Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1581 • 2018 ACR/ARHP Annual Meeting
Lack of Specificity in Testing for Murine Tissue Specific Autoantibodies for the Diagnosis of Sjogren’s Syndrome
Frederick B Vivino¹, Michael D. George², Chadwick Johr³, Nora Sandorfi⁴, Vatinee Bunya⁵, Giacomina Massaro-Giordano⁵, Andrew Diederich⁶, Brandon Eilberg⁶, Lakshmanan Suresh⁷ and Long Shen⁷, ¹Rheumatolgy Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, ²Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA, ⁴Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵Ophthalmology, University of Pennsylvania, Philadelphia, PA, ⁶Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA, ⁷Trinity Biotech, Inc., Buffalo, NY
Background/Purpose: A group of murine parotid tissue specific autoantibodies (TSAs) which includes anti-SP1 (salivary protein 1), anti-PSP (parotid secretory protein) and anti-CA6 (carbonic anhydrase) are…
Abstract Number: 2882 • 2018 ACR/ARHP Annual Meeting
Minimal Progression of Disease Manifestation in Patients with Sjögren’s Syndrome Re-Evaluated Multiple Years after Initial Disease Classification
Astrid Rasmussen¹, Lida Radfar², Kimberly Hefner³, David M. Lewis⁴, C. Erick Kaufman⁵, Donald U. Stone⁶, Kerry M. Leehan¹, Kiely Grundahl⁷, Christopher J. Lessard¹, A. Darise Farris⁸, R. Hal Scofield⁹ and Kathy L. Sivils¹⁰, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ³Hefner Eye Care Center, Oklahoma City, OK, ⁴Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁵Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, ⁶Ophthalmology, Johns Hopkins University, Baltimore, MD, ⁷Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ⁸Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Classical connective tissue diseases, such as SLE and RA have well documented progression of disease and damage accrual. However, the natural history of Sjögren’s…
Abstract Number: 1557 • 2018 ACR/ARHP Annual Meeting
Visualization of Dorsal Root Ganglionitis with Three-Tesla Magnetic Resonance Neurography in Sensory Ataxic Neuropathy Associated with Sjögren’s Syndrome
Takeshi Yoshida¹, Takeshi Sueyoshi², Mitsuyo Kinjo³, Shugo Suwazono⁴ and Hiroyuki Nodera⁵, ¹Rheumatology, Chikamori Hospital, Kochi, Japan, ²Radiology, Minei Daiichi Hospital, Urasoe, Japan, ³Rheumatology, Okinawa Chubu Hospital, Uruma, Japan, ⁴Brain-Nerve-Muscle Research Center, National Hospital Organization Okinawa Hospital, Uruma, Japan, ⁵Neurology, Tokushima University School of Medicine, Tokushima, Japan
Background/Purpose: Sjögrenfs syndrome (SS)-associated neuropathy manifests as various forms of neuropathy, including sensory ataxic neuropathy (SAN). Dorsal root ganglionitis, pathologically defined as the lymphocytic infiltration…
Abstract Number: 1582 • 2018 ACR/ARHP Annual Meeting
Clinical Correlations and Expression Pattern of the Autoimmunity Susceptibility Factor Diora-1 in Primary Sjögren’s Syndrome
Lauro Meneghel¹, Lara Aqrawi^1,2,3, Lara Mentlein¹, Albin Björk¹, Gudny Ella Thorlacius¹, Margarita Ivanchenko¹, Jorge Ramírez¹, Kathrine Skarstein^2,4, Marika Kvarnström¹, Susanna Brauner¹, Alexander Espinosa¹ and Marie Wahren-Herlenius¹, ¹Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²The Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Bergen, Norway, ³Department of Oral Surgery and Oral Medicine, Institute of Clinical Odontology, University of Oslo, Oslo, Norway, Oslo, Norway, ⁴Department of Pathology, Haukeland University Hospital, Bergen, Bergen, Norway
Background/Purpose: Genome-wide association studies of multiple autoimmune diseases, including primary Sjögren’s syndrome (pSS), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) have revealed an association…
Abstract Number: 2883 • 2018 ACR/ARHP Annual Meeting
Testing for Anti-Microbial Antibodies with Cross-Reactivity to Human Tissue in Autoimmune Diseases
Peilin Zhang, Lawrence Minardi, J. Todd Kuenstner and Stephen Zekan, PZM Diagnostics, LLC, Charleston, WV
Background/Purpose: Autoantibodies are defining features of autoimmune diseases. How and why the autoantibodies are produced and how these autoantibodies relate to pathogenesis is poorly understood.…
Abstract Number: 1558 • 2018 ACR/ARHP Annual Meeting
Intravenous Immunoglobulin Efficacy for Primary Sjögren’s Syndrome Associated Small Fiber Neuropathy
Antoine Gaillet¹, Karine Champion¹, Jean-Pascal Lefaucheur², Herve Trout³, Jean-François Bergmann¹ and Damien Sène⁴, ¹Internal Medicine Department, Lariboisière Hospital, Paris, France, ²Clinical Neurophysiology Unit,, Henri-Mondor Hospital, Créteil, France, ³Pharmacy Department, Lariboisière Hospital, Paris, France, ⁴Lariboisière Hospital, Paris Diderot University, Paris, France
Background/Purpose: To analyze the efficacy and tolerance of intravenous immunoglobulin (IVIG) therapy in 11 patients with primary Sjögren's syndrome (pSS)-associated small-fiber neuropathy (SFN).Methods: Retrospective, single-center…
Abstract Number: 1583 • 2018 ACR/ARHP Annual Meeting
Low-Dose IL-2 Promotes the Proliferation of Peripheral Regulatory T Cells in Primary Sjogren’s Syndrome to Restore Its Balances with Pro-Inflammatory Lymphocytes
Miao Miao¹, Zhenye Hao¹, Yingying Guo¹, Xiaoying Zhang¹, Sheng-Xiao Zhang¹, Jing Luo², Jinfang Zhao³, Chong Gao⁴ and Xiao-Feng Li⁵, ¹The Second Hospital of Shanxi Medical University, Taiyuan, China, ²the Second Hospital of Shanxi Medical University, Taiyuan, China, ³The Shanxi Medical University, Taiyuan, China, ⁴Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, ⁵Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China
Background/Purpose: To investigate the effect of low-dose IL-2 on the balance of Treg with Teff and other pro-inflammatory lymphocytes in peripheral blood of pSS patients.Methods:…
Abstract Number: 2884 • 2018 ACR/ARHP Annual Meeting
Correlation between Salivary Gland Ultrasonography, Minor Salivary Gland Histhopatology and Sialometry: Towards a Composite Assessment of Salivary Gland Involvement in Primary Sjögren’s Syndrome
Chiara Baldini¹, Nicoletta Luciano¹, Francesco Ferro¹, Antonella Cecchettini², Valentina Donati³, Marta Mosca¹ and Stefano Bombardieri¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²IFC, CNR, Pisa, Italy, ³Pathology Unit, University of Pisa, Pisa, Italy
Background/Purpose:: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease that specifically involves salivary glands. Several complementary tools including salivary gland ultrasonography (SGUS), histology and…
Abstract Number: 553 • 2017 ACR/ARHP Annual Meeting
Decreased Circulating CXCR3+CCR9+ Th Cells Coincides with Elevated Levels of Their Ligands CXCL10 and CCL25 in the Salivary Gland of Sjögren’s Syndrome Patients Which Synergistically Facilitate Th Cell Migration
Sofie L.M. Blokland^1,2, Maarten R. Hillen^3,4, Stephan Meller⁵, Bernhard Homey⁵, Glennda Smithson⁶, Aike A. Kruize², Timothy R.D.J. Radstake^2,7 and Joel A.G. van Roon^2,3, ¹Rheumatology & Clinical Immunology/ Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Department of Dermatology, University of Düsseldorf, Düsseldorf, Germany, ⁶Takeda Global Research & Development Center, Inc, Chicago, IL, ⁷Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Primary Sjögren’s syndrome (pSS) is characterized by dryness and lymphocytic infiltration in the salivary glands. CXCR3+ T cells and ligands CXCL9/10/11 are known to…
Abstract Number: 874 • 2017 ACR/ARHP Annual Meeting
Effect of Rituximab on a Salivary Gland Ultrasound Score in Primary Sjögren’s Syndrome: Results of Multicentre Double-Blind Randomised Controlled Trial Sub-Study
Benjamin Fisher¹, Colin Everett², John Rout³, John O'Dwyer², Paul Emery⁴, Costantino Pitzalis⁵, Wan-Fai Ng⁶, Andrew Carr⁷, Colin Pease², Elizabeth Price⁸, Nurhan Sutcliffe⁹, Jimmy Makdissi¹⁰, Anwar Tappuni¹⁰, Nagui Gendi¹¹, Frances Hall¹², Sharon Ruddock², Catherine Fernandez², Claire Hulme², Kevin Davies¹³, Christopher J. Edwards¹⁴, Peter Lanyon¹⁵, Robert J. Moots¹⁶, Euthalia Roussou¹⁷, Linda Sharples¹⁸, Michele Bombardieri¹⁹ and Simon Bowman²⁰, ¹Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, ²University of Leeds, Leeds, United Kingdom, ³Birmingham Dental Hospital, Birmingham, United Kingdom, ⁴NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁶Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ⁷Newcastle Dental Hospital, Newcastle, United Kingdom, ⁸Great Western Hospital, Swindon, United Kingdom, ⁹Royal London Hospital, London, UK, London, United Kingdom, ¹⁰Barts Health NHS Trust, London, United Kingdom, ¹¹Basildon and Thurrock University Hospital, Basildon, UK, Basildon, United Kingdom, ¹²School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom, ¹³University of Sussex, Brighton, United Kingdom, ¹⁴University of Southampton, Southampton, United Kingdom, ¹⁵University of Nottingham, Nottingham, United Kingdom, ¹⁶University of Liverpool, Liverpool, United Kingdom, ¹⁷Barking Havering and Redbridge University hospitals NHS Trust, London, United Kingdom, ¹⁸London School of Hygiene and Tropical Medicine, London, United Kingdom, ¹⁹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, UK, London, United Kingdom, ²⁰Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, Birmingham, United Kingdom
Background/Purpose: B lymphocytes are important in the pathogenesis of primary Sjögren’s syndrome (PSS), but two phase III trials (TEARS and TRACTISS) of the B cell…
Abstract Number: 1492 • 2017 ACR/ARHP Annual Meeting
Total Body Water Correlates with Ocular Sicca Symptoms in Primary SjöGren’s Syndrome
Gabriela Hernandez-Molina¹, Paloma Almeda-Valdés², Guadalupe López-Carrasco², Miguel Astudillo-Angel¹, Victor Zamora-Legoff³, Carlos Aguilar-Salinas⁴ and Ivette Cruz-Bautista⁵, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, ²Endocrinology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, ³Rheumatology and Immunology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico D.F., Mexico, ⁴Endocrinology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico D.F., Mexico, ⁵Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico
Background/Purpose: Patients with primary Sjögrens’ syndrome (PSS) suffer from severe alterations in both the quality and quantity of saliva and tears. Body water represents around…
Abstract Number: 2874 • 2017 ACR/ARHP Annual Meeting
Thymic Stromal Lymphopoietin (TSLP) Expression Is Associated with Lymphoproliferation and Lymphoma in Primary Sjögren’s Syndrome
Saviana Gandolfo¹, Cinzia Fabro¹, Michela Bulfoni², Sabino Russi³, Luca Quartuccio¹, Domenico Ettore Sansonno³, Carla Di Loreto², Daniela Cesselli² and Salvatore De Vita¹, ¹Rheumatology Clinic, Academic Hospital S. M. della Misericordia, Medical Area Department, University of Udine, Italy, Udine, Italy, ²Institute of Anatomic Pathology, Academic Hospital S. M. della Misericordia, Medical Area Department, University of Udine, Italy, Udine, Italy, ³Department of Biomedical Sciences and Human Oncology, University of Bari, Italy, Bari, Italy
Background/Purpose: Primary Sjögren’s syndrome (pSS) is an autoimmune and lymphoproliferative systemic disease with B cell hyperactivity and increased risk of non-Hodgkin lymphoma (NHL) evolution. In…
Abstract Number: 554 • 2017 ACR/ARHP Annual Meeting
Prognostic Significance of Double Positive Anti Ro/SS-a and La/SS-B Antibodies in Patients with Primary Sjogren’s Syndrome: Prospective Salivary Gland Ultrasound Study
Sang Heon Lee¹, Kyung-Ann Lee² and Hae-Rim Kim³, ¹Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea, Republic of (South), ²Department of Nuclear medicine, Konkuk University Medical center, seoul, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea, Republic of (South)
Background/Purpose: The aim of the study was to assess the diagnostic value of salivary gland ultrasonography (SGUS) as a single test for the detection of…
Abstract Number: 875 • 2017 ACR/ARHP Annual Meeting
Serum Autoantibody Profiling of Primary Sjoegren’s Syndrome Patients Reveals Novel Biomarkers Associated with the Disease, Disease Activity, and Clinical Response to VAY736
Petra Budde¹, Julie Doucet², Hans-Dieter Zucht¹, Remi Kazma², Paul Maguire², Alexandre Avrameas², Marie-Anne Valentin², Stephen Oliver², Peter Schulz-Knappe¹ and Alessandra Vitaliti², ¹Protagen AG, Dortmund, Germany, ²Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland
Background/Purpose: Overexpression of B cell activating factor (BAFF) in salivary glands contributes to the pathogenesis of primary Sjögren’s syndrome (pSS) by promoting autoantibody (AAB) production.…
Abstract Number: 1494 • 2017 ACR/ARHP Annual Meeting
Validation of New Criteria in “The Guidance for Diagnosis of Sjögren’s Syndrome in Pediatric Patients”
Minako Tomiita¹, Ichiro Kobayashi², Yuzaburo Inoue³, Nami Okamoto⁴, Naomi Iwata⁵, Yukiko Nonaka⁶, Ryoki Hara⁷, Hiroaki Umebayashi⁸, Yasuhiko Itoh⁹ and Masaaki Mori¹⁰, ¹Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan, ²Department of Allergy and Rheumatology, Chiba Children’s Hospital, Sapporo, Japan, ³Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan, ⁴Pediatrics, Graduate School of Medicine, Osaka Medical College, Takatsuki, Japan, ⁵Department of Immunology and Infectious Diseases, Aichi Children’s Health and Medical Center, Obu, Japan, ⁶Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, Kagoshima, Japan, ⁷Department of Pediatrics, Yokohama City University, Graduate School of Medicine, Yokohama, Japan, ⁸Department of Rheumatics, Miyagi Children’s Hospital, Sendai, Japan, ⁹Department of Pediatrics, Nippon Medical School, Tokyo, Japan, ¹⁰Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: Sjögren’s syndrome (SS) has been thought rare during pediatric age. Because patients in this age group lack gsicca symptomsh, the diagnosis of SS is…

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