Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 2244 • 2012 ACR/ARHP Annual Meeting
Predicting Sjögren’s Syndrome At Diagnosis of Systemic Lupus Erythematosus
Gabriela Hernandez-Molina¹, Tatiana Zamora-Legoff¹, Juanita Romero-Diaz¹, Carlos Alberto Nuñez-Alvarez¹, Francisco Cárdenas-Velázquez², Carlos Hernández-Hernández³, Maria Luisa Calderillo³, Martha Marroquín³, Claudia Recillas-Gispert⁴, Carmen Ávila-Casado⁵ and Jorge Sánchez-Guerrero⁶, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Ophtalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Dental Service, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁴Ophtalmology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁵Pathology, University Health Network, Toronto Canada., Toronto, ON, Canada, ⁶Rheumatology, Mount Sinai Hospital, Toronto Canada., Canada
Background/Purpose: Sjogren’s syndrome (SS) overlaps with systemic lupus erythematosus (SLE) in up to 20% of patients. Attempts to identify the characteristics of the SLE patients…
Abstract Number: 514 • 2012 ACR/ARHP Annual Meeting
Frequencies and Numbers of Circulating IL-10 Producing Regulatory B Cells Are Not Disturbed in Pss-Patients but Correlate Negatively with the EULAR Sjögren Syndrome Disease Activity Score (ESSDAI)
Wayel H. Abdulahad¹, Gwenny Verstappen¹, Arjan Vissink², Minke G. Huitema¹, Petra M. Meiners², Hendrika Bootsma³ and Frans Kroese⁴, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, ³Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁴University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Recently, a specific and functionally important subset of regulatory B cells (Breg) that negatively regulate autoimmunity and inflammation has been described. Breg cells exert…
Abstract Number: 293 • 2012 ACR/ARHP Annual Meeting
Usefulness of Cardiac Magnetic Resonance in the Assessment of Myocardial Inflammation and Fibrosis in Children Born to Mothers with Anti-SSA/Ro Antibodies: A Prospective Study of 23 Cases and 6 Controls
Nathalie Costedoat-Chalumeau¹, Alice Maltret², Kateri Levesque¹, Shelby Kutty³, Elisabeth Villain², Phalla Ou⁴ and Gaëlle Guettrot-Imbert⁵, ¹Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ²Cardiology, Groupe Hospitalier Necker - Enfants Malades, Paris, France, ³Division of Pediatric Cardiology, university of Nebraska Medical Center and Children's Hospital ans Medical Center, Omaha, NE, USA, Omaha, ⁴Radiology,, Groupe Hospitalier Necker - Enfants Malades, Paris, France, ⁵Internal Medicine, Hopital Gabriel Montpied, Clermont-Ferrand, France
Background/Purpose: Besides congenital heart blocks (CHB), others manifestations of cardiac neonatal lupus erythematosus syndrome (NLES) include endocardial fibroelastosis (EFE), and dilated cardiomyopathy. Recently, autopsy of…
Abstract Number: 2182 • 2012 ACR/ARHP Annual Meeting
Prevalence of Fibromyalgia Is Increased in Primary Sjögren’s Syndrome Compared with SLE and Associated with Depression and Severe Vitamin D Deficiency
Byoong Yong Choi¹, Hye Jin Oh², Jun Won Park³, Bon Seung Ku², Sung Hae Chang², Eun Young Lee², Eun Bong Lee² and Yeong Wook Song⁴, ¹Division of Rheumatology, Department of Internal Medicine, Seoul Medical Center, Seoul, South Korea, Seoul, South Korea, ²Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Rheumatology, Seoul National University, Seoul, South Korea, ⁴Internal Medicine,, Seoul National University Hospital, Seoul, South Korea
Background/Purpose: Although clinical features of primary Sjögren's syndrome (pSS) overlap with those of fibromyalgia (FM), the relationship between FM and pSS has remained unclear. Furthermore,…
Abstract Number: 515 • 2012 ACR/ARHP Annual Meeting
Stages of Sjogren’s Syndrome Defined by Immune Mediators
Lakshmanan Suresh¹, Julian Ambrus Jr.² and Long Shen³, ¹Laboratory Medicine, IMMCO Diagnostics Inc., Amherst, NY, ²Division of Allergy, Immunology and Rheumatology, Department of Medicine, State University of New York at Buffalo, Buffalo, NY, ³Department of Medicine, SUNY at Buffalo, Buffalo, NY
Background/Purpose: Sjogren’s syndrome (SS) is characterized by destruction of the salivary and lachrymal glands but also systemic manifestations such as lung disease, kidney disease and…
Abstract Number: 127 • 2012 ACR/ARHP Annual Meeting
Ultrasonographic Evaluation of the Hands of Patients with Primary and Secondary Sjögren´s Syndrome
Cristina Hernández-Díaz¹, Luis M. Amezcua-Guerra², Angélica Vargas², Alberto Lopez-Reyes³ and Carlos Pineda⁴, ¹Musculoskeletal Ultrasound, Instituto Nacional de Rehabilitación, Mexico City, Mexico, ²Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, ³Synovial fluid and molecular analysis laboratory, Instituto Nacional de Rehabilitacion, Mexico City, Mexico, ⁴Biomedical Research, Instituto Nacional de Rehabilitacion, Mexico City, Mexico
Background/Purpose: Primary Sjögren’s syndrome (pSS) is an autoimmune disease characterized by lymphocyte infiltration of various exocrine glands, often associated with joint involvement traditionally described as…
Abstract Number: 2184 • 2012 ACR/ARHP Annual Meeting
Pregnancy and Fetal Outcome in Patients with an Established Diagnosis of Primary Sjögren’s Syndrome.
Roberta Priori¹, Angelica Gattamelata², Mariagrazia Modesti³, Serena Colafrancesco³, Marta Maset⁴, Luca Quartuccio⁴, Salvatore De Vita⁵, Elena Bartoloni Bocci⁶, Alessia Alunno⁷, Roberto Gerli⁶, Francesca Strigini⁸, Chiara Baldini⁹, Chiari Tani⁹, Marta Mosca⁹, Stefano Bombardieri⁹ and Guido Valesini³, ¹Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, ²Sapienza University of Rome, Rome, Italy, ³Rheumatology Unit, Sapienza University of Rome, Rome, Italy, ⁴Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, ⁵Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, ⁶Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Perugia, Perugia, Italy, ⁷Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, ⁸Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁹Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: To investigate pregnancy and fetal outcome in patients with an established diagnosis of primary Sjögren’s syndrome (pSS) Methods: The clinical charts of 1075 women with…
Abstract Number: 517 • 2012 ACR/ARHP Annual Meeting
Overexpression of BMP6 Is Associated with Loss of Salivary Gland Activity in Sjögren’s Syndrome Patients and Mice
Hongen Yin¹, Javier Cabrera-Perez¹, Zhennan Lai¹, Drew Michael², Melodie Weller¹, Bill Swaim¹, Noreen Rana¹, Xibao Liu¹, Ilias Alevizos³, Indu Ambudkar⁴ and John A. Chiorini¹, ¹Mptb, NIH/NIDCR, Bethesda, MD, ²Mptb, NIDCR, Bethesda, MD, ³Sjogren's Clinic, NIDCR/ NIH #10 1N110, Bethesda, MD, ⁴Molecular Physiology and Therapeutics Branch, NIDCR, Bethesda, MD
Background/Purpose: A hallmark of Sjögren’s syndrome (SS) is the loss of activity in secretory epithelia, specifically the larcrimal and salivary glands. The mechanism(s) driving this…
Abstract Number: 2671 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide Association Study Establishes Muliple Susceptibility Loci for Sjögren’s Syndrome
Christopher J. Lessard¹, He Li², Indra Adrianto³, John A. Ice³, Roland Jonsson⁴, Gabor G. Illei⁵, Maureen Rischmueller⁶, Gunnel Nordmark⁷, Xavier Mariette⁸, Corinne Miceli-Richard⁹, Marie Wahren-Herlenius¹⁰, Torsten Witte¹¹, Michael T. Brennan¹², Roald Omdal¹³, Patrick M. Gaffney³, James A. Lessard¹⁴, Wan-Fai Ng¹⁵, Nelson L. Rhodus¹⁶, Barbara M. Segal¹⁷, R. Hal Scofield¹⁸, Judith A. James¹⁹, Juan-Manuel Anaya²⁰, John B. Harley²¹, Courtney G. Montgomery³ and Kathy Moser Sivils¹⁹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Broegelmann Research Laboratory, the Gade Institute, University of Bergen, Bergen, Norway, ⁵Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD, ⁶Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, ⁷Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁸Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France, ⁹Hopital Bicêtre, Le Kremlin Bicêtre, France, ¹⁰Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹¹Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ¹²Nidcr NIH, Carolinas Medical Center, Charlotte, NC, ¹³Department of Internal Medicine, Stavanger university Hospital, Stavanger, Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹⁴Valley Bone and Joint Clinic, Grand Forks, ND, ¹⁵Musculoskeletal Research Group Institute of Cellular Medicine, Newcastle University, Newcastle University, Newcastle, England, ¹⁶University of Minnesota, Minneapolis, MN, ¹⁷Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹⁸Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²⁰School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, ²¹Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH
Background/Purpose: Sjögren’s syndrome (SS) is a common, clinically heterogeneous autoimmune disease characterized by exocrine gland dysfunction that involves both innate and adaptive immune responses. A…
Abstract Number: 2185 • 2012 ACR/ARHP Annual Meeting
Prevalence of Severe Extra-Glandular Manifestations in a Large Cohort of Patients with Primary Sjögren’s Syndrome
Chiara Baldini¹, Pasquale Pepe², Luca Quartuccio³, Roberta Priori⁴, Elena Bartoloni Bocci⁵, Alessia Alunno⁶, Serena Colafrancesco⁷, Angelica Gattamelata⁸, Marta Maset⁹, Mariagrazia Modesti⁷, Antonio Tavoni¹⁰, Salvatore De Vita⁹, Roberto Gerli⁵, Guido Valesini⁷ and Stefano Bombardieri¹¹, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, ⁴Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, ⁵Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Perugia, Perugia, Italy, ⁶Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, ⁷Rheumatology Unit, Sapienza University of Rome, Rome, Italy, ⁸Sapienza University of Rome, Rome, Italy, ⁹Rheumatology Clinic, DSMB, University of Udine, Italy, Udine, Italy, ¹⁰University of Pisa, Immunoallergology Unit, Pisa, Italy, ¹¹Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: i) to describe the clinico- serological features of a cohort of 1115 patients with primary Sjögren’s syndrome (pSS); ii) to assess the prevalence of systemic extra-glandular…
Abstract Number: 518 • 2012 ACR/ARHP Annual Meeting
Spontaneous Sialadenitis Like Sjögren’s Syndrome in Orphan Nuclear Receptor γt (RORγt) Transgenic Mice
Mana Iizuka¹, Hiroto Tsuboi¹, Hiromitsu Asashima¹, Yuya Kondo¹, Satoru Takahashi², Isao Matsumoto¹ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: The nuclear receptors retinoic-acid-receptor-related orphan receptors gt (RORγt) is required for the generation of Th17 cells expressing the proinflammatory cytokine IL-17. Th17 cells expressing…
Abstract Number: 2672 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren’s Syndrome (SS) According to Specific Subphenotypes and Ancestry
Lindsey A. Criswell¹, Kimberly E. Taylor², Caitlin McHugh³, Cathy Laurie³, Kimberly Doheny⁴, Mi Y. Lam², Joanne Nititham⁵, Laura Bierut⁶, Emily L. Harris⁷, Alan N. Baer⁸, Stephen Challacombe⁹, Yi Dong¹⁰, Hector Lanfranchi¹¹, Morten Schiodt¹², M. Srinivasan¹³, Susumu Sugai¹⁴, Hisanori Umehara¹⁵, Frederick B. Vivino¹⁶, Zhao Yan¹⁷, Stephen Shiboski², Troy Daniels¹⁸, John S. Greenspan¹⁹, Caroline Shiboski¹⁹ and SICCA²⁰, ¹Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA, ³University of Washington, Biostatistics, Seattle, WA, ⁴Center for Inherited Disease Research, Baltimore, MD, ⁵Medicine, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ⁶Psychiatry, Washington University, St. Louis, MO, ⁷National Institute of Dental and Craniofacial Research, Bethesda, MD, ⁸Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁹Kings College London, London, United Kingdom, ¹⁰Dept of Rheumatology, Peking Univ Med Coll Hospital, East City Beijing, China, ¹¹University of Buenos Aires, Buenos Aires, Argentina, ¹²Righospitalet, Copenhagen, Denmark, ¹³Aravind Eye Hospital, Madurai, India, ¹⁴Kanazawa Medical University, Ishikawa, Japan, ¹⁵Internal Medicine, Division of Hematology and Immunology, Kanazawa Medical University, Kanazawa, Japan, ¹⁶Medicine, Penn Presbyt Med Ctr, Philadelphia, PA, ¹⁷Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, ¹⁸Orofacial Sciences, Box 0422, UCSF Schools of Medicine & Dentistry, San Francisco, CA, ¹⁹Orofacial Sciences, University of California, San Francisco, San Francisco, CA, ²⁰San Francisco, CA
Background/Purpose: Our goal is to define the contribution of genetic factors to SS and related subphenotypes. Methods: We studied 2,459 participants in the Sjögren’s International…
Abstract Number: 2189 • 2012 ACR/ARHP Annual Meeting
Efficacy of Belimumab On Non-Malignant Parotid Swelling and Systemic Manifestations of Sjögren’s Syndrome: Results of the Beliss Study
Salvatore De Vita¹, Raphaèle Seror², Luca Quartuccio³, Frederic Desmoulins⁴, Sara Salvin⁵, Gabriel Baron⁶, Martina Fabris⁷, Philippe Ravaud⁸, Miriam Isola⁹ and Xavier Mariette¹⁰, ¹Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, ²Rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, LE Kremlin-Bicetre, France, ³Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, ⁴Rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, Le Kremlin Bicetre, France, ⁵Rheumatology Clinic, DSMB, University of Udine,, Udine, Italy, ⁶Epidemiology & Clinical Research, Groupe Hospitalier Bichat-Claude Bernard, Paris, France, ⁷Institute of Clinical Pathology, Udine, Italy, ⁸Epidemiology, Université Paris-Descartes, Paris, Paris, France, ⁹Institute of Statistics, DSMB, University of Udine, Udine, Italy, ¹⁰Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France
Background/Purpose: to report the effects of anti-BAFF/BLyS antibody belimumab (BEL) on the different ogan manifestations of primary Sjögren’s syndrome (pSS), by evaluating the ESSDAI score…
Abstract Number: 519 • 2012 ACR/ARHP Annual Meeting
Sex-Specific Regulatory T Cell Dysfunction in a Mouse Model of Sjögren Syndrome
Scott M. Lieberman¹, Portia A. Kreiger² and Gary A. Koretzky³, ¹Pediatrics, Div Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Pathology, Nemours/A.I. DuPont Hospital for Children, Wilmington, DE, ³Medicine, University Pennsylvania, Philadelphia, PA
Background/Purpose: CD4+Foxp3+ regulatory T cells (Tregs) are a specialized population of lymphocytes which prevent autoimmunity in normal hosts. Treg dysfunction has been implicated in autoimmunity; however results…
Abstract Number: 2673 • 2012 ACR/ARHP Annual Meeting
Sibling Relative Risk and Heritability of Sjögren’s Syndrome: A Nationwide Population Study in Taiwan
Chang-Fu Kuo¹, Matthew J. Grainge², Kuang-Hui Yu³, Lai-Chu See⁴, Shue-Fen Luo³, Ana M. Valdes⁵, I-Jun Chou⁶, Hsiao-Chun Chang³, Weiya Zhang¹ and Michael Doherty⁷, ¹Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ²Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom, ³Division of Rheumatology, Immunology and Allergy, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁴Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁵Dept of Twin Research and Genetic Epidemiology, St. Thomas' Hospital, King's College London, Dept of Twin Research and Genetic Epidemiology, St. Thomas' Hospital, King's College London, London, United Kingdom, ⁶Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁷Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
Background/Purpose: Although familial aggregation has been found in many autoimmune diseases, the evidence for familial aggregation in Sjögren’s syndrome is lacking. The aims of this…

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