SLE and autoantibodies Archives - ACR Meeting Abstracts

Abstract Number: 1092 • ACR/ARHP Annual Meeting 2018
Immune Complex-Driven Neutrophil Activation and BAFF Production Promote B Cell Activation and Autoantibody Production in Human SLE
Andrew Vasconcellos¹, John Marken¹, Sladjana Skopelja-Gardner¹, Christian Lood² and Natalia V. Giltiay¹, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: The production of anti-nuclear auto-antibodies (Ab) and the formation of immune complexes (IC) are hallmarks of Systemic Lupus Erythematosus (SLE). Enhanced neutrophil (PMN) activation…
Abstract Number: 1088 • ACR/ARHP Annual Meeting 2016
Expansion of Transitional B Cells in SLE Patients Correlates with Increased Toll-like Receptor 7 Expression
Ting Wang^1,2, John Marken¹, Karen Cerosaletti³ and Natalia V. Giltiay¹, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA, Seattle, WA, ²Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, Beijing, China, ³Translational Research Program Benaroya Research Institute at Virginia Mason, Seattle, WA, USA, Seattle, WA
Background/Purpose: B cell hyperactivation and autoantibody (auto-Ab) production are hallmarks of SLE. Auto-Abs, reactive to RNA-containing antigens are found in a fraction of SLE patients,…
Abstract Number: 2831 • ACR/ARHP Annual Meeting 2016
Associations of BAFF and Anti-BAFF Autoantibodies with Disease Activity in Oriental Systemic Lupus Erythematosus
Hwee-Siew Howe¹, Bernard Thong², Kok Ooi Kong³, Hiok-Hee Chng², Tsui Yee Lian², Faith Chia², Karine Tay², Tang Ching Lau⁴, Weng Giap Law², Ee Tzun Koh⁵ and Bernard Pui Lam Leung^6,7, ¹Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, SINGAPORE, Singapore, ²Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, ., Singapore, ³Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ⁴Yong Loo Lin School of Medicine,, National University of Singapore, ., Singapore, ⁵Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, ., Singapore, ⁶Physiology, National University of Singapore, ., Singapore, ⁷Rheumatology, Allergy & Immunology, Tan Tock Seng Hospital, ., Singapore
Background/Purpose: B cell activating factor (BAFF) is implicated in the pathogenesis of systemic lupus erythematosus (SLE). A previous small scale study reported that endogenous neutralizing…
Abstract Number: 1626 • ACR/ARHP Annual Meeting 2014
Autoantibodies Against High Mobility Group Box 1 (HMGB1) in Patients with SLE
Fleur Schaper¹, Gerda Horst¹, Daan van Beijeren Bergen en Henegouwen¹, Johan Bijzet¹, Karina de Leeuw¹, Alja Stel¹, Pieter C Limburg², Peter Heeringa³ and Johanna Westra¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: High mobility group box 1 (HMGB1) is a damage-associated molecular pattern and can be divided in three separate domains: the A Box, B Box…
Abstract Number: 1599 • ACR/ARHP Annual Meeting 2013
High Proportion Of Intrathecal Ro52 SSA Antibodies In Neuropsychiatric Lupus Patients – Relations To Neuropsychiatric Manifestations
Johanna Estelius¹, Liisa Hopia², Vijole Dzikaite-Ottosson³, Magnus LA. Andersson⁴, Elisabet Svenungsson⁵ and Jon Lampa⁶, ¹Department of Medicine, Rheumatology Unit, Center for Molecular medicine (CMM), Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Centre for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden, ⁴Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, ⁵Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Neuropsychiatric (NP) manifestations in Systemic Lupus Erythematosus (SLE) are often associated with significant impact on quality of life and work capability. The underlying mechanisms…

Abstracts tagged "SLE and autoantibodies"

Immune Complex-Driven Neutrophil Activation and BAFF Production Promote B Cell Activation and Autoantibody Production in Human SLE

Expansion of Transitional B Cells in SLE Patients Correlates with Increased Toll-like Receptor 7 Expression

Associations of BAFF and Anti-BAFF Autoantibodies with Disease Activity in Oriental Systemic Lupus Erythematosus

Autoantibodies Against High Mobility Group Box 1 (HMGB1) in Patients with SLE

High Proportion Of Intrathecal Ro52 SSA Antibodies In Neuropsychiatric Lupus Patients – Relations To Neuropsychiatric Manifestations