Abstracts tagged "SLE and kinase"

Abstract Number: 646 • 2014 ACR/ARHP Annual Meeting
ONO-4059 – a Highly Potent and Dual Oral Inhibitor of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase: Improves Anti-Nuclear Antibodies–mediated SLE in Mice
Yuko Ariza¹, Toshio Yoshizawa¹, Yoshiko Ueda¹, Masayuki Murata¹ and Kazuhito Kawabata², ¹Exploratory Research Laboratories 1, Ono Pharmaceutical Co., Ltd., Osaka, Japan, ²Discovery Research Laboratories 3, Ono Pharmaceutical Co., Ltd., Osaka, Japan
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex and heterogeneous autoimmune disease associated with the over production of high affinity autoantibodies, mainly raised against nuclear…

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Abstracts tagged "SLE and kinase"

ONO-4059 – a Highly Potent and Dual Oral Inhibitor of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase: Improves Anti-Nuclear Antibodies–mediated SLE in Mice