ACR Meeting Abstracts

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Abstracts tagged "Sjogren’s syndrome"

  • Abstract Number: 1253 • 2015 ACR/ARHP Annual Meeting

    Identification and Validation of Novel Putative Salivary Proteomic Biomarkers in Sjögren’s Syndrome and Different Disease Subsets

    Chiara Baldini1, Daniela Martini1, Nadia Ucciferri2, Silvia Rocchiccioli2, Letizia Mattii3, Antonietta Raffaella Maria Sabbatini3, Francesca Sernissi1, Francesco Ferro1, Nicoletta Luciano1, Leonardo Lorenzini1, Marta Mosca4, Stefano Bombardieri1 and Antonella Cecchettini3, 1Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 2Institute of Clinical Physiology, Pisa, Italy, Pisa, Italy, 3Department of Clinical and Experimental Medicine, University of Pisa, Italy, Pisa, Italy, 4University of Pisa, Pisa, Italy

    Background/Purpose: Salivary proteomics has recently appeared as a promising tool for the identification of novel diagnostic biomarkers for primary Sjögren’s syndrome (SS). However, to date…
  • Abstract Number: 2795 • 2015 ACR/ARHP Annual Meeting

    Fatigue in Primary Sjögren’s Syndrome: Clinical, Laboratory, Psychometric and Biological Associations

    Theofanis Karageorgas1, Sofia Fragkioudaki2, Adrianos Nezos3, Dimitris Karaiskos4, Clio Mavragani5 and Haralampos M. Moutsopoulos6, 1Clinical Immunology and Rheumatology, "Attikon" University Hospital of Athens, Athens, Greece, 2Physiology, Medical School of Athens, Department of Physiology, Athens, Greece, 3Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, 4Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, 5Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, 6Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece

    Background/Purpose: To identify independent predictors of fatigue in primary Sjogren’s Syndrome (pSS) patients taking into account clinical, laboratory and psychological features and to explore the…
  • Abstract Number: 634 • 2015 ACR/ARHP Annual Meeting

    Big Data International Primary Sjögren Syndrome Registry: Baseline Characterization and Diagnostic Approach in 6047 Patients Fulfilling the 2002 AE Criteria

    Pilar Brito-Zerón1, Soledad Retamozo1,2, Margit Zeher3, Astrid Rasmussen4, Elke Theander5, Jacques Gottenberg6, Chiara Baldini7, Luca Quartuccio8, Roberta Priori9, Valeria Valim10, Marika Kvarnström11, Aike Kruize12, Gabriela Hernandez-Molina13, Elena Bartoloni-Bocci14, Sonja Praprotnik15, David A. Isenberg16, Gunnel Nordmark17, Michele Bombardieri18, Yasunori Suzuki19, Roser Solans20, Roberto Giacomelli21, Daniel S. Hammenfors22, Steven E. Carsons23, Hendrika Boostma24, Cristina F. Vollenweider25, Fabiola Atzeni26, Kathy Sivils27, Thomas Mandl28, Salvatore De Vita29, Marie Wahren-Herlenius11, Mitsuhiro Kawano30, Roberto Gerli31, Arjan Vissink32, Johan G. Brun33, Virginia Trevisani34, Jorge Sánchez-Guerrero35, Xavier Mariette36, Manuel Ramos-Casals1 and on behalf of the EULAR-SS Task Force, 1Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, 2Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 3University of Debrecen, Debrecen, Hungary, 4Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Skåne University Hospital Malmö, Lund University, Malmo, Sweden, 6Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 7Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 8Clinic of Rheumatology, Department of Medical and Biological Sciences (DSMB), Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, 9Rheumatology Unit, Sapienza University of Rome, Rome, Italy, 10Rheumatology, Universidade Federal do Espírito Santo, Vitória, Brazil, 11Department of medicine, Rheumatology unit, Karolinska Institutet, Stockholm, Sweden, 12Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 13Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, 14Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, 15Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 16Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 17Medical Sciences, Uppsala University, Uppsala, Sweden, 18Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 19Kanazawa University Graduate School of Medicine, Kanazawa, Japan, 20Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, 21University of L'Aquila, L'Aquila, Italy, 22Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, 23Rheumatology, Allergy and Immunology, Winthrop University Hospital, Mineola, NY, 24University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 25Rheumatology, German Hospital, Buenos Aires, Argentina, 26Rheumatology Unit, L. Sacco University Hospital of Milan, Milan, Italy, 27Oklahoma Medical Research Foundation, Oklahoma City, OK, 28Dept of Rheumatology, Skåne University Hospital Malmö, Lund University, Malmo, Sweden, 29Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, 30Division of Rheumatology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan, 31University of Perugia, Perugia, Italy, 32Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 33Haukeland University Hospital, Bergen, Norway, 34Health Evidence Based, Universidade Federal de São Paulo, Sâo Paulo, Brazil, 35Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada, 36Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France

    Background/Purpose: To analyse the epidemiological, clinical and immunological characteristics at diagnosis of the largest international cohort of patients diagnosed with primary Sjögren syndrome (SS) according…
  • Abstract Number: 1262 • 2015 ACR/ARHP Annual Meeting

    Epigenome-Wide DNA Methylation Patterns Associated with Fatigue in Primary Sjögren’s Syndrome

    Katrine B Norheim1, Juliana Imgenberg-Kreuz2, Kristin Jonsdottir3, Emiel Janssen4, Ann-Christine Syvänen2, Johanna K Sandling2, Gunnel Nordmark5 and Roald Omdal6, 1Dept of Internal Medicine, Clinical immunology Unit, Stavanger, Norway, 2Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 3Dept. of Pathology, Stavanger University Hospital, Stavanger, Norway, 4Dept. of Pathology, Stavanger university Hospital, Stavanger, Norway, 5Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 6Department of internal medicine, Clinical Immunology unit, Stavanger, Norway

    Background/Purpose: Chronic fatigue is a common, often disabling, and poorly understood phenomenon of many diseases. Recent studies indicate that epigenetic mechanisms may be involved in…
  • Abstract Number: 2796 • 2015 ACR/ARHP Annual Meeting

    Elevated Serum Immunoglobulin G Is a Prognostic Factor for Progression of Interstitial Lung Disease in Primary Sjögren’s Syndrome

    Eriko Ishioka1, Katsuya Suzuki2, Naoshi Nishina2, Hidekata Yasuoka3, Kunihiro Yamaoka2 and Tsutomu Takeuchi2, 1Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Lung involvement is a systemic manifestation of primary Sjögren's syndrome (pSS), however, the prevalence in pSS is various (9-75 %) and details are still…
  • Abstract Number: 635 • 2015 ACR/ARHP Annual Meeting

    Seronegative Sjögren’s Syndrome Is Associated with a Higher Frequency of Patient-Reported Neuropathic Pain: An Analysis of the Sjögren’s International Collaborative Clinical Alliance Cohort

    Alan N. Baer1 and Julius Birnbaum2, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Patients with Sjögren’s syndrome (SS) and negative SSA/SSB serology (ie. seronegative SS) have phenotypic characteristics different than seropositive ones, and thus may constitute a…
  • Abstract Number: 1358 • 2015 ACR/ARHP Annual Meeting

    Detection of a Unique Viral Infection in Salivary Glands of Sjögren’s Syndrome Patients and Viral-Mediated Recapitulation of Disease in Vivo

    Melodie Weller1, Matthew Gardner1, Zoe Bogus1, Michael Smith1, Elisa Astorri2, Drew Michael1, Changyu Zheng1, Peter Burbelo3, Paul A. Wilson4, Zhennan Lai1, Bill Swaim1, Beverly Handelman1, Sandra Afione1, Michele Bombardieri2 and John A. Chiorini1, 1Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 2Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 3Clinical Dental Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 4National Intramural Database, Division of Enterprise and Custom Applications, Center for Information Technology, National Institutes of Health, Bethesda, MD

    Background/Purpose: A viral infection is thought to be one of the triggers in the development of primary Sjögren’s syndrome (pSS).  Multiple studies have shown stimulation…
  • Abstract Number: 2797 • 2015 ACR/ARHP Annual Meeting

    Identification of Serum Biomarker for the Glandular Dysfunction of Primary Sjögren’s Syndrome

    Ayumi Nishikawa1, Katsuya Suzuki1, Yoshiaki Kassai2, Yuumi Gotou3, Takahiro Miyazaki4, Maiko Takiguchi4, Rimpei Morita5, Akihiko Yoshimura5 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Takeda Pharmaceutical Company, Fujisawa, Japan, 3Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, 4Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, 5Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by dry eye and mouth. Measurements of un-stimulated salivary flow and Schirmer’s test are…
  • Abstract Number: 636 • 2015 ACR/ARHP Annual Meeting

    Utility of IgA Anti-Alpha-Fodrin Antibodies in Combination with Rheumatoid Factor and/or Antinuclear Antibodies As Substitute Immunological Criterion for Sjögren’s Syndrome

    Gabriela Hernandez-Molina1, Carlos Núñez-Álvarez2, Juanita Romero-Diaz1, Carmen Ávila-Casado3, Carlos Hernández-Hernández4, Maria Luisa Calderillo4, Martha Marroquín4, Claudia Recillas-Gispert5 and Jorge Sánchez-Guerrero6, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Pathology, University Health Network, Toronto Canada., Toronto, ON, Canada, 4Dental Service, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, 5Ophtalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, 6Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada

    Background/Purpose:   Anti-SSA/SSB antibodies represent the most specific serologic marker of Sjögren’s syndrome; however, in up to 30% of SS patients the test is negative.…
  • Abstract Number: 1363 • 2015 ACR/ARHP Annual Meeting

    Changes in Cyclooxygenase-2’s Expression, and PGE2’s and 6-Keto-PGF1α Levels in the Presence of the Muscarinic Acethylcholine Receptor Antibody in Primary Sjogren Syndrome

    Micaela Ana Cosatti1, Silvia Reina2, Cecilia N. Pisoni3, Alicia Eimon4, Sabrina Ganzinelli2 and Enri Borda2, 1Section Rheumatology and Immunology, CEMIC, CABA, Argentina, 2Pharmacology Unit, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina; National Research Council of Argentina (CONICET), Buenos Aires, Argentina, 3Lupus Research Unit, The Rayne Institute, St Thomas' Hospital and Kings College London, London, United Kingdom, 4CEMIC, Buenos Aires, Argentina

    Background/Purpose: to assess the inflammatory process provoked by the M3 muscarinic acetylcholine receptor antibody from primary Sjogren Syndrome (pSS) patient’s sera in rat submandibular gland…
  • Abstract Number: 2798 • 2015 ACR/ARHP Annual Meeting

    Increased Frequency of the PTPN22W* Variant in Primary Sjögren’s Syndrome-Association with Low Type I IFN Scores in Peripheral Blood

    Nikolaos Vlachogiannis1, Eliona Gkioka2, Adrianos Nezos3 and Clio Mavragani4, 1Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, Athens, Greece, 2Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, Athens, Greece, 3Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, 4Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece

    Background/Purpose:  Protein tyrosine phosphatase non-receptor 22 (PTPN22) gene encodes a protein tyrosine phosphatase previously shown to inhibit antigen-receptor signaling in T cells and promoting type…
  • Abstract Number: 206 • 2015 ACR/ARHP Annual Meeting

    Activation of Non-Canonical NF-Kappa B Signalling in Dendritic Cells Induces Extrathymic Autoimmune Regulator (AIRE) Expression

    Leonie Huitema1, Boy Helder1, Ae-Ri Noort2, Chrissta Maracle1, Louis Boon3, Cristina Lebre4, Frans G.M. Kroese5 and Sander W. Tas6, 1Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Bioceros, Utrecht, Netherlands, 4Div. of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 6Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Immune regulation is necessary for limiting excessive immune responses and for preventing autoimmune diseases. Nuclear factor (NF)-κB signalling plays an important role in the…
  • Abstract Number: 638 • 2015 ACR/ARHP Annual Meeting

    Assessment of Myocardial Abnormalities in Primary Sjögren Syndrome Using a Comprehensive Cardiac Magnetic Resonance Approach

    Natsumi Ikumi1, Hitomi Kobayashi2, Yasuyuki Kobayashi3, Hirotake Inomata4, Yosuke Nagasawa4, Kaita Sugiyama4, Hiromi Karasawa1, Takamasa Nozaki4, Hidetaka Shiraiwa4, Mitsuhiro Iwata2, Noboru Kitamura5, Yoshihiro Matsukawa1 and Masami Takei2, 1Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 2Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 3Advanced Biomedical Imaging Informatics, St.Marianna University School of Medicine, Kawasaki, Japan, 4Nihon University School of Medicine, Tokyo, Japan, 5NIhon University School of Medicine, Tokyo, Japan

    Background/Purpose: Primary Sjögren syndrome (pSS) shares many clinical, inflammatory, and immunological features with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). SLE and RA are…
  • Abstract Number: 1374 • 2015 ACR/ARHP Annual Meeting

    Mucosal-Associated Invariant T- Cells Are Decreased and Functionally Immature in Peripheral Blood of Patients with Primary Sjögren Syndrome

    Tatjana Banovic1,2,3, Jing Jing Wang4, Dimitra Beroukas5, Pravin Hissaria6 and Tom Gordon2,6, 1Immunology, Level 3, SA Pathology, Adelaide, Australia, 2Flinders University, Adelaide, Australia, 3Pediatrics, University of Adelaide, Adelaide, Australia, 4Immunology, Flinders University, Adelaide, Australia, 5SA Pathology, Adelaide, Australia, 6Immunology, SA Pathology, Adelaide, Australia

    Background/Purpose: Primary Sjögren Syndrome (pSS) is characterized by organ-specific autoimmune destruction of salivary and lacrimal glands. Patients typically experience debilitating symptoms of dry mouth and…
  • Abstract Number: 2799 • 2015 ACR/ARHP Annual Meeting

    Varicella Zoster Reactivation in Patients with Primary Sjögren’s Syndrome and SLE

    Eliza F. Chakarvarty1, Jacy Odell2, Astrid Rasmussen3, Kathy L. Sivils2, Joel M. Guthridge2 and Judith A. James4, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, CA, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Increasing data has suggested that individuals with systemic lupus (SLE) are at increased risk of herpes zoster (HZ) reactivation compared to healthy controls and…
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