Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1253 • 2015 ACR/ARHP Annual Meeting
Identification and Validation of Novel Putative Salivary Proteomic Biomarkers in Sjögren’s Syndrome and Different Disease Subsets
Chiara Baldini¹, Daniela Martini¹, Nadia Ucciferri², Silvia Rocchiccioli², Letizia Mattii³, Antonietta Raffaella Maria Sabbatini³, Francesca Sernissi¹, Francesco Ferro¹, Nicoletta Luciano¹, Leonardo Lorenzini¹, Marta Mosca⁴, Stefano Bombardieri¹ and Antonella Cecchettini³, ¹Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ²Institute of Clinical Physiology, Pisa, Italy, Pisa, Italy, ³Department of Clinical and Experimental Medicine, University of Pisa, Italy, Pisa, Italy, ⁴University of Pisa, Pisa, Italy
Background/Purpose: Salivary proteomics has recently appeared as a promising tool for the identification of novel diagnostic biomarkers for primary Sjögren’s syndrome (SS). However, to date…
Abstract Number: 2795 • 2015 ACR/ARHP Annual Meeting
Fatigue in Primary Sjögren’s Syndrome: Clinical, Laboratory, Psychometric and Biological Associations
Theofanis Karageorgas¹, Sofia Fragkioudaki², Adrianos Nezos³, Dimitris Karaiskos⁴, Clio Mavragani⁵ and Haralampos M. Moutsopoulos⁶, ¹Clinical Immunology and Rheumatology, "Attikon" University Hospital of Athens, Athens, Greece, ²Physiology, Medical School of Athens, Department of Physiology, Athens, Greece, ³Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ⁴Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, ⁵Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ⁶Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece
Background/Purpose: To identify independent predictors of fatigue in primary Sjogren’s Syndrome (pSS) patients taking into account clinical, laboratory and psychological features and to explore the…
Abstract Number: 634 • 2015 ACR/ARHP Annual Meeting
Big Data International Primary Sjögren Syndrome Registry: Baseline Characterization and Diagnostic Approach in 6047 Patients Fulfilling the 2002 AE Criteria
Pilar Brito-Zerón¹, Soledad Retamozo^1,2, Margit Zeher³, Astrid Rasmussen⁴, Elke Theander⁵, Jacques Gottenberg⁶, Chiara Baldini⁷, Luca Quartuccio⁸, Roberta Priori⁹, Valeria Valim¹⁰, Marika Kvarnström¹¹, Aike Kruize¹², Gabriela Hernandez-Molina¹³, Elena Bartoloni-Bocci¹⁴, Sonja Praprotnik¹⁵, David A. Isenberg¹⁶, Gunnel Nordmark¹⁷, Michele Bombardieri¹⁸, Yasunori Suzuki¹⁹, Roser Solans²⁰, Roberto Giacomelli²¹, Daniel S. Hammenfors²², Steven E. Carsons²³, Hendrika Boostma²⁴, Cristina F. Vollenweider²⁵, Fabiola Atzeni²⁶, Kathy Sivils²⁷, Thomas Mandl²⁸, Salvatore De Vita²⁹, Marie Wahren-Herlenius¹¹, Mitsuhiro Kawano³⁰, Roberto Gerli³¹, Arjan Vissink³², Johan G. Brun³³, Virginia Trevisani³⁴, Jorge Sánchez-Guerrero³⁵, Xavier Mariette³⁶, Manuel Ramos-Casals¹ and on behalf of the EULAR-SS Task Force, ¹Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, ²Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ³University of Debrecen, Debrecen, Hungary, ⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Skåne University Hospital Malmö, Lund University, Malmo, Sweden, ⁶Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ⁷Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ⁸Clinic of Rheumatology, Department of Medical and Biological Sciences (DSMB), Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, ⁹Rheumatology Unit, Sapienza University of Rome, Rome, Italy, ¹⁰Rheumatology, Universidade Federal do Espírito Santo, Vitória, Brazil, ¹¹Department of medicine, Rheumatology unit, Karolinska Institutet, Stockholm, Sweden, ¹²Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ¹³Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ¹⁴Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, ¹⁵Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ¹⁶Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ¹⁷Medical Sciences, Uppsala University, Uppsala, Sweden, ¹⁸Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ¹⁹Kanazawa University Graduate School of Medicine, Kanazawa, Japan, ²⁰Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, ²¹University of L'Aquila, L'Aquila, Italy, ²²Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ²³Rheumatology, Allergy and Immunology, Winthrop University Hospital, Mineola, NY, ²⁴University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²⁵Rheumatology, German Hospital, Buenos Aires, Argentina, ²⁶Rheumatology Unit, L. Sacco University Hospital of Milan, Milan, Italy, ²⁷Oklahoma Medical Research Foundation, Oklahoma City, OK, ²⁸Dept of Rheumatology, Skåne University Hospital Malmö, Lund University, Malmo, Sweden, ²⁹Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, ³⁰Division of Rheumatology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan, ³¹University of Perugia, Perugia, Italy, ³²Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³³Haukeland University Hospital, Bergen, Norway, ³⁴Health Evidence Based, Universidade Federal de São Paulo, Sâo Paulo, Brazil, ³⁵Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada, ³⁶Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France
Background/Purpose: To analyse the epidemiological, clinical and immunological characteristics at diagnosis of the largest international cohort of patients diagnosed with primary Sjögren syndrome (SS) according…
Abstract Number: 1262 • 2015 ACR/ARHP Annual Meeting
Epigenome-Wide DNA Methylation Patterns Associated with Fatigue in Primary Sjögren’s Syndrome
Katrine B Norheim¹, Juliana Imgenberg-Kreuz², Kristin Jonsdottir³, Emiel Janssen⁴, Ann-Christine Syvänen², Johanna K Sandling², Gunnel Nordmark⁵ and Roald Omdal⁶, ¹Dept of Internal Medicine, Clinical immunology Unit, Stavanger, Norway, ²Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ³Dept. of Pathology, Stavanger University Hospital, Stavanger, Norway, ⁴Dept. of Pathology, Stavanger university Hospital, Stavanger, Norway, ⁵Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁶Department of internal medicine, Clinical Immunology unit, Stavanger, Norway
Background/Purpose: Chronic fatigue is a common, often disabling, and poorly understood phenomenon of many diseases. Recent studies indicate that epigenetic mechanisms may be involved in…
Abstract Number: 2796 • 2015 ACR/ARHP Annual Meeting
Elevated Serum Immunoglobulin G Is a Prognostic Factor for Progression of Interstitial Lung Disease in Primary Sjögren’s Syndrome
Eriko Ishioka¹, Katsuya Suzuki², Naoshi Nishina², Hidekata Yasuoka³, Kunihiro Yamaoka² and Tsutomu Takeuchi², ¹Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Lung involvement is a systemic manifestation of primary Sjögren's syndrome (pSS), however, the prevalence in pSS is various (9-75 %) and details are still…
Abstract Number: 635 • 2015 ACR/ARHP Annual Meeting
Seronegative Sjögren’s Syndrome Is Associated with a Higher Frequency of Patient-Reported Neuropathic Pain: An Analysis of the Sjögren’s International Collaborative Clinical Alliance Cohort
Alan N. Baer¹ and Julius Birnbaum², ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Patients with Sjögren’s syndrome (SS) and negative SSA/SSB serology (ie. seronegative SS) have phenotypic characteristics different than seropositive ones, and thus may constitute a…
Abstract Number: 1358 • 2015 ACR/ARHP Annual Meeting
Detection of a Unique Viral Infection in Salivary Glands of Sjögren’s Syndrome Patients and Viral-Mediated Recapitulation of Disease in Vivo
Melodie Weller¹, Matthew Gardner¹, Zoe Bogus¹, Michael Smith¹, Elisa Astorri², Drew Michael¹, Changyu Zheng¹, Peter Burbelo³, Paul A. Wilson⁴, Zhennan Lai¹, Bill Swaim¹, Beverly Handelman¹, Sandra Afione¹, Michele Bombardieri² and John A. Chiorini¹, ¹Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ³Clinical Dental Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁴National Intramural Database, Division of Enterprise and Custom Applications, Center for Information Technology, National Institutes of Health, Bethesda, MD
Background/Purpose: A viral infection is thought to be one of the triggers in the development of primary Sjögren’s syndrome (pSS). Multiple studies have shown stimulation…
Abstract Number: 2797 • 2015 ACR/ARHP Annual Meeting
Identification of Serum Biomarker for the Glandular Dysfunction of Primary Sjögren’s Syndrome
Ayumi Nishikawa¹, Katsuya Suzuki¹, Yoshiaki Kassai², Yuumi Gotou³, Takahiro Miyazaki⁴, Maiko Takiguchi⁴, Rimpei Morita⁵, Akihiko Yoshimura⁵ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Takeda Pharmaceutical Company, Fujisawa, Japan, ³Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, ⁴Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, ⁵Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by dry eye and mouth. Measurements of un-stimulated salivary flow and Schirmer’s test are…
Abstract Number: 636 • 2015 ACR/ARHP Annual Meeting
Utility of IgA Anti-Alpha-Fodrin Antibodies in Combination with Rheumatoid Factor and/or Antinuclear Antibodies As Substitute Immunological Criterion for Sjögren’s Syndrome
Gabriela Hernandez-Molina¹, Carlos Núñez-Álvarez², Juanita Romero-Diaz¹, Carmen Ávila-Casado³, Carlos Hernández-Hernández⁴, Maria Luisa Calderillo⁴, Martha Marroquín⁴, Claudia Recillas-Gispert⁵ and Jorge Sánchez-Guerrero⁶, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Pathology, University Health Network, Toronto Canada., Toronto, ON, Canada, ⁴Dental Service, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ⁵Ophtalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ⁶Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada
Background/Purpose: Anti-SSA/SSB antibodies represent the most specific serologic marker of Sjögren’s syndrome; however, in up to 30% of SS patients the test is negative.…
Abstract Number: 1363 • 2015 ACR/ARHP Annual Meeting
Changes in Cyclooxygenase-2’s Expression, and PGE2’s and 6-Keto-PGF1α Levels in the Presence of the Muscarinic Acethylcholine Receptor Antibody in Primary Sjogren Syndrome
Micaela Ana Cosatti¹, Silvia Reina², Cecilia N. Pisoni³, Alicia Eimon⁴, Sabrina Ganzinelli² and Enri Borda², ¹Section Rheumatology and Immunology, CEMIC, CABA, Argentina, ²Pharmacology Unit, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina; National Research Council of Argentina (CONICET), Buenos Aires, Argentina, ³Lupus Research Unit, The Rayne Institute, St Thomas' Hospital and Kings College London, London, United Kingdom, ⁴CEMIC, Buenos Aires, Argentina
Background/Purpose: to assess the inflammatory process provoked by the M3 muscarinic acetylcholine receptor antibody from primary Sjogren Syndrome (pSS) patient’s sera in rat submandibular gland…
Abstract Number: 2798 • 2015 ACR/ARHP Annual Meeting
Increased Frequency of the PTPN22W* Variant in Primary Sjögren’s Syndrome-Association with Low Type I IFN Scores in Peripheral Blood
Nikolaos Vlachogiannis¹, Eliona Gkioka², Adrianos Nezos³ and Clio Mavragani⁴, ¹Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ²Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ³Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ⁴Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Protein tyrosine phosphatase non-receptor 22 (PTPN22) gene encodes a protein tyrosine phosphatase previously shown to inhibit antigen-receptor signaling in T cells and promoting type…
Abstract Number: 206 • 2015 ACR/ARHP Annual Meeting
Activation of Non-Canonical NF-Kappa B Signalling in Dendritic Cells Induces Extrathymic Autoimmune Regulator (AIRE) Expression
Leonie Huitema¹, Boy Helder¹, Ae-Ri Noort², Chrissta Maracle¹, Louis Boon³, Cristina Lebre⁴, Frans G.M. Kroese⁵ and Sander W. Tas⁶, ¹Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Bioceros, Utrecht, Netherlands, ⁴Div. of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁶Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Immune regulation is necessary for limiting excessive immune responses and for preventing autoimmune diseases. Nuclear factor (NF)-κB signalling plays an important role in the…
Abstract Number: 638 • 2015 ACR/ARHP Annual Meeting
Assessment of Myocardial Abnormalities in Primary Sjögren Syndrome Using a Comprehensive Cardiac Magnetic Resonance Approach
Natsumi Ikumi¹, Hitomi Kobayashi², Yasuyuki Kobayashi³, Hirotake Inomata⁴, Yosuke Nagasawa⁴, Kaita Sugiyama⁴, Hiromi Karasawa¹, Takamasa Nozaki⁴, Hidetaka Shiraiwa⁴, Mitsuhiro Iwata², Noboru Kitamura⁵, Yoshihiro Matsukawa¹ and Masami Takei², ¹Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ²Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ³Advanced Biomedical Imaging Informatics, St.Marianna University School of Medicine, Kawasaki, Japan, ⁴Nihon University School of Medicine, Tokyo, Japan, ⁵NIhon University School of Medicine, Tokyo, Japan
Background/Purpose: Primary Sjögren syndrome (pSS) shares many clinical, inflammatory, and immunological features with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). SLE and RA are…
Abstract Number: 1374 • 2015 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T- Cells Are Decreased and Functionally Immature in Peripheral Blood of Patients with Primary Sjögren Syndrome
Tatjana Banovic^1,2,3, Jing Jing Wang⁴, Dimitra Beroukas⁵, Pravin Hissaria⁶ and Tom Gordon^2,6, ¹Immunology, Level 3, SA Pathology, Adelaide, Australia, ²Flinders University, Adelaide, Australia, ³Pediatrics, University of Adelaide, Adelaide, Australia, ⁴Immunology, Flinders University, Adelaide, Australia, ⁵SA Pathology, Adelaide, Australia, ⁶Immunology, SA Pathology, Adelaide, Australia
Background/Purpose: Primary Sjögren Syndrome (pSS) is characterized by organ-specific autoimmune destruction of salivary and lacrimal glands. Patients typically experience debilitating symptoms of dry mouth and…
Abstract Number: 2799 • 2015 ACR/ARHP Annual Meeting
Varicella Zoster Reactivation in Patients with Primary Sjögren’s Syndrome and SLE
Eliza F. Chakarvarty¹, Jacy Odell², Astrid Rasmussen³, Kathy L. Sivils², Joel M. Guthridge² and Judith A. James⁴, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, CA, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Increasing data has suggested that individuals with systemic lupus (SLE) are at increased risk of herpes zoster (HZ) reactivation compared to healthy controls and…

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