Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1566 • 2018 ACR/ARHP Annual Meeting
Prevalence and Prognosis of Interstitial Lung Disease in a Large Cohort of Chinese Primary Sjögren’s Syndrome Patients
Hui Gao^1,2, Xuewu Zhang¹, Jing He³, Jing Zhang⁴, Ye Sun⁵ and Zhan-Guo Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China, ³Rheumatology, Peking University People's Hospital, Beijing, China, ⁴Peking University International Hospital, Beijing, China, ⁵Department of Radiology, Peking University People's Hospital, Beijing, China
Background/Purpose: To determine the prevalence and identify the prognosis associated with pulmonary involvement in pSS patients. Methods: A total of 1341 hospitalized patients (853 with…
Abstract Number: 1826 • 2018 ACR/ARHP Annual Meeting
From Cancer to Autoimmunity : A New Model of Rheumatoid Arthritis Emerging from a Constitutional Genetic Approach Used in Low Penetrance Cancers
Geraldine Falgarone^1,2, Morad El Bouchtaoui³, Marcio Do Cruzeiro⁴, Christophe Leboeuf^5,6,7, Irmine Loisel-Ferreira^5,6, Carèle Frédonie⁷, Chrystophe Ferreira⁸, Rachida Ait El Far⁵, Marc Espié⁹, Bruno Cassinat¹⁰, Jean-Jacques Kiladjian¹¹, Jean-Paul Feugeas^12,13, Anne Janin^5,6,14 and Guilhem Bousquet^2,5,15, ¹HUPSSD, Avicenne Hospital, Rheumatology, APHP, Bobigny, France, ²Paris 13 University, SMBH, Bobigny, France, ³INSERM UMR-S 1165, PARIS, France, ⁴Plateforme de Recombinaison Homologue, Institut Cochin, INSERM U1016, Paris, France, ⁵INSERM UMR-S 1165, Paris, France, ⁶Université Paris Diderot, Paris, France, ⁷INSERM U944, Paris, France, ⁸Plateforme ANIMA5, Université Paris Descartes, Paris, France, ⁹Centre des Maladies du Sein, APHP, Hôpital Saint-Louis, Paris, France, ¹⁰Laboratoire de BIologie Cellulaire, APHP, Hôpital Saint-Louis, Paris, France, ¹¹Centre d'Inverstigation Clinique, APHP, Hôpital Saint-Louis, Paris, France, ¹²INSERM U1137, Paris, France, ¹³Département de Biologie, Université Franche-Comté, Besançon, France, ¹⁴Service de Pathologie, APHP, Hôpital Saint-Louis, Paris, France, ¹⁵Service d'Oncologie médicale, APHP, Hôpital Avicenne, Bobigny, France
Background/Purpose: High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic…
Abstract Number: 140 • 2018 ACR/ARHP Annual Meeting
Inhibition of Cathepsin S Leads to Suppression of SS-a/SS-B Specific T Cells from Patients with Primary Sjøgren Syndrome
Patrick Hargreaves^1,2, Michel Theron¹, Fabrice Kolb¹, Marianne Manchester¹, Bernhard Reis¹, Andre Tiaden², Diego Kyburz² and Tobias Manigold², ¹Hoffmann La Roche, Basel, Switzerland, ²Rheumatology, University Hospital Basel, Basel, Switzerland
Background/Purpose: Primary Sjögren syndrome (pSS) is an autoimmune disease characterised by an infiltration of T and B cells into exocrine gland tissue and its subsequent…
Abstract Number: 1568 • 2018 ACR/ARHP Annual Meeting
Azathioprine and Mycophenolate for Management of Sjögren’s Syndrome-Related Interstitial Lung Disease: A Retrospective Cohort Study
Barkha Amlani¹, Umang Barvalia², Ghada Metwally Ahmed Elsayed³, Jeffrey P. Kanne⁴, Zhanhai Li⁵ and Sara S. McCoy⁶, ¹Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²Pulmonary And Critical Care, university of wisconsin Hospital and clinics, Madison, WI, ³Rheumatology, University of Wisconsin Hospital and clinics, Madison, WI, ⁴Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁵University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁶Department of Medicine, Rheumatology Division, University of Wisconsin School of Medicine and Public Health, Madison, WI
Background/Purpose: Interstitial lung disease (ILD) is a common extraglandular manifestation of Sjögren’s syndrome (SS). There is a paucity of literature on the management of SS-ILD.…
Abstract Number: 2158 • 2018 ACR/ARHP Annual Meeting
Clinical Significance of Anti-Ro52 Antibody in Chinese Patients with Connective Tissue Diseases: A Single-Center Experience
Si Wu, Xiaojun Tang and Xuebing Feng, Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Autoantibody targeting Ro52 has been implied as a unique antibody with distinct clinical properties. However, its relations with anti-Ro60 antibody and various connective tissue…
Abstract Number: 365 • 2018 ACR/ARHP Annual Meeting
Monoclonal Gammopathy in Rheumatic Diseases
Yue Yang, Yuan Jia, Shi Chen, Yin Su and Zhan-Guo Li, Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
Background/Purpose: To analyze the clinical spectrum, laboratory characteristics, and outcomes of monoclonal gammopathy (MG) in patients with rheumatic diseases. Methods: Screening for the presence of…
Abstract Number: 1569 • 2018 ACR/ARHP Annual Meeting
Diagnostic Performance of Labial Salivary Gland Biosy, Serological and Clinical Data in Sjogrens Syndrome. in Argentinian Multicenter
Janet Flores¹, Diego Baenas², Maria Jezabel Haye Salinas³, Soledad Retamozo⁴, Juan Pablo Pirola⁵, Nadia Benzaquén³, Nadia Riscanevo⁶, María Flavia Ceballos⁷, Ana C. Alvarez³, Verónica Saurit⁸, Alejandro Alvarellos⁹, Priscila Serravalle¹⁰, Alberto Ortiz¹¹, Sergio Paira¹¹ and Francisco Caeiro⁵, ¹Rheumatology Unit, Hospital privado Universitario de Córdoba, Cordoba, Argentina, ²Reumatologia, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ³Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Córdoba, Argentina, ⁴Sociedad Argentina de Reumatologia, Córdoba, Argentina, ⁵Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ⁶Rheumatology, Rheumatology Unit, Hospital privado Universitario de Córdoba, Cordoba, Argentina, ⁷Rheumatology, Rheumatology Unit, Hospital privado Universitario de Córdoba., Cordoba, Argentina, ⁸Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, ⁹Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, ¹⁰Hospital Cullen, Santa Fe, Argentina, ¹¹Reumatologia, Hospital J M Cullen, Santa Fe, Argentina
Background/Purpose:Labial salivary gland biopsy (LSGB) is a safe and minimally invasive procedure used in the diagnostic evaluation of Sjogren’s Syndrome (SS). The objectives of this…
Abstract Number: 2162 • 2018 ACR/ARHP Annual Meeting
The Prevalence, Incidence, and Determinants of Depression and Anxiety in Less Common Systemic Autoimmune Rheumatic Diseases: A Systematic Review and Meta-Analysis
Alyssa Howren^1,2,3, Enav Z. Zusman^1,2,3, J. Antonio Avina-Zubieta^2,4 and Mary A. De Vera^1,2,3, ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Collaboration for Outcomes Research and Evaluation (CORE), Vancouver, BC, Canada, ⁴Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Individuals with systemic autoimmune rheumatic diseases (SARDs), including systemic lupus erythematosus (SLE), systemic sclerosis/scleroderma (SSc), Sjogren’s syndrome (SjS), dermatomyositis/polymyositis (DM/PM), and systemic vasculitides (SV),…
Abstract Number: 566 • 2017 ACR/ARHP Annual Meeting
Immune Response to Seasonal Flu Vaccination in Patients with Primary Sjogren’s Syndrome
Albin Björk¹, Marika Kvarnström², Gudny Ella Thorlacius² and Marie Wahren-Herlenius², ¹Department of Medicine, Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Vaccination of rheumatic patients has been reported to induce lower antibody titers than in healthy individuals. However, studies have primarily included patients treated with…
Abstract Number: 1480 • 2017 ACR/ARHP Annual Meeting
Risk of Ischemic Stroke in Sjögren’s Syndrome Patients: A Systematic Review and Meta-Analysis
Jirapat Teerakanok¹, Daniel Cordoba², Sakolwan Suchartlikitwong³ and Kenneth Nugent⁴, ¹Internal medicine, Texas Tech University health and sciences center, Lubbock, TX, ²Internal Medicine, Texas Tech University Health and Sciences Center, Lubbock, TX, ³Internal medicine, Texas Tech University Health Sciences Center, Lubbock, TX, ⁴Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX
Background/Purpose: Primary Sjögren’s syndrome (SS) is an autoimmune disease of the exocrine glands with lymphocytic infiltration into lacrimal and salivary glands. Autoimmune diseases increase cardiovascular…
Abstract Number: 2123 • 2017 ACR/ARHP Annual Meeting
Protein-Losing Enteropathy in Patients with Systemic Autoimmune Diseases: Characterization of 263 Cases (GEAS-SEMI Spanish Cohort)
Alejandra Flores-Chavez^1,2,3, Soledad Retamozo^4,5,6, Angel Robles⁷, Guadalupe Fraile Rodriguez⁸, Sofia Arteaga^9,10, Celeste Galceran-Chaves¹¹, Roberto Pérez-Alvarez¹², Marta Pérez de Lis¹², Belchin Kostov¹³, Manuel Ramos-Casals^14,15 and Pilar Brito-Zerón^14,16, ¹Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, ²Unidad de Investigación Biomédica 02 (Unidad de Investigación en Epidemiología Clínica), UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Jalisco, Mexico, ³Programa de Doctorado en Ciencias Médicas, Centro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, Mexico, Mexico, Mexico, ⁴Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, ⁵Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, ⁶Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, ⁷Department of Internal Medicine, Hospital La Paz, Madrid, Madrid, Spain, ⁸Internal Medicine, Hospital Ramón y Cajal, Madrid, Madrid, Spain, ⁹Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Barcelona, Spain, ¹⁰Universidad de Antioquía, Medellín, Colombia, Medellin, Colombia, ¹¹Neuroscience Clinical Institute, Hospital Clínic, Barcelona, Barcelona, Spain, ¹²Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Vigo, Spain, ¹³Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, CAPSE, Barcelona, Barcelona, Spain, ¹⁴Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, ¹⁵Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain, ¹⁶Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain
Background/Purpose: Protein-losing enteropathy (PLE) is a rare condition characterized by a loss of serum protein into the gastrointestinal tract resulting in hypoproteinemia, which can be…
Abstract Number: 569 • 2017 ACR/ARHP Annual Meeting
Is the Oral Microbiome Involved in the Pathogenesis of Sjogren’s Syndrome?
Taco A van der Meulen¹, Frans G.M. Kroese², S.C. Liefers², Arnau Vich Vila³, Hermie J.M. Harmsen⁴, Hendrika Bootsma², Fred K.L. Spijkervet¹ and Arjan Vissink⁵, ¹Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Gastroenterology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Environmental factors involved in the pathogenesis of primary Sjögren’s syndrome (pSS) are still largely unknown. The oral cavity is the microbial habitat closest to…
Abstract Number: 1481 • 2017 ACR/ARHP Annual Meeting
Risk of Ischemic Heart Disease in Sjögren’s Syndrome Patients: A Systematic Review and Meta-Analysis of Observational Studies
Jirapat Teerakanok¹, Sakolwan Suchartlikitwong², Thammasak Mingbunjerdsuk³, Praveen Ratanasrimetha³, Yuttiwat Vorakunthada³ and John S. Pixley³, ¹Internal medicine, Texas Tech University health and sciences center, Lubbock, TX, ²Internal medicine, Texas Tech University Health Sciences Center, Lubbock, TX, ³Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX
Background/Purpose: Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are associated with an increased risk of ischemic heart disease (IHD). The risk of IHD in…
Abstract Number: 2703 • 2017 ACR/ARHP Annual Meeting
Single Cell Analysis of TCRs from CD8+ T Cells in Sjogren’s Syndrome
Michelle L. Joachims¹, Christina Lawrence¹, Richard C. Pelikan¹, Kerry M. Leehan¹, Lida Radfar², David M. Lewis³, Astrid Rasmussen¹, R. Hal Scofield¹, Kiely Grundahl¹, Kathy L. Sivils¹, Linda F. Thompson¹ and A. Darise Farris¹, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ³Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune exocrinopathy characterized by focal lymphocytic infiltration of the salivary and lacrimal glands, severe dry eyes and mouth, fatigue…
Abstract Number: 570 • 2017 ACR/ARHP Annual Meeting
Signalling Pathways Identified in Salivary Glands from Primary Sjögren’s Syndrome Patients Reveal Enhanced Adipose Tissue Development, As Demonstrated By Microarray Analysis, Real-Time PCR and Immunohistochemistry
Lara A Aqrawi¹, Janicke C Liaaen Jensen¹, Gunnvor Øijordsbakken², Ann-Kristin Ruus³, Ståle Nygård^4,5, Marit Holden⁶, Roland Jonsson^7,8, Hilde Kanli Galtung⁹ and Kathrine Skarstein^10,11, ¹Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway, ²Department of Clinical Medicine, University of Bergen, Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, ³Department of Oral Biology, University of Oslo, Oslo, Norway, ⁴Department of Informatics, University of Oslo, Oslo, Norway, ⁵Bioinformatics core facility, Institute for Cancer research, Oslo University Hospital, Oslo, Norway, ⁶Norwegian Computing Center, Oslo, Oslo, Norway, ⁷Broegelmann Research laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁸Department of Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway, ⁹Department of Oral Biology, University of Oslo, Oslo, Pakistan, ¹⁰Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, ¹¹Department of Pathology, Haukeland University Hospital, Bergen, Bergen, Norway
Background/Purpose: : A characteristic feature of Sjögren’s syndrome (SS) is the destruction of salivary and lacrimal glands mediated by mononuclear cell infiltration. Adipocytes can also…

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