Abstracts tagged "skin fibrosis and systemic sclerosis"

Abstract Number: 1715 • 2018 ACR/ARHP Annual Meeting
Safety and Efficacy of Lenabasum in an Open-Label Extension of a Phase 2 Study in Diffuse Cutaneous Systemic Sclerosis Subjects
Robert F. Spiera¹, Laura K. Hummers², Lorinda Chung³, Tracy M. Frech⁴, Robyn T. Domsic⁵, Vivien Hsu⁶, Daniel E. Furst⁷, Jessica K. Gordon¹, Maureen D. Mayes⁸, Robert W. Simms⁹, Elizabeth Lee¹⁰, Scott Constantine¹⁰ and Barbara White¹⁰, ¹Hospital for Special Surgery, New York, NY, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ⁴Division of Rheumatology, University of Utah, Salt Lake City, UT, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology, Robert Wood Johnson Medical School, New Brunswick, NJ, ⁷Pacific Arthritis Associates, Los Angeles; University of California, Los Angeles; University of Washington, Seattle; University of Florence, Italy, Los Angeles, CA, ⁸Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁹Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁰Corbus Pharmaceuticals, Inc., Norwood, MA
Background/Purpose: Lenabasum is a synthetic, non-immunosuppressive, selective cannabinoid receptor type 2 agonist that activates resolution of innate immune responses. Lenabasum had acceptable safety and tolerability,…
Abstract Number: 1718 • 2018 ACR/ARHP Annual Meeting
Skin Gene Expression Profiling Predicts Longitudinal Modified Rodnan Skin Score Change
Chase Correia¹, Mary A. Carns², Kathleen Aren², Monique Hinchcliff³ and J. Matthew Mahoney⁴, ¹Rheumatology, Northwestern Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Rheumatology, Northwestern University, Chicago, IL, ⁴Neurological Sciences, University of Vermont College of Medicine, Burlington, VT
Background/Purpose: Systemic sclerosis (SSc) causes varying degrees of skin fibrosis with varying trajectory. Extent of skin involvement is measured by the modified Rodnan skin score…
Abstract Number: 1719 • 2018 ACR/ARHP Annual Meeting
High-Throughput Quantitative Histology in Systemic Sclerosis Skin Disease Using Computer Vision
Chase Correia¹, Seamus Mawe², Mary A. Carns³, Kathleen Aren³, Aileen Hoffman⁴, Monique Hinchcliff⁵ and J. Matthew Mahoney⁶, ¹Northwestern University, Chicago, IL, ²Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington, VT, ³Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁴Northwestern Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University, Chicago, IL, ⁶Neurological Sciences, University of Vermont College of Medicine, Burlington, VT
Background/Purpose: The lack of a reproducible and quantitative method to accurately assess histological skin fibrosis in patients with systemic sclerosis (SSc) has long plagued clinical…
Abstract Number: 2690 • 2018 ACR/ARHP Annual Meeting
Potential Markers of Skin Involvement in Systemic Sclerosis
Radim Becvar¹, Hana Storkanova², Barbora Sumova¹, Maja Spiritovic¹, Sabina Oreska², Ladislav Šenolt¹ and Michal Tomcik², ¹Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ²Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Skin fibrosis is a hallmark of systemic sclerosis (SSc). There are no widely accepted biomarkers of skin involvement in this condition. Several serum or…
Abstract Number: 806 • 2018 ACR/ARHP Annual Meeting
Estradiol Levels Are Elevated in Older Men with Diffuse Cutaneous SSc and Are Associated with Decreased Survival
DeAnna Baker Frost¹, Bethany J Wolf², Christine Peoples³, Katherine Silver⁴, Maureen Laffoon⁵, Thomas A. Medsger Jr.^3,6 and Carol A. Feghali-Bostwick⁴, ¹Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Public Health Sciences, Medical University of South Carolina, Charleston, SC, ³Department of Medicine, University of Pittsburgh, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA, ⁴Department of Medicine, Medical University of South Carolina, Division of Rheumatology and Immunology, Charleston, SC, ⁵Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁶Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by excessive extracellular matrix deposition (ECM), leading to dermal and internal organ fibrosis. As in other…
Abstract Number: 729 • 2017 ACR/ARHP Annual Meeting
Clinically Relevant Serum Proteins in Patients with Early Diffuse Cutaneous Systemic Sclerosis
Guoshuai Cai¹, Kelsey S. Flood², Shervin Assassi³, Elana J. Bernstein⁴, Robyn T. Domsic⁵, Jessica K. Gordon⁶, Faye Hant⁷, Elena Schiopu⁸, Virginia D. Steen⁹, Tracy M. Frech¹⁰, Dinesh Khanna¹¹, Ami A. Shah¹², Victoria K. Shanmugam¹³, Flavia V. Castelino¹⁴ and Monique Hinchcliff¹⁵, ¹Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Internal Medicine, Northwestern Medicine, Chicago, IL, ³University of Texas McGovern Medical School, Houston, TX, ⁴Rheumatology, Columbia University, New York, NY, ⁵Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁸Internal Medicine, University of Michigan Medical System, Ann Arbor, MI, ⁹Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ¹⁰Division of Rheumatology, University of Utah, Salt Lake City, UT, ¹¹Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ¹²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹³Rheumatology, The George Washington University, Washington, DC, ¹⁴Rheumatology, Harvard Medical School, Boston, MA, ¹⁵Rheumatology, Northwestern Medicine, Chicago, IL
Background/Purpose: The Prospective Registry of Early Systemic Sclerosis (PRESS), an 11 center US cohort study of early diffuse cutaneous systemic sclerosis (dcSSc) patients, was designed…
Abstract Number: 732 • 2017 ACR/ARHP Annual Meeting
Progression of Skin Fibrosis Is Associated with Decline in Lung Function in Patients with Diffuse Cutaneous Systemic Sclerosis: A European Scleroderma Trials and Research (EUSTAR) Analysis
Wanlong Wu¹, Suzana Jordan², Nicole Graf³, Janethe Pena⁴, John Curram⁵, Yannick Allanore⁶, Marco Matucci-Cerinic⁷, Janet E. Pope⁸, Christopher Denton⁹, Dinesh Khanna¹⁰ and Oliver Distler¹, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Graf Biostatistics, Winterthur, Switzerland, ⁴Bayer HealthCare Pharmaceuticals Inc, Whippany, NJ, ⁵Bayer Plc, Newbury, United Kingdom, ⁶Department of Rheumatology, Cochin Hospital, Paris Descartes University, Paris, France, ⁷Dept of Medicine/Div of Rheum, University of Florence, Florence, Italy, ⁸Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ⁹Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom, ¹⁰Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI
Background/Purpose: Previously, we have identified short disease duration (≤15 months) and low baseline modified Rodnan skin score (mRSS) (≤22/51) as independent predictors of progressive skin…
Abstract Number: 764 • 2017 ACR/ARHP Annual Meeting
Application of a Novel Computational Approach to Identify New Targets and Pathways for Therapeutic Intervention in Scleroderma
Elma Kurtagic, Joel Pradines, Anthony Manning and Ishan Capila, Research, Momenta Pharmaceuticals, Inc., Cambridge, MA
Background/Purpose: Systemic Sclerosis (SSc) is a complex autoimmune disease with chronic progressive course and high interpatient variability. It is characterized by inflammation, vascular dysfunction and…
Abstract Number: 1018 • 2017 ACR/ARHP Annual Meeting
Comprehensive Identification of Differentially Methylated Regions Associated with Systemic Sclerosis in Dermal Fibroblasts from African-American Patients
Paula S. Ramos^1,2, Willian da Silveira³, E. Starr Hazard³, Ilia Atanelishvili⁴, Robert C. Wilson⁵, Jim C. Oates¹, Galina S. Bogatkevich⁴ and Gary Hardiman^1,2,3, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, ³Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African-Americans are disproportionally affected by SSc, yet dramatically underrepresented in…
Abstract Number: 1680 • 2017 ACR/ARHP Annual Meeting
Higher Baseline Monocyte Count Is Associated with More Extensive Skin Involvement and Higher Mortality in Systemic Sclerosis
Vishnu Mohan¹, Purvesh Khatri², Samuel Theodore¹, Julio Charles¹, Hau Pham¹, Deepthi Nair¹, Madeleine Scott², John D. Reveille¹, Maureen D. Mayes¹ and Shervin Assassi¹, ¹University of Texas McGovern Medical School, Houston, TX, ²Stanford University, Stanford, CA
Background/Purpose: Macrophages are the primary inflammatory cell type present in the systemic sclerosis (SSc) skin. Circulating monocytes can give rise to profibrotic inflammatory cells such…
Abstract Number: 1701 • 2017 ACR/ARHP Annual Meeting
Can Durometer Differentiate Limited Versus Diffuse Cutaneous Systemic Sclerosis?
Vivek Nagaraja¹, Amber Young¹, Veronica J. Berrocal² and Dinesh Khanna¹, ¹Department of Medicine, University of Michigan Scleroderma Program, Ann Arbor, MI, ²Department of Biostatistics- School of Public Health, University of Michigan, Ann Arbor, MI
Background/Purpose: The durometer is a handheld device that measures the hardness of a surface. It has been used to measure skin hardness in patients with…
Abstract Number: 2663 • 2017 ACR/ARHP Annual Meeting
Changes in Disability over Time, and Their Relationship with Degree of Skin Thickening, in Patients with Limited and Diffuse Cutaneous Systemic Sclerosis: A Retrospective Cohort Study
Sébastien Peytrignet¹, Joanne Manning², Elizabeth Wragg³, Tonia Moore⁴, Muditha Samaranayaka³ and Ariane L. Herrick⁵, ¹Manchester Academic Health Sciences Centre, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²Rheumatology Department, Salford Royal NHS Foundation Trust, Salford, United Kingdom, ³Salford Royal NHS Foundation Trust, Salford, United Kingdom, ⁴Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Salford, United Kingdom, ⁵Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom
Background/Purpose: The burden of disability of systemic sclerosis (SSc) is increasingly recognised. What is less known are the factors driving this disability and how it…
Abstract Number: 2776 • 2017 ACR/ARHP Annual Meeting
Plasmacytoid Dendritic Cells in Systemic Fibrosis: Pathogenic Role in Bleomycin-Induced Fibrosis Model and Correlation with Disease in Patients with Systemic Sclerosis
Suzanne Kafaja¹, Isela Valera², Anagha Divekar³, Rajan Saggar⁴, Dinesh Khanna⁵, Daniel E. Furst⁶ and Ram R. Singh⁷, ¹Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ²Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ³Biolegend, Sa Diego, CA, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵University of Michigan, Ann Arbor, MI, ⁶David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁷Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA
Background/Purpose: Fibrosis is the end-result of most inflammatory conditions, but its pathogenesis remains unclear. Studies in patients and animal models suggest a role for T-cells…
Abstract Number: 2884 • 2017 ACR/ARHP Annual Meeting
A Phase 2 Study of Safety and Efficacy of Anabasum (JBT-101), a Cannabinoid Receptor Type 2 Agonist, in Diffuse Cutaneous Systemic Sclerosis
Robert F. Spiera¹, Laura K. Hummers², Lorinda Chung³, Tracy M. Frech⁴, Robyn T. Domsic⁵, Vivien Hsu⁶, Daniel E. Furst⁷, Jessica K. Gordon¹, Maureen D. Mayes⁸, Robert W. Simms⁹, Scott Constantine¹⁰ and Barbara White¹⁰, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Medical and Rheumatology, Johns Hopkins University, Baltimore, MD, ³Rheumatology, Stanford University Medical Center, Palo Alto, CA, ⁴Division of Rheumatology, University of Utah, Salt Lake City, UT, ⁵Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology, Robert Wood Johnson University Scleroderma Program, New Brunswick, NJ, ⁷David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁸University of Texas McGovern Medical School, Houston, TX, ⁹Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁰Corbus Pharmaceuticals, Inc., Norwood, MA
Background/Purpose: Systemic sclerosis (SSc) is characterized in part by chronic activation of the innate immune system with fibrosis. Anabasum is a non-immunosuppressive, synthetic, orally administered…
Abstract Number: 803 • 2016 ACR/ARHP Annual Meeting
Multi-Organ RNA-Sequencing of Systemic Sclerosis (SSc) Patients Shows Reproducible Gene Expression Profiles Across Organ Systems
Bhaven K. Mehta¹, Michael E. Johnson¹, Kimberly A. Archambault¹, Tammara A. Wood², Antonia Valenzuela³, Amanda Crawford⁴, David Fiorentino⁵, Nielsen Fernandez-Becker⁶, Laren Becker⁶, Linda Nguyen⁶, Francesco Boin⁷, Paul Wolters⁸, Lorinda Chung⁹ and Michael Whitfield², ¹Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Stanford University School of Medicine, Stanford, CA, ⁴Dermatology, Stanford University, Redwood City, CA, ⁵Dermatology, Stanford University, Stanford, CA, ⁶Gastroenterology & Hepatology, Stanford University School of Medicine, Palo Alto, CA, ⁷Rheumatology, University California San Francisco, San Francisco, CA, ⁸Pulmonary Division, Department of Medicine, University of California, San Francisco, San Francisco, CA, ⁹Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose: While a hallmark of systemic sclerosis (SSc) is skin fibrosis, internal organ involvement is the primary cause of mortality. Pulmonary Arterial Hypertension (PAH), Interstitial…

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