Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 2177 • 2012 ACR/ARHP Annual Meeting
The Forced Oscillation Technique Is a Sensitive Method for Detection of Obstructive Airway Disease in Patients with Primary Sjögren’s Syndrome
Anna M. Nilsson¹, Elke Theander², Roger Hesselstrand³, Per Wollmer⁴ and Thomas Mandl⁵, ¹Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmo, Sweden, ²Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, ³Rheumatology, Lund University, Lund, Sweden, ⁴Dept of Clinical Physiology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, ⁵Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden
Background/Purpose: To study signs of obstructive airway disease in patients with primary Sjögren’s syndrome (pSS) by the forced oscillation technique (FOT), a method that may…
Abstract Number: 529 • 2012 ACR/ARHP Annual Meeting
The Axis P2X7 Receptor-Inflammasome: A Role in Modulating Inflammatory Response in Primary Sjögren’s Syndrome?
Chiara Baldini¹, Chiara Rossi¹, Eleonora Santini¹, Francesco Ferro¹, Alessia Gallo², Daniela Martini¹, Francesca Sernissi¹, Valentina Donati¹, Camillo Giacomelli¹, Nicoletta Luciano¹, Anna Solini¹ and Stefano Bombardieri¹, ¹Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ²Sjogren's Clinic, NIDCR, Bethesda, MD
Background/Purpose: The exact cause of exocrine gland dysfunction in primary Sjögren’s syndrome (pSS) has not been fully delineated, but it is thought that both innate…
Abstract Number: 2181 • 2012 ACR/ARHP Annual Meeting
Concomitant Atheosclerosis and Impaired Bone Health in Patients with Primary Sjogren’s Syndrome
Clio P. Mavragani¹, Fotini Gravani², Andrianos Nezos¹, Eleni Antypa³, Kiki Maselou⁴, Dimitrios Ioakeimidis⁵, Michael Koutsilieris¹ and Haralampos M. Moutsopoulos⁶, ¹Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, ²Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Athens, Greece, ³Department of Radiology, General Hospital of Athens, Greece, ⁴Department of Immunolgy, General Hospital of Athens, Greece, ⁵Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Greece, Greece, ⁶Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
Background/Purpose: To determine the prevalence of subclinical atherosclerosis and impaired bone health in primary Sjogren’s syndrome (pSS) patients and to explore whether they associate with…
Abstract Number: 504 • 2012 ACR/ARHP Annual Meeting
Pathogenic Autoantibodies to the Anti-Muscarinic Type 3 Receptor Act by Competitive Inhibition of Acetylcholine-Mediated Receptor Signalling in Sjögren’s Syndrome
Michael W. Jackson¹, Isabell Bastian² and Thomas P. Gordon³, ¹Immunology, Flinders University, Adelaide, Australia, ²Immunology, Allergy and Arthritis, Flinders University and Flinders Medical Centre, Adelaide, Australia, ³Immunology Allergy & Arthritis, Flinders Medical Centre, Bedford Park, Australia
Background/Purpose: Primary Sjögren’s syndrome (SS) is a systemic autoimmune disorder characterized by exocrine failure and widespread autonomic dysfunction. Functional autoantibodies (Abs) directed against the muscarinic…
Abstract Number: 1487 • 2012 ACR/ARHP Annual Meeting
Incidence of Fibromyalgia Syndrome in Systemic Sclerosis and Rheumatoid Arthritis. Comparative Results According to Clinical Diagnosis, Screening Test with Fibromyalgia Rapid Screening Tool, Diagnosis with ACR1990 and ACR 2010 Criteria
Serge Perrot¹, Mariana Peixoto², Philippe Dieude³, Eric Hachulla⁴, Sébastien Ottaviani⁵ and Yannick Allanore⁶, ¹Internal Medicine and Pain Clinic, Hopital Hotel Dieu, Paris, France, ²Rheumatology Department, Cochin Hospital, Paris, France, ³Rheumatology, Rheumatology departement & INSERM U699, Paris Diderot university, APHP, Bichat hospital, Paris, France, ⁴Department of Internal Medicine, Claude Huriez University Hospital, Lille, France, ⁵Service de Rhumatologie, Hôpital Bichat, APHP, APHP, Paris, France, ⁶Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France
Background/Purpose: Fibromyalgia (FMS) is a chronic widespread pain condition that may be associated with inflammatory chronic disorders like rheumatoid arthritis (RA) and systemic sclerosis (SSc).…
Abstract Number: 506 • 2012 ACR/ARHP Annual Meeting
Ebv-Mir-Bart13 Affects the Expression of AQP5 in Human Salivary Gland Cell Lines Contributing to the Pathogenesis of Sjögren’s Syndrome
Alessia Gallo¹, Mayank Tandon¹, Shyh-Ing Jang², Hwei Ling Ong², Indu Ambudkar², Gabor G. Illei³ and Ilias Alevizos⁴, ¹Sjogren's Clinic, NIDCR, Bethesda, MD, ²Molecular Physiology and Therapeutics Branch, NIDCR, Bethesda, MD, ³Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD, ⁴Sjogren's Clinic, NIDCR/ NIH #10 1N110, Bethesda, MD
Background/Purpose: Loss of secretory function of salivary glands is one of the most important functional effects of Sjögren’s syndrome (SS), a chronic systemic autoimmune disease.…
Abstract Number: 530 • 2012 ACR/ARHP Annual Meeting
S100A8/A9 Is Upregulated and Triggers the Secretion of Pro-Inflammatory Cytokines in Primary Sjögren’s Syndrome
Laura Weichselbaum¹ and Muhammad S. Soyfoo², ¹Rheumatology, Department of rheumatology ,Hôpital Erasme, Brussels, Belgium, ²Rheumatology, Hôpital Erasme,Université Libre de Bruxelles, Brussels, Belgium
Background/Purpose: To determine the involvement of S100A8/A9 in the pathogenesis of primary Sjögren’s syndrome (pSS) Methods: The serum levels of S100A8/A9, IL-17A and IL-17C were…
Abstract Number: 508 • 2012 ACR/ARHP Annual Meeting
TLR3-Signaling Induces the Expression of Ro/SSA and La/SSB Autoantigens in Salivary Gland Epithelial Cells (SGECs)
Nikolaos C. Kyriakidis¹, Efstathia K. Kapsogeorgou¹, Vasiliki C. Gourzi¹, Haralampos M. Moutsopoulos² and Athanasios G. Tzioufas³, ¹Pathophysiology, School of Medicine, National University of Athens, Greece, Athens, Greece, ²Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ³Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
Background/Purpose: Previous studies have shown that the mRNA expression levels of the Ro52/TRIM21, Ro60/TROVE2 and La/SSB intracellular autoantigens are elevated within the immunopathologic lesions of…
Abstract Number: 510 • 2012 ACR/ARHP Annual Meeting
IL-7 and IL-7 Receptor Blockade to Selectively Inhibit TLR7-Induced B Cell Activation in Primary Sjögren’s Syndrome
A. Bikker¹, C.R. Willis², A.a. Kruize¹, J.W.J. Bijlsma³, F.P.J.G. Lafeber³ and J.A.G. van Roon⁴, ¹Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Amgen Inc., Seattle, WA, ³Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Toll-like receptors (TLRs) are involved in the recognition of nucleic acids (viral, bacterial, and possibly self) and have been implicated in several auto-immune diseases.…
Abstract Number: 509 • 2012 ACR/ARHP Annual Meeting
IL-7 and Toll-Like Receptor 7 Synergistically Increase Th1/Th17/Th22 Cytokine Secretion and Activity of B Cells
A. Bikker¹, A.a. Kruize¹, F. Redegeld², W. de Jager³, F.P.J.G. Lafeber⁴ and J.A.G. van Roon⁵, ¹Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Dept Pharmacology UU, Utrecht, Netherlands, ³Dept Immunology, UMC Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: IL-7 is a potent T cell activating cytokine that has been shown to cause proliferation, survival and differentiation of T cells as well as…

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