Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1499 • 2013 ACR/ARHP Annual Meeting
Detection Of CD4⁺CD25^lowGITR⁺ T Lymphocytes In Sjogren’s Syndrome-Interstitial Lung Disease
Wu Zhenbiao¹ and Chen Lina², ¹Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, Xi'An, China, ²Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, Xi‘an, China
Background/Purpose: CD4+CD25lowGITR+ T lymphocytes expressing FoxP3 and showing regulatory function have been recently described in healthy donors (HD). The objective of this study was to…
Abstract Number: 400 • 2013 ACR/ARHP Annual Meeting
Parotid Ultrasound Abnormalities Among Rheumatoid Arthritis Patients: Prevalence and Clinical Correlates
Hong Yang¹, Doquyen H. Huynh², Arnold Ceponis³ and Arthur Kavanaugh⁴, ¹Rheumatology, UCSD, San Diego, CA, ²Rheumatology, UC San Diego School of Medicine, San Diego, CA, ³Medicine/Rheumatology, University of California San Diego, La Jolla, CA, ⁴University of California San Diego, San Diego, CA
Background/Purpose: Sjögren's syndrome (SS) occurs commonly among rheumatoid arthritis (RA) patients. It may be an indicator of, and even a contributor to, increased RA disease…
Abstract Number: 2882 • 2013 ACR/ARHP Annual Meeting
B-Cell Depletion Modulates T-Helper Cell Balance In Patients With Primary Sjögren’s Syndrome
WH Abdulahad¹, FGM Kroese², Gwenny Verstappen³, MG Huitema¹, PM Meiners⁴, A Vissink⁵ and H Bootsma¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and clinical immunology, University Medical Center Groningen, Groningen, Netherlands, ³University of Groningen and University Medical Center Groningen, Groningen, Netherlands, ⁴Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: B-cell depletion therapy with a chimeric anti-human CD20 antibody (rituximab; RTX) is an effective treatment modality for patients with primary Sjögren’s syndrome (pSS). However,…
Abstract Number: 883 • 2013 ACR/ARHP Annual Meeting
Sex Bias In Autoimmune Diseases: Increased Risk Of 47,XXX In Systemic Lupus Erythematosus (SLE) and Sjögren’s Syndrome (SS) Supports The Gene Dose Hypothesis
Ke Liu¹, Kenneth M. Kaufman^2,3, Judith A. James^4,5, Roland Jonsson^6,7, Biji T. Kurien^4,5,8, Xavier Mariette⁹, Joan T. Merrill¹⁰, Roald Omdal¹¹, Maureen Rischmueller^12,13, Timothy J. Vyse¹⁴, Marie Wahren-Herlenius¹⁵, Torsten Witte¹⁶, Christopher J. Lessard^4,5, Sarah L. Zimmerman¹⁷, Susan D. Thompson¹⁸, Gideon Hirschfield¹⁹, Gang Xie^20,21, Courtney G. Montgomery^8,22, Wan-Fai Ng²³, Gunnel Nordmark²⁴, Patrick M. Gaffney^4,8, Katherine A. Siminovitch^20,25, Kathy L. Sivils^4,26, Slegen (International Consortium For The Genetics Of SLE)²⁷ and R. Hal Scofield^4,5,28, ¹Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, ²U.S. Department of Veterans Affairs Medical Center, Cincinnati, OH, ³1Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁷Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ⁸U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁹Paris-Sud University, Paris, France, ¹⁰Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹²Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, ¹³Discipline of Medicine, University of Adelaide, Adelaide, Australia, ¹⁴Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, United Kingdom, ¹⁵Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹⁶Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ¹⁷Divison of human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹⁸Division and Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁹Centre for Liver Research, Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ²⁰Mount Sinai Hospital, Toronto, ON, Canada, ²¹University Of Toronto, Toronto, ON, Canada, ²²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²³Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ²⁴Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²⁵University of Toronto, Toronto, ON, Canada, ²⁶University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁷Center for Autoimmune Genomics and Etiology and Rheumatology Division, International Consortium For The Genetics Of Systemic Lupus Erythematosus, Cincinnati, OH, ²⁸US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Female preponderance is a hallmark of most autoimmune diseases, the mechanism for which is unknown. We hypothesize that this is a consequence of a…
Abstract Number: 218 • 2013 ACR/ARHP Annual Meeting
The Role Of Salivary GLAND Ultrasound In Sjogren Syndrome: A Single Center Experience
Giuseppe Germanò¹, Niccolò Possemato², Olga Addimanda¹, Pierluigi Macchioni¹ and Carlo Salvarani³, ¹Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²S.C. Reumatologia, Arcispedale Santa Maria Nuova, I.R.C.C.S., Reggio Emilia, Italy, ³Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: There is increasingly scientific evidence of salivary gland ultrasonography accuracy and usefulness in diagnosing Sjogren Syndrome. [1-2] Methods: 82 patients with suspected Sjogren Syndrome…
Abstract Number: 2883 • 2013 ACR/ARHP Annual Meeting
Clinical Characteristics of Rheumatoid Arthritis Patients with Secondary Sjögren’s Syndrome and Association with Joint Damage
Lindsay E. Brown¹, Michelle A. Frits², Christine K. Iannaccone², Michael E. Weinblatt², Nancy A. Shadick³ and Katherine P. Liao⁴, ¹Internal Medicine, Massachusetts General Hospital, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Secondary Sjögren's syndrome (sSS) is a common extra-articular manifestation of rheumatoid arthritis (RA). However, the clinical characteristics of this subgroup of patients are not…
Abstract Number: 850 • 2013 ACR/ARHP Annual Meeting
Salivary Gland Ultrasonography: A Highly Specific Tool For The Early Diagnosis Of Primary Sjögren’s Syndrome
Nicoletta Luciano¹, Chiara Baldini¹, Gaia Tarantini², Rachele Pascale², Francesca Sernissi¹, Linda Carli¹, Francesco Ferro¹, Rosaria Talarico¹, Marta Mosca³, Davide Caramella⁴ and Stefano Bombardieri¹, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Department of Diagnostic and Interventional Radiology, University of Pisa, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴University of Pisa, Department of Diagnostic and Interventional Radiology, University of Pisa, Pisa, Italy
Background/Purpose: Recently, Cornec D. et al. reported that salivary gland ultrasonography (SGUS) was characterized by a sensitivity of 65.8% and a specificity of 95.3%, in…
Abstract Number: L20 • 2013 ACR/ARHP Annual Meeting
Association Between Germinal Center Formation in Labial Salivary Gland Biopsies and Predictors of Lymphoma Among Participants of the Sjӧgren’s International Collaborative Clinical Alliance (SICCA)
Annie Chou¹, Kimberly E. Taylor², Richard C.K. Jordan³, John S. Greenspan⁴, Troy E. Daniels⁴, Caroline H. Shiboski¹ and Lindsey A. Criswell^5,6, ¹Orofacial Sciences, University of California San Francisco, San Francisco, CA, ²Department of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Orofacial Sciences, Pathology, & Radiation Oncology, University of California San Francisco, San Francisco, CA, ⁴Orofacial Sciences & Pathology, University of California San Francisco, San Francisco, CA, ⁵University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ⁶University of California, San Francisco, Department of Medicine, San Francisco, CA
Background/Purpose: Sjӧgren’s Syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of the lacrimal and salivary glands causing dry eyes and dry mouth. …
Abstract Number: 2770 • 2013 ACR/ARHP Annual Meeting
Complex Functional Effects Within The HLA Contribute To Sjögren’s Syndrome Pathogenesis and May Influence Both Transcriptional Regulation and Peptide Binding
Christopher J. Lessard^1,2, He Li¹, Indra Adrianto¹, John A. Ice¹, Mikhail G. Dozmorov³, Roland Jonsson⁴, Maureen Rischmueller⁵, Gunnel Nordmark⁶, Xavier Mariette⁷, Corinne Miceli-Richard⁸, Marie Wahren-Herlenius⁹, Torsten Witte¹⁰, Michael T. Brennan¹¹, Roald Omdal¹², Lars Rönnblom¹³, Patrick M. Gaffney¹, Wan-Fai Ng¹⁴, Nelson L. Rhodus¹⁵, Barbara M. Segal¹⁶, Jonathan D. Wren¹, R. Hal Scofield^1,17,18, Juan-Manuel Anaya¹⁹, John B. Harley^20,21, Courtney G. Montgomery¹ and Kathy L. Sivils^1,2, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, ⁶Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁷Paris-Sud University, Paris, France, ⁸Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ⁹Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹⁰Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ¹¹Nidcr NIH, Carolinas Medical Center, Charlotte, NC, ¹²Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹³Department of Medical Science, Uppsala University, Uppsala, Sweden, ¹⁴Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ¹⁵University of Minnesota, Minneapolis, MN, ¹⁶Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹⁷Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁸US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ¹⁹School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, ²⁰Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²¹US Department of Veterans Affairs Medical Center, Cincinnati, OH
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a common, heterogeneous exocrinopathy. Etiology involves complex environmental, genetic and genomic influences driving innate and adaptive autoimmune responses. This…
Abstract Number: 851 • 2013 ACR/ARHP Annual Meeting
Salivary Gland Ultrasonography Improves The Diagnostic Performance Of ACR 2012 Classification Criteria For Sjögren’s Syndrome, Even In The Early Stages Of The Disease
Divi Cornec¹, Sandrine jousse-Joulin², Thierry Marhadour³, Jacques-Olivier Pers⁴, Yves Renaudineau⁴, Alain Saraux⁵ and Valerie Devauchelle-Pensec⁶, ¹Department of rheumatology, Brest Occidentale University, Brest, France, ²Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, ³Rheumatology, CHU de la Cavale Blanche, Brest, France, ⁴Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, ⁵Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France, ⁶Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France
Background/Purpose: Recently published ACR classification criteria for primary Sjögren’s syndrome (pSS) include only 3 objective tests: 1) a serological item: anti-SSA/SSB antibodies or [antinuclear antibody…
Abstract Number: 2772 • 2013 ACR/ARHP Annual Meeting
Identification Of a Sjögren’s Syndrome-Associated Variant That Influences OAS1 Isoform Switching
He Li^1,2, John A. Ice³, Jennifer A. Kelly³, Indra Adrianto¹, Stuart B. Glenn³, Kimberly S. Hefner⁴, Evan G. Vista⁵, Donald U. Stone⁶, Raj Gopalakrishnan⁷, Glen D. Houston⁸, David M. Lewis⁹, Michael Rohrer⁷, Pamela Hughes⁷, John B. Harley^10,11, Courtney G. Montgomery³, James Chodosh¹², James A. Lessard¹³, Juan-Manuel Anaya¹⁴, Barbara M. Segal¹⁵, Nelson L. Rhodus¹⁶, Lida Radfar², R. Hal Scofield¹⁷, Christopher J. Lessard^3,18 and Kathy L. Sivils¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Hefner Eye Care and Optical Center, Oklahoma City, OK, ⁵Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, ⁶Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, ⁸Collage of Denistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁹College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹¹US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹²Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, ¹³Valley Bone and Joint Clinic, Grand Forks, ND, ¹⁴Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ¹⁵Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹⁶University of Minnesota, Minneapolis, MN, ¹⁷Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁸Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a common, progressive autoimmune exocrinopathy characterized by symptoms of dry eyes and mouth present in 0.7-1% of the European population.…
Abstract Number: 522 • 2013 ACR/ARHP Annual Meeting
Abatacept Reduces Disease Activity In Early Primary Sjögren’s Syndrome:One Year Results From a Phase II Open-Label Study
PM Meiners¹, A Vissink², Fkl Spijkervet³, EA Haacke⁴, WH Abdulahad⁵, E Brouwer⁵, MG Huitema⁵, N Sillevis Smitt-Kamminga⁶, FGM Kroese⁷, S Arends⁵ and H Bootsma⁵, ¹Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁴Pathology, University Medical Center Groningen, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁶Opthalmology, University Medical Center Groningen, Groningen, Netherlands, ⁷Rheumatology and clinical immunology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Traditional DMARDs have limited effects in primary Sjögren's (pSS) patients. B cell depletion therapy with rituximab showed efficacy, but had some side-effects. T and…
Abstract Number: 2774 • 2013 ACR/ARHP Annual Meeting
Distinct Role Of Plasmacytoid Dendritic Cells and Mast Cells In The Pathogenesis Of Sjӧgren’s Syndrome
Jidong Zhao¹, Kunihiro Yamaoka¹, Satoshi Kubo¹, Shingo Nakayamada² and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Sjögren’s Syndrome (SS) is characterized by the destruction of the lacrimal and salivary grands due to autoreactive lymphocyte infiltration in the early phase and…
Abstract Number: 505 • 2013 ACR/ARHP Annual Meeting
Damage Accrual In a Single Centre Cohort Of Patients With Primary Sjögren’s Syndrome Followed Up For Over 10 Years
Chiara Baldini¹, Francesco Ferro¹, Pasquale Pepe², Nicoletta Luciano¹, Francesca Sernissi¹, Carlotta Cacciatore¹, Daniela Martini¹, Antonio Tavoni³, Marta Mosca⁴ and Stefano Bombardieri¹, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Institute of Clinical Physiology, National Research Council, Pisa, Italy, ³University of Pisa, Immunoallergology Unit, Pisa, Italy, ⁴Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: 1) To describe the progression and cumulative prevalence of damage accrued over the time in a single center cohort of patients with primary Sjögren’s…
Abstract Number: 2775 • 2013 ACR/ARHP Annual Meeting
Adenosine A2b Receptor Agonist Bay60-6583 Restores Salivary Gland Function In a Mouse Model For Sjögren’s Syndrome
Barbara Szczerba¹, Paulina Rybakowska¹, Paromita Dey¹, Harini Bagavant¹ and Umesh Deshmukh², ¹Department of Medicine, University of Virginia, Charlottesville, VA, ²Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disorder mainly affecting the exocrine glands. However, it is now clear that both immune and non-immune…

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