Abstracts tagged "Spondylarthritis and tumor necrosis factor (TNF)"

Abstract Number: 2598 • 2018 ACR/ARHP Annual Meeting
Efficacy of Anti-Tumor Necrosis Factor (TNF) Alpha Therapy, in Patients with Spondylarthritis in the University Center of Rouen in France, Divived to the Berlin Algorithm Modified By the Assessement Spondylarthritis Group: A Ten Years Retrospective Study
Christelle Princivil¹, thierry Lequerre², Didier Alcaix³ and Olivier Vittecoq⁴, ¹Jacques Monod hospital center, 76290 Montivilliers, France, montivilliers, France, ²Rheumatology Department, Rouen University Hospital, University of Rouen, 76031 Rouen, France., ROUEN, France, ³Rheumatology Department, Jacques Monod Hospital Center, 76290 Montivilliers, France, montivilliers, France, ⁴INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France
Background/Purpose: Treatments and diagnosis of SpA is a public health problem. The efficacy of anti-TNF alpha treatment is different from one patient to an other.…
Abstract Number: 276 • 2018 ACR/ARHP Annual Meeting
Gender Differences in TNFi Treatment Adherence and Response in As Patients: A Prospective Longitudinal Cohort Study
S. Hoekstra¹, Tamara Rusman², Michael T. Nurmohamed³, Christiaan van Denderen⁴ and Irene van der Horst-Bruinsma⁵, ¹Rheumatology, VU Univeresity Medical Center, Amsterdam, Netherlands, ²Rheumatology, VU University medical centre, Amsterdam, Netherlands, ³Rheumatology, Amsterdam Rheumatology and immunology Center, VU University Medical Center, Amsterdam, Netherlands, ⁴Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁵Rheumatology, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Despite several observations of gender differences in TNF inhibitor (TNFi) treatment response and adherence in ankylosing spondylitis (AS) patients, limited studies were conducted. Our…
Abstract Number: 1547 • 2017 ACR/ARHP Annual Meeting
Dose Tapering of TNFi in Patients with Axial Spondyloarthritis: An Observational Cohort Study from Nationwide Korean College of Rheumatology Biologic Registry (KOBIO)
Jun Won Park¹, Jin Kyun Park¹, Kichul Shin², Yong-Beom Park³, Eun Bong Lee¹, Yeong Wook Song⁴ and Eun Young Lee¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ²Kyungnam villa #102, Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of (South), ³Yonsei University Severance Hospital, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: To compare the clinical efficacy of dose-tapering strategy of tumor-necrosis factor inhibitor (TNFi) with that of standard-dose TNFi treatment in patients with spondyloarthritis (SpA)…
Abstract Number: 2463 • 2017 ACR/ARHP Annual Meeting
Golimumab in Biologic-NaïVe Patients with Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA) or Ankylosing Spondylitis (AS) – Subanalysis from a Non-Interventional Evaluation in Germany
Klaus Krüger¹, Gerd R. Burmester², Siegfried Wassenberg³, Martin Bohl-Buehler⁴ and Matthias H. Thomas⁵, ¹Praxiszentrum St. Bonifatius München, München, Germany, ²Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, ³Rheumazentrum Ratingen, Ratingen, Germany, ⁴Friedrich-Ebert-Str. 35, Rheumahaus, Potsdam, Germany, ⁵Medical Affairs, MSD Sharp & Dohme GmbH, Bünde, Germany
Background/Purpose: Golimumab (GLM) has demonstrated efficacy and safety in several randomized clinical trials with biologic-naïve patients (pts.). However, more data regarding the effectiveness and patient-reported…
Abstract Number: 2481 • 2017 ACR/ARHP Annual Meeting
Long-Term Safety of Adalimumab (HUMIRA) in Adult Patients from Global Clinical Trials across Multiple Indications: An Updated Analysis in 29,987 Patients Representing 56,951 Patient-Years
Gerd R. Burmester¹, Remo Panaccione², Kenneth B. Gordon³, James T. Rosenbaum⁴, Dilek Arikan⁵, Winnie L. Lau⁵ and Rita Tarzynski-Potempa⁵, ¹Charité - University Medicine Berlin, Berlin, Germany, ²University of Calgary, Calgary, AB, Canada, ³Medical College of Wisconsin, Milwaukee, WI, ⁴Ophthalmology, Oregon Health & Science University and Legacy Devers Eye Institute, Portland, OR, ⁵AbbVie Inc., North Chicago, IL
Background/Purpose: Adalimumab is an anti–tumor necrosis factor-α (TNF-α) agent indicated for the treatment of immune-mediated diseases. The long-term safety of adalimumab was previously reported in…
Abstract Number: 2725 • 2016 ACR/ARHP Annual Meeting
Elevated Disease Activity in Disease-Related Spondyloarthritis Despite Use of Tumor Necrosis Factor Inhibitor Therapies
Delamo Bekele¹, Ryan Duong², Patrick R. Wood³, Mena Hashim⁴, Jason Hou⁵, Jessica Walsh⁶, Maureen Dubreuil^7,8, Daniel Clegg⁹, Prashant Kaushik¹⁰, Bernard Ng^11,12, Elizabeth Chang¹³, Andreas M. Reimold¹⁴, Liron Caplan¹⁵ and Gail S. Kerr¹⁶, ¹Medicine, Howard University Hospital, Washington, DC, ²Rheumatology, Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, ³Internal Medicine, University of Colorado School of Medicine, Aurora, CO, ⁴Denver VAMC, Denver, CO, ⁵Gastroenterology, Houston VAMC and Baylor College of Medicine, Houston, TX, ⁶Division of Rheumatology, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, ⁷Rheumatology, Boston VA HealthCare System, Boston, MA, ⁸Rheumatology, Boston University Medical Center, Boston, MA, ⁹Rheumatology, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, ¹⁰Rheumatology/Medicine, Stratton VAMC, Albany, NY, ¹¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ¹²Rheumatology, VA Puget Sound Healthcare System, Seattle, WA, ¹³Rheumatology, Veterans Affairs, Phoenix, AZ, ¹⁴Rheumatology, VAMC and University of Texas Southwestern, Dallas, TX, ¹⁵Div of Rheumatology, Denver VA and University of Colorado School of Medicine, Aurora, CO, ¹⁶Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC
Background/Purpose: Spondyloarthritis (SpA) includes a wide range of overlapping diseases for which there are a limited number of approved pharmacologic agents that have been…
Abstract Number: 1916 • 2014 ACR/ARHP Annual Meeting
Stromal Overexpression of Transmembrane TNF Induces Spa-like Arthritis and Spondylitis in Mice
Leonie M. van Duivenvoorde^1,2, Melissa N. van Tok³ and Dominique L. Baeten^1,4, ¹Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ³Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: The immunopathology of spondyloarthritis (SpA) is determined by inflammation and structural damage, in particular osteoproliferation, of axial and peripheral joints. The failure of TNF…
Abstract Number: 2467 • 2013 ACR/ARHP Annual Meeting
Response to Tumor Necrosis Factor inhibitors In Axial Spondyloarthritis: Does Sacroiliitis Make Any Difference?
Julien Girodon¹, Vianney Jouhet² and Elisabeth Solau-Gervais¹, ¹Rheumatology, University Hospital of Poitiers, Poitiers, France, ²Informatic, University hospital Bordeaux, Bordeaux, France
Background/Purpose: Axial spondyloarthritis (SpA) are characterized by sacroiliitis. The TNF inhibitors (TNFi) have been proven to be highly effective in ankylosing spondylitis. Recently, adalimumab demonstrate…
Abstract Number: 536 • 2013 ACR/ARHP Annual Meeting
Membrane-Bound TNF Drives Axial and Peripheral Inflammation and Pathologic New Bone Formation
Leonie M. van Duivenvoorde¹, Melissa N. van Tok¹ and Dominique L. Baeten², ¹Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: The morbidity of spondyloarthritis (SpA) is determined not only by inflammation but also by structural damage, in particular osteoproliferation leading to joint ankylosis. The…

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