Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 2438 • 2019 ACR/ARP Annual Meeting
Autoantibody Mediated Salivary Gland Hypofunction in Sjögren’s Syndrome Involves Activation of Innate Immunity and Endothelial Cells
Harini Bagavant ¹, Joanna Papinska ¹, Marta Trzeciak ², Indranil Biswas ¹, Nataliya Smith ², Debra Saunders ², Rheal Towner ² and Umesh Deshmukh¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City
Background/Purpose: The presence of autoantibodies reactive against the Ro52/TRIM21 protein is a hallmark of Sjögren’s syndrome. We have reported that Ro52-immunized mice develop IgG deposits…
Abstract Number: 84 • 2019 ACR/ARP Annual Meeting
Cenerimod, a Potent and Selective Sphingosine-1-Phosphate Receptor 1 Modulator, Controls Systemic Autoimmunity and Organ Pathology in Mouse Models of Systemic Lupus Erythematosus and Sjögren’s Syndrome
Estelle Gerossier ¹, Saba Nayar ², Charlotte Smith ², Sylvie Froidevaux ³, Francesca Barone ² and Marianne Martinic¹, ¹Idorsia Pharmaceuticals Ltd., Allschwil, Basel-Landschaft, Switzerland, ²Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, ³Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
Background/Purpose: Autoimmune diseases including SLE and SS are characterized by aberrant lymphocyte activation and autoantibody production. This results in systemic manifestations and the formation of…
Abstract Number: 1466 • 2019 ACR/ARP Annual Meeting
Evaluation of Changes in Oral Health-Related Quality of Life over Time in Patients with Sjögren’s Syndrome
Naoto Azuma¹, Yoshinori Katada ², Aki Nishioka ³, Masahiro Sekiguchi ⁴, Masayasu Kitano ⁵, Sachie Kitano ¹, Hajime Sano ⁶ and Kiyoshi Matsui ¹, ¹Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan, ²Department of Rheumatology, Sakai City Medical Center, Sakai, Japan, ³Department of Rheumatology, Nishinomiya Watanabe Hospital, Nishinomiya, Japan, ⁴Departement of Rheumatology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan, ⁵Department of Rheumatology, Kyoto Okamoto Memorial Hospital, Kumiyama, Japan, ⁶Kyoto Okamoto Memorial Hospital, Kumiyama, Japan
Background/Purpose: In addition to xerostomia symptoms, patients with Sjögren’s syndrome (SS) experience pain and discomfort in the oral cavity, and difficulties in speaking and eating,…
Abstract Number: 2420 • 2019 ACR/ARP Annual Meeting
Role of T Follicular Helper Cells and T Peripheral Helper Cells in the Activation of B Cells in Sjögren Syndrome
Anastasia Dupré¹, Juliette Pascaud ¹, Elodie Rivière ², Michael Mingueneau ³, Gaetane Nocturne ⁴ and Xavier Mariette ⁵, ¹IMVA - IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre, Paris, France, ²IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre ; Arthritis R&D, France, Paris, France, ³Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique, C3IB, Institut Pasteur, Paris, France, ⁴Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, ⁵Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France
Background/Purpose: Primary Sjögren's Syndrome (pSS) is a rare systemic autoimmune disease characterized by a dysregulation of cellular and humoral immunity, leading to a hyper-activation of…
Abstract Number: 2807 • 2019 ACR/ARP Annual Meeting
Activation of the STING Pathway Is a Shared Feature of Salivary Gland and Lung Inflammation in Sjogren’s Syndrome
Joanna Papinska ¹, Grzegorz Gmyrek ², Umesh Deshmukh¹ and Harini Bagavant ¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City
Background/Purpose: Sjögren’s syndrome is a chronic autoimmune disorder characterized by an increased type 1 interferon gene signature. The engagement of stimulator of interferon genes (STING)…
Abstract Number: 295 • 2019 ACR/ARP Annual Meeting
Assessing the Vascularization of Salivary Glands in Patients with Sjögren’s Syndrome – An OMERACT Ultrasound Group Reliability Exercise
Alojzija Hocevar¹, Sandrine Jousse-Joulin ², Nejc Perko ³, STEPHANIE FINZEL ⁴, PETRA HANOVA ⁵, ANNAMARIA IAGNOCCO ⁶, Nevsun Inanc ⁷, ESPERANZA NAREDO ⁸, WOLFGANG A. SCHMIDT ⁹, Lene Terslev ¹⁰, ALEN ZABOTTI ¹¹, Matija Tomšič ¹² and George A. W. Bruyn ¹³, ¹Department of Rheumatology, University Medical Center Ljubljana, Slovenia, LJUBLJANA, Slovenia, ²Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, ³Faculty of electrical engineering, University of Ljubljana, LJUBLJANA, Slovenia, ⁴Department of Rheumatology and Clinical Immunology, University Medical Centre, FREIBURG, Germany, ⁵5Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, PRAGUE, Czech Republic, ⁶Academic Rheumatology Centre, Università degli Studi di Torino, TURIN, Italy, ⁷Marmara University, Faculty of Medicine, Division of Rheumatology, Istanbul, Turkey, ISTANBUL, Turkey, ⁸Rheumatology Department, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, MADRID, Spain, ⁹Medical Center of Rheumatology, Immanuel Krankenhaus Berlin Buch, BERLIN, Germany, ¹⁰Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen, Denmark, ¹¹Department of Medical and Biological Sciences, Rheumatology Clinic, University Hospital Santa Maria della Misericordia, UDINE, Italy, ¹²Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, LJUBLJANA, Slovenia, ¹³Department of Rheumatology, MC Groep Hospitals., Lelystad, Netherlands
Background/Purpose: The vascularization of salivary glands (SG) in Sjögren's syndrome (SS) has not been extensively studied by imaging methods, and currently no agreement exists on…
Abstract Number: 1467 • 2019 ACR/ARP Annual Meeting
Clinical Characteristics of Primary Sjögren’s Syndrome in Adult Patients Diagnosed at Age Less Than or Equal to 35 Years versus Those over 35 Years of Age
Noel Agustin Callahuara Goiburu¹, Patricia Sasaki ¹, Anastasia Secco ², Catalan Pellet ³, Nadia Riscanevo ⁴, Janet Flores ⁵, Francisco Caeiro ⁵, cristina Amitrano ⁶, Cecilia Asnal ⁷, Alejandro Nitsche ⁸, Carolina Segura Escobar ⁹, Julia Demarchi ¹⁰, Damian Duartes ¹⁰, Lida santiago ¹¹, Laura Raiti ¹², Vanesa Cruzat ¹³, Carla Gobbi ¹⁴, Paula Alba ¹⁵, Silvia Papasidero ¹⁶, Sofia Velez ¹⁷, Vicente Juarez ¹⁸ and Gabriela Salvatierra ¹⁹, ¹Rivadavia, CABA, Ciudad Autonoma de Buenos Aires, Argentina, ²Hospital Rivadavia, Caba, Buenos Aires, Argentina, ³Rivadavia, CABA, Argentina, ⁴Hospital Privado de Córdoba, Cordoba, Cordoba, Argentina, ⁵Hospital Privado de Córdoba, Cordoba, Argentina, ⁶Hospital Aleman, CABA, Argentina, ⁷Instituto Centenario, Buenos Aires, Buenos Aires, Argentina, ⁸Hospital Aleman, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ⁹Hospital Británico, Buenos Aires, Buenos Aires, Argentina, ¹⁰Hospital Británico, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ¹¹OMI, Ciudad Autonoma de Buenos Aires, Argentina, ¹²Clinica Bessone, Buenos Aires, Buenos Aires, Argentina, ¹³Clinica Bessone, Buenos Aires, Argentina, ¹⁴CÁTEDRA DE CLÍNICA MÉDICA I, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, ¹⁵UNIDAD DE REUMATOLOGÍA, CÁTEDRA DE SEMIOLOGÍA, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, ¹⁶Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, ¹⁷Consultorio Privado S.V, Buenos Aires, Buenos Aires, Argentina, ¹⁸Hospital Milagros de Salta, Salta, Salta, Argentina, ¹⁹IPRI, Santiago del estero, Santiago del Estero, Argentina
Background/Purpose: Although there is little information, the debut of primary Sjögren's syndrome in adult patients aged less than or equal to 35 years, would be…
Abstract Number: 2421 • 2019 ACR/ARP Annual Meeting
Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate Disease Activity and Glandular Inflammation in Patients with Primary Sjögren’s Syndrome
Ji-Won Kim¹, Jaeseon Lee ², Ui Hong Jung ¹, Sung-Hoon Park ¹, Jennifer Lee ³, Seung-Ki Kwok ³ and Sung-Hwan Park ³, ¹Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, ²Catholic University of Korea, College of Medicine, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Background/Purpose: Since primary Sjögren’s syndrome (pSS) is an autoummune disease of B cell hyperactivity and pathologic autoantibody response, follicular helper T (Tfh) cells and follicular…
Abstract Number: 976 • 2019 ACR/ARP Annual Meeting
Identification of Novel Genes Associated with Dysregulation of B Cells in Patients with Primary Sjögren’s Syndrome
Jun Inamo¹, Katsuya Suzuki ², Masaru Takeshita ², Yoshiaki Kassai ³, Maiko Takigchi ⁴, Rina Kurisu ⁴, Yuumi Okuzono ⁴, Shinya Tasaki ⁵ and Tsutomu Takeuchi ⁶, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, ³Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Shinjuku-ku, Tokyo, Japan, ⁴Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Shinjuku-ku, Japan, ⁵Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Shinjuku-ku, Japan, ⁶Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Dysregulation of B cells play a critical role in the pathogenesis of primary Sjögren’s syndrome (pSS). Long non-coding RNAs (lncRNAs), which have become the…
Abstract Number: 1468 • 2019 ACR/ARP Annual Meeting
Effects of Resistive Exercise on Fatigue and Disease Activity in Women with Primary Sjogren’s Syndrome
Luciana Paula Dardin ¹, Fernanda Gazoni ¹, Ana Beatriz Garcia ¹, Paulo Alexandre Minali ² and Virginia Fernandes Moça Trevisani³, ¹Sao Paulo Federal University - Brazil, Sao Paulo, Sao Paulo, Brazil, ²Sao Paulo Federal University - Brazil, Sao Paulo, Brazil, ³Department of Evidence-Based Medicine, Brazilian Cochrane Centre, Federal University of São Paulo, Sao Paulo, Brazil, Sao Paulo, Brazil
Background/Purpose: Fatigue is a frequent symptom of pSS, considered debilitating and the most important cause of dysfunction in these patients. The present study aimed to…
Abstract Number: 2423 • 2019 ACR/ARP Annual Meeting
In Primary Sjogren’s Syndrome (pSS) IL7 Promotes the Crosstalk Between T Lymphocytes and Salivary Gland Epithelial Cells and Participates to IFN Signature
Gaetane Nocturne¹, Juliette Pascaud ², Elodie Rivière ³, Alexandre Virone ⁴, Anastasia Dupré ², Vanessa Gauttier ⁵, Nicolas Poirier ⁵ and Xavier Mariette ⁶, ¹Université Paris Sud, Le Kremlin Bicetre, France, ²IMVA - IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre, Paris, France, ³IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre ; Arthritis R&D, France, Paris, France, ⁴Université Paris Sud, Le Kremlin Bicetre, ⁵OSE Immunotherapeutics, Nantes, France, ⁶Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France
Background/Purpose: pSS is characterized by lymphocytic infiltration of salivary gland epithelial cells (SGEC). This infiltrate is made of T (TL) and B (BL) lymphocytes. SGEC…
Abstract Number: 1395 • 2019 ACR/ARP Annual Meeting
Risk of Immunization to Rituximab in Systemic Autoimmune Diseases and Rheumatoid Arthritis: Frequency and Risk Factors. Analysis of the Efficacy of an Alternative Treatment by Ofatumumab
Alice Combier¹, Gaetane Nocturne ², Julien Henry ³, Rakiba Belkhir ¹, Stephan Pavy ⁴, Clotilde Le Tiec ⁵, Elise Descamps ⁴, Raphaele Seror ⁶ and Xavier Mariette ⁷, ¹Rheumatology Departement - Bicêtre Hospital, Paris, France, ²Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, ³Rheumatology Departement - Bicêtre Hospital, Paris, ⁴Rheumatology Departement - Bicètre Hospital, Paris, France, ⁵Pharmacy Departement - Bicètre Hospital, Paris, France, ⁶Hopitaux universitaires Paris Sud, Kremlin-Bicetre, France, ⁷Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France
Background/Purpose: The most widely used B cell targeted therapies in auto-immune diseases (AID) is Rituximab (RTX), a murine chimeric monoclonal antibody. Among RTX’s side effects,…
Abstract Number: 1470 • 2019 ACR/ARP Annual Meeting
Health-Related Quality of Life in Primary Sjogren’s Syndrome: Insights from Using PROMIS and Comparison to ESSPRI
Dana DiRenzo¹, Susan Robinson ², Clifton Bingham ¹ and Thomas Grader-Beck ², ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins University, Baltimore
Background/Purpose: Background. Sjogren’s Syndrome (SS) is a chronic, autoimmune disease affecting the exocrine glands that may negatively affect health-related quality of life (HRQL). The importance…
Abstract Number: 2424 • 2019 ACR/ARP Annual Meeting
RORγt Antagonist Attenuates Experimental Sialadenitis Like Sjögren’s Syndrome via Inhibition of CD25 Expression on CD4+ T Cells
Yuko Ono¹, Hiroto Tsuboi ², Masafumi Moriyama ³, Hiroyuki Takahashi ², Fumika Honda ², Saori Abe ², Yuya Kondo ², Isao Matsumoto ², Seiji Nakamura ⁴ and Takayuki Sumida ², ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Science, Faculty of Dental Science, Kyushu University, Tsukuba, Japan, ²Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ³Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Science, Faculty of Dental Science, Kyusyu University, Fukuoka, Japan, ⁴Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Science, Faculty of Dental Science, Kyusyu University, Fukuoka
Background/Purpose: Our previous study demonstrated that T cells specific RORγt transgenic-mice under human CD2 promoter (RORγt-Tg mice) developed severe spontaneous sialadenitis like Sjögren’s syndrome (SS)…
Abstract Number: 1447 • 2019 ACR/ARP Annual Meeting
Comparison of Ultra High‐resolution Ultrasound (UHFUS) of Labial Salivary Glands and Conventional Salivary Gland Ultrasonography in Primary Sjögren’s Syndrome Assessment
Chiara Baldini¹, Francesco Ferro ¹, Nicoletta Luciano ¹, Saverio Vitali ², Rossana Izzetti ³, Silvia Fonzetti ⁴, Veronica Iodice ², Marta Mosca ⁵, Valentina Donati ⁶ and Davide Caramella ², ¹Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, Pisa, Italy, ²Department of Diagnostic and Interventional Radiology, University of Pisa, Pisa, Italy, ³Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa,, Pisa, Italy, ⁴University of Pisa, Pisa, Italy, ⁵Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, Pisa, Italy, ⁶University of Pisa, Pisa
Background/Purpose: Labial salivary gland (LSG) biopsy remains a key tool for the diagnosis of primary Sjögren’s syndrome (pSS). Nowadays, however, interest is growing in non‐invasive…

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