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Abstracts tagged "spondylarthritis and tofacitinib"

  • Abstract Number: 984 • ACR/ARHP Annual Meeting 2015

    Tofacitinib Inhibits Inflammation and New Bone Formation in Murine Spondyloarthritis but Does Not Adversely Inhibit Normal Human MSC Function

    Rik Lories1, Katelijne De Wilde2, Kerri Heritage1, Richard Cuthbert3, Elena Jones3, Karlijn Debusschere4, Dennis McGonagle3 and Dirk Elewaut5, 1Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven and University Hospitals Leuven., Leuven, Belgium, 2Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology,, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, 5Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium

    Background/Purpose: Inflammation and new bone formation at entheseal sites are hallmarks of spondyloarthritis (SpA).  As TNF inhibition has only limited impact on new bone formation,…

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