    Fully Automated Detection of Active Sacroiliitis in Patients with Axial Spondyloarthritis: A Machine Learning-Based Analysis Magnetic Resonance Image

    Go-Eun Lee1, Sang-Il Choi1, Jungchan Cho2, Seon Ho Kim3, Geun Young Lee4 and Sang Tae Choi5, 1Department of Computer Engineering, Dankook University, Seongnam, South Korea, 2School of Computing, Gachon University, Seongnam, South Korea, 3Integrated Media Systems Center, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, 4Department of Radiology, Chung-Ang University College of Medicine, Seoul, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea

    Background/Purpose: Magnetic Resonance Imaging (MRI) is a crucial modality for early diagnosis of active inflammation in the sacroiliac joint in patients with axial spondyloarthritis (axSpA).…
  • Abstract Number: 1780 • ACR Convergence 2023

    Biomarkers Predicting Structural Progression of Axial Spondyloarthritis: A Pilot Study

    Jiri Baloun1, Kristyna Bubova1, Aneta Pekacova2, Lucia Ondrejcakova3, Vladimir Cervenak4, Monika Gregova5, Sarka Forejtova5, Jana Horinkova1, Jindriska Gatterova6, Michal Tomcik7, Jiri Vencovsky7, Karel Pavelka8 and Ladislav Senolt9, 1Institute of Rheumatology, Prague, Czech Republic, 2First faculty of medicine, Charles University, Prague, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 4Department of Medical Imaging, St Anne's University Hospital, and Faculty of Medicine, Masaryk University, Brno, Czech Republic, 5Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Prague, Czech Republic, 6Rheumatology Institute, Prague, Czech Republic, 7Institute of Rheumatology, Prague, Czech Republic, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 8Institut of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Praha, Czech Republic, 9Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Praha, Czech Republic

    Background/Purpose: Axial spondyloarthritis (AxSpA) is a frequent inflammatory disease with a significant impact on a patient's quality of life. Therefore, early diagnosis and recognition of…
  • Abstract Number: 2007 • ACR Convergence 2023

    Effects of IL-17 Blockade on Skeletal Microarchitecture in Patients with Axial Spondyloarthritis: An HR-pQCT Study

    Insa Mannstadt, Donald McMahon, Douglas Mintz, Weija Yuan, Linda Russell, Susan Goodman, Emily Stein and Dalit Ashany, Hospital for Special Surgery, New York, NY

    Background/Purpose: Axial spondyloarthritis (AxSpA), a chronic inflammatory rheumatic disease causes abnormal bone growth at the spine and paradoxically has been linked to osteoporosis and fragility…
  • Abstract Number: 2209 • ACR Convergence 2023

    Prevalence and Clinical Characteristics of Late Onset Axial Spondyloarthritis: Results from a Multicentre Nationwide Study

    Margarida Lucas Rocha1, Rita Torres2, Sofia Ramiro3, Alice Morais Castro4, Alice Neves5, Ana Martins6, Ana Teodósio Chícharo1, Beatriz Mendes7, Carolina Ochôa Matos8, Catarina Soares9, Cláudia Miguel10, Cláudia Pinto Oliveira11, Hugo Parente12, J. A. Melo Gomes13, Mariana Luís14, Mariana Santos15, Maura Couto16, Miguel Bernardes17, Paula Valente18, Roberto Costa19, Sandra Sousa4, Jaime Branco20, Fernando Pimentel-Santos21 and Alexandre Sepriano22, 1Rheumatology Department, Centro Hospitalar Universitário do Algarve, Faro, Portugal, 2Hospital Egas Moniz, Lisboa, Portugal, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Departamento de Reumatologia, Hospital Garcia de Orta, Almada, Portugal, 5Instituto Português de Reumatologia, Lisboa, Portugal, 6Serviço de Reumatologia, Centro Hospitalar Universitário São João; Serviço de Medicina, Faculdade de Medicina da Universidade do Porto, Porto, Portugal, 7Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 8Centro Académico de Medicina de Lisboa, Lisbon, Portugal, 9Centro Unidade Local de Saúde do Alto Minho, Viana do Castelo, Portugal, 10Instituto Português de Reumatologia, Lisbon, Portugal, 11Serviço de Reumatologia, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal, 12Serviço de Reumatologia do Centro Unidade Local de Saúde do Alto Minho, Viana do Castelo, Portugal, 13Clínica Reumatológica Dr. Melo Gomes, Lisboa, Portugal, 14Serviço de Reumatologia – Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 15Serviço de Reumatologia do Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz EPE, Lisboa, Portugal, 16Unidade de Reumatologia, Centro Hospitalar Tondela-Viseu, Viseu, Portugal, 17Rheumatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal, 18Serviço de Reumatologia, Centro Hospitalar Entre o Douro e o Vouga, Santa Maria da Feira, Portugal, 19Centro Hospitalar Lisboa Norte, Lisboa, Portugal, 20CHLO, EPE - Hospital Egas Moniz, Lisbon, Portugal, 21NOVA Medical School; Universidade NOVA e Lisboa, Lisboa, Portugal, 22Leiden University Medical Centre, Portela Loures, Portugal

    Background/Purpose: Axial spondyloarthritis (axSpA) typically starts before the fourth decade of life. Consistent with that, the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for…
  • Abstract Number: 2237 • ACR Convergence 2023

    Upadacitinib in Refractory Psoriatic Arthritis. Multicenter Study of 134 Patients in Clinical Practice

    Eva Galindez-Agirregoikoa1, Diana Prieto-Peña2, Maria Luz Garcia Vivar1, Lucia Vega-Alvarez1, Cristina Vergara3, Irati Urionaguena4, Consuelo Ramos-Giráldez5, Raquel Almodovar6, Beatriz Joven Ibáñez7, Rosario Garcia-Vicuna8, Vega Jovani9, Teresa González10, Àngels Martínez-Ferrer11, Ana Urruticoechea Arana12, Bryan Josue Flores Robles13, Cristina Campos Fernández14, Lilian Maria Lopez Nunez15, Joaquin Maria Belzunegui Otano16, Marina Pavia Pascual17, Esteban Rubio18, Angel Ramos-Calvo19, Noemi Busquets20, Ana Pérez Gómez21, Francisco Miguel Ortiz Sanjuan22, Rafael Benito Melero-Gonzalez23, Cristina Macía24, María Ángeles Puche Larrubia25, Jose Antonio Pinto Tasende26, Cristina Fernandez27, Maria Paz Martinez-Vidal28, Jaime Calvo- Alén29, Emma Beltran-Catalan30, Mireia Moreno31, Silvia Pérez-Barrio32, iñigo Gorostiza Hormaeche1 and Ricardo Blanco33, 1Basurto University Hospital, Bilbao, Spain, 2Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Hospital Universitario Infanta Sofía, Madrid, Spain, 4GALDAKAO-USANSOLO UNIVERSITY HOSPITAL, GERNIKA-LUMO, Spain, 5Rheumatology Department Hospital Universitario Virgen de Valme, Sevilla, Spain, 6Alcorcón Foundation University Hospital, Madrid, Spain, 7Hospital Universitario 12 de Octubre, Madrid, Spain, 8Hospital Universitario de la Princesa, Madrid, Spain, 9Department of Rheumatology, Hospital General Universitario Dr. Balmis, Alicante, Spain, 10Hospital General Universitario Gregorio Marañón, Madrid, Spain, 11Hospital Universitario Dr Peset Valéncia, Valéncia, Spain, 12Hospital Can Misses, Ibiza, Spain, 13Hospital Universitario San Pedro, Logroño, Spain, 14Hospital General Universitario Valencia, Valencia, Spain, 15Son llatzer, Palmanyola, Spain, 16University Hospital Donostia, Donostia-San Sebasti, Spain, 17Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, 18Servicio Andaluz Salud, Sevilla, Spain, 19Complejo Hospitalario de Soria, Soria, Spain, 20HOSP. GENERAL DE GRANOLLERS, GRANOLLERS, Spain, 21Rheumatology, Hospital Principe de Asturias, Alcalá de Henares, Spain, 22Hospital Universitario y Politecnico La Fe, Valencia, Spain, 23CHU Vigo, O Carballino, Spain, 24Hospital Universitario Ramón y Cajal, Madrid, Spain, 25Department of Rheumatology, Reina Sofia University Hospital, Cordoba, Spain, 26Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain, 27Hospital Universitario San Juan de Alicante, Alicante, Spain, 28Hospital Universitario San Juan Alicante, Alicante, Spain, 29Rheumatology, Bioaraba Research Unit, Hospital Universitario Araba, Vitoria, Spain, 30HOSPITAL DEL MAR, Barcelona, Spain, 31Parc Tauli Hospital Universitari, I3PT(UAB), Barcelona, Spain, 32Hospital Universitario de Basurto, Bilbao, Spain, 33Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: The EMA authorized Upadacitinib (UPA) in PsA in January 2021. UPA has shown efficacy in PsA refractory to anti-TNF in a clinical trial (RCT).…
  • Abstract Number: 0466 • ACR Convergence 2023

    Impact of Postpartum on Patients with Inflammatory Rheumatic Diseases: The P2Rheum Study

    Marie Hornez1, Anna Molto2, Maxime Leroy3, beatrice banneville4, Rakiba Belkhir5, elodie chauvet6, Marion Couderc7, Emanuelle Dernis8, sandra Desouches9, Valerie Devauchelle10, Aline Frazier-Mironer11, Laure Gossec12, elisabeth Gervais13, Hubert Marotte14, Christophe Richez15, Jeremie SELLAM16, Raphaele Seror17, Véronique Le Guern18, Gaelle Guettrot-Imbert18, Nathalie Costedoat-Chalumeau19, Rene-Marc Flipo20 and Jean-Guillaume Letarouilly21, 1University of Lille, Lille, France, 2HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, 3CHU Lille - Department of Biostatistics, Lille, France, 4Sorbonne universite and Pitié Salpêtrière Hospital, la Garenne Colombes, France, 5Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin-Bicêtre, France, 6CH Perpignan, Perpignan, France, 7CHU Gabriel Montpied, Clermont Ferrand, France, 8CH Le Mans, Le Mans, France, 9Hôpital Saint Antoine, Assistance Publique Hôpitaux de Paris, Paris, France, 10UBO, Brest, France, 11APHP Lariboisiere Hospital, Paris, France, 12Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France, 13CHU Poitiers, Poitiers, France, 14CHU Saint-Etienne, Saint-Etienne, France, 15Université de Bordeaux, Bordeaux, France, 16Sorbonne Université APHP, Paris, France, 17University Hospital Paris Saclay, Le Kremlin-Bicêtre, France, 18APHP Hôpital Cochin, Paris, France, 19Inserm DR Paris 5, Paris, France, 20La Lettre du Rhumatologue, Paris, France, 21CHU Lille, Lille, France

    Background/Purpose: There are limited data on the impact of the postpartum period (PP) on the activity of inflammatory rheumatic disorders (IRD), and the data available…
  • Abstract Number: 0526 • ACR Convergence 2023

    Bimekizumab Improved Physical Function and Health-Related Quality of Life in Patients with Axial Spondyloarthritis: 52-Week Results from Two Phase 3 Studies

    Maureen Dubreuil1, Karl Gaffney2, Jonathan Kay3, Victoria Navarro-Compán4, Christine de la Loge5, Alicia Ellis6, Carmen Fleurinck7, Ute Massow8, Vanessa Taieb9 and Atul Deodhar10, 1Department of Rheumatology, Boston University School of Medicine, Milton, MA, 2Norfolk and Norwich University Hospital NHS Trust, Norfolk, United Kingdom, 3Division of Rheumatology, Department of Medicine, UMass Chan Medical School and UMass Memorial Medical Center, Worcester, MA, 4Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, 5UCB Pharma, Brussels, Belgium, 6UCB Pharma, Raleigh, NC, 7UCB Pharma, Oosterzele, Belgium, 8UCB Pharma, Monheim am Rhein, Germany, 9UCB Pharma, Colombes, France, 10Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, Portland, OR

    Background/Purpose: Axial spondyloarthritis (axSpA) severely impairs physical function and health-related quality of life (HRQoL).1 Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits IL-17F in…
  • Abstract Number: 0844 • ACR Convergence 2023

    Facet Joint Inflammation Is Rare, but When Present It Is Associated with Facet Joint Ankylosis in Radiographic Axial Spondyloarthritis Patients from the SIAS Cohort

    Manouk de Hooge1, Rosalinde Stal2, Alexandre Sepriano3, Xenofon Baraliakos4, Monique Reijnierse5, Juergen Braun6, Désirée van der Heijde7, Floris Van Gaalen2 and Sofia Ramiro7, 1Ghent University Hospital, Hesperange, Luxembourg, 2Leiden University Medical Center, Department of Rheumatology, Leiden, Netherlands, 3Leiden University Medical Centre, Portela Loures, Portugal, 4Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 5Leiden University Medical Center, Leiden, Netherlands, 6Ruhr-Universität Bochum and Rheumazentrum Ruhrgebiet, Herne, Germany, 7Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: To assess whether posterior element (PE) inflammation, in particular in the facet joints (FJ), is associated with new facet joint ankylosis on MRI one…
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