Abstracts tagged "SLE and clinical trials"

Abstract Number: L5 • 2014 ACR/ARHP Annual Meeting
Improvement of Disease Activity and Reduction of Severe Flares Following Subcutaneous Administration of an IL-6 Monoclonal Antibody (mAb) in Subjects with Active Generalized Systemic Lupus Erythematosus (SLE)
Daniel J Wallace¹, Serghei Popa², Alberto J. Spindler³, Alicia Eimon⁴, Tania González-Rivera⁵, Tammy O. Utset⁶, Michelle Petri⁷, Peter E. Lipsky⁸, Joan T. Merrill⁹, Vibeke Strand¹⁰, Joseph Wajdula¹¹, Jared Christensen¹², Cheryl Li¹³, Annette Diehl¹¹, Michael Vincent¹⁴, Jean Beebe¹² and Sudhakar Sridharan¹¹, ¹Cedars-Sinai Medical Center, Los Angeles, CA, ²Arensia Exploratory Medicine, Chisinau, Moldova, ³Centro Medico Privado de Reumatologia, Tucuman, Argentina, ⁴CEMIC, Buenos Aires, Argentina, ⁵Department of Medicine, Division of Rheumatology, University of Michigan School of Medicine, Ann Arbor, MI, ⁶University of Chicago, Chicago, IL, ⁷Johns Hopkins Lupus Center, Johns Hopkins University School of Medicine, Baltimore, MD, ⁸AMPEL BioSolutions, Charlottesville, VA, ⁹Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Stanford University, Palo Alto, CA, ¹¹Global Innovative Pharma Business, Pfizer Inc, Collegeville, PA, ¹²BioTherapeutics Clinical R&D, Pfizer Inc, Cambridge, MA, ¹³Pfizer Inc, Cambridge, MA, ¹⁴BioTx Clinical R&D, Pfizer Inc, Cambridge, MA
Background/Purpose: PF-04236921 is a fully human mAb that binds to circulating IL-6 and neutralizes its activity. This may be beneficial in reducing the disease…

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