Abstract Number: 46 • 2017 ACR/ARHP Annual Meeting
Secondary Light Chain Editing and Allelic Inclusion in Antibody Secreting Cells from the Minor Salivary Gland
Background/Purpose: Heavy and light chain gene usage and mutational analyses of the Ig variable regions (V-regions) enable the identification of gene usage within B cell…Abstract Number: 722 • 2017 ACR/ARHP Annual Meeting
Differential Diagnosis of Autoimmune Diseases, Outlier Detection Plus Subgrouping in Clinical Trials By High Content Autoantibody Profiling
Background/Purpose: Early diagnosis as well as initiation of successful treatment are two big challenges in the management of patients with autoimmune diseases (AID). Overlap of…Abstract Number: 1489 • 2017 ACR/ARHP Annual Meeting
Development and Validation of a Questionnaire to Assess Healthcare Utilization and Access in Cohorts of Patients with Primary Sjögren’s Syndrome
Background/Purpose: The geographic variation in healthcare service utilization and quality across and within countries is well documented. Part of this geographic variation is linked to…Abstract Number: 2830 • 2017 ACR/ARHP Annual Meeting
Epigenetic Cell Counting: A Novel Tool to Quantify Immune Cells in Salivary Glands Detects Robust Correlations of T Follicular Helper Cells with Immunopathology
Background/Purpose: Histological analysis of salivary glands for decades has been a valuable tool in the characterization of patients with primary Sjögren’s syndrome (pSS) and non-Sjögren’s…Abstract Number: 552 • 2017 ACR/ARHP Annual Meeting
Mast Cells Are Involved in the Pathogenesis of Sjögren Syndrome By Inducing Tissue Fibrosis
Background/Purpose: Mast cells have been implicated in many immune-inflammatory disorders. They mediate a variety of inflammatory and fibrotic conditions, but their role in sialadenitis and…Abstract Number: 873 • 2017 ACR/ARHP Annual Meeting
Type I High-IFN Gene Signature in Associated with Higher Essdai at Enrollmment and Follow-up in the Prospective Multicenter Assess Cohort of 395 Patients
Background/Purpose: The type I interferon (IFN) signature is a hallmark of the pathogenesis of primary Sjögren’s syndrome (pSS). However, little is known regarding the clinical…Abstract Number: 1491 • 2017 ACR/ARHP Annual Meeting
Is There a Seasonal Effect on Fatigue, Pain, and Dryness in Primary Sjögren’s Syndrome? Data from the Prospective Assess Cohort and from 3 Randomized Controlled Trials
Background/Purpose: A seasonal effect was reported on fatigue and pain in rheumatoid arthritis. We speculated that fall and winter could be associated with increased fatigue…Abstract Number: 2873 • 2017 ACR/ARHP Annual Meeting
DNA Microarray Analysis Identifies Nuclear Receptor Subfamily 4 Group a Member 2 (NR4A2) As a Novel Molecule Involved in the Pathogenesis of Sjogren’s Syndrome
Background/Purpose:Some reports on DNA microarray analysis in labial salivary glands (LSGs) of Sjögren’s syndrome (SS) and healthy controls (HCs) showed that the genes associated with…Abstract Number: 553 • 2017 ACR/ARHP Annual Meeting
Decreased Circulating CXCR3+CCR9+ Th Cells Coincides with Elevated Levels of Their Ligands CXCL10 and CCL25 in the Salivary Gland of Sjögren’s Syndrome Patients Which Synergistically Facilitate Th Cell Migration
Background/Purpose: Primary Sjögren’s syndrome (pSS) is characterized by dryness and lymphocytic infiltration in the salivary glands. CXCR3+ T cells and ligands CXCL9/10/11 are known to…Abstract Number: 874 • 2017 ACR/ARHP Annual Meeting
Effect of Rituximab on a Salivary Gland Ultrasound Score in Primary Sjögren’s Syndrome: Results of Multicentre Double-Blind Randomised Controlled Trial Sub-Study
Background/Purpose: B lymphocytes are important in the pathogenesis of primary Sjögren’s syndrome (PSS), but two phase III trials (TEARS and TRACTISS) of the B cell…Abstract Number: 1492 • 2017 ACR/ARHP Annual Meeting
Total Body Water Correlates with Ocular Sicca Symptoms in Primary SjöGren’s Syndrome
Background/Purpose: Patients with primary Sjögrens’ syndrome (PSS) suffer from severe alterations in both the quality and quantity of saliva and tears. Body water represents around…Abstract Number: 2874 • 2017 ACR/ARHP Annual Meeting
Thymic Stromal Lymphopoietin (TSLP) Expression Is Associated with Lymphoproliferation and Lymphoma in Primary Sjögren’s Syndrome
Background/Purpose: Primary Sjögren’s syndrome (pSS) is an autoimmune and lymphoproliferative systemic disease with B cell hyperactivity and increased risk of non-Hodgkin lymphoma (NHL) evolution. In…Abstract Number: 554 • 2017 ACR/ARHP Annual Meeting
Prognostic Significance of Double Positive Anti Ro/SS-a and La/SS-B Antibodies in Patients with Primary Sjogren’s Syndrome: Prospective Salivary Gland Ultrasound Study
Background/Purpose: The aim of the study was to assess the diagnostic value of salivary gland ultrasonography (SGUS) as a single test for the detection of…Abstract Number: 875 • 2017 ACR/ARHP Annual Meeting
Serum Autoantibody Profiling of Primary Sjoegren’s Syndrome Patients Reveals Novel Biomarkers Associated with the Disease, Disease Activity, and Clinical Response to VAY736
Background/Purpose: Overexpression of B cell activating factor (BAFF) in salivary glands contributes to the pathogenesis of primary Sjögren’s syndrome (pSS) by promoting autoantibody (AAB) production.…Abstract Number: 1494 • 2017 ACR/ARHP Annual Meeting
Validation of New Criteria in “The Guidance for Diagnosis of Sjögren’s Syndrome in Pediatric Patients”
Background/Purpose: Sjögren’s syndrome (SS) has been thought rare during pediatric age. Because patients in this age group lack gsicca symptomsh, the diagnosis of SS is…
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