Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 510 • 2013 ACR/ARHP Annual Meeting
Multicentric Analysis Of Inter and Intra Observer Reliabilities For Histopathological Abnormalities In Salivary Gland Biopsy In Primary Sjögren Syndrome
Sebastian Costa¹, Isabelle Quintin Roue², Agnes Lesourd², Sandrine Jousse-Joulin³, Pascale Marcorelles⁴, Eric Hachulla⁵, Vincent Goeb⁶, Marie-Christine Copin⁷, Jean-Marie Berthelot⁸, Jacques-Olivier Pers⁹, Olivier Vittecoq¹⁰, Emmanuel Nowak¹¹, Alain Saraux¹² and Valerie Devauchelle-Pensec¹³, ¹anatomopathological department, Brest university hospital, Brest, France, ²anatomopathological department, Morvan hospital, Brest, France, ³Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, ⁴anatomopathological department, Brest university hospital, CHU Morvan, Brest, France, ⁵Internal Medicine, Lille CEDEX, France, ⁶Rheumatology, Amiens University Hospital, Amiens, France, ⁷anatomopathological department, Lille university, Lille, France, ⁸Rheumatology Unit, Nantes University Hospital, Nantes, France, ⁹Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, ¹⁰Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France, ¹¹CIC, CHU Brest, Brest, France, ¹²Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France, ¹³Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France
Background/Purpose: : Histopathologic evaluation of minor labial salivary gland (MLSG) is a major goal for the classification of patients with a primary Sjögren syndrome (pSS)…
Abstract Number: 1502 • 2013 ACR/ARHP Annual Meeting
Antibodies To Anti-Type -3 Muscarinic Acetylcholine Receptor Are Highly Prevalent To Rabbits Immunized With 4-Hydroxy-2-Noneal-Modified and 60-Kda Ro
Valerie Harris¹, Biji T. Kurien², R. Hal Scofield³, Timothy Gross⁴ and Mary Girton⁵, ¹Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK, ²College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: In Sjörgen’s Syndrome, an autoimmune disease, the lacrimal and salivary glands are the primarily affected glands. Previous studies have proposed autoantibodies that target type-3…
Abstract Number: 511 • 2013 ACR/ARHP Annual Meeting
Salivary Gland Lymphocyte Pattern Associated With Response To Belimumab In Primary sjogren’ssyndrome: Results Of The Beliss Study
Raphaèle Seror¹, Thierry Lazure², Frederic Desmoulins³, Stephan Pavy⁴, Corinne Miceli-Richard⁵, Gabriel Baron⁶, Philippe Ravaud⁷ and Xavier Mariette⁸, ¹Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ²Pathology, INSERM U1012 - Université Paris XI, Le Kremlin Bicêtre, France, ³Rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, Le Kremlin Bicetre, France, ⁴Rheumatology, Hopital Bicetre, Paris, France, ⁵Rheumatology Department, Université Paris-Sud 11, Bicêtre Hospital,, Kremlin Bicêtre, France, ⁶Hotel Dieu University Hospital Paris, Epidemiology, Paris, France, ⁷Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, ⁸Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France
Background/Purpose: To address the change in labial salivary gland (LSG) inflammation after Belimumab (biological treatment inhibiting soluble BAFF/BLyS) therapy in pSS patients and identify predictor…
Abstract Number: 1503 • 2013 ACR/ARHP Annual Meeting
The Suppressive Ability Of Altered Peptide Ligands To M3R Reactive T Cells In M3R Induced Autoimmune Sialadenitis
Hiromitsu Asashima¹, Hiroto Tsuboi¹, Naomi Matsuo¹, Chihiro Hagiya¹, Tomoya Hirota¹, Mana Iizuka¹, Yuya Kondo¹, Isao Matsumoto² and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Internal Medicine, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Previous studies have shown that Rag1-/- mice transferred with splenocytes of M3 muscarinic acetylcoline receptor (M3R)-/- mice immunized with M3R peptides mixture (three N-terminal…
Abstract Number: 512 • 2013 ACR/ARHP Annual Meeting
The Significance Of Ectopic Germinal Center In Minor Salivary Gland Of Patients With Sjögren’s Syndrome
Kyung-Eun Lee¹, Dong-Jin Park¹, Jeong-Won Lee², Ji-Hyoun Kang², Lihui Wen¹, Tae-Jong Kim³, Yong-Wook Park¹ and Shin-Seok Lee⁴, ¹Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ²Chonnam National University Medical School, Gwangju, South Korea, ³Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ⁴Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose: To investigate whether the presence of germinal center (GC) in minor salivary glands of patients with Sjögren’s syndrome (SS) is associated with different clinical…
Abstract Number: 1492 • 2013 ACR/ARHP Annual Meeting
Histone Deacetylase 1 But Not 2 Is Highly Expressed In The Lymphocyte Foci In The Labial Glands Of Patients With Sjogren’s Syndrome
Juan Guo and Wei Zhou, Department of Rheumatology and Immunology, Peking University First Hospital, Beijing, China
Background/Purpose: Sjogren’s syndrome (SS) is an autoimmune disease with abnormally infiltrating lymphocytes in exocrine glands expressing Th1 cytokines and increased incidence of lymphoma. Histone deacetylases…
Abstract Number: 513 • 2013 ACR/ARHP Annual Meeting
Diagnostic Value Of Labial Minor Salivary Gland Biopsy For Primary Sjögren’s Syndrome
Raquel Altoe¹, Valeria Valim², Maria Carmem S. Santos³, Erica V. Serrano¹ and Samira T. Miyamoto⁴, ¹Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil, ²Clínica Médica - Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil, ³Farmacologia, Universidade de Vila Velha, Vitória, Brazil, ⁴Educação Integrada em Saúde - Reumatologia, Universidade Federal do Espírito Santo, Vitoria, Brazil
Background/Purpose: The presence of lymphocytic infiltrate with ≥ 1 focus score/4mm2 in minor salivary gland is a useful tool for the diagnosis of Sjögren's syndrome…
Abstract Number: 1490 • 2013 ACR/ARHP Annual Meeting
Comparative Study Of The Transcriptome Of Minor Salivary Gland Of Sjögren’s Syndrome Patients Versus Healthy Controls Based On RNA-Seq
Alessia Gallo¹, Shih-Ing Jang², Stamatina Danielides³, Ana Paola Cotrim² and Ilias Alevizos⁴, ¹Sjogren's Clinic, NIDCR, Bethesda, MD, ²NIDCR, NIH, Bethesda, MD, ³Nidcr, NIH, Bethesda, MD, ⁴Sjogren's Clinic, NIDCR/ NIH #10 1N110, Bethesda, MD
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a complex autoimmune disease characterized by a progressive hypofunction of the salivary and lachrymal glands. In order to better…
Abstract Number: 517 • 2013 ACR/ARHP Annual Meeting
Antibody Responses To Oral Bacteria In Patients With Primary Sjögren’s Syndrome and Comparison With Rheumatoid Arthritis and Periodontitis
Bozo Lugonja¹, Michael Milward², Diana Pearson³, Thomas Dietrich⁴, Iain Chapple⁵, John Hamburger⁶, Francesca Barone¹, Saaeha Rauz⁷, Lorraine Yeo⁸, Ana Povedo-Gallego⁹, Geraint Williams⁷, Paola de Pablo¹, Andrea Richards⁹, Christopher D. Buckley¹, Dagmar Scheel-Toellner⁸ and Simon J. Bowman¹⁰, ¹Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, ²Dept of Periodontology, University of Birmingham, Birmingham, United Kingdom, ³Dept of Periodontology, Birmingham Dental Hospital, Birmingham, United Kingdom, ⁴School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ⁵Periodontology Dept, School of Dentistry, University of Birmingham, Birmingham, United Kingdom, ⁶Dept of Oral Medicine, School of Dentistry, University of Birmingham, Birmingham, United Kingdom, ⁷Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom, ⁸Rheumatology Research Group, Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK, Birmingham, United Kingdom, ⁹Dept of Oral Medicine, Birmingham Dental Hospital, Birmingham, United Kingdom, ¹⁰Department of Rheumatology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
Background/Purpose: We set out to examine peripheral blood antibody ELISA responses to common oral bacteria in primary Sjögren’s syndrome (pSS) to identify potential bacterial triggers…
Abstract Number: 2879 • 2013 ACR/ARHP Annual Meeting
Prognostic Value Of Minor Salivary Gland Assessments In Primary Sjögren’s Syndrome
Anna Risselada¹, A.a. Kruize², J.A.G. van Roon³, F.P.J.G. Lafeber⁴ and J.W.J. Bijlsma⁴, ¹Clinical immunology and Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Salivary gland assessment is important for diagnosing primary Sjögren’s syndrome (pSS), as the lymphocytic focus score (LFS) is part of pSS classification criteria. Quantitative…
Abstract Number: 1497 • 2013 ACR/ARHP Annual Meeting
Endosomal TLR Triggering Of B Cells In Sjögren’s Syndrome Induces Increased Plasma Cells Differentiation, Ig Class Switch and Immunoglobulin Production
Marie Wahren-Herlenius¹, Susanna Brauner¹, Marika Kvarnström¹, Lasse Folkersen¹, Sabrina Görgen¹, Christina Trollmo², Vivianne Malmström³ and Gunnel Nordmark⁴, ¹Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Karolinska Institutet, Stochkolm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Background/Purpose: Patients with primary Sjögren’s syndrome have B cell disturbances resulting in hypergammaglobulinemia and autoantibody production. Most patients are not treated by immunomodulatory drugs, enabling…
Abstract Number: 518 • 2013 ACR/ARHP Annual Meeting
Vitamin D In Sjogren’s Syndrome
Suneet Grewal¹, Judith A. James², R. Hal Scofield³, Kathy L. Sivils⁴, Michael H. Weisman⁵ and Swamy Venuturupalli⁶, ¹Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁶Cedars-Sinai Medical Center, West Hollywood, CA
Background/Purpose: Unlike other autoimmune diseases in which an association with vitamin D deficiency has been established, the role of vitamin D in Sjogren’s syndrome has…
Abstract Number: 2880 • 2013 ACR/ARHP Annual Meeting
Impact Of Different End Points On The Patient Cohort Size Needed To Demonstrate The Efficacy Of a Therapeutic Intervention In Pss. A Post Hoc Analysis Of The Tears Study (Tolerance and efficacy of Rituximab in primary Sjogren Syndrome study)
Valerie devauchelle-Pensec¹, Sandrine jousse-Joulin², Xavier Mariette³, Jean-Marie Berthelot⁴, Aleth Perdriger⁵, Eric Hachulla⁶, Xavier Puechal⁷, Véronique le Guern⁸, Jean Sibilia⁹, Jacques-Eric Gottenberg¹⁰, Laurent Chiche Sr.¹¹, Vincent Goeb¹², Gilles Hayem¹³, Jacques Morel¹⁴, Charles Zarnitsky¹⁵, Jean Jacques Dubost¹⁶, Jacques-Olivier Pers¹⁷, Divi Cornec¹⁸, Raphaèle Seror¹⁹, Emmanuel Nowak²⁰ and Alain Saraux²¹, ¹Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France, ²Rheumatology/Immunology, CHU de la Cavale Blanche, Brest, France, ³Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, ⁴Rheumatology Unit, Nantes University Hospital, Nantes, France, ⁵Rheumatology, Hôpital Sud, Rennes, France, ⁶Internal Medicine, Lille CEDEX, France, ⁷Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁸Department of Internal Medicine, Hôpital Cochin, Paris, France, ⁹Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ¹⁰Strasbourg University Hospital, Strasbourg, France, ¹¹Internal Medicine, CHU Marseille, Marseille, France, ¹²Rheumatology, Amiens University Hospital, Amiens, France, ¹³Rheumatology Unit, Bichat Hospital, Paris, France, ¹⁴Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France, ¹⁵Rheumatology, Le Havre General Hospital, Le Havre, France, ¹⁶Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France, ¹⁷Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, ¹⁸Department of rheumatology, Brest Occidentale University, Brest, France, ¹⁹Rheumatology, Bicetre university hospital, LE Kremlin-Bicetre, France, ²⁰CIC, CHU Brest, Brest, France, ²¹Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France
Background/Purpose: To calculate the sample sizes needed in future randomized controlled trials (RCTs) testing a therapeutic intervention in pSS, methodologists usually rely on data obtained…
Abstract Number: 1498 • 2013 ACR/ARHP Annual Meeting
Hypofunction In Intact Cell Lobules Reflect Salivary Flow Rates In Sjogren’s Patients
Leyla Y Teos¹, Bill Swaim², Ana Paola Cotrim¹, Margaret Grisius³, Lolita Bebris⁴, Indu Ambudkar⁵, Gabor G. Illei⁶ and Ilias Alevizos⁷, ¹NIDCR, NIH, Bethesda, MD, ²Mptb, NIH/NIDCR, Bethesda, MD, ³NIH, Bethesda, MD, ⁴Sjogren's Clinic, NIDCR/NIH, Bethesda, MD, ⁵Molecular Physiology and Therapeutics Branch, NIDCR, Bethesda, MD, ⁶Clinical Development, MedImmune, LLC, Gaithersburg, MD, ⁷Sjogren's Clinic, NIDCR/ NIH #10 1N110, Bethesda, MD
Background/Purpose: Neurotransmitter stimulation of fluid secretion in salivary glands is regulated by increases in intracellular calcium concentration. The increase in cytosolic calcium triggers ion channel…
Abstract Number: 519 • 2013 ACR/ARHP Annual Meeting
Identification Of IgG4-Related Disease and Analysis Of IgG4 Serum Levels In Different Subgroups Of Patients With Sjögren’s Syndrome
Antónia Szántó¹, Gábor Nagy², Csaba Molnár³ and Margit Zeher¹, ¹Clinical Immunology, University of Debrecen, Medical and Health Science Center, Institute for Medicine, Debrecen, Hungary, ²Regional Immunological Laboratory, University of Debrecen, Medical and Health Science Center, Institute for Medicine, Debrecen, Hungary, ³University of Debrecen, Medical and Health Science Center, Institute for Pathology, Debrecen, Hungary
Background/Purpose: In the clinical diagnostic criteria of IgG4-related disease (IgG4-RD), Sjögren’s syndrome (SS) appears as one of the exclusion criteria. However, in Europe, where Mikulicz’s…

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