Abstracts tagged "SLE and apoptosis"

Abstract Number: 90 • 2018 ACR/ARHP Annual Meeting
Deoxyribonuclease 1-like-3 Digests Self-DNA from Dead Cells and Prevents Autoimmunity
Shoichiro Inokuchi¹, Hiroki Mitoma², Shotaro Kawano², Masahiro Ayano², Yasutaka Kimoto³, Mitsuteru Akahoshi², Yojiro Arinobu², Koichi Akashi², Takahiko Horiuchi⁴ and Hiroaki Niro⁵, ¹Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ²Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, ⁴Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ⁵Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose: Deoxyribonuclease 1-like-3 (DNase1L3) belongs to Deoxyribonuclease 1(DNase1) family. This nuclease originally identified as one of apoptosis- and necrosis-related endonucleases that fragmentates intranucleosomal DNA. Unlike…
Abstract Number: 2193 • 2013 ACR/ARHP Annual Meeting
Altered Apoptosis Profile and Associated Soluble Factors In Patients With Juvenile-Onset Systemic Lupus Erythematosus
Bernadete Liphaus¹, Maria H. B. Kiss¹, Solange Carrasco² and Cláudia Goldenstein-Schainberg³, ¹Pediatria, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ²University of São Paulo, São Paulo, Brazil, ³Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Apoptosis has been demonstrated to be involved in immune dysregulation and development of adult systemic lupus erythematosus (SLE) but less is known about its…