Abstracts tagged "SLE and animal models"

Abstract Number: 2786 • 2016 ACR/ARHP Annual Meeting
The Janus Kinase Inhibitor Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction
Yasuko Furumoto¹, Carolyne K. Smith², Luz P. Blanco³, Wanxia L. Tsai⁴, Wenpu Zhao⁵, Victoria Hoffmann⁶, Seth Thacker⁷, Giuseppe Sciumè⁸, Leti Nuñez¹, Alan Remaley⁹, John J O'Shea¹⁰, Mariana Kaplan¹¹ and Massimo G. Gadina¹², ¹NIAMS NIH, Translational Immunology Section, Office of Science and Technology, Bethesda, MD, ²Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ⁵NIAMS NIH, Systemic Autoimmunity Branch, Bethesda, MD, ⁶Division of Veterinary Resources, National Institutes of Health, Bethesda, MD, ⁷NHLBI NIH, Lipoprotein Metabolism Section, Bethesda, MD, ⁸NIAMS NIH, Molecular Immunology and Inflammation Branch, Bethesda, MD, ⁹NHLBI, National Institutes of Health, Bethesda, MD, ¹⁰NIAMS NIH, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ¹¹NIAMS/NIH, Bethesda, MD, ¹²Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Dysregulation of innate and adaptive immune responses contributes to the pathogenesis of systemic lupus erythematosus (SLE) and its associated premature vascular damage. To date,…
Abstract Number: 1948 • 2014 ACR/ARHP Annual Meeting
A Dual Role for IFN-γ in Development of Peripheral B Cells in Lupus-Prone MRL/Lpr Mice
Takeshi Machida¹, Natsumi Sakamoto¹, Gary S. Gilkeson² and Hideharu Sekine¹, ¹Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, ²Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: It had been reported previously that IFN-gamma and IFN-gamma-receptor-1 (IFNGR1) were required for auto-Ab production and development of renal disease in lupus-prone MRL/lpr mice.…