Abstracts tagged "skin fibrosis and transforming growth factor"

Abstract Number: 1926 • 2015 ACR/ARHP Annual Meeting
Wnt5a Activates Wnt/PCP-Signaling to Promote Fibroblast Activation and Fibrosis
Chih-Wei Chen¹, Neng-Yu Lin¹, Yun Zhang¹, Jingang Huang¹, Katrin Palumbo-Zerr¹, Alexandra Schambony², Christian Beyer¹, Georg Schett¹ and Jeorg HW Distler¹, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Biology, Development Biology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: While canonical Wnt/beta-catenin signaling has been identified as a core pathway of fibrosis in SSc, non-canonical Wnt signaling pathways have not yet been analyzed.…

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Abstracts tagged "skin fibrosis and transforming growth factor"

Wnt5a Activates Wnt/PCP-Signaling to Promote Fibroblast Activation and Fibrosis