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Abstracts tagged "Sjogren’s syndrome"

  • Abstract Number: 1584 • 2018 ACR/ARHP Annual Meeting

    Evaluation of the Performance of the 2016 American College of Rheumatology-European League Against Rheumatism (Acr-Eular) Classification Criteria for Primary Sjogren`S Syndrome in Different Centers of Argentina

    Hugo Najera1, Marta Mamani2, Anastasia Secco1, Fernando Melo3, Cristian Troitiño4, Felix Romanini Sr.2, Emmanuel Guerra2, Antonio Catalan Pellet5, Silvia Beatriz Papasidero6, Rodrigo Aguila Maldonado7, Mercedes Garcia7, Mariano Rivero8, Juan Carlos Barreira9, ivan remolina10, A. perdomo11, quevedo mayorga10, M.J. santacruz12 and j demarchi10, 1Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, 2Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 3Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 4Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, 5Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 6Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, Buenos Aires, Argentina, 7Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, 8Rheumatology, Consultorios Externos Vacarezza,Alberdi,Pcia Buenos Aires, Pcia Buenos Aires, Argentina, 9Rheumatology Unit, Hospital Británico, Buenos Aires, Buenos Aires, Argentina, 10hospital britanico, Buenos Aires, Argentina, 11hospital nuestra señora de la merced, alberti, Argentina, 12hospital tornu, Buenos Aires, Argentina

    Background/Purpose: Primary Sjögren`s Syndrome (pSS) is a multisystemic, autoimmunity disease, characterized mainly by the hypofunction of the salivary and lacrimal glands, however the clinical spectrum…
  • Abstract Number: 1562 • 2018 ACR/ARHP Annual Meeting

    Large Granular Lymphocyte Proliferations in Primary Sjögren’s Syndrome: An Iatrogenic Manifestation

    Alistair Baber1, Gaetane Nocturne2, Xavier Mariette3 and Raphaele Seror4, 1Rheumatology, Université Paris-Sud, Le Kremlin-Bicêtre, France, 2Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 3Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France, 4Hopitaux Universitaires Paris Sud, Kremlin Bicetre, France, Rheumatology, Université Paris Sud, Le Kremlin Bicetre, France

    Background/Purpose: Large granular lymphocyte (LGL) proliferations can be observed in some auto-immune disorders, especially rheumatoid arthritis. However, reports of LGL proliferations in primary Sjogren’s syndrome…
  • Abstract Number: 1585 • 2018 ACR/ARHP Annual Meeting

    Primary Sjögren’s Syndrome Stratification Based on the Severity of Patient-Reported Fatigue

    Saviana Gandolfo, Elena Doriguzzi Breatta, Cinzia Fabro and Salvatore De Vita, Rheumatology Clinic, Academic Hospital S. M. della Misericordia, Medical Area Department, University of Udine, Italy, Udine, Italy

    Background/Purpose: Fatigue is one of the most common symptoms reported by patients affected by primary Sjögren’s syndrome (pSS), and a major contributor to impaired quality…
  • Abstract Number: 1563 • 2018 ACR/ARHP Annual Meeting

    Risk of Overall Malignancies in Korean Patients with Primary Sjögren Syndrome

    Hyoungyoung Kim1, Juyeon Kang1, Seongmi Choi2, Jinwook Kim3, Sun-Young Jung4, Eun Jin Jang5, Soo-Kyung Cho1 and Yoon-Kyoung Sung6, 1Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 2Statistics, Kyungpook National University, Daegu, Korea, Republic of (South), 3Department of Statistics, Kyungpook National University, Daegu, Korea, Republic of (South), 4College of Pharmacy, Chung-Ang University, Seoul, Korea, Republic of (South), 5Information Statistics, Andong National University, Andong-si, Korea, Republic of (South), 6Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South)

    Background/Purpose: A significant association has been found between primary Sjögren syndrome (pSS) and non-hodgkin's lymphoma (NHL), but few studies have been conducted to explore the…
  • Abstract Number: 1586 • 2018 ACR/ARHP Annual Meeting

    Expression of JAK Proteins and Autophagy Markers in Sjögren’s Syndrome Patients

    María-José Barrera1,2, Sergio Aguilera3, Isabel Castro2, Patricia Carvajal2, Sergio González4, Claudio Molina1, Ulises Urzua2 and María-Julieta González2, 1Facultad de Odontología, Universidad San Sebastián, Santiago, Chile, 2Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile, 3Reumatologia, Clinica Indisa, Santiago, Chile, 4Facultad de Odontología, Universidad Mayor, Santiago, Chile

    Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune epitheliitis that mainly affects the salivary and lachrymal glands. The glandular hypofunction has been associated to loss of…
  • Abstract Number: 6 • 2018 ACR/ARHP Annual Meeting

    Ro52/Trim21 Influences Follicular B Cell Homeostasis and Immunoglobulin Production

    Margarita Ivanchenko1, Susanna Brauner2, Gudny Ella Thorlacius1, Aurélie Ambrosi1 and Marie Wahren-Herlenius1, 1Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 2Neuroimmunology Unit, Department of Clinical Neurosciences, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, Solna, Sweden

    Background/Purpose: Systemic rheumatic diseases are characterized by abnormal B cell activation with autoantibody production and hypergammaglobulinemia. The autoantigen Ro52/SSA, also denoted TRIM21, is a major…
  • Abstract Number: 1564 • 2018 ACR/ARHP Annual Meeting

    Severe, Life-Threatening Phenotype of Primary Sjögren Syndrome: Clinical Characterization and Outcomes in 1580 Patients (GEAS-SS Registry)

    Soledad Retamozo1,2,3, Alejandra Flores-Chavez4, Belchin Kostov5, Roser Solans6, Guadalupe Fraile7, Brenda Maure8, Carlos Feijoo9, Francisco-Javier Rascón10, Roberto Pérez-Alvarez11, Mónica Zamora12, Alicia García-Pérez13, Miguel Lopez-Dupla14, Jesús Canora15, Mar Ripoll16, Eva Fonseca17, Pablo Guisado18, Blanca Pinilla19, Gloria de-la-Red20, Antonio-J. Chamorro21, César Morcillo22, Patricia Fanlo23, Mª José Soto-Cárdenas24, Manuel Ramos-Casals25 and Pilar Brito-Zerón4,22, 1Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, 2Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 3Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, 4Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, ICMiD, Hospital Clínic, Barcelona, Spain, Barcelona, Spain, 5Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC, Barcelona, Spain., Barcelona, Spain, 6Systemic Autoimmune Diseases Unit, Hospital Vall d’Hebron, Barcelona, Barcelona, Spain, 7Systemic Autoimmune Diseases Unit, Hospital Ramón y Cajal, Madrid, Madrid, Spain, 8Department of Internal Medicine, Complejo Hospitalario Universitario, Vigo, Vigo, Spain, 9Systemic Autoimmune Diseases Unit, Hospital Parc Taulí, Sabadell, Sabadell, Spain, 10Systemic Autoimmune Diseases Unit, Hospital Son Espases, Palma de Mallorca, Palma de Mallorca, Spain, 11Department of Internal Medicine, Hospital do Meixoeiro, Vigo, Vigo, Spain, 12Systemic Autoimmune Diseases Unit, Hospital Virgen de las Nieves, Granada, Granada, Spain, 13Systemic Autoimmune Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Oviedo, Spain, 14Systemic Autoimmune Diseases Unit, Hospital Joan XXIII, Tarragona, Tarragona, Spain, 15Systemic Autoimmune Diseases Unit, Hospital de Fuenlabrada, Madrid, Madrid, Spain, 16Department of Internal Medicine, Hospital Infanta Sofía, Madrid, Madrid, Spain, 17Systemic Autoimmune Diseases Unit, Hospital de Cabueñes, Gijón, Gijón, Spain, 18Department of Internal Medicine, Complejo Hospitalario Ruber Juan Bravo, Madrid, Madrid, Spain, 19Systemic Autoimmune Diseases Unit Medicine, Hospital Gregorio Marañón, Madrid, Madrid, Spain, 20Systemic Autoimmune Diseases Unit, Hospital Esperit Sant, Santa Coloma de Gramenet, Santa Coloma de Gramenet, Spain, 21Systemic Autoimmune Diseases Unit, Hospital Universitario de Salamanca, Salamanca, Salamanca, Spain, 22Systemic Autoimmune Diseases Unit, Hospital CIMA-Sanitas, Barcelona, Barcelona, Spain, 23Systemic Autoimmune Diseases Unit, Hospital Virgen del Camino, Pamplona, Pamplona, Spain, 24Department of Medicine, University of Cadiz, Cadiz, Cadiz, Spain, 25University of Barcelona, Hospital Clínic, Barcelona, Barcelona, Spain

    Background/Purpose: To analyse the clinical features and outcomes of patients presenting with life-threatening systemic disease in a large cohort of Spanish patients with primary Sjogren…
  • Abstract Number: 1587 • 2018 ACR/ARHP Annual Meeting

    Pathogenic Role of Interleukin 27 in the Nonobese Diabetic Mouse Model of Sjögren Syndrome

    Scott Lieberman1, Jennifer Barr2, Xiaofang Wang2 and Yi-Guang Chen3, 1Division of Rheumatology, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, 2Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, 3Pediatrics, Medical College of Wisconsin, Milwaukee, WI

    Background/Purpose: Sjögren syndrome is an immunologically complex autoimmune disease characteristically targeting the lacrimal and salivary glands leading to progressively worsening oral and ocular health and…
  • Abstract Number: 557 • 2017 ACR/ARHP Annual Meeting

    Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Peripheral Blood Mononuclear Cells in Sjögren’s Syndrome

    Seong-Kyu Kim1, Jung-Yoon Choe2, Sung-Hoon Park3 and Hwajeong Lee2, 1Rheumatology, Catholic University of Daegu School of Medicine, Daegu, Korea, Republic of (South), 2Catholic University of Daegu School of Medicine, Daegu, Korea, Republic of (South), 3Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea, Republic of (South)

    Background/Purpose: Sjögren's syndrome is a systemic autoimmune disease characterized by lymphocyte infiltration and subsequent dysfunction of exocrine glands, finally leading to dryness in the exocrine…
  • Abstract Number: 878 • 2017 ACR/ARHP Annual Meeting

    Diagnosis of Salivary Gland Lymphoma in Sjogren’s Syndrome Utilizing Ultrasound-Guided Core Needle Biopsies

    Alan N. Baer1, Thomas Grader-Beck1, Brendan Antiochos1, Julius Birnbaum1, Qing Kay Li2, Deborah Belchis2 and Joel Fradin3, 1Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, 2Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Radiology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Ultrasound (US)-guided core needle biopsy (CNB) with or without concomitant fine needle aspiration (FNA) is a standard method for pre-operative evaluation of salivary gland…
  • Abstract Number: 1499 • 2017 ACR/ARHP Annual Meeting

    Major Salivary Gland Ultrasonography Bed-Side and Still Image Scoring – a Pilot Comparison in Juvenile Sjögren’s Syndrome

    Daniel S. Hammenfors1, Valeria Valim2, Sandra Gofinet Pasoto3, Vibke Lilleby4, Juan Carlos Nieto5, Clovis Silva6, Rosa M R Pereira7, Blanca Bica8, Johan G. Brun9, Roland Jonsson9 and Malin V. Jonsson10, 1Department of Rheumatology, Haukeland University Hospital, University of Bergen, Bergen, Norway, 2Rheumatology, Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, 3Internal Medicine, Division of Rheumatology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, São Paulo, Brazil, 4Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, 5Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 6Department of Pediatric Rheumatology, Federal University of São Paulo, São Paulo, Brazil, 7Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, 8Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genova, Italy, 9Department of Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway, 10Section for Oral and Maxillofacial Radiology, Department of Clinical Dentistry, University of Bergen, Bergen, Norway, Bergen, Norway

    Background/Purpose: Adding major salivary gland ultrasonography (SGUS) improves the diagnostics of primary Sjögren’s syndrome (pSS). Juvenile Sjögren’s syndrome (jSS) is a rare, poorly defined disease.…
  • Abstract Number: 560 • 2017 ACR/ARHP Annual Meeting

    Clinical Relevance of Serum Free Light Chain Level As Biomarker in Primary Sjögren′s Syndrome

    Gwenny M. Verstappen1, Johan Bijzet1, Jolien F. van Nimwegen1, Martha S. van Ginkel1, Arjan Vissink2, Hendrika Bootsma1 and Frans G.M. Kroese1, 1Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: During immunoglobulin synthesis in B-cells, kappa and lambda light chains are produced in excess compared to heavy chains, and the surplus of light chains…
  • Abstract Number: 1064 • 2017 ACR/ARHP Annual Meeting

    Characterization of Human Tolerogenic Dendritic Cells Generated with Protein Kinase C Inhibitor and Induction from Patients with Autoimmune Diseases

    Hitoshi Hasegawa1, Takuya Matsumoto1, Endy Adnan2, Jun Ishizaki1, Koichiro Suemori1 and Masaki Yasukawa1, 1Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan, 2Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan

    Background/Purpose: Tolerogenic dendritic cells (tDCs) are a promising therapeutic tool for specific induction of immunological tolerance. Human tDCs can be generated ex vivo using various…
  • Abstract Number: 1500 • 2017 ACR/ARHP Annual Meeting

    Longitudinal Analysis of Different Therapeutic Strategies in Patients with Primary Sjögren’s Syndrome

    Kristen Davies1, Kamran Mirza1, Jessica Tarn2, Marian Regan3, Saravanan Vadivelu4, Gavin Clunie5, Jacqueline Andrews6, Elizabeth Price7, Steve Young-Min8, Ian Giles9, Bhaskar Dasgupta10, Cathy Lawson11, Nagui Gendi12, Neil J. McHugh13, Michele Bombardieri14, Costantino Pitzalis14, Nurhan Sutcliffe14, Simon Bowman15, Dennis Lendrem16,17 and Wan-Fai Ng2,18, 1Institute of Cellular Medicine, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, 2Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, 3Royal Derby Hospital, Derby, UK, Derby, United Kingdom, 4Queen Elizabeth Hospital, Gateshead, UK, Gateshead, United Kingdom, 5Ipswich Hospital NHS Trust, Ipswich, UK, Ipswich, United Kingdom, 6Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom, 7Great Western Hospital, Swindon, UK, Swindon, United Kingdom, 8Queen Alexander Hospital, Portsmouth, UK, Portsmouth, United Kingdom, 9Centre for Rheumatology, University College London, Centre for Rheumatology, University College London, UK, London, United Kingdom, 10Rheumatology, Southend University Hospital NHS Foundation Trust, Southend, UK, Westcliff-on-Sea, United Kingdom, 11Harrogate District Hospital, Harrogate, UK, Harrogate, United Kingdom, 12Basildon and Thurrock University Hospital, Basildon, UK, Basildon, United Kingdom, 13Royal National Hospital for Rheumatic Diseases, Bath, UK, Bath, United Kingdom, 14Barts Health NHS Trust & Barts and the London School of Medicine & Dentistry, London, UK, London, United Kingdom, 15Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, Birmingham, United Kingdom, 16Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-upon-Tyne, United Kingdom, 17Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle, United Kingdom, 18Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune rheumatic disease characterised by sicca features and systemic manifestations such as pain and fatigue. The classic…
  • Abstract Number: 562 • 2017 ACR/ARHP Annual Meeting

    Anti-Muscarinic Receptor 3 Antibodies – a Cross Reactive Result of Ro60 Immunization

    Syed M.S. Quadri1, Biji T Kurien2, Kristi A. Koelsch3 and R. Hal Scofield4, 1Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, 4Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Sjogren’s syndrome (SS) is a chronic autoimmune inflammatory disease characterized by impaired function of salivary and lacrimal glands leading to dry mouth and dry…
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