ACR Meeting Abstracts

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Abstracts tagged "Sjogren’s syndrome"

  • Abstract Number: 523 • 2012 ACR/ARHP Annual Meeting

    Use of Global Gene Expression Profiling to Characterize Sjögren’s Patients Who Underexpress Interferon-Inducible Genes

    John A. Ice1, He Li2, Jennifer A. Kelly1, Indra Adrianto1, Stuart B. Glenn3, Kimberly S. Hefner4, Evan G. Vista5, Donald U. Stone6, Raj Gopalakrishnan7, Glen D. Houston8, David M. Lewis9, Michael Rohrer7, Pamela Hughes7, John B. Harley10, Courtney G. Montgomery11, James Chodosh12, James A. Lessard13, Juan-Manuel Anaya14, Barbara M. Segal15, Nelson L. Rhodus16, Lida Radfar17, Mark B. Frank1, R. Hal Scofield18, Christopher J. Lessard19 and Kathy Moser Sivils1, 1Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Hefner Eye Care and Optical Center, Oklahoma City, OK, 5Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, 6Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 7Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, 8Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 9College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 10Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 11Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 12Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 13Valley Bone and Joint Clinic, Grand Forks, ND, 14School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, 15Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 16University of Minnesota, Minneapolis, MN, 17University of Oklahoma Health Sciences Center, Oklahoma City, OK, 18Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 19Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren’s syndrome (SS) is a progressive autoimmune exocrinopathy characterized by symptoms of dry eyes and mouth.  We previously reported overexpression of interferon-inducible (IFI) genes…
  • Abstract Number: 2676 • 2012 ACR/ARHP Annual Meeting

    Long-Term Humoral Autoimmunity to Ro60 in Primary Sjögren’s Syndrome Is Driven by Clonal Succession

    Rhianna Lindop1, Isabell Bastian1, Georgia Arentz1, Lauren Thurgood1, Andrew Whyte1, Tim, K. Chataway2, Michael Jackson1 and Tom Gordon1, 1Immunology, Flinders Medical Centre and Flinders University, Adelaide, Australia, 2Human Physiology, School of Medicine, Flinders University, Adelaide, Australia

    Background/Purpose : Long-lived humoral autoimmunity to Ro60 is considered a hallmark of primary Sjögren’s syndrome (SS), but the mechanism by which this immunity is sustained over…
  • Abstract Number: 2193 • 2012 ACR/ARHP Annual Meeting

    Validity of Low Titers of SSA/B Antibodies in Predicting A Key Feature of Sjögren’s Syndrome

    Mara McAdams DeMarco1, Mi Y. Lam2, Stephen Shiboski2, Lindsey A. Criswell3, Caroline Shiboski4 and Alan N. Baer5, 1Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2University of California, San Francisco, San Francisco, CA, 3Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, 4Orofacial Sciences, University of California, San Francisco, San Francisco, CA, 5Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: The validity of low titers of SSA and/or SSB (SSA/B) antibodies (Ab) in the diagnosis of Sjögren’s syndrome (SS) has not been defined.  We…
  • Abstract Number: 525 • 2012 ACR/ARHP Annual Meeting

    Gene Expression Profiling in a Large Cohort of Europeans with Sjögren’s Syndrome Reveals Candidate Genes in Viral, Immune, and Interferon-Related Pathways

    He Li1, John A. Ice2, Jennifer A. Kelly3, Indra Adrianto2, Stuart B. Glenn4, Kimberly S. Hefner5, Evan G. Vista6, Donald U. Stone7, Raj Gopalakrishnan8, Glen D. Houston9, David M. Lewis10, Michael Rohrer8, Pamela Hughes8, John B. Harley11, Courtney G. Montgomery2, James Chodosh7, James A. Lessard12, Juan-Manuel Anaya13, Barbara M. Segal14, Nelson L. Rhodus15, Lida Radfar16, Mark B. Frank17, R. Hal Scofield18, Christopher J. Lessard19 and Kathy Moser Sivils3, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Hefner Eye Care and Optical Center, Oklahoma City, OK, 6Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, 7Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 8Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, 9Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 10College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 11Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 12Valley Bone and Joint Clinic, Grand Forks, ND, 13School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, 14Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 15University of Minnesota, Minneapolis, MN, 16University of Oklahoma Health Sciences Center, Oklahoma City, OK, 17Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 18Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 19Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren’s syndrome (SS), characterized by lymphocytic infiltration of exocrine glands, is a progressive autoimmune exocrinopathy present in 0.7-1% of Europeans. To better understand the…
  • Abstract Number: 2197 • 2012 ACR/ARHP Annual Meeting

    Diagnostic Value of Blood B-Cell Subset Profiling and Autoimmunity Markers in Anti-SSA-Negative Sjögren’s Syndrome Patients

    Divi Cornec1, Alain Saraux2, Jacques-Olivier Pers3, Sandrine Jousse-Joulin4, Yves Renaudineau3, Thierry Marhadour5 and Valerie Devauchelle-Pensec6, 1Department of rheumatology, Brest Occidentale University, Brest, France, 2Department of rheumatology and unit of immunology (EA 2216), Brest Occidentale university, Brest, France, 3Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, 4Rheumatology/Immunology, CHU de la Cavale Blanche, Brest, France, 5Rheumatology, CHU de la Cavale Blanche, Brest, France, 6Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France

    Background/Purpose: Recently published ACR classification criteria for primary Sjögren’s syndrome (pSS) suggest considering antinuclear antibodies (ANA) titer and rheumatoid factor (RF) positivity in patients negative…
  • Abstract Number: 526 • 2012 ACR/ARHP Annual Meeting

    Use of a Novel Probe to Demonstrate Granzyme B Activity in Sjogren’s Syndrome Salivary Glands

    Kimberly Doering Maurer1, Laura Gutierrez-Alamillo1, Efstathia K. Kapsogeorgou2, Athanasios G. Tzioufas3, Livia Casciola-Rosen4 and Antony Rosen4, 1Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, 2Pathophysiology, School of Medicine, National University of Athens, Greece, Athens, Greece, 3Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, 4Division of Rheumatology, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Salivary glands are a prominent target organ in Sjögren’s   syndrome (SS), with patients having abnormal secretory function and inflammatory infiltration of these glands.  Little…
  • Abstract Number: 2201 • 2012 ACR/ARHP Annual Meeting

    Involvement of Interleukin-33 in the Pathogenesis of Sjögren’s Syndrome

    Ahmad Awada, Valérie Gangji and Muhammad S. Soyfoo, Rheumatology, Hôpital Erasme,Université Libre de Bruxelles, Brussels, Belgium

    Background/Purpose: To investigate the role of IL-33/ST2 in the pathophysiology of primary Sjögren’s syndrome (pSS) Methods: Serum levels of IL-33 and sST2 was determined by…
  • Abstract Number: 528 • 2012 ACR/ARHP Annual Meeting

    Mxa As a Biomarker for Systemic Interferon Type I Activation in Primary Sjögren′s Syndrome

    Naomi I. Maria1, Zana Brkic1, Matti Waris2, Cornelia G. van Helden-Meeuwsen1, Kim Heezen1, Joop P. van de Merwe1, Paul L. van Daele3, Virgil A. Dalm3, Hemmo A. Drexhage3 and Marjan A. Versnel3, 1Immunology, Erasmus Medical Center, Rotterdam, Netherlands, 2Department of Virology, University of Turku, Turku, Finland, 3Erasmus Medical Center, Immunology, Rotterdam, Netherlands

    Background/Purpose: To establish an easy and practical assay for detection of systemic Interferon (IFN) type I activation in primary Sjögren's syndrome (pSS). The monocyte IFN…
  • Abstract Number: 2177 • 2012 ACR/ARHP Annual Meeting

    The Forced Oscillation Technique Is a Sensitive Method for Detection of Obstructive Airway Disease in Patients with Primary Sjögren’s Syndrome

    Anna M. Nilsson1, Elke Theander2, Roger Hesselstrand3, Per Wollmer4 and Thomas Mandl5, 1Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmo, Sweden, 2Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, 3Rheumatology, Lund University, Lund, Sweden, 4Dept of Clinical Physiology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, 5Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden

    Background/Purpose: To study signs of obstructive airway disease in patients with primary Sjögren’s syndrome (pSS) by the forced oscillation technique (FOT), a method that may…
  • Abstract Number: 529 • 2012 ACR/ARHP Annual Meeting

    The Axis P2X7 Receptor-Inflammasome: A Role in Modulating Inflammatory Response in Primary Sjögren’s Syndrome?

    Chiara Baldini1, Chiara Rossi1, Eleonora Santini1, Francesco Ferro1, Alessia Gallo2, Daniela Martini1, Francesca Sernissi1, Valentina Donati1, Camillo Giacomelli1, Nicoletta Luciano1, Anna Solini1 and Stefano Bombardieri1, 1Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 2Sjogren's Clinic, NIDCR, Bethesda, MD

    Background/Purpose: The exact cause of exocrine gland dysfunction in primary Sjögren’s syndrome (pSS) has not been fully delineated, but it is thought that both innate…
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