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Abstracts tagged "spondyloarthritis"

  • Abstract Number: LB09 • ACR Convergence 2025

    Rotation or Change of Biologic After TNF blocker treatment failure for axial Spondyloarthritis

    Elisa Dalix1, Philippe Goupille2, Daniel Wendling3, Christian Roux4, Jean-Hughes Samon5, Olivier Brocq6, Anne Tournadre7, Arnaud Constantin8, Maxime Breban9, Gregoire Cormier10, Tristan Pascart11, Thierry Lequerre12, Pascal Claudepierre13, Eric Lespessailles14, Benoit Legoff15, Jeremie Sellam16, Athan Baillet17, Thierry Schaeverbeke18, Stephan Pavy19, Valerie Devauchelle-Pensec20, Elisabeth Gervais21, Laure Gossec22, Corinne Miceli23, Yves-Marie Pers24, Cedric Lukas25, Renaud Felten26, Beatrice Bouvard27, Amelie Denis28, Emmanuelle Dernis28, Emilie Presles29, Florence Rancon29 and Hubert Marotte30, 1Université Jean Monnet, CHU Saint-Etienne, Mines Saint-Etienne, INSERM, Saint-Etienne, France, 2Department of Rheumatology and INSERM-CIC1415, University Hospital of Tours, EA 7501 GICC, University of Tours, Tours, France, 3Rhumatologie, CHU de Besançon, Besancon, France, 4Service de rhumatologie, CHU de Nice, IbV, Université Cote d'Azur, Nice, France, 5Service de Rhumatologie, Hôpital Maison Blanche, Centre Hospitalier Universitaire de Reims, Reims, France; Université de Reims Champagne-Ardenne, Faculté de Médicine, EA 3797, Reims, France, 6Rheumatology Department, CHPG Monaco, Monaco, Monaco, 7Rheumatology Department, CHU Clermont-Ferrand, Clermont-Ferrand, France, 8Rheumatology Center, Toulouse University Hospital, Toulouse, France, 9INSERM UMR1173, INFLAMEX, Laboratoire d'Excellence, Rheumatology Division, Ambroise Paré Hospital (AP-HP), Paris, France, 10Rheumatology, Centre Hospitalier Departemental Vendee, La Roche-sur-Yon, France, 11Department of Rheumatology, Université Catholique de Lille Hôpital Saint Philibert, Lomme, France, 12Department of Rheumatology & CIC-CRB 1404, Inserm, PANTHER UMR 1234, University of Rouen Normandie, Normandie University, CHU Rouen, Rouen, France, 13AP-HP, Henri-Mondor Hospital, Department of Rheumatology, EpiDermE, Université Paris Est Créteil, Créteil, France, 14Translational Medicine Research Platform, PRIMMO, University Hospital Centre of Orleans, Orleans, France, 15Nantes Université, ONIRIS, Univ Angers, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France, 16Rheumatology Department, Sorbonne Université, Saint-Antoine Hospital Assistance Publique Hôpitaux de Paris (AP-HP), Centre de Recherche Saint-Antoine (CRSA) Inserm UMRS-938,, Paris, France, 17Université Grenoble Alpes, 4UMR5525, Grenoble, France, 18Department of Rheumatology, Hôpital Pellegrin, Bordeaux, France, 19Department of Rheumatology, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, Le Kremlin-Bicetre, 20Department of Rheumatology, Université de Bretagne Occidentale, CHU Brest, INSERM (U1227), LabEx IGO, Brest, France, 21LITEC, Université de Poitiers, CHU Poitiers, Poitiers, France, 22Sorbonne Université, AP-HP & EULAR, Paris, France, 23Immunoregulation Unit, Institut Pasteur, Cochin AP-HP, Paris, France, 24IRMB, University of Montpellier, Inserm U1183, CHU Montpellier, Montpellier, France, 25Rheumatology department, CHU and University of Montpellier, Montpellier, France; UMR UA11 Inserm (IDESP), University of Montpellier, Montpellier, France, 26Service de Rhumatologie, CHU de Strasbourg - Hôpital de Hautepierre, Strasbourg, France, 27Rhumatologie, Centre Hospitalier Universitaire, Angers, France, 28CH Le Mans, Le Mans, France, 29CHU Saint-Etienne, CIC 1408, Saint-Etienne, France, 30Université Jean Monnet, CHU de Saint-Etienne, CIC 1408, Mines Saint-Etienne, INSERM, SSINBIOSE 1059, Saint-Etienne, France

    Background/Purpose: Axial spondyloarthritis (axSpA) is initially treated with non-steroidal anti-inflammatory drugs. In case of inadequate response, ACR/EULAR recommend biological disease-modifying antirheumatic drugs (bDMARDs). Up to…
  • Abstract Number: 2358 • ACR Convergence 2025

    Bimekizumab Demonstrated Early and Sustained Efficacy Regardless of Baseline Characteristics in Patients with Active Psoriatic Arthritis: Pooled Post Hoc Results up to 1-Year from Two Phase 3 Studies

    Lihi Eder1, Philip J. Mease2, Iain McInnes3, M. Elaine Husni4, Mitsumasa Kishimoto5, Barbara Ink6, Rajan Bajracharya6, Jason Coarse7 and Fabian Proft8, 1University of Toronto, Toronto, ON, Canada, 2Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 3University of Glasgow, Glasgow, United Kingdom, 4Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 5Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, 6UCB, Slough, England, United Kingdom, 7UCB, Morrisville, NC, 8Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

    Background/Purpose: Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)‑17F in addition to IL‑17A, has demonstrated clinical efficacy and safety to 3 years…
  • Abstract Number: 2320 • ACR Convergence 2025

    Sleep Disturbance in Psoriatic Arthritis: Prevalence by Minimal Disease Activity Status and Associated Clinical Factors

    Lourdes Perez Chada1, Vivi Feather2, Grace Carter2, Helen Early3, Emily Tsai2, Jing Cui4, Avery LaChance5, Rochelle Castillo6, Neda shahriari2, Alexis Ogdie7, Monika Haack2, Elizabeth Klerman2, Michael Weinblatt8, Nancy Shadick9, Joseph Merola10 and Chinmayi Naik3, 1Harvard Medical School, Wayland, MA, 2Mass General Brigham, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham Women's Hospital, Boston, MA, 5Brigham and Women's Hospital, Jamaica Plain, MA, 6Brigham and Women's Hospital, Brookline, MA, 7Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, 8Brigham and Women's Hospital/ Harvard Medical School, Waban, MA, 9Brigham & Women's Hospital, Boston, MA, 10UT Southwestern Medical Center, Dallas, TX

    Background/Purpose: Sleep disturbance is a common and burdensome symptom in psoriatic arthritis (PsA), but its clinical determinants remain poorly understood. Using data from the Cohort…
  • Abstract Number: 1930 • ACR Convergence 2025

    Can a Multinational Awareness Campaign Improve Referral Rates and Reduce Diagnostic Delays in Patients with Chronic Inflammatory Rheumatic Diseases? The Impact of a Prospective Interventional Study

    Nelly Ziade1, Karen Mechleb2, Fatima Alnaimat3, Sherif Gamal4, Avin Maroof5, Bassel Elzorkany6, Manal Mashaleh7, Manal El Rakawi8, Mahmoud Adly9, Lina Elkibbi10, ERRAOUI Mariam11, Krystel Aouad12, Chafika Haouichat13, Nizar Abdullateef14, ASAL ADNAN RIDHA15, Fatemah Baron16 and Ihsane Hmamouchi17, 1Department of Rheumatology, Saint-Joseph University and Hotel-Dieu de France, Beirut, Lebanon, 2Saint Joseph University Beirut, Beirut, Lebanon, 3The University of Jordan, amman, Jordan, 4Cairo University, Cairo, Egypt, 5University of Kurdistan Hawler, Erbil, Iraq, 6Private (BZRC), Cairo, Egypt, 7Al Saudi Hospital, Amman, Jordan, 8Djillali Bounaama University Hospital, Algiers, Algeria, Algiers, Algeria, 9Ministry of Health, Kuwait, Kuwait, Saad Elabdulla, Kuwait, 10Specialized Medical Center, Riyadh, Saudi Arabia, Riyadh, Saudi Arabia, 11CHU Agadir, Agadir, Morocco, 12Department of Rheumatology, Saint George Hospital University Medical Center, Beirut, Lebanon, 13Djillali Bounaama University Hospital, Algiers, Algeria, 14Baghdad College of Medicine, Baghdad, Iraq, 15Baghdad Teaching Hospital, Baghdad, Iraq, 16Al-Jahra Hospital, Kuwait, Kuwait, Kuwait, Kuwait, 17Health Sciences Research Center (CReSS).Faculty of Medicine, International University of Rabat, Rabat, Morocco

    Background/Purpose: Delayed diagnosis and treatment in chronic inflammatory rheumatic diseases (CIRDs), including rheumatoid arthritis (RA), axial spondyloarthritis (axSpA), and psoriatic arthritis (PsA), is associated with…
  • Abstract Number: 1435 • ACR Convergence 2025

    Impact of Treatment With Upadacitinib on Non-Nociceptive Pain and Its Relevance for the Presence of Residual Symptoms in Axial Spondyloarthritis: Results from a Multicountry Observational Study

    Denis Poddubnyy1, Victoria Navarro-Compan2, Neil Basu3, Mohammad Naffaa4, Tianming Gao5, Christopher Saffore6, Jamie Urbanik7, Bhumik Parikh8, Peter Taylor9 and Philip J. Mease10, 1Division of Rheumatology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada, and Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Department of Epidemiology, German Rheumatism Research Centre, Berlin, Germany, 2Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, 3Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, 4The Azriel's Faculty of Medicine, Bar-Ilan University, Safed, Israel; The Rheumatology Unity, Galilee Medical Center, Naharyia, Israel, 5AbbVie, North Chicago, IL, 6AbbVie Inc., waukegan, IL, 7AbbVie, Grayslake, IL, 8AbbVie, Hillsborough Township, NJ, 9University of Oxford, Oxford, United Kingdom, 10Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA

    Background/Purpose: Upadacitinib (UPA), an oral JAK inhibitor, has demonstrated improvements in inflammation and nociceptive pain in late phase clinical trials of patients with axSpA.1,2,3 However,…
  • Abstract Number: 0592 • ACR Convergence 2025

    An Interim Analysis of Health-Related Quality of Life Outcomes from an International Multicentre Observational Study in Patients with Axial Spondyloarthritis Initiating Bimekizumab in Real-World Clinical Practice

    Xenofon Baraliakos1, Uta Kiltz1, Kurt de Vlam2, Adeline Ruyssen-Witrand3, Julio Ramírez Garcia4, Jessica A. Walsh5, Denis Poddubnyy6, David Nicholls7, Marga Oortgiesen8, Francesca Maria Ester Castagna9, Marie-Alix Bonny10, Hervé Besson11, Rajan Bajracharya12, Patrik Öhagen13, Christine de La Loge10 and William Tillett14, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 2Department of Rheumatology, UZ Leuven, Leuven, Belgium, 3CHU of Toulouse - Pierre-Paul Riquet Hospital (Inflammation, Infection, Immunology and Locomotor Center - Rheumatology Service, Toulouse, France, 4Rheumatology Department, Hospital Clinic and IDIBAPS of Barcelona, Barcelona, Spain, 5Division of Rheumatology, Salt Lake City Veterans Affairs Health and University of Utah Health, Salt Lake City, UT, 6Division of Rheumatology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada, and Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Department of Epidemiology, German Rheumatism Research Centre, Berlin, Germany, 7Clinical Trials Unit, University of the Sunshine Coast, Queensland, Australia, 8UCB, Raleigh, NC, 9UCB SpA, Milano, Italy, 10UCB, Brussels, Belgium, 11UCB, Breda, Netherlands, 12UCB, Slough, England, United Kingdom, 13UCB, Stockholm, Sweden, 14Department of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom

    Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease with a significant burden on patients’ (pts) health-related quality of life (HRQoL).1 Bimekizumab (BKZ), a monoclonal…
  • Abstract Number: 0544 • ACR Convergence 2025

    Prevalence and Baseline Characteristics associated with Difficult-to-Manage Axial Spondyloarthritis in the DESIR Cohort

    Olivier Fakih1, Anna Molto2, Frank Verhoeven1, Clément Prati1 and WENDLING Daniel1, 1CHU de Besançon, Besançon, Franche-Comte, France, 2Assistance Publique Hôpitauxde Paris, Paris, France

    Background/Purpose: Despite a choice of multiple targeted DMARDs, with different modes of action (MoA), a number of patients with axial spondyloarthritis (axSpA) have failed several…
  • Abstract Number: 0428 • ACR Convergence 2025

    The OMERACT Juvenile Idiopathic Arthritis MRI Score for Active and Structural Lesions in the Sacroiliac Joints: Development and Validation in Two Longitudinal Cohorts

    Walter P. Maksymowych1, Michael Francavilla2, Nele Herregods3, Robert G. W. Lambert4, Arthur Meyers5, Joel Paschke6, Jennifer Stimec7, Pamela Weiss8 and Dax Rumsey9, 1Department of Medicine, University of Alberta, 568 Heritage Building, Edmonton, AB, Canada, 2Department of Pediatric Radiology, Children’s Hospital Philadelphia, Philadelphia, PA, 3Department of Pediatric Radiology, Ghent University Hospital, Ghent, Belgium, 4University of Alberta, Department of Radiology & Diagnostic Imaging, Edmonton, AB, Canada, 5Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 6CARE Arthritis Limited, Edmonton, AB, Canada, 7Department of Diagnostic Imaging, SickKids, University of Toronto, Toronto, Canada, 8Childrens Hospital of Philadelphia, Philadelphia, PA, 9Department of Pediatrics, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: The OMERACT Juvenile Idiopathic Arthritis MRI (JAMRIS) Working group has defined a spectrum of MRI lesions in the sacroiliac joint (SIJ) in youth with…
  • Abstract Number: 2359 • ACR Convergence 2025

    Combination Of ­TNF Inhibitors And NSAIDs Versus ­TNF Inhibitors Alone On The Progression Of Structural Damage In The Spine And Hip: a Retrospective Study In 262 Patients With Radiographic Axial Spondyloarthritis

    MARIA KONSTA1, Michael Nurmohamed2, Alexios Iliopoulos3, Petros Sfikakis4, Ingrid Visman5, Grigorios Sakellariou6 and Irene E. van der Horst-Bruinsma7, 1Sismanoglion Hospital, Athens, Greece, Marousi, Attiki, Greece, 2Amsterdam Rheumatology and Immunology Center, Reade; Department of Rheumatology and Amsterdam Rheumatology Center, Amsterdam University Medical Centers, Amsterdam, Netherlands, 3417 Army Share Fund Hospital (NIMTS), Department of Rheumatology, Athens, Greece, ZOGRAFOU, Greece, 4NKUA - SCHOOL OF MEDICINE, Athens, Greece, 5Reade Amsterdam, Amsterdam, Noord-Holland, Netherlands, 6424 General Military Hospital, Thessaloniki, Greece, 7Department of Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands

    Background/Purpose: The inhibitory effect of TNF inhibitor (TNFi) treatment on spinal radiographic progression in patients with radiographic Axial Spondyloarthritis (r-axSpA), remains controversial. However, current evidence…
  • Abstract Number: 2319 • ACR Convergence 2025

    Reducing selection bias while maintaining precision through an integrated analysis: 2-year longitudinal analysis of imaging outcomes in the SPondyloArthritis Caught Early cohort

    Liese de Bruin1, Floris A. van Gaalen1, Manouk de Hooge2, Miranda van Lunteren1, Mary Lucy Marques3, Monique Reijnierse4, Roberta Ramonda5, Inger Jorid Berg6, Carl Turesson7, Robert Landewé8, Désirée Van Der Heijde1 and Sofia Ramiro9, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands; and Coimbra Local Health Unit, Coimbra, Portugal, 4Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 5Rheumatology Unit-DIMED-University of Padova ITALY, Padova, Padua, Italy, 66Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Nepal, 7Lund University, Malmö, Sweden, 8Department of Rheumatology, Amsterdam University Medical Center, Amsterdam, Netherlands; and Zuyderland Medical Center, Heerlen, Netherlands, 9Leiden University Medical Center, Bunde, Netherlands

    Background/Purpose: Imaging outcomes in ongoing cohort studies are typically evaluated across multiple reading rounds by several readers. Often, only scores from the most recent reading…
  • Abstract Number: 1815 • ACR Convergence 2025

    New-Onset Juvenile Spondyloarthritis is Characterized by Bone Metabolism Disturbances with Biomarker Potential

    Brittney Newby1, Timothy Brandon1, Pamela Weiss2 and E. John Wherry3, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2Childrens Hospital of Philadelphia, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Juvenile spondyloarthritis (JSpA) management is hindered by the lack of reliable biomarkers to predict which patients will develop progressive structural changes, such as erosions…
  • Abstract Number: 1434 • ACR Convergence 2025

    Safety of Prescription NSAIDs in Adults with IBD: Data from a Large Administrative Claims Cohort

    Adam Mayer1, Rui Xiao2, Meenakshi Bewtra3, Michael George4 and Pamela Weiss5, 1University of Pennsylvania/Children's Hospital of Philadelphia, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, 4University of Pennsylvania, Philadelphia, PA, 5Childrens Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: The potential that nonsteroidal anti-inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing joint pain in…
  • Abstract Number: 0591 • ACR Convergence 2025

    An Interim Analysis of Health-Related Quality of Life Outcomes from an International Multicentre Observational Study in Patients with Psoriatic Arthritis Initiating Bimekizumab in Real-World Clinical Practice

    Xenofon Baraliakos1, Uta Kiltz1, Kurt de Vlam2, Adeline Ruyssen-Witrand3, Felipe Julio Ramirez Garcia4, Jessica A. Walsh5, Denis Poddubnyy6, David Nicholls7, Marga Oortgiesen8, Francesca Maria Ester Castagna9, Marie-Alix Bonny10, Hervé Besson11, Jérémy Lambert12, Rajan Bajracharya13, Patrik Öhagen14 and William Tillett15, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 2Department of Rheumatology, UZ Leuven, Leuven, Belgium, 3CHU of Toulouse - Pierre-Paul Riquet Hospital (Inflammation, Infection, Immunology and Locomotor Center - Rheumatology Service, Toulouse, France, 4Rheumatology Department, Hospital Clinic and IDIBAPS of Barcelona, Barcelona, Spain, 5Division of Rheumatology, Salt Lake City Veterans Affairs Health and University of Utah Health, Salt Lake City, UT, 6Division of Rheumatology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada, and Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Department of Epidemiology, German Rheumatism Research Centre, Berlin, Germany, 7Clinical Trials Unit, University of the Sunshine Coast, Queensland, Australia, 8UCB, Raleigh, NC, 9UCB SpA, Milano, Italy, 10UCB, Brussels, Belgium, 11UCB, Breda, Netherlands, 12UCB, Colombes, France, 13UCB, Slough, England, United Kingdom, 14UCB, Stockholm, Sweden, 15Department of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom

    Background/Purpose: PsA is a chronic inflammatory disease with a significant burden on patients’ (pts) health-related quality of life (HRQoL).1 Bimekizumab (BKZ), a monoclonal IgG1 antibody…
  • Abstract Number: 0545 • ACR Convergence 2025

    Temporal trends in the phenotype and treatment outcomes in axial spondyloarthritis patients included in randomized clinical trials over 25 years: a systematic literature review and meta-regression analysis

    Omar-Javier Calixto1, Uta Kiltz2, Brikena Lalazi3, Franziska Neinert3, Philipp Sewerin4 and Xenofon Baraliakos2, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Cellular and Molecular Immunology Group (InmuBo), Universidad El Bosque, Herne, Nordrhein-Westfalen, Germany, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 3Rheumazentrum Ruhrgebiet, Herne, Germany, 4Rheumazentrum Ruhrgebiet Herne; Ruhr-Universität Bochum, Germany, Herne, Germany

    Background/Purpose: The phenotypes of axial spondyloarthritis (axSpA) and clinical responses to placebo and study drugs in randomized controlled trials (RCTs) have changed over time. We…
  • Abstract Number: 0412 • ACR Convergence 2025

    The Association of Obesity with Juvenile Spondyloarthritis

    Katelyn Baggett1, Timothy Brandon2 and Pamela Weiss3, 1Johns Hopkins University, Newtown Square, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3Childrens Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Childhood obesity is a global public health concern that impacts the health and wellbeing of all children and particularly negatively affects children living with…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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