Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 2774 • 2013 ACR/ARHP Annual Meeting
Distinct Role Of Plasmacytoid Dendritic Cells and Mast Cells In The Pathogenesis Of Sjӧgren’s Syndrome
Jidong Zhao¹, Kunihiro Yamaoka¹, Satoshi Kubo¹, Shingo Nakayamada² and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Sjögren’s Syndrome (SS) is characterized by the destruction of the lacrimal and salivary grands due to autoreactive lymphocyte infiltration in the early phase and…
Abstract Number: 505 • 2013 ACR/ARHP Annual Meeting
Damage Accrual In a Single Centre Cohort Of Patients With Primary Sjögren’s Syndrome Followed Up For Over 10 Years
Chiara Baldini¹, Francesco Ferro¹, Pasquale Pepe², Nicoletta Luciano¹, Francesca Sernissi¹, Carlotta Cacciatore¹, Daniela Martini¹, Antonio Tavoni³, Marta Mosca⁴ and Stefano Bombardieri¹, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Institute of Clinical Physiology, National Research Council, Pisa, Italy, ³University of Pisa, Immunoallergology Unit, Pisa, Italy, ⁴Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: 1) To describe the progression and cumulative prevalence of damage accrued over the time in a single center cohort of patients with primary Sjögren’s…
Abstract Number: 2775 • 2013 ACR/ARHP Annual Meeting
Adenosine A2b Receptor Agonist Bay60-6583 Restores Salivary Gland Function In a Mouse Model For Sjögren’s Syndrome
Barbara Szczerba¹, Paulina Rybakowska¹, Paromita Dey¹, Harini Bagavant¹ and Umesh Deshmukh², ¹Department of Medicine, University of Virginia, Charlottesville, VA, ²Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disorder mainly affecting the exocrine glands. However, it is now clear that both immune and non-immune…
Abstract Number: 506 • 2013 ACR/ARHP Annual Meeting
Hospitalization In Patients With Primary Sjögren’s Syndrome
Yemil Atisha-Fregoso¹, Yahaira Rivera² and Gabriela Hernandez-Molina², ¹Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubirán, Mexico City, Mexico
Background/Purpose: There is scant information on the frequency, main causes and associated risk factors of hospitalization in patients with primary Sjögren syndrome (PSS).We aimed to…
Abstract Number: 2032 • 2013 ACR/ARHP Annual Meeting
How Does Age At Onset Influence Autoimmune Rheumatic Diseases?
Jenny Amaya-Amaya¹, Juan-Camilo Sarmiento-Monroy², Nicolás Molano-González¹, Mónica Rodríguez-Jiménez¹, Rubén-Darío Mantilla², Adriana Rojas-Villarraga¹ and Juan-Manuel Anaya², ¹Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ²School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia
Background/Purpose: Age at onset of disease (AOD) refers to the time period at which a patient experiences the first sign (s) and symptom(s). AOD varies…
Abstract Number: 507 • 2013 ACR/ARHP Annual Meeting
Level Of Agreement Of The AECG 2002 and ACR 2012 Classification Criteria For Sjögren’s Syndrome In The Brittany Cohort: Clues To Understand Discrepancies
Divi Cornec¹, Alain Saraux², Jacques-Olivier Pers³, Sandrine Jousse-Joulin⁴, Yves Renaudineau³, Beatrice Cochener⁵, Thierry Marhadour⁶ and Valerie Devauchelle-Pensec⁷, ¹Department of rheumatology, Brest Occidentale University, Brest, France, ²Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France, ³Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, ⁴Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, ⁵Department of ophtalmology, Brest Occidentale University, Brest, France, ⁶Rheumatology, CHU de la Cavale Blanche, Brest, France, ⁷Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France
Background/Purpose: New classification criteria for primary Sjögren’s syndrome (pSS) have been proposed in 2012 and approved by the ACR. They differ substantially from the currently…
Abstract Number: 1844 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis, Sjogren’s Syndrome and Systemic Lupus Erythematosus Patients Have a Distinct Spectrum Of Serum Anticytokine Autoantibodies
Sarthak Gupta^1,2, Ioanna P. Tatouli³, Lindsey B. Rosen², Sarfaraz A. Hasni¹, Richard M. Siegel¹, Steven M. Holland², Haralampos M. Moutsopopoulos³ and Sarah K. Browne², ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ³School of Medicine, National University of Athens, Athens, Greece
Background/Purpose: Anticytokine autoantibodies are pathogenic in many hematologic, pulmonary and infectious diseases. However, the prevalence and significance of anticytokine autoantibodies in rheumatic conditions is poorly…
Abstract Number: 508 • 2013 ACR/ARHP Annual Meeting
Is Ultrasonography Of Salivary Gland a Validate Tool In Sjögren Syndrome? Study 1: Interobserver Reliability Between International Group Of Experts
Sandrine Jousse-Joulin¹, Vera Milic², Elke Theander³, Malin V. Jonsson⁴, Wan-Fai Ng⁵, Chiara Baldini⁶, Marina Carotti⁷, Alan N. Baer⁸, Joel Fradin⁹, Pascale Rachele¹⁰, Hendrika Bootsma¹¹, Jacqueline Brown¹², Nicoletta Luciano⁶, S Bombardieri¹³, Roland Jonsson¹⁴, Salvatore De Vita¹⁵, Alojzija Hocevar¹⁶, Matija Tomsic^17,18, Alain Saraux¹⁹, Emmanuel Nowak²⁰, Alessandro Ciapetti Sr.²¹, Arjan Vissink²², John Rout²³, Thomas Mandl²⁴, Simon J. Bowman²⁵ and Valerie Devauchelle-Pensec²⁶, ¹Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, ²rheumatology, belgrade university, belgrade, Serbia, ³Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Department of Clinical Dentistry - Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway, ⁵Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁶University of Pisa, Rheumatology Unit, Pisa, Italy, ⁷Rheumatology and radiology, Ospedali Riuniti, Ancona, Italy, ⁸Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁹Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁰radiology, university of Pisa, Pisa, Italy, ¹¹Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ¹²dental division, Tower Wing Guy's hospital, london, United Kingdom, ¹³Department of Clinical and Experimental Medicine, Department of Rheumatology, University of Pisa, Pisa, Pisa, Italy, ¹⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ¹⁵Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, ¹⁶Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ¹⁷Department of Rheumatology, BioRx.si, University Medical Centre Ljubjana, Ljubljana, Slovenia, ¹⁸Faculty of Medicine, Unversity Ljubljana, Ljubljana, Slovenia, ¹⁹Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France, ²⁰CIC, CHU Brest, Brest, France, ²¹Department of Rheumatology, Politechnic University of the Marche, Ancona, Ancona, Italy, ²²Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²³Birmingham Dental Hospital, Birmingham, United Kingdom, ²⁴Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden, ²⁵Department of Rheumatology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom, ²⁶Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France
Background/Purpose: Ultrasonography (US) of salivary glands is a relatively new test to diagnose primary Sjögren syndrome (pSS)1-6. In 2012, an international group of interest was…
Abstract Number: 1656 • 2013 ACR/ARHP Annual Meeting
Interferon Type I and T Helper 17: A Dangerous Liaison In Primary Sjögren’s Syndrome?
Zana Brkic¹, Sandra M.J. Paulissen², Cornelia G. van Helden-Meeuwsen³, Naomi I. Maria³, Odilia B.J. Corneth⁴, Nadine Davelaar⁵, Jan Piet van Hamburg⁵, Paul L. Van Daele³, Virgil A. Dalm¹, Martin van Hagen³, Erik Lubberts⁶ and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ³Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Rheumatology and Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁵Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: The T helper 17 (Th17) cell subset, which produces IL-17A, IL-17F, IL-22 and IL-21, has been implicated in the pathogenesis of primary Sjögren’s syndrome…
Abstract Number: 510 • 2013 ACR/ARHP Annual Meeting
Multicentric Analysis Of Inter and Intra Observer Reliabilities For Histopathological Abnormalities In Salivary Gland Biopsy In Primary Sjögren Syndrome
Sebastian Costa¹, Isabelle Quintin Roue², Agnes Lesourd², Sandrine Jousse-Joulin³, Pascale Marcorelles⁴, Eric Hachulla⁵, Vincent Goeb⁶, Marie-Christine Copin⁷, Jean-Marie Berthelot⁸, Jacques-Olivier Pers⁹, Olivier Vittecoq¹⁰, Emmanuel Nowak¹¹, Alain Saraux¹² and Valerie Devauchelle-Pensec¹³, ¹anatomopathological department, Brest university hospital, Brest, France, ²anatomopathological department, Morvan hospital, Brest, France, ³Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, ⁴anatomopathological department, Brest university hospital, CHU Morvan, Brest, France, ⁵Internal Medicine, Lille CEDEX, France, ⁶Rheumatology, Amiens University Hospital, Amiens, France, ⁷anatomopathological department, Lille university, Lille, France, ⁸Rheumatology Unit, Nantes University Hospital, Nantes, France, ⁹Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, ¹⁰Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France, ¹¹CIC, CHU Brest, Brest, France, ¹²Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France, ¹³Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France
Background/Purpose: : Histopathologic evaluation of minor labial salivary gland (MLSG) is a major goal for the classification of patients with a primary Sjögren syndrome (pSS)…
Abstract Number: 1502 • 2013 ACR/ARHP Annual Meeting
Antibodies To Anti-Type -3 Muscarinic Acetylcholine Receptor Are Highly Prevalent To Rabbits Immunized With 4-Hydroxy-2-Noneal-Modified and 60-Kda Ro
Valerie Harris¹, Biji T. Kurien², R. Hal Scofield³, Timothy Gross⁴ and Mary Girton⁵, ¹Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK, ²College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: In Sjörgen’s Syndrome, an autoimmune disease, the lacrimal and salivary glands are the primarily affected glands. Previous studies have proposed autoantibodies that target type-3…
Abstract Number: 511 • 2013 ACR/ARHP Annual Meeting
Salivary Gland Lymphocyte Pattern Associated With Response To Belimumab In Primary sjogren’ssyndrome: Results Of The Beliss Study
Raphaèle Seror¹, Thierry Lazure², Frederic Desmoulins³, Stephan Pavy⁴, Corinne Miceli-Richard⁵, Gabriel Baron⁶, Philippe Ravaud⁷ and Xavier Mariette⁸, ¹Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ²Pathology, INSERM U1012 - Université Paris XI, Le Kremlin Bicêtre, France, ³Rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, Le Kremlin Bicetre, France, ⁴Rheumatology, Hopital Bicetre, Paris, France, ⁵Rheumatology Department, Université Paris-Sud 11, Bicêtre Hospital,, Kremlin Bicêtre, France, ⁶Hotel Dieu University Hospital Paris, Epidemiology, Paris, France, ⁷Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, ⁸Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France
Background/Purpose: To address the change in labial salivary gland (LSG) inflammation after Belimumab (biological treatment inhibiting soluble BAFF/BLyS) therapy in pSS patients and identify predictor…
Abstract Number: 1503 • 2013 ACR/ARHP Annual Meeting
The Suppressive Ability Of Altered Peptide Ligands To M3R Reactive T Cells In M3R Induced Autoimmune Sialadenitis
Hiromitsu Asashima¹, Hiroto Tsuboi¹, Naomi Matsuo¹, Chihiro Hagiya¹, Tomoya Hirota¹, Mana Iizuka¹, Yuya Kondo¹, Isao Matsumoto² and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Internal Medicine, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Previous studies have shown that Rag1-/- mice transferred with splenocytes of M3 muscarinic acetylcoline receptor (M3R)-/- mice immunized with M3R peptides mixture (three N-terminal…
Abstract Number: 512 • 2013 ACR/ARHP Annual Meeting
The Significance Of Ectopic Germinal Center In Minor Salivary Gland Of Patients With Sjögren’s Syndrome
Kyung-Eun Lee¹, Dong-Jin Park¹, Jeong-Won Lee², Ji-Hyoun Kang², Lihui Wen¹, Tae-Jong Kim³, Yong-Wook Park¹ and Shin-Seok Lee⁴, ¹Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ²Chonnam National University Medical School, Gwangju, South Korea, ³Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ⁴Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose: To investigate whether the presence of germinal center (GC) in minor salivary glands of patients with Sjögren’s syndrome (SS) is associated with different clinical…
Abstract Number: 1492 • 2013 ACR/ARHP Annual Meeting
Histone Deacetylase 1 But Not 2 Is Highly Expressed In The Lymphocyte Foci In The Labial Glands Of Patients With Sjogren’s Syndrome
Juan Guo and Wei Zhou, Department of Rheumatology and Immunology, Peking University First Hospital, Beijing, China
Background/Purpose: Sjogren’s syndrome (SS) is an autoimmune disease with abnormally infiltrating lymphocytes in exocrine glands expressing Th1 cytokines and increased incidence of lymphoma. Histone deacetylases…

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