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Abstracts tagged "SLE and auto-immunity"

  • Abstract Number: 2648 • ACR/ARHP Annual Meeting 2017

    The SLE Risk Variant, Reference Single Nucleotide Polymorphism (rs)10499197, Upstream of Tumor Necrosis Factor Alpha-Induced Protein 3  (TNFAIP3) Modulates Enhancer Function and TNFAIP3 Gene Expression

    Ajay Nair1, Satish Pasula2, Yao Fu3 and Patrick Gaffney4, 1Arthritis and Clinical immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, oklahoma city, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Genome Wide Association studies (GWAS) have identified several variants in the tumor necrosis factor alpha-induced protein 3 (TNFAIP3) gene associated with autoimmune disease. TNFAIP3…
  • Abstract Number: 1951 • ACR/ARHP Annual Meeting 2014

    A Novel CD27(-) Spleen Tyrosine Kinase (Syk) Bright Memory B-Cell Subset Is Expanded in SLE

    Sarah Fleischer1, Claudia Giesecke1, Henrik Mei1, Peter E. Lipsky2, Capucine Daridon3 and Thomas Dörner3, 1Charité University Medicine Berlin, CC12, Dept. Medicine/Rheumatology and Clinical Immunology and German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany, Berlin, Germany, 2Peking Union Medical College Hospital, Beijing, China, 3CC12, Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease known to be associated with a breakdown of self-tolerance, B-cell hyperactivity and disturbed B-cell homeostasis of…
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