Abstracts tagged "skin and systemic sclerosis"

Abstract Number: 724 • 2019 ACR/ARP Annual Meeting
Biomechanical Properties of Skin for Assessment of Scleroderma: A Systemic Review
Peiyun Ni¹, Lilit Garibyan ² and Rox Anderson ², ¹Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA, ²Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
Background/Purpose: Skin involvement is one of the early features of scleroderma and an important predictor of internal organ involvement and mortality. Skin fibrosis alters the…
Abstract Number: 2935 • 2018 ACR/ARHP Annual Meeting
A Practical Classification of Systemic Sclerosis Using Subset and Autoantibodies for the Purpose of Early Risk Stratification
Svetlana I. Nihtyanova¹, Emma C. Derrett-Smith², Carmen Maria Fonseca³, Voon H. Ong² and Christopher P. Denton⁴, ¹Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²Division of Medicine, University College London, London, United Kingdom, ³Department of Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴University College London, London, United Kingdom
Background/Purpose: The Le Roy et al. classification of SSc into limited and diffuse cutaneous subtype remains the most commonly used. Nevertheless, autoantibodies are much better…
Abstract Number: 1741 • 2018 ACR/ARHP Annual Meeting
Disease Duration and Autoantibodies Predict Distinct Skin Score Trajectories in Diffuse Cutaneous Systemic Sclerosis
Svetlana I. Nihtyanova¹, Alper Sari², Voon H. Ong³ and Christopher P. Denton⁴, ¹Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Division of Medicine, University College London, London, United Kingdom, ⁴University College London, London, United Kingdom
Background/Purpose: Although severity of skin involvement and change in skin thickness over time vary substantially between patients with diffuse cutaneous systemic sclerosis (dcSSc), for the…
Abstract Number: 756 • 2017 ACR/ARHP Annual Meeting
Novel Machine Learning Classifier Accurately Predicts Intrinsic Molecular Subsets for Patients with Systemic Sclerosis
Jennifer Franks¹, Viktor Martyanov¹, Guoshuai Cai¹ and Michael L. Whitfield², ¹Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: High-throughput gene expression profiling of skin biopsies from patients with systemic sclerosis (SSc) has identified four “intrinsic” gene expression subsets conserved across multiple cohorts…
Abstract Number: 3000 • 2014 ACR/ARHP Annual Meeting
Comparison of Systemic Sclerosis Subsets As Predictors of Mortality and Morbidity
Hebah Alhajeri¹, Marie Hudson^2,3, Canadian Scleroderma Research Group CSRG⁴ and Murray Baron⁵, ¹Rheumatology, McGill University, Montreal, QC, Canada, ²Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Division of Rheumatology, McGill University, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Identifying systemic sclerosis (SSc) subsets that predict mortality and morbidity could provide useful prognostic information. We undertook this study to compare the predictive ability…
Abstract Number: 2721 • 2014 ACR/ARHP Annual Meeting
Patients’ Perspective of Skin Involvement in Systemic Sclerosis
Ada Man¹, Amy Wu¹, Jessica Ziemek², Romy Christmann¹, Robert W. Simms¹, David T. Felson³ and Robert Lafyatis⁴, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology/Arthritis Center, Boston University School of Medicine, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Arthritis Center, Boston University, Boston, MA
Background/Purpose: Skin tightness and other abnormalities of the skin are the hallmark features of systemic sclerosis (SSc). While skin involvement may significantly impact a…
Abstract Number: 2713 • 2014 ACR/ARHP Annual Meeting
The Relationship of Patient Reported Skin Symptoms to the Scleroderma HAQ, the Modified Rodnan Skin Score and Skin Pathology.
Jessica Ziemek¹, Ada Man², Robert W. Simms² and Robert Lafyatis², ¹Rheumatology/Arthritis Center, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: Changes in skin are a cardinal feature of systemic sclerosis (SSc). However, there are no SSc specific patient reported outcome measures validated for use…
Abstract Number: 1887 • 2014 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis of Twin Pairs Discordant for Systemic Sclerosis Reveals Distinct Signatures in Blood and Dermal Fibroblasts
Paula S. Ramos¹, Rick Jordan², James Lyons-Weiler², Thomas A. Medsger Jr.³ and Carol A. Feghali-Bostwick⁴, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, ³Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose Systemic sclerosis (SSc) is a chronic, multisystem, autoimmune inflammatory disease with genetic and non-genetic contributions to risk. The etiology of SSc, including the reasons…
Abstract Number: 2915 • 2013 ACR/ARHP Annual Meeting
Effect Of Menopause On Skin Thickening In Systemic Sclerosis
Evelyne Vinet¹, Sasha Bernatsky², Christian A. Pineau³, Marie Hudson⁴, Murray Baron⁵ and the Canadian Scleroderma Research Group⁶, ¹McGill University Health Center, Montreal, QC, Canada, ²Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada, ³Rheumatology, McGill University Health Center, Montreal, QC, Canada, ⁴Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Menopause, characterized by a low estrogenic state, is associated with skin thinning, due to decreased extracellular matrix protein deposition by fibroblasts. Although systemic sclerosis…
Abstract Number: 2602 • 2013 ACR/ARHP Annual Meeting
Reduced Frequencies Of Circulating CD8 T Cells In Early Diffuse Cutaneous Systemic Sclerosis Is Associated With Worse Skin Scores
Marie Hudson¹, Maximilien Lora², Christopher Di Ioia³, Solene Tatibouet⁴, Sasha Bernatsky⁵ and Ines Colmegna⁶, ¹Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ²Rheumatology, McGill University Health Centre, Montréal, QC, Canada, ³McGill University, Montreal, QC, Canada, ⁴Jewish General Hospital, McGill University, Montreal, QC, Canada, ⁵Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada, ⁶Rheumatology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Diffuse cutaneous systemic sclerosis (dcSSc) is associated with significant morbidity and mortality. Measurement of skin thickness (modified Rodnan skin score (mRss)) is a surrogate…
Abstract Number: 2604 • 2013 ACR/ARHP Annual Meeting
Longitudinal Assessment Of Scleroderma Skin By Optical Coherence Tomography: Preliminary Validation Of Sensitivity To Change Over-Time
Giuseppina Abignano¹, Lesley-Anne Bissell¹, Jason Britton², Daniel Woods³, Maya H. Buch¹, Dennis McGonagle¹, Paul Emery¹ and Francesco Del Galdo¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ²Medical Physics Department, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Michelson Diagnostics Ltd, Kent, United Kingdom
Background/Purpose: Optical coherence tomography (OCT) has been shown to be a quantitative reliable tool to assess skin involvement in Systemic Sclerosis (SSc) (1). However the…
Abstract Number: 2573 • 2013 ACR/ARHP Annual Meeting
The Role Of STAT-3 In The Development Of Pulmonary and Dermal Fibrosis
Mesias Pedroza¹, Sarah To¹, Anuh T. George¹, David J. Tweardy² and Sandeep K. Agarwal¹, ¹Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ²Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibrosis is the accumulation of excessive extra-cellular matrix in tissues, leading to tissue damage. In systemic sclerosis, the trigger is postulated to be an…
Abstract Number: 2569 • 2013 ACR/ARHP Annual Meeting
Serum S100A4 Levels Correlate With Skin Fibrosis and Lung Involvement In Systemic Sclerosis
Michal Tomcik¹, Lucie Andres Cerezo¹, Simona Skacelova², Martin Komarc³, Radim Becvar¹, Mariam Grigorian⁴, Joerg HW Distler⁵ and Ladislav Senolt¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Institute of Biophysics and Informatics of the First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark, ⁵Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Our previous study demonstrated that S100A4 is overexpressed in scleroderma (SSc) skin, fibroblasts and preclinical models of SSc in a TGF-β dependent manner. Furthermore,…
Abstract Number: 702 • 2013 ACR/ARHP Annual Meeting
Prediction Of Worsening Of Skin Fibrosis In Patients With Diffuse Systemic Sclerosis Using The EULAR Scleroderma Trials and Research (EUSTAR) Registry
Britta Maurer¹, Nicole Graf², Beat A. Michel³, Carola Metzig⁴, Vivian Lanius⁴, Dinesh Khanna⁵ and Oliver Distler¹, ¹Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²graf biostatistics, Winterthur, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Bayer Pharma AG, Berlin, Germany, ⁵University of Michigan Health System, Ann Arbor, MI
Background/Purpose: To identify predictive parameters for the progression of skin fibrosis in patients with diffuse cutaneous SSc (dcSSc) to enable 1) risk-stratification in clinical practice…

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