ACR Meeting Abstracts

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Abstracts tagged "SLE and animal models"

  • Abstract Number: 2786 • 2016 ACR/ARHP Annual Meeting

    The Janus Kinase Inhibitor Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction

    Yasuko Furumoto1, Carolyne K. Smith2, Luz P. Blanco3, Wanxia L. Tsai4, Wenpu Zhao5, Victoria Hoffmann6, Seth Thacker7, Giuseppe Sciumè8, Leti Nuñez1, Alan Remaley9, John J O'Shea10, Mariana Kaplan11 and Massimo G. Gadina12, 1NIAMS NIH, Translational Immunology Section, Office of Science and Technology, Bethesda, MD, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 5NIAMS NIH, Systemic Autoimmunity Branch, Bethesda, MD, 6Division of Veterinary Resources, National Institutes of Health, Bethesda, MD, 7NHLBI NIH, Lipoprotein Metabolism Section, Bethesda, MD, 8NIAMS NIH, Molecular Immunology and Inflammation Branch, Bethesda, MD, 9NHLBI, National Institutes of Health, Bethesda, MD, 10NIAMS NIH, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 11NIAMS/NIH, Bethesda, MD, 12Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: Dysregulation of innate and adaptive immune responses contributes to the pathogenesis of systemic lupus erythematosus (SLE) and its associated premature vascular damage. To date,…
  • Abstract Number: 1948 • 2014 ACR/ARHP Annual Meeting

    A Dual Role for IFN-γ in Development of Peripheral B Cells in Lupus-Prone MRL/Lpr Mice

    Takeshi Machida1, Natsumi Sakamoto1, Gary S. Gilkeson2 and Hideharu Sekine1, 1Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, 2Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: It had been reported previously that IFN-gamma and IFN-gamma-receptor-1 (IFNGR1) were required for auto-Ab production and development of renal disease in lupus-prone MRL/lpr mice.…
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