Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1574 • 2018 ACR/ARHP Annual Meeting
Autoantibodies Present in Saliva from Sjogren’s Syndrome and Non-Sjogren’s Sicca Patients Are Not Detectible in Serum
Kristi A. Koelsch^1,2,3, Joshua Cavett^3,4, Kenneth Smith³, Jacen Maier-Moore⁵, Astrid Rasmussen³, David M. Lewis⁶, Lida Radfar⁷, Biji T. Kurien^2,4,8, Judith A. James^3,9, Kathy L. Sivils¹⁰, A. Darise Farris¹¹ and R. Hal Scofield^2,11,12, ¹Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Okalahoma City, OK, ²U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Clinical Laboratory Science, University of Texas at El Paso, El Paso, TX, ⁶Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁷Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁸Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, ¹¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: There is evidence for B cell involvement in the pathogenesis of Sjögren’s syndrome by the presence of autoantigen-specific B cells. Autoantibodies toward Ro/SSA and…
Abstract Number: 2506 • 2018 ACR/ARHP Annual Meeting
The Joint Disease Burden in Patients with Secondary Sjögren’s Syndrome and RA Compared to Patients with RA Only
Evo Alemao¹, Yogesh Saini², Ying Bao¹, Aarti Rao², Christine K Iannaccone³, Michael E Weinblatt³ and Nancy A. Shadick³, ¹Bristol-Myers Squibb, Princeton, NJ, ²Mu Sigma, Bangalore, India, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Secondary Sjögren’s syndrome (sSS) is considered a poor prognostic factor in RA and is a common extra-articular manifestation of RA. We estimated prevalence of…
Abstract Number: 1213 • 2018 ACR/ARHP Annual Meeting
Simplified Salivary Gland Ultrasonography for Sjögren Syndrome and Sicca Symptoms: Experience from a Single Medical Center in Taiwan
Yen-Po Tsao¹, Ming-Han Chen², Wei-Sheng Chen³, Chien Chih Lai⁴ and Chang Youh Tsai⁵, ¹Division of Allergy- Immunology- Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ²Division of Allergy- Immunology- Rheumatology, Department of Medicine, Division of Allergy- Immunology- Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ³Taipei Veterans General Hospital, Taipei, Taiwan, ⁴Department of medicine, division of allergy, immunology, rheumatology, Division of Allergy- Immunology- Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ⁵National Yang-Ming University, Taipei, Taiwan
Background/Purpose: Sjögren’s syndrome is an autoimmune disease involving multiple organs, especially the lacrimal and salivary glands. Salivary gland ultrasonography (SGUS) provided a rapid and direct…
Abstract Number: 1577 • 2018 ACR/ARHP Annual Meeting
Soluble Siglec-5 Is a Novel Salivary Biomarker for Primary Sjogren’s Syndrome
Jennifer Lee¹, Hong-Ki Min², Ji-Won Kim³, Seung-Ki Kwok⁴ and Sung-Hwan Park⁵, ¹Rheumatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ³Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁴Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul., Seoul, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
Background/Purpose: Despite advances in the understanding of the pathogenesis, disease-specific biomarkers have not been included in the classification criteria for Primary Sjogren's syndrome (pSS). Based…
Abstract Number: 2507 • 2018 ACR/ARHP Annual Meeting
Healthcare Resource Utilization in Patients with Secondary Sjögren’s Syndrome Associated with RA Compared with Patients with RA in an Insured Population
Evo Alemao¹, Aarti Rao², Chidananda Samal² and Robert Wong¹, ¹Bristol-Myers Squibb, Princeton, NJ, ²Mu Sigma, Bangalore, India
Background/Purpose: Secondary Sjögren’s syndrome (sSS) is a rheumatic disease that may coexist with RA. Joint disease is more severe in patients (pts) with RA with…
Abstract Number: 1214 • 2018 ACR/ARHP Annual Meeting
Comparison of Ultrasound Features of Major Salivary Glands in Sarcoidosis, Amyloidosis, and Sjögren’s Syndrome
Shing Law¹, Praveen Govender², S. Reza Jafarzadeh³, Xianbang Sun⁴, Vaishali Sanchorawala⁵ and Eugene Y. Kissin⁶, ¹Rheumatology, Boston Medical Center, Boston, MA, ²The Pulmonary Center, Sarcoidosis Center, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Boston University, Boston, MA, ⁵Division of Hematology and Oncology, Boston University School of Medicine, Boston, MA, ⁶Rheumatology, Boston University, Boston, MA
Background/Purpose: Salivary gland enlargement occurs in conditions such as Sjögren’s syndrome (SS), sarcoidosis (SAR), and AL amyloidosis (AL). Salivary gland ultrasound (US) has been shown…
Abstract Number: 1578 • 2018 ACR/ARHP Annual Meeting
Exercise Increases Aerobic Capacity in Primary Sjögren´s Syndrome: A Randomized Controlled Trial
Ana Beatriz Andreo Garcia, MD¹, Virginia Fernandes Moça Trevisani², Luciana Dardin³ and Paulo Alexandre Minali⁴, ¹Evidence-based Health, UNIFESP, São Paulo, Brazil, São Paulo, Brazil, ²UNIFESP, Sao Paulo, Brazil, San Paulo, Brazil, ³Emergency Medicine and Evidence-Based Medicine Department, UNIFESP, São Paulo Brazil, SÃO PAULO, Brazil, ⁴UNIFESP, São Paulo, Brazil, São Paulo, Brazil
Background/Purpose: Recent studies have shown increased cardiovascular risk in patients with primary Sjögren's syndrome (pSS). As physical exercise is one of the pillars in primary…
Abstract Number: 2663 • 2018 ACR/ARHP Annual Meeting
Comparison of Clinical and Laboratory Profiles in 3575 Systemic Lupus Erythematosus Patients with and without Sjögren’s Syndrome: Data from the Spanish Society for Rheumatology Lupus Registry
Juan Gabriel Ovalles-Bonilla^1,2, Francisco Javier López Longo³, Iñigo Rúa-Figueroa⁴, María Galindo⁵, Jaime Calvo-Alén⁶, Juan Carlos Nieto², Julia Martínez-Barrio³, Roberto González⁷, Belen Serrano⁸, Iustina Janta², Carlos M Gonzalez⁹, Indalecio Monteagudo² and JM Pego-Reigosa¹⁰, ¹Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, ²Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ³Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁴Rheumatology Division, Hospital Doctor Negrin, Las Palmas GC, Spain, ⁵Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ⁶Rheumatology Department, Hospital Universitario Araba. Vitoria-Gasteiz, Alava, Spain, ⁷Rheumatology, Hospital general Universitario Gregorio Marañón, Madrid, Spain, ⁸Rheumatology, Hospital General Universitario Gregorio Marañón, Genoa, Italy, ⁹Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹⁰Complexo Hospitalario Universitario de Vigo, Vigo, Spain
Background/Purpose: The clinical coexistence of Systemic Lupus Erythematosus (SLE) and Sjögren's Syndrome (SS) was recognized in 1959. The prevalence of SS among patients with SLE…
Abstract Number: 573 • 2017 ACR/ARHP Annual Meeting
Subepithelial Infiltrate of the Vagina in Primary Sjogren’s Syndrome: The Cause of Vaginal Dryness?
Jolien F. van Nimwegen¹, Karin van der Tuuk², Ellen R. Klinkert², Erlin A. Haacke³, Frans G.M. Kroese¹, Harry Hollema³, Marian J. Mourits² and Hendrika Bootsma¹, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Women with primary Sjögren’s syndrome (pSS) often experience vaginal dryness. The cause of this symptom is unknown. This study compared the vaginal and cervical…
Abstract Number: 1485 • 2017 ACR/ARHP Annual Meeting
Association between Primary Sjogren’s Syndrome, Cardiovascular and Cerebrovascular Events: A Systematic Review and Meta-Analysis
Wai Chung Yong, Anawin Sanguankeo and Sikarin Upala, Bassett Medical Center, Cooperstown, NY
AbstractBackground/Purpose: Studies have demonstrated that acute systemic inflammation and chronic systemic vasculitis are associated with endothelial dysfunction and atherosclerotic plaque formation, subsequently leading to cardiovascular…
Abstract Number: 2817 • 2017 ACR/ARHP Annual Meeting
Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero
Gudny Ella Thorlacius¹, Malin Hedlund¹, Margarita Ivanchenko¹, Vijole Ottosson¹, Amina Ossoinak¹, Linda Lagnefeldt¹, Lars Rönnblom², Sven-Erik Sonesson³, Maija-Leena Eloranta⁴ and Marie Wahren-Herlenius¹, ¹Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ³Pediatric Cardiology Unit, Department of Women´s and Children´s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁴Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden
Background/Purpose: Women with Sjögren’s syndrome and autoantibodies against Ro/SSA are at risk for pregnancy complications, including neonatal lupus erythematosus (NLE) and a congenital heart block…
Abstract Number: 30 • 2017 ACR/ARHP Annual Meeting
Specificity of Salivary Gland-Derived Monoclonal Antibodies from Sjogren’s Syndrome Patients Using Human Proteome Arrays
Sherri Longobardi¹, Christina Lawrence², Kristi A. Koelsch³, Kenneth Smith², Constantin Georgescu², Michelle L. Joachims², Lida Radfar⁴, Astrid Rasmussen², Kathy L. Sivils², Jonathan Wren², R. Hal Scofield² and A. Darise Farris², ¹Graduate Program in Biological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, ⁴Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by focal lymphocytic infiltrations in the lacrimal and salivary glands, autoantibodies to the ubiquitous Ro…
Abstract Number: 574 • 2017 ACR/ARHP Annual Meeting
Is Elastography a New Tool to Differentiate Sjögren Syndrome to Sicca Syndrome?: Results of the Elsa (elastography of salivary glands) Study
Sandrine Jousse-Joulin¹, luc Bressollette², thibault depinoy³, guillermo carvajal Alegria³, Divi Cornec⁴, Thierry Marhadour⁵, Dewi Guellec⁶, Valérie Devauchelle-Pensec⁷ and Alain Saraux⁸, ¹Rheumatology, CHu La cavle Blanche, Brest, France, ²Doppler unit, Cavale Blanche hospital, brest, France, ³rheumatology department, cavale blanche hospital, brest, France, ⁴CHU Brest, Brest, France, ⁵Rheumatology, CHU La Cavale Blanche, Brest, France, ⁶Rheumatology, CHU Brest, Brest, France, ⁷Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, ⁸Rheumatology, Brest University Medical School Hospital, Brest, France
Background/Purpose: Ultrasonography (US) has been developed in salivary glands (SG) and particularly in primary Sjögren syndrome (pSS) for 10 years. However, the training curve is…
Abstract Number: 1487 • 2017 ACR/ARHP Annual Meeting
Salivary Gland Ultrasonography (SGUS) and Subclinical Parotid Involvement: Usefulness of Sgus in the Identification of a Subset of Patients with Sjögren’s Syndrome at Higher Risk for Extraglandular Disease Manifestations
Chiara Baldini¹, Nicoletta Luciano², Francesco Ferro², Elena Elefante², Rosaria Talarico³, Chiara Tani² and Marta Mosca², ¹Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ²Rheumatology Unit, University of Pisa, Pisa, Italy, ³Rheumatology Unit, University of Pisa, PISA, Italy
Background/Purpose: Salivary gland ultrasonography (SGUS) has recently appeared as a promising tool for the diagnosis and the early stratification of patients affected by primary Sjögren’s…
Abstract Number: 2828 • 2017 ACR/ARHP Annual Meeting
A Graph-Theoretic-Approach Applied to Modular-Repertoire-Analysis Identifies Shared Gradual Whole Blood Interferon Signatures in Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome Patients and Reveals New Interferon-Related Modules in Disease Progression
Ilya Korsunski¹, Noémie Jourde-Chiche², Peter Gregersen³, Damien Chaussabel⁴, Laurent Chiche⁵ and Naomi I. Maria⁶, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, ³Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Med Res, Manhasset, NY, ⁴Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, ⁵Internal medicine, Hopital europeen, Marseille, France, ⁶Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: There is significant clinical and molecular heterogeneity among patients suffering from systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and primary Sjögren’s Syndrome…

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