Abstracts tagged "SLE and T cells"

Abstract Number: 1748 • 2017 ACR/ARHP Annual Meeting
Cbl-b Associates with Bcl-6 and Is Differentially Expressed in Circulating Follicular T Helper Cells of Patients with Systemic Lupus Erythematosus
Jeffrey Hampton¹, Giancarlo R. Valiente², Armin Munir³, Takuma Tsuzuki Wada³, William Willis³, Nicholas A. Young³, Lai-Chu Wu⁴, Jian Zhang⁵ and Wael Jarjour³, ¹Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ²Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Activation of polyclonal CD4+ T cells and B cells is a hallmark of human and murine lupus, which suggests a global defect in the…
Abstract Number: 2639 • 2017 ACR/ARHP Annual Meeting
Pathological Relevance of T Follicular Helper Cell and Plasmablast in Patients with Systemic Lupus Erythematosus
Shingo Nakayamada¹, Satoshi Kubo², Maiko Yoshikawa², Yusuke Miyazaki², Shigeru Iwata³, Ippei Miyagawa⁴, Shunsuke Fukuyo⁵, Kazuhisa Nakano¹ and Yoshiya Tanaka⁶, ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁴University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁵University of Occupational and Environmental Health, Japan, Fukuoka, Japan, ⁶The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Increasing evidence points to immunological heterogeneity in the pathogenesis of SLE. Indeed, targeted therapy for SLE showed considerable variability of efficacy. Thus, it seems…
Abstract Number: 2861 • 2016 ACR/ARHP Annual Meeting
Proportions of Circulating Follicular Helper T Cells and Complement Levels, White Blood Cell Counts, and Skin Manifestations in Patients with Active Systemic Lupus Erythematosus
Jun Kikuchi¹, Masaru Takeshita¹, Katsuya Suzuki², Yoshiaki Kassai³, Takahiro Miyazaki³ and Tsutomu Takeuchi², ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ³Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan
Background/Purpose: Although circulating B cells and T cells, including follicular helper T (Tfh) cells, are reported to be involved in systemic lupus erythematosus (SLE) 1,2),…
Abstract Number: 3216 • 2015 ACR/ARHP Annual Meeting
T Cell Restricted Deletion of Serine/Arginine-Rich Splicing Factor 1 (SRSF1) in Mice Causes Immune Cell Dysfunction and Contributes to Lupus-like Nephritis
Vaishali R. Moulton¹, Michael W. Mosho², Hao Li², Andrew R. Gillooly² and George C. Tsokos³, ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) express reduced amounts of the critical CD3 zeta signaling chain, and are poor producers of…
Abstract Number: 2729 • 2014 ACR/ARHP Annual Meeting
To Live or Let Die… the Battle Between PD-1 and OX40 on SLE T Cells
Julie Kristine Laustsen¹, Stinne Greisen², Bent Deleuran³ and Tue Kruse Rasmussen⁴, ¹Aarhus University, Aarhus C, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Dept of Biomedicine, Aarhus University, Aarhus C, Denmark
Background/Purpose: Programmed cell death 1 (PD-1) is a co-inhibitory receptor, which inhibits T cell proliferation and survival by inhibiting IL-2 signalling. By this PD-1 has…
Abstract Number: 2682 • 2014 ACR/ARHP Annual Meeting
Serine Arginine-Rich Splicing Factor 1 (SRSF1) Regulates Transcriptional Activation of the T Cell Receptor CD3 Zeta Chain in Human T Cells
Vaishali Moulton¹, Andrew R. Gillooly² and George C. Tsokos³, ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose T cells from patients with systemic lupus erythematosus (SLE) express reduced amounts of the critical CD3 zeta signaling chain, and are poor producers of…
Abstract Number: 1628 • 2013 ACR/ARHP Annual Meeting
Decreased Levels Of Splicing Factor 2 / Alternative Splicing Factor (SF2/ASF) Correlate With Lower Transcript Levels Of The RasGRP1 Normal Isoform In Lupus T Cells
Takashi Kurita¹, Shinsuke Yasuda¹, Vaishali R. Moulton², Michihito Kono¹, Hideyuki Koide¹, Kenji Oku¹, Toshiyuki Bohgaki¹, Olga Amengual¹, Tetsuya Horita¹, George C. Tsokos³ and Tatsuya Atsumi¹, ¹Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: Down-regulation of MAP kinase pathway has been recognized in T cells from patients with SLE that results in hypo-methylation of DNA. RasGRP1 is an…
Abstract Number: 721 • 2013 ACR/ARHP Annual Meeting
T Cell Activation Induces Increased mRNA Expression Of The Splicing Factor SF2/ASF But Simultaneous Protein Downregulation Via Proteasome Mediated Degradation
Vaishali R. Moulton¹, Andrew R. Gillooly¹ and George C. Tsokos², ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) are poor producers of the vital cytokine interleukin (IL)-2. We recently showed that SLE…
Abstract Number: 629 • 2013 ACR/ARHP Annual Meeting
Altered ER Stress-Induced Autophagic Reactions Are Associated With Increased Apoptosis of T Lymphocytes in Systemic Lupus Erythematosus
Won Seok Lee¹, Myung-Soon Sung¹, Eun-Gyeong Lee¹, Chang-Hoon Lee², Myeung Su Lee³, Yun-Hong Cheon⁴, Sang-il Lee⁴, Yun Kyoung Hong⁵ and Wan-Hee Yoo⁶, ¹Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ²Department of Internal Medicine, School of medicine, Wonkwang university, Iksan, Chonbuk, South Korea, ³Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ⁵Rheumatology, Department of internal medicine, Presbyterian medical center, Jeonju, South Korea, ⁶Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea
Background/Purpose: The autophagic responses to ER stress are involved in the regulation of the maintenance of lymphocyte homeostasis and has been implicated in the pathogenesis…

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