Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 3202 • 2015 ACR/ARHP Annual Meeting
Functional Anti-Muscarinic Receptor-3 Monoclonal Antibodies Derived from Salivary Gland in Patients of Sjögren’s Syndrome
Syed M.S. Quadri^1,2, Kristi A. Koelsch³, Valerie Harris⁴, Biji T Kurien⁵ and R. Hal Scofield⁶, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, ⁴University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Sjögren's syndrome (SS) is a chronic autoimmune inflammatory disease characterized by bilateral hypofunction of lacrimal and salivary glands leading to keratoconjuctivitis and xerostomia. The…
Abstract Number: 628 • 2015 ACR/ARHP Annual Meeting
Poor Prognosis of Patients with Primary Sjögren Syndrome Who Fulfilled at Diagnosis the Classification Criteria for Concomitant Cryoglobulinemic Vasculitis
Soledad Retamozo^1,2, Hoda Gheitasi³, Luca Quartuccio⁴, Belchin Kostov⁵, Laura Corazza⁴, Albert Bové³, Antoni Sisó-Almirall⁵, Myriam Gandía³, Manuel Ramos-Casals¹, Salvatore De Vita⁶ and Pilar Brito-Zerón¹, ¹Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, ²Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ³Department of Autoimmune Diseases, IDIBAPS, Hospital Clínic, Barcelona, Spain, ⁴S. Maria della Misericordia, University of Udine, Italy, Udine, Italy, ⁵Primary Care Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Primary Care Centre Les Corts, CAPSBE, Barcelona, Spain, ⁶Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy
Background/Purpose: To evaluate the fulfilment of classification criteria for cryoglobulinemic vasculitis (CV) at diagnosis in a large cohort of patients with primary Sjögren syndrome (SS)…
Abstract Number: 1052 • 2015 ACR/ARHP Annual Meeting
Identification of Novel Sjogren’s Syndrome Risk Loci in the Regions of TNFAIP3 and PRDM1
Christopher J. Lessard^1,2, He Li^1,2, John Ice², Indra Adrianto³, Astrid Rasmussen², Kiely Grundahl⁴, Jennifer A. Kelly⁵, Corinne Miceli⁶, Simon Bowman⁷, Susan Lester⁸, Johan G. Brun^9,10, Lasse G. Goransson¹¹, Erna Harboe¹¹, Joel M. Guthridge², Kenneth M. Kaufman^12,13, Per Eriksson¹⁴, Maija-Leena Eloranta¹⁵, Marika Kvarnström¹⁶, Deborah S. Cunninghame-Graham¹⁷, A. Darise Farris², Michael T. Brennan¹⁸, James Chodosh¹⁹, Raj Gopalakrishnan²⁰, Andrew J.W. Huang²¹, Pamela Hughes²², David M. Lewis²³, Lida Radfar²⁴, Michael D. Rohrer²⁵, Donald U. Stone²⁶, Timothy J. Vyse¹⁷, Patrick M. Gaffney², Judith A. James^1,5,27, John B. Harley^12,28, Roald Omdal¹¹, Marie Wahren-Herlenius¹⁶, Gabor G. Illei²⁹, Torsten Witte³⁰, Roland Jonsson^10,31, Maureen Rischmueller^32,33, Lars Rönnblom³⁴, Xavier Mariette³⁵, Juan-Manuel Anaya³⁶, Wan-Fai Ng³⁷, Gunnel Nordmark³⁴, Courtney G. Montgomery², Nelson L. Rhodus³⁸, Barbara M. Segal³⁹, R. Hal Scofield^2,27,40 and Kathy L. Sivils^1,2, ¹Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ⁵Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Rheumatology, PARIS, France, ⁷Rheumatology Dept, University Hospital Birmingham, Birmingham, United Kingdom, ⁸Queen Elizabeth Hospital, Adelaide, Australia, ⁹Institute of Internal Medicine, University of Bergen, Bergen, Norway, ¹⁰Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ¹¹Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹²US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹³Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁴Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping University, Linköping, Sweden, Linköping, Sweden, ¹⁵Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ¹⁶Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹⁷Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, ¹⁸Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, ¹⁹Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, ²⁰Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota, Minneapolis, MN, ²¹Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, ²²Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN, ²³College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁴Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, ²⁵Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, ²⁶Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁷Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁸Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²⁹National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, ³⁰Hannover Medical School, Hanover, Germany, ³¹Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway, ³²University of Adelaide, Adelaide, Australia, ³³Department of Rheumatology, The Queen Elizabeth Hospital, Adelaide, Australia, ³⁴Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, ³⁵AP-HP, Hopitaux Universitaires Paris-Sud, Université Paris-Sud, Paris, France, ³⁶Center for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogotá, Colombia, ³⁷Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³⁸Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, ³⁹Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ⁴⁰US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a complex autoimmune disease with both environmental and genetic factors playing important roles in its pathophysiology. The goal of this…
Abstract Number: 2784 • 2015 ACR/ARHP Annual Meeting
Faecal Levels of Calprotectin Are Increased in Patients with Primary Sjögren’s Syndrome and Correlates with Disease Activity
Thomas Mandl¹, Bodil Ohlsson² and Kristofer Andreasson³, ¹Dept of Rheumatology, Skåne University Hospital Malmö, Lund University, Malmo, Sweden, ²Dept of Internal Medicine, Skane University Hospital Malmo, Lund University, Sweden, Malmo, Sweden, ³Dept of Rheumatology, Skane University Hospital Lund, Lund University, Sweden, Lund, Sweden
Background/Purpose: FC is a validated biomarker differentiating inflammatory bowel disease from irritable bowel syndrome. We have evaluated faecal levels of calprotectin (FC) in patients with…
Abstract Number: 3204 • 2015 ACR/ARHP Annual Meeting
Hypoechoic Lesions on Parotid Gland Ultrasound Are a Surrogate Marker of Focal Lymphocytic Sialadenitis on Minor Salivary Gland Biopsy in Sjögren’s Syndrome
Thomas Grader-Beck¹, Joel Fradin², Jean Kim³, Esen Akpek⁴, Brendan Antiochos⁵, Julius Birnbaum⁶ and Alan N. Baer⁷, ¹Medicine Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ³Otolaryngology, Head & Neck Surgery, Johns Hopkins University, Baltimore, MD, ⁴Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Medicine-Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁶Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: To determine whether hypoechoic lesions on parotid gland ultrasound can serve as a surrogate marker for a focus score ≥1 on minor salivary gland…
Abstract Number: 629 • 2015 ACR/ARHP Annual Meeting
Salivary Gland Ultrasonography As an Useful Tool to Distinguish Patients with Sjögren’s Syndrome at Risk for Non-Hodgkin’s Lymphoma Development
Chiara Baldini¹, Nicoletta Luciano¹, Francesco Ferro¹, Chiara Stagnaro¹, Daniela Martini¹, Marta Mosca² and Stefano Bombardieri¹, ¹Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ²University of Pisa, Pisa, Italy
Background/Purpose: Salivary gland ultrasonography has been proposed as a promising novel tool for the diagnosis of primary Sjögren’s syndrome (SS). An increasing number of studies…
Abstract Number: 1053 • 2015 ACR/ARHP Annual Meeting
Phosphatidylinositol-3-Kinase Delta Pathway a Novel Therapeutic Target for Sjogren’s Syndrome
Saba Nayar¹, Joana Campos¹, Christopher Buckley¹, Rodger Allen², W.A. Fahy², Andrew Payne² and Francesca Barone¹, ¹University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, ²UCB Pharma, Slough, United Kingdom
Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by B cell hyper-activation and exocrine gland infiltration that results in loss of glandular function,…
Abstract Number: 2785 • 2015 ACR/ARHP Annual Meeting
Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome
Yoshiyuki Arinuma^1,2, Yuko Sakuma³, Eisuke Ogawa², Tatsuhiko Wada⁴, Tatsuo Nagai², Sumiaki Tanaka² and Shunsei Hirohata², ¹Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ³Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ⁴Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation such as…
Abstract Number: 3205 • 2015 ACR/ARHP Annual Meeting
Treatment with Abatacept or Rituximab Targets T Follicular Helper Cells in Patients with Primary Sjogren s Syndrome
Gwenny M. Verstappen¹, Petra M. Meiners², Odilia B.J. Corneth³, Rudi W. Hendriks³, Arjan Vissink⁴, Frans G.M. Kroese⁵ and Hendrika Bootsma⁵, ¹Rheumatology & Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Pulmonary Medicine, Erasmus MC, Rotterdam, Netherlands, ⁴Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Background/Purpose: T cell-dependent B cell hyperactivity is a characteristic pathogenetic feature of primary Sjögren’s syndrome (pSS). This is illustrated by the finding that treatment of…
Abstract Number: 631 • 2015 ACR/ARHP Annual Meeting
Usefulness of the Minimally-Invasive Minor Salivary Gland Biopsy in Patients Presenting with Sicca Syndrome: Prospective Evaluation of 200 Patients
Soledad Retamozo¹, Pilar Brito-Zerón¹, Albert Bové², Hoda Gheitasi², Courtney Grant³, Daphne Superville⁴, Belchin Kostov⁵, Antoni Sisó-Almirall⁵, Llucia Alós⁶ and Manuel Ramos-Casals¹, ¹Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, ²Department of Autoimmune Diseases, IDIBAPS, Hospital Clínic, Barcelona, Spain, ³University of Glasgow, Glasgow, United Kingdom, ⁴Massachusetts Institute of Technology (MIT), Cambridge, MA, ⁵Primary Care Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Primary Care Centre Les Corts, CAPSBE, Barcelona, Spain, ⁶Department of Pathology, Hospital Clínic, Barcelona, Spain
Background/Purpose: Sicca syndrome is a clinical presentation that is common for several systemic diseases that may infiltrate the exocrine glands. The most frequent disease is…
Abstract Number: 1055 • 2015 ACR/ARHP Annual Meeting
Expansions of Salivary Gland CD4+ T Cells from Sjögren’s Syndrome Patients: Single-Cell Repertoire Analysis and Correlation with Clinical Measures of Disease
Michelle L. Joachims¹, Kerry M. Leehan^2,3, Christina M. Lawrence³, Astrid Rasmussen³, Lida Radfar⁴, David M. Lewis⁵, Glen D Houston⁶, Kiely Grundahl³, Donald U. Stone^7,8, Kimberly Hefner⁹, R. Hal Scofield^2,10,11, Kathy L. Sivils^2,3, Linda F. Thompson¹² and A. Darise Farris^1,2, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, ⁵College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Heartland Pathology, Oklahoma City, OK, ⁷Department of Ophthalmology, Johns Hopkins University, Baltimore, MD, ⁸King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁹Hefner Eye Care and Optical Center, Oklahoma City, OK, ¹⁰College of Medicine, Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: CD4+ T cells predominate in salivary gland (SG) focal lymphocytic infiltrates in primary Sjögren’s syndrome (pSS). However, their antigen specificity, degree of clonal…
Abstract Number: 2787 • 2015 ACR/ARHP Annual Meeting
Expression of Interferons Lambda in Salivary Glands of Patients with Sjögren’s Syndrome
Eirini Apostolou¹, Efstathia K. Kapsogeorgou¹, Orsia D. Konsta¹, Maria Ioanna Saridaki², Evangelos Andreakos² and Athanasios G. Tzioufas¹, ¹Pathophysiology, Faculty of Medicine, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece, ²Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece
Background/Purpose: Type I and II interferons (IFNs) have been implicated in the pathophysiology of Sjögren’s Syndrome (SS). Recently a new family of IFNs, namely type…
Abstract Number: 632 • 2015 ACR/ARHP Annual Meeting
Isolated Atrioventricular Block of Unknown Origin in the Adult and Autoimmunity: Diagnostic and Therapeutic Considerations Exemplified By Three Anti-Ro/SSA-Associated Cases
Antonio Brucato¹, Pietro Enea Lazzerini², Pier Leopoldo Capecchi³, Anna Valenti⁴, Lucia Baldi⁵, Maria Romana Bacarelli³, Claudia Nucci⁵, Valentina Moscadelli³, Gabriella Morozzi³, Mohamed Butjdir^6,7,8 and Franco Laghi Pasini³, ¹Internal Medicine, Ospedale Papa Giovanni XXIII Bergamo, Bergamo, Italy, ²Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy, ³Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy, ⁴Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ⁵Cardiology, University of Siena, Siena, Italy, ⁶Medicine, Cell Biology and Pharmacology, State University of New York at Downstate Medical Center, New York, NY, ⁷NYU School of Medicine, New York, NY, ⁸Research Department, VA New York Harbor Healthcare System, New York, NY
Background/Purpose: Circulating anti-Ro/SSA antibodies may rarely affect the adult conduction-system. A direct autoantibody-mediated electrophysiological inhibition of cardiomyocyte calcium-channels (acquired form) or an ante-natal subclinical injury…
Abstract Number: 1056 • 2015 ACR/ARHP Annual Meeting
Aquaporin Gene Therapy Corrects Bone Morphogenetic Protein 6 Associated Exocrine Gland Dysfunction in Mouse Model of Sjögren’s Syndrome
Hongen Yin¹, Zhennan Lai², Javier Cabrera-Perez³, Patricia Glenton⁴, Ankur Patel⁵, William Swaim⁵, Changyu Zheng⁵, Maria Guimaro⁵, Sandra Afione⁶, Cuong Nguyen⁵, Fred Nyberg⁷ and John A. Chiorini², ¹NIDCR, NIH, Bethesda, MD, ²Mptb, NIH/NIDCR, Bethesda, MD, ³Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Bethesda, MD, ⁴Department of Pathology and Infectious Diseases, University of Florida, Gaineville, FL, ⁵Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁶National Institute of Dental and Craniofacial Research, Bethesda, MD, ⁷Department of Pharmaceutical Bioscience, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, MD, Sweden
Background/Purpose: Loss of secretory epithelial function is a hallmark of primary Sjögren’s syndrome (pSS). Previously we reported that bone morphogenetic protein 6 (BMP-6) inhibits cell volume…
Abstract Number: 2794 • 2015 ACR/ARHP Annual Meeting
A New Scoring System for Ultrasonographic Evaluation of Salivary Gland in Sjogren: Multireader Reliability
Sandrine Jousse-Joulin¹, Malin V. Jonsson², Nicoletta Luciano³, Elke Theander⁴, Vera Milic⁵, Alojzija Hocevar⁶, Jacqueline Brown⁷, Andrew Carr⁸, Divi Cornec⁹, Marina Carotti¹⁰, Benjamin A. Fisher¹¹, Joel Fradin¹², John Rout¹³, Alain Saraux¹⁴, Alja Stel¹⁵, Arjan Vissink¹⁶, Simon Bowman¹⁷, Alan N. Baer¹⁸, Matija Tomšič⁶, Wan-Fai Ng¹⁹, Chiara Baldini³ and Valerie Devauchelle²⁰, ¹Rheumatology, CHu La cavle Blanche, Brest, France, ²Department of Clinical Dentistry, Section for Oral and Maxillofacial Radiology,, University of Bergen, Bergen, Norway, ³Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ⁴Skåne University Hospital Malmö, Lund University, Malmo, Sweden, ⁵rheumatology, belgrade university, belgrade, Serbia, ⁶Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁷dental division, Tower Wing Guy's hospital, london, United Kingdom, ⁸departement of radiology, University of Newcastle, New castle, United Kingdom, ⁹Department of rheumatology, Brest Occidentale University, Brest, France, ¹⁰Istituto di Radiologia, Ospedali Riuniti di Ancona, Ancona, Italy, ¹¹Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom, ¹²Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ¹³Birmingham Dental Hospital, Birmingham, United Kingdom, ¹⁴Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ¹⁵Hanzeplein 1, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ¹⁶Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ¹⁷Rheumatology Dept, University Hospital Birmingham, Birmingham, United Kingdom, ¹⁸Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁹Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²⁰Service de Rhumatologie, CHU Brest, Brest, France
Background/Purpose: A new consensual scoring system for Ultrasonography (US) of the salivary gland in pSS is required and endorsed by an international group of experts…

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