Abstracts tagged "SLE and epigenetics"

Abstract Number: 2558 • 2017 ACR/ARHP Annual Meeting
DNA Methylation-Dependent Regulation of Cathepsin E Gene Expression By the Transcription Factor Kaiso in MRL/Lpr Mice
Sumie Hiramatsu¹, Katsue S. Watanabe¹, Yoshinori Matsumoto², Yosuke Asano², Sonia Zeggar¹, Keiji Ohashi¹, Michiko Morishiata³, Eri Katsuyama¹, Takayuki Katsuyama¹, Haruki Watanabe¹, Mariko Narazaki¹, Noriko Tatebe¹, Tomoko Kawabata¹, Ken-ei Sada¹ and Jun Wada¹, ¹Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ²Department of Nephrology, Rheumatology, Endocrinology and Metabolism,, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ³Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Background/Purpose: To identify new candidate genes regulated by DNA methylation and involved in the pathogenesis of systemic lupus erythematosus (SLE), we integrated genome-wide DNA methylation…
Abstract Number: 1073 • 2015 ACR/ARHP Annual Meeting
B Cell Subsets Are Epigenetically and Transcriptionally Dysregulated in Systemic Lupus Erythematosus
Emily Blalock¹, Chris Scharer², Ben Barwick², Scott Jenks³, Bridget Neary³, Jeremy Boss² and Ignacio Sanz^3,4, ¹Emory University School of Medicine, Atlanta, GA, ²Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, ³Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁴Medicine, Emory University, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by multiple B cell abnormalities, including the production of autoantibodies, a major contributing factor to disease pathogenesis. Epigenetic…

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