ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "skin fibrosis and systemic sclerosis"

  • Abstract Number: 806 • 2018 ACR/ARHP Annual Meeting

    Estradiol Levels Are Elevated in Older Men with Diffuse Cutaneous SSc and Are Associated with Decreased Survival

    DeAnna Baker Frost1, Bethany J Wolf2, Christine Peoples3, Katherine Silver4, Maureen Laffoon5, Thomas A. Medsger Jr.3,6 and Carol A. Feghali-Bostwick4, 1Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 2Public Health Sciences, Medical University of South Carolina, Charleston, SC, 3Department of Medicine, University of Pittsburgh, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA, 4Department of Medicine, Medical University of South Carolina, Division of Rheumatology and Immunology, Charleston, SC, 5Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, 6Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by excessive extracellular matrix deposition (ECM), leading to dermal and internal organ fibrosis. As in other…
  • Abstract Number: 1715 • 2018 ACR/ARHP Annual Meeting

    Safety and Efficacy of Lenabasum in an Open-Label Extension of a Phase 2 Study in Diffuse Cutaneous Systemic Sclerosis Subjects

    Robert F. Spiera1, Laura K. Hummers2, Lorinda Chung3, Tracy M. Frech4, Robyn T. Domsic5, Vivien Hsu6, Daniel E. Furst7, Jessica K. Gordon1, Maureen D. Mayes8, Robert W. Simms9, Elizabeth Lee10, Scott Constantine10 and Barbara White10, 1Hospital for Special Surgery, New York, NY, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, 4Division of Rheumatology, University of Utah, Salt Lake City, UT, 5Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 6Rheumatology, Robert Wood Johnson Medical School, New Brunswick, NJ, 7Pacific Arthritis Associates, Los Angeles; University of California, Los Angeles; University of Washington, Seattle; University of Florence, Italy, Los Angeles, CA, 8Rheumatology, University of Texas McGovern Medical School, Houston, TX, 9Rheumatology, Boston University School of Medicine, Boston, MA, 10Corbus Pharmaceuticals, Inc., Norwood, MA

    Background/Purpose: Lenabasum is a synthetic, non-immunosuppressive, selective cannabinoid receptor type 2 agonist that activates resolution of innate immune responses. Lenabasum had acceptable safety and tolerability,…
  • Abstract Number: 1718 • 2018 ACR/ARHP Annual Meeting

    Skin Gene Expression Profiling Predicts Longitudinal Modified Rodnan Skin Score Change

    Chase Correia1, Mary A. Carns2, Kathleen Aren2, Monique Hinchcliff3 and J. Matthew Mahoney4, 1Rheumatology, Northwestern Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 3Rheumatology, Northwestern University, Chicago, IL, 4Neurological Sciences, University of Vermont College of Medicine, Burlington, VT

    Background/Purpose: Systemic sclerosis (SSc) causes varying degrees of skin fibrosis with varying trajectory. Extent of skin involvement is measured by the modified Rodnan skin score…
  • Abstract Number: 1719 • 2018 ACR/ARHP Annual Meeting

    High-Throughput Quantitative Histology in Systemic Sclerosis Skin Disease Using Computer Vision

    Chase Correia1, Seamus Mawe2, Mary A. Carns3, Kathleen Aren3, Aileen Hoffman4, Monique Hinchcliff5 and J. Matthew Mahoney6, 1Northwestern University, Chicago, IL, 2Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington, VT, 3Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 4Northwestern Feinberg School of Medicine, Chicago, IL, 5Rheumatology, Northwestern University, Chicago, IL, 6Neurological Sciences, University of Vermont College of Medicine, Burlington, VT

    Background/Purpose: The lack of a reproducible and quantitative method to accurately assess histological skin fibrosis in patients with systemic sclerosis (SSc) has long plagued clinical…
  • Abstract Number: 2690 • 2018 ACR/ARHP Annual Meeting

    Potential Markers of Skin Involvement in Systemic Sclerosis

    Radim Becvar1, Hana Storkanova2, Barbora Sumova1, Maja Spiritovic1, Sabina Oreska2, Ladislav Šenolt1 and Michal Tomcik2, 1Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 2Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Skin fibrosis is a hallmark of systemic sclerosis (SSc). There are no widely accepted biomarkers of skin involvement in this condition. Several serum or…
  • Abstract Number: 729 • 2017 ACR/ARHP Annual Meeting

    Clinically Relevant Serum Proteins in Patients with Early Diffuse Cutaneous Systemic Sclerosis

    Guoshuai Cai1, Kelsey S. Flood2, Shervin Assassi3, Elana J. Bernstein4, Robyn T. Domsic5, Jessica K. Gordon6, Faye Hant7, Elena Schiopu8, Virginia D. Steen9, Tracy M. Frech10, Dinesh Khanna11, Ami A. Shah12, Victoria K. Shanmugam13, Flavia V. Castelino14 and Monique Hinchcliff15, 1Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Internal Medicine, Northwestern Medicine, Chicago, IL, 3University of Texas McGovern Medical School, Houston, TX, 4Rheumatology, Columbia University, New York, NY, 5Rheumatology, University of Pittsburgh, Pittsburgh, PA, 6Rheumatology, Hospital for Special Surgery, New York, NY, 7Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 8Internal Medicine, University of Michigan Medical System, Ann Arbor, MI, 9Rheumatology, MedStar Georgetown University Hospital, Washington, DC, 10Division of Rheumatology, University of Utah, Salt Lake City, UT, 11Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, 12Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 13Rheumatology, The George Washington University, Washington, DC, 14Rheumatology, Harvard Medical School, Boston, MA, 15Rheumatology, Northwestern Medicine, Chicago, IL

    Background/Purpose: The Prospective Registry of Early Systemic Sclerosis (PRESS), an 11 center US cohort study of early diffuse cutaneous systemic sclerosis (dcSSc) patients, was designed…
  • Abstract Number: 732 • 2017 ACR/ARHP Annual Meeting

    Progression of Skin Fibrosis Is Associated with Decline in Lung Function in Patients with Diffuse Cutaneous Systemic Sclerosis: A European Scleroderma Trials and Research (EUSTAR) Analysis

    Wanlong Wu1, Suzana Jordan2, Nicole Graf3, Janethe Pena4, John Curram5, Yannick Allanore6, Marco Matucci-Cerinic7, Janet E. Pope8, Christopher Denton9, Dinesh Khanna10 and Oliver Distler1, 1Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Graf Biostatistics, Winterthur, Switzerland, 4Bayer HealthCare Pharmaceuticals Inc, Whippany, NJ, 5Bayer Plc, Newbury, United Kingdom, 6Department of Rheumatology, Cochin Hospital, Paris Descartes University, Paris, France, 7Dept of Medicine/Div of Rheum, University of Florence, Florence, Italy, 8Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, 9Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom, 10Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI

    Background/Purpose: Previously, we have identified short disease duration (≤15 months) and low baseline modified Rodnan skin score (mRSS) (≤22/51) as independent predictors of progressive skin…
  • Abstract Number: 764 • 2017 ACR/ARHP Annual Meeting

    Application of a Novel Computational Approach to Identify New Targets and Pathways for Therapeutic Intervention in Scleroderma

    Elma Kurtagic, Joel Pradines, Anthony Manning and Ishan Capila, Research, Momenta Pharmaceuticals, Inc., Cambridge, MA

    Background/Purpose: Systemic Sclerosis (SSc) is a complex autoimmune disease with chronic progressive course and high interpatient variability. It is characterized by inflammation, vascular dysfunction and…
  • Abstract Number: 1018 • 2017 ACR/ARHP Annual Meeting

    Comprehensive Identification of Differentially Methylated Regions Associated with Systemic Sclerosis in Dermal Fibroblasts from African-American Patients

    Paula S. Ramos1,2, Willian da Silveira3, E. Starr Hazard3, Ilia Atanelishvili4, Robert C. Wilson5, Jim C. Oates1, Galina S. Bogatkevich4 and Gary Hardiman1,2,3, 1Department of Medicine, Medical University of South Carolina, Charleston, SC, 2Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 3Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC, 4Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 5Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African-Americans are disproportionally affected by SSc, yet dramatically underrepresented in…
  • Abstract Number: 1680 • 2017 ACR/ARHP Annual Meeting

    Higher Baseline Monocyte Count Is Associated with More Extensive Skin Involvement and Higher Mortality in Systemic Sclerosis

    Vishnu Mohan1, Purvesh Khatri2, Samuel Theodore1, Julio Charles1, Hau Pham1, Deepthi Nair1, Madeleine Scott2, John D. Reveille1, Maureen D. Mayes1 and Shervin Assassi1, 1University of Texas McGovern Medical School, Houston, TX, 2Stanford University, Stanford, CA

    Background/Purpose: Macrophages are the primary inflammatory cell type present in the systemic sclerosis (SSc) skin. Circulating monocytes can give rise to profibrotic inflammatory cells such…
  • Abstract Number: 1701 • 2017 ACR/ARHP Annual Meeting

    Can Durometer Differentiate Limited Versus Diffuse Cutaneous Systemic Sclerosis?

    Vivek Nagaraja1, Amber Young1, Veronica J. Berrocal2 and Dinesh Khanna1, 1Department of Medicine, University of Michigan Scleroderma Program, Ann Arbor, MI, 2Department of Biostatistics- School of Public Health, University of Michigan, Ann Arbor, MI

    Background/Purpose: The durometer is a handheld device that measures the hardness of a surface. It has been used to measure skin hardness in patients with…
  • Abstract Number: 2663 • 2017 ACR/ARHP Annual Meeting

    Changes in Disability over Time, and Their Relationship with Degree of Skin Thickening, in Patients with Limited and Diffuse Cutaneous Systemic Sclerosis: A Retrospective Cohort  Study

    Sébastien Peytrignet1, Joanne Manning2, Elizabeth Wragg3, Tonia Moore4, Muditha Samaranayaka3 and Ariane L. Herrick5, 1Manchester Academic Health Sciences Centre, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 2Rheumatology Department, Salford Royal NHS Foundation Trust, Salford, United Kingdom, 3Salford Royal NHS Foundation Trust, Salford, United Kingdom, 4Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Salford, United Kingdom, 5Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom

    Background/Purpose: The burden of disability of systemic sclerosis (SSc) is increasingly recognised. What is less known are the factors driving this disability and how it…
  • Abstract Number: 2776 • 2017 ACR/ARHP Annual Meeting

    Plasmacytoid Dendritic Cells in Systemic Fibrosis: Pathogenic Role in Bleomycin-Induced Fibrosis Model and Correlation with Disease in Patients with Systemic Sclerosis

    Suzanne Kafaja1, Isela Valera2, Anagha Divekar3, Rajan Saggar4, Dinesh Khanna5, Daniel E. Furst6 and Ram R. Singh7, 1Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, 2Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 3Biolegend, Sa Diego, CA, 4Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 5University of Michigan, Ann Arbor, MI, 6David Geffen School of Medicine at UCLA, Los Angeles, CA, 7Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Fibrosis is the end-result of most inflammatory conditions, but its pathogenesis remains unclear. Studies in patients and animal models suggest a role for T-cells…
  • Abstract Number: 2884 • 2017 ACR/ARHP Annual Meeting

    A Phase 2 Study of Safety and Efficacy of Anabasum (JBT-101), a Cannabinoid Receptor Type 2 Agonist, in Diffuse Cutaneous Systemic Sclerosis

    Robert F. Spiera1, Laura K. Hummers2, Lorinda Chung3, Tracy M. Frech4, Robyn T. Domsic5, Vivien Hsu6, Daniel E. Furst7, Jessica K. Gordon1, Maureen D. Mayes8, Robert W. Simms9, Scott Constantine10 and Barbara White10, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Medical and Rheumatology, Johns Hopkins University, Baltimore, MD, 3Rheumatology, Stanford University Medical Center, Palo Alto, CA, 4Division of Rheumatology, University of Utah, Salt Lake City, UT, 5Rheumatology, University of Pittsburgh, Pittsburgh, PA, 6Rheumatology, Robert Wood Johnson University Scleroderma Program, New Brunswick, NJ, 7David Geffen School of Medicine at UCLA, Los Angeles, CA, 8University of Texas McGovern Medical School, Houston, TX, 9Rheumatology, Boston University School of Medicine, Boston, MA, 10Corbus Pharmaceuticals, Inc., Norwood, MA

    Background/Purpose: Systemic sclerosis (SSc) is characterized in part by chronic activation of the innate immune system with fibrosis.  Anabasum is a non-immunosuppressive, synthetic, orally administered…
  • Abstract Number: 2018 • 2016 ACR/ARHP Annual Meeting

    A Clinical Risk Prediction Model for Skin Thickness Progression in Early Diffuse Scleroderma

    Robyn T. Domsic1, Mary Lucas2, Virginia D. Steen3 and Thomas A. Medsger Jr.4, 1Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 2Medicine, University of Pittsburgh Scleroderma Center, Pittsburgh, PA, 3Rheumatology, Georgetown University Medical Center, Washington, DC, 4Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose:   Systemic sclerosis (SSc) is a rapidly evolving field with multiple potential therapeutic agents under development and several active clinical trials focused on treating…
  • 1
  • 2
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology