Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1906 • 2019 ACR/ARP Annual Meeting
Using Multi-modal Ultrasound to Assess Disease Activity Within the Salivary Glands of Patients with Primary Sjögren’s Syndrome Treated with Ianalumab (VAY736)
Torsten Diekhoff ¹, Maximilian Posch ², Frank Wagner ², Thomas Fischer ¹, Quirino Schefer ², Thomas Dörner ³, Didier Laurent ⁴, Yue Li ⁴ and Stephen Oliver⁴, ¹Charité University Hospital, Berlin, Germany, ²Charité Research Organisation, Berlin, Germany, ³Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany, ⁴Novartis Pharma AG, Basel, Switzerland
Background/Purpose: To use ultrasound (US) to demonstrate that ianalumab, a monoclonal antibody with dual mechanisms-of-action of BAFF:BAFF-R blockade and enhanced, ADCC-mediated B cell depletion, can…
Abstract Number: 2431 • 2019 ACR/ARP Annual Meeting
Extracellular Vesicles in Primary Sjögren’s Syndrome: A Promising Source for Novel Proteomic Biomarkers
Chiara Baldini¹, Francesco Finamore ², Francesco Ferro ¹, Silvia Rocchiccioli ², Marta Mosca ³, Letizia Mattii ⁴ and Antonella Cecchettini ⁴, ¹Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, Pisa, Italy, ²National Research Council – Clinical Institute of Physiology, PISA, Italy, ³Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, Pisa, Italy, ⁴University of Pisa, Pisa, Italy
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a complex autoimmune disorder characterized by the specific involvement of salivary and lachrymal glands. In the recent past several…
Abstract Number: 1452 • 2019 ACR/ARP Annual Meeting
Comparison of Clinical Phenotype, Serological Characteristics and Histologic Features Between Males and Females Patients with Primary Sjögren’s Syndrome (pSS)
Loukas Chatzis¹, Saviana Gandolfo ², Francesco Ferro ³, Marco Binutti ², Valentina Donati ⁴, Sara Zandonella Callegher ⁵, Vasilis Pezoulas ⁶, Aliki Venetsanopoulou ⁷, Argyropoulou Ourania ⁷, Georgios Michalopoulos ⁷, maria pappa ⁷, Clio Mavragani ⁷, Dimitris fotiadis ⁸, Chiara Baldini ³, Salvatore De Vita ², Athanasios Tzioufas ¹ and Andreas Goules ⁷, ¹Department of Pathophysiology, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ²Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, ³Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, Pisa, Italy, ⁴University of Pisa, Pisa, ⁵Rheumatology Clinic, Udine University Hospital, Udine, Italy, Udine, Italy, ⁶Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, GR45110, Ioannina, Greece, Ioannina, Greece, ⁷Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ⁸Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Ioannina, Greece
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a female predominant autoimmune disease and very few studies have been conducted to investigate the phenotypic differences of the…
Abstract Number: 2413 • 2019 ACR/ARP Annual Meeting
LOU064: A Highly Selective and Potent Covalent Oral BTK Inhibitor with Promising Pharmacodynamic Efficacy on B Cells for Sjoegren’s Syndrome
Bruno Cenni¹, Peter End ¹, Maciej Cabanski ¹, Annamaria Jakab ¹, Enrico Funhoff ¹, Magdalena Kistowska ¹, Arvind Kinhikar ², Alessio Maiolica ¹, Masaru Hirano ³, Barbara Nuesslein-Hildesheim ¹, Amanda Littlewood-Evans ¹, Daniela Angst ¹, Robert Pulz ⁴ and Martin Kaul ¹, ¹Novartis Institutes for BioMedical Research, Basel, Switzerland, ²Novartis Institutes for BioMedical Research, Cambridge, MA, ³Novartis Institutes for BioMedical Research, Tokyo, Japan, ⁴Novartis Institues for BioMedical Research, Basel, Switzerland
Background/Purpose: Bruton’s Tyrosine Kinase (BTK) is a cytoplasmic tyrosine kinase selectively expressed in B cells, macrophages, mast cells and basophils. The essential role of BTK…
Abstract Number: 2432 • 2019 ACR/ARP Annual Meeting
Thymic Stromal Lymphopoietin (TSLP) as a Biomarker of Primary Sjögren’s Syndrome (pSS) and Related Lymphoma: Results in Independent Cohorts
Saviana Gandolfo¹, Cinzia Fabro ¹, Serena Colafrancesco ², Francesco Carubbi ³, Francesco Ferro ⁴, Elena Bartoloni ⁵, Efstathia Kapsogeorgou ⁶, Andreas Goules ⁶, Luca Quartuccio ¹, Roberta Priori ², Alessia Alunno ⁵, Guido Valesini ², Roberto Giacomelli ³, Roberto Gerli ⁵, Chiara Baldini ⁴, Athanasios Tzioufas ⁶ and Salvatore De Vita ¹, ¹Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, ²Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy, Roma, Italy, ³Rheumatology Unit, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy, L'Aquila, Italy, ⁴Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, Pisa, Italy, ⁵Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy, Perugia, Italy, ⁶Department of Pathophysiology, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece
Background/Purpose: Thymic stromal lymphopoietin (TSLP) has been implicated in primary Sjögren’s syndrome (pSS) and related B-cell lymphoproliferation / lymphoma (NHL) by tissue studies on salivary…
Abstract Number: 1453 • 2019 ACR/ARP Annual Meeting
Baseline EULAR Sjögren’s Syndrome Patient-Reported Index Has a Significant Impact on the Longitudinal Course of Sjögren’s Syndrome
Eun Hye Park¹, You-Jung Ha ¹, Eun Ha Kang ¹, Yeong-Wook Song ² and Yun Jong Lee ³, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Seongnam, Republic of Korea, ²Seoul National University Hospital, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Seongnam, Republic of Korea
Background/Purpose: The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) and EULAR SS Patient-Reported Index (ESSPRI) have been validated as disease activity and outcome measures…
Abstract Number: 2414 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of Abatacept in Patients with Early Active Primary Sjögren’s Syndrome – Open-label Extension Phase of a Randomized Controlled Phase III Trial
Jolien van Nimwegen¹, Esther Mossel ¹, Robin Wijnsma ¹, Greetje van Zuiden ¹, Konstantina Delli ¹, Alja Stel ¹, Bert van der vegt ¹, Erlin Haacke ¹, Lisette Olie ¹, Leonie Los ¹, Gwenny Verstappen ¹, Sarah Pringle ¹, Fred Spijkervet ¹, Frans Kroese ¹, Arjan Vissink ¹, Suzanne Arends ² and Hendrika Bootsma ³, ¹University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Dept. of Rheumatology and Clinical Immunology - University Medical Center Groningen (UMCG), University of Groningen, Groningen, Netherlands, ³University of Groningen, Groningen, Netherlands
Background/Purpose: Abatacept (CTLA-4-Ig) targets the CD80/CD86:CD28 co-stimulatory pathway required for full T-cell activation and T-cell dependent activation of B-cells. The Abatacept Sjögren Active Patients phase…
Abstract Number: 2433 • 2019 ACR/ARP Annual Meeting
Fatigue in Primary Sjögren’s Syndrome as a Manifestation of Heavier Disease Activity of Mucosa-Associated Lymphoid Tissue (MALT)
Saviana Gandolfo¹, Marco Binutti ¹, Elena Doriguzzi Breatta ¹, Cinzia Fabro ¹ and Salvatore De Vita ¹, ¹Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy
Background/Purpose: Fatigue is one of the most prevalent and impacting symptoms in primary Sjögren’s syndrome (pSS), significantly impairing the patient quality of life. To date,…
Abstract Number: 1454 • 2019 ACR/ARP Annual Meeting
Sjӧgren’s Syndrome Foundation National Survey: The Impact and Burden of Oral Symptoms
Sara McCoy¹, Christie Bartels ², Esen Akpek ³, Ian Saldanha ⁴, Vatinee Bunya ⁵, Matthew Makara ⁶ and Alan Baer ⁷, ¹University of Wisconsin School of Medicine and Public Health, Madison, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Johns Hopkins University, Baltimore, ⁴Brown University School of Public Health, Providence, RI, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Sjogren's Syndrome Foundation, Reston, VA, ⁷Johns Hopkins University, Baltimore, MD
Background/Purpose: Sjӧgren’s syndrome (SS) is the second most common systemic autoimmune disease, typically characterized by ocular and oral sicca. SS is associated with reduced quality…
Abstract Number: 2415 • 2019 ACR/ARP Annual Meeting
Evaluation of Pharmacokinetics and Immunogenicity Following Subcutaneous Administration of Abatacept in Primary Sjogren ’s Syndrome (pSS) and RA Patients
Yash Gandhi¹, Mehmooda Shaikh ², Blisse Vakkalagadda ¹, Grigor Abelian ¹, Neelanjana Ray ¹, Robert Wong ¹ and Bindu Murthy ¹, ¹Bristol-Myers Squibb, Princeton, ²Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Abatacept (ABA) has proven efficacy in autoimmune diseases and is being evaluated in pSS. The purpose of this investigation was to evaluate the pharmacokinetics…
Abstract Number: 2434 • 2019 ACR/ARP Annual Meeting
Risk of Lymphoma and Thyroid Cancer in Primary Sjögren’s Syndrome Measured Using the Korean Health Insurance Claims Database
Joong Kyong Ahn ¹, Jiwon Hwang² and Gi Hyeon Seo ³, ¹Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, ²Division of Rheumatology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon-si, Republic of Korea, ³Health Insurance Review and Assessment Service, Wonju, Republic of Korea
Background/Purpose: The development of lymphomas is one of the most serious complications of SjS but the incidence, prevalence and estimated risk of lymphoma in primary…
Abstract Number: 1455 • 2019 ACR/ARP Annual Meeting
B and T Cell Immunologic Features Associated with Higher Disease Activity Score and Focus Score in Primary Sjögren Syndrome
Alice Mai¹, Yuriy Baglaenko ², Dario Ferri ³, Kieran Manion ⁴, Dennisse Bonilla ⁵, Arthur Bookman ⁶ and Joan Wither ⁷, ¹University of British Columbia Department of Rheumatology, Vancouver, Canada, ²Brigham Woman's Hospital, Boston, ³University Health Network, Toronto, ON, Canada, ⁴Krembil Research Institute, Toronto, ON, Canada, ⁵University Health Network, University of Toronto, Toronto, ON, Canada, ⁶University Health Network, Toronto, Canada, ⁷University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease with an incompletely understood pathogenesis and heterogenous disease manifestations. Identifying cellular immune changes that may…
Abstract Number: 2416 • 2019 ACR/ARP Annual Meeting
ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Associated with Sjögren’s Syndrome
Stacey Dillon¹, Lawrence Evans ¹, Katherine Lewis ¹, Susan Bort ¹, Erika Rickel ¹, Jing Yang ¹, Martin Wolfson ¹, Kayla Susmilch ¹, Sherri Mudri ¹, Steven Levin ¹, Janhavi Bhandari ¹, Fariha Ahmed-Qadri ¹, Mark Rixon ¹, Jan Hillson ², Stanford Peng ¹ and Kristine Swiderek ¹, ¹Alpine Immune Sciences, Seattle, WA, ²Alpine Immune Sciences, Seattle, WI
Background/Purpose: ALPN-101 is an Fc fusion protein of a human inducible T cell costimulator ligand (ICOSL) variant immunoglobulin domain (vIgDTM) designed to inhibit simultaneously the…
Abstract Number: 2435 • 2019 ACR/ARP Annual Meeting
Data Driven Prediction Lymphoma Model and 10-year Overall Survival Rates of a Large Harmonized Cohort of Patients with Primary Sjögren’s Syndrome Associated Lymphomas
Andreas Goules ¹, Michael Voulgarelis ², Loukas Chatzis², Vasilis Pezoulas ³, Francesco Ferro ⁴, Saviana Gandolfo ⁵, Valentina Donati ⁶, Luca Quartuccio ⁷, Cathryn Scott ⁸, Ginevra De Marchi ⁹, Georgios Michalopoulos ¹, Aliki Venetsanopoulou ¹, Aristea Papageorgiou ¹, Dimitris Ziogas ¹, Marina Sikara ¹, Argyropoulou Ourania ¹, Clio Mavragani ¹, Dimitris fotiadis ¹⁰, Salvatore De Vita ⁵, Chiara Baldini ⁴ and Athanasios Tzioufas ², ¹Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, athens, Greece, ²Department of Pathophysiology, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ³Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, GR45110, Ioannina, Greece, Ioannina, Greece, ⁴Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, Pisa, Italy, ⁵Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, ⁶University of Pisa, Pisa, ⁷Rheumatology Clinic, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, ⁸Institute of Anatomic Pathology, Department of Medical Area, University of Udine, Udine, Italy. *equally contributed, Udine, Italy, ⁹Rheumatology Clinic, Udine University Hospital, Udine, Italy, Udine, Italy, ¹⁰Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Ioannina, Greece
Background/Purpose: Non-Hodgkin’s lymphomas (NHLs) may complicate primary Sjögren’s syndrome (pSS) with significant impact on morbidity and mortality among patients. A large cohort of SS associated…
Abstract Number: 1458 • 2019 ACR/ARP Annual Meeting
Dual Analysis with Nerve Ultrasound and Skin Biopsy in Painful Neuropathy Associated with Sjögren’s Syndrome
Takeshi Yoshida¹, Hiroyuki Nodera ², Yoshitaka Kumon ³ and Hiroki Mizukami ⁴, ¹Chikamori Hospital, Kochi, Japan, ²Kanazawa Medical University, Kanazawa, Japan, ³Chikamori Hospital, Kochi, ⁴Hirosaki University, Hirosaki, Japan
Background/Purpose: 6% of primary Sjögren's syndrome (pSS) patients manifests as various forms of neuropathies including painful sensory neuropathy (PSN), which can be treatable with immunomodulatory drugs such…

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