Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1484 • 2017 ACR/ARHP Annual Meeting
Association between Primary Sjogren’s Syndrome, Arterial Stiffness and Subclinical Atherosclerosis: A Systematic Review and Meta-Analysis
Wai Chung Yong, Anawin Sanguankeo and Sikarin Upala, Bassett Medical Center, Cooperstown, NY
AbstractBackground/Purpose: In rheumatoid arthritis and systemic lupus erythematosus, cardiovascular disease is frequently a major cause of mortality or morbidity. Studies have shown that acute systemic…
Abstract Number: 2816 • 2017 ACR/ARHP Annual Meeting
Prediction of Connective Tissue Disease in an at-Risk Cohort Using a Novel Interferon Stimulated Gene Expression Score
Md Yuzaiful Md Yusof^1,2, Yasser M El-Sherbiny^1,3, Antonios Psarras¹, Elizabeth M.A. Hensor^1,4, Adewonuola Alase¹, Alaa Mohamed¹, Miriam Wittmann^1,4, Paul Emery^1,4 and Edward M Vital^1,4, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Clinical Pathology dept., School of Medicine, Mansoura University, Mansoura, Egypt, ⁴NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Prediction of connective tissue disease in an at-risk cohort using a novel interferon stimulated gene expression scoreBackground/Purpose: A period of ANA positivity and other immune…
Abstract Number: 573 • 2017 ACR/ARHP Annual Meeting
Subepithelial Infiltrate of the Vagina in Primary Sjogren’s Syndrome: The Cause of Vaginal Dryness?
Jolien F. van Nimwegen¹, Karin van der Tuuk², Ellen R. Klinkert², Erlin A. Haacke³, Frans G.M. Kroese¹, Harry Hollema³, Marian J. Mourits² and Hendrika Bootsma¹, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Women with primary Sjögren’s syndrome (pSS) often experience vaginal dryness. The cause of this symptom is unknown. This study compared the vaginal and cervical…
Abstract Number: 1485 • 2017 ACR/ARHP Annual Meeting
Association between Primary Sjogren’s Syndrome, Cardiovascular and Cerebrovascular Events: A Systematic Review and Meta-Analysis
Wai Chung Yong, Anawin Sanguankeo and Sikarin Upala, Bassett Medical Center, Cooperstown, NY
AbstractBackground/Purpose: Studies have demonstrated that acute systemic inflammation and chronic systemic vasculitis are associated with endothelial dysfunction and atherosclerotic plaque formation, subsequently leading to cardiovascular…
Abstract Number: 2817 • 2017 ACR/ARHP Annual Meeting
Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero
Gudny Ella Thorlacius¹, Malin Hedlund¹, Margarita Ivanchenko¹, Vijole Ottosson¹, Amina Ossoinak¹, Linda Lagnefeldt¹, Lars Rönnblom², Sven-Erik Sonesson³, Maija-Leena Eloranta⁴ and Marie Wahren-Herlenius¹, ¹Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ³Pediatric Cardiology Unit, Department of Women´s and Children´s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁴Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden
Background/Purpose: Women with Sjögren’s syndrome and autoantibodies against Ro/SSA are at risk for pregnancy complications, including neonatal lupus erythematosus (NLE) and a congenital heart block…
Abstract Number: 30 • 2017 ACR/ARHP Annual Meeting
Specificity of Salivary Gland-Derived Monoclonal Antibodies from Sjogren’s Syndrome Patients Using Human Proteome Arrays
Sherri Longobardi¹, Christina Lawrence², Kristi A. Koelsch³, Kenneth Smith², Constantin Georgescu², Michelle L. Joachims², Lida Radfar⁴, Astrid Rasmussen², Kathy L. Sivils², Jonathan Wren², R. Hal Scofield² and A. Darise Farris², ¹Graduate Program in Biological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, ⁴Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by focal lymphocytic infiltrations in the lacrimal and salivary glands, autoantibodies to the ubiquitous Ro…
Abstract Number: 574 • 2017 ACR/ARHP Annual Meeting
Is Elastography a New Tool to Differentiate Sjögren Syndrome to Sicca Syndrome?: Results of the Elsa (elastography of salivary glands) Study
Sandrine Jousse-Joulin¹, luc Bressollette², thibault depinoy³, guillermo carvajal Alegria³, Divi Cornec⁴, Thierry Marhadour⁵, Dewi Guellec⁶, Valérie Devauchelle-Pensec⁷ and Alain Saraux⁸, ¹Rheumatology, CHu La cavle Blanche, Brest, France, ²Doppler unit, Cavale Blanche hospital, brest, France, ³rheumatology department, cavale blanche hospital, brest, France, ⁴CHU Brest, Brest, France, ⁵Rheumatology, CHU La Cavale Blanche, Brest, France, ⁶Rheumatology, CHU Brest, Brest, France, ⁷Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, ⁸Rheumatology, Brest University Medical School Hospital, Brest, France
Background/Purpose: Ultrasonography (US) has been developed in salivary glands (SG) and particularly in primary Sjögren syndrome (pSS) for 10 years. However, the training curve is…
Abstract Number: 1487 • 2017 ACR/ARHP Annual Meeting
Salivary Gland Ultrasonography (SGUS) and Subclinical Parotid Involvement: Usefulness of Sgus in the Identification of a Subset of Patients with Sjögren’s Syndrome at Higher Risk for Extraglandular Disease Manifestations
Chiara Baldini¹, Nicoletta Luciano², Francesco Ferro², Elena Elefante², Rosaria Talarico³, Chiara Tani² and Marta Mosca², ¹Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ²Rheumatology Unit, University of Pisa, Pisa, Italy, ³Rheumatology Unit, University of Pisa, PISA, Italy
Background/Purpose: Salivary gland ultrasonography (SGUS) has recently appeared as a promising tool for the diagnosis and the early stratification of patients affected by primary Sjögren’s…
Abstract Number: 2828 • 2017 ACR/ARHP Annual Meeting
A Graph-Theoretic-Approach Applied to Modular-Repertoire-Analysis Identifies Shared Gradual Whole Blood Interferon Signatures in Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome Patients and Reveals New Interferon-Related Modules in Disease Progression
Ilya Korsunski¹, Noémie Jourde-Chiche², Peter Gregersen³, Damien Chaussabel⁴, Laurent Chiche⁵ and Naomi I. Maria⁶, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, ³Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Med Res, Manhasset, NY, ⁴Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, ⁵Internal medicine, Hopital europeen, Marseille, France, ⁶Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: There is significant clinical and molecular heterogeneity among patients suffering from systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and primary Sjögren’s Syndrome…
Abstract Number: 46 • 2017 ACR/ARHP Annual Meeting
Secondary Light Chain Editing and Allelic Inclusion in Antibody Secreting Cells from the Minor Salivary Gland
Kristi A. Koelsch¹, Kenneth Smith², Astrid Rasmussen³, C. Erick Kaufman⁴, David M. Lewis⁵, Lida Radfar⁶, Christopher J Lessard², Biji T Kurien², Judith A. James³, Kathy L. Sivils³, A. Darise Farris⁷ and R. Hal Scofield⁸, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, ⁵Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁶Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁷Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Heavy and light chain gene usage and mutational analyses of the Ig variable regions (V-regions) enable the identification of gene usage within B cell…
Abstract Number: 722 • 2017 ACR/ARHP Annual Meeting
Differential Diagnosis of Autoimmune Diseases, Outlier Detection Plus Subgrouping in Clinical Trials By High Content Autoantibody Profiling
Peter Schulz-Knappe, Petra Budde and Hans-Dieter Zucht, Protagen AG, Dortmund, Germany
Background/Purpose: Early diagnosis as well as initiation of successful treatment are two big challenges in the management of patients with autoimmune diseases (AID). Overlap of…
Abstract Number: 1489 • 2017 ACR/ARHP Annual Meeting
Development and Validation of a Questionnaire to Assess Healthcare Utilization and Access in Cohorts of Patients with Primary Sjögren’s Syndrome
Chiara Seghieri¹, Chiara Baldini², Luca Quartuccio³, Francesco Ferro⁴, Saviana Gandolfo⁵, Salvatore De Vita⁶ and Stefano Bombardieri⁴, ¹Istituto di Management Scuola Superiore Sant'Anna, Pisa, Italy, ²Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, Udine, Italy, ⁴Rheumatology Unit, University of Pisa, Pisa, Italy, ⁵Rheumatology Clinic, Medical Area Department, University of Udine, Udine, Italy, ⁶Rheumatology Clinic, Academic Hospital S. M. della Misericordia, Medical Area Department, University of Udine, Italy, Udine, Italy
Background/Purpose: The geographic variation in healthcare service utilization and quality across and within countries is well documented. Part of this geographic variation is linked to…
Abstract Number: 2830 • 2017 ACR/ARHP Annual Meeting
Epigenetic Cell Counting: A Novel Tool to Quantify Immune Cells in Salivary Glands Detects Robust Correlations of T Follicular Helper Cells with Immunopathology
Joel A.G. van Roon¹, Frederique M. Moret¹, Sofie L.M. Blokland¹, Aike A. Kruize², Gerben Bouma³, Andre van Maurik³, Sven Olek⁴, Ulrich Hoffmueller⁴ and Timothy R.D.J. Radstake⁵, ¹Rheumatology & Clinical Immunology/ Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Immunoinflammation TAU, GlaxoSmithKline, Stevenage, United Kingdom, ⁴Epiontis GmbH, Berlin, Germany, ⁵Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Histological analysis of salivary glands for decades has been a valuable tool in the characterization of patients with primary Sjögren’s syndrome (pSS) and non-Sjögren’s…
Abstract Number: 552 • 2017 ACR/ARHP Annual Meeting
Mast Cells Are Involved in the Pathogenesis of Sjögren Syndrome By Inducing Tissue Fibrosis
Shinjiro Kaieda¹, Kyoko Fujimoto², Masaki Okamoto³, Masaki Tominaga², Tomoaki Hoshino⁴ and Hiroaki Ida⁵, ¹Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, ²Kurume University School of Medicine, Kurume, Japan, ³Medicine, Kurume University School of Medicine, Kurume, Japan, ⁴Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, ⁵Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan
Background/Purpose: Mast cells have been implicated in many immune-inflammatory disorders. They mediate a variety of inflammatory and fibrotic conditions, but their role in sialadenitis and…
Abstract Number: 873 • 2017 ACR/ARHP Annual Meeting
Type I High-IFN Gene Signature in Associated with Higher Essdai at Enrollmment and Follow-up in the Prospective Multicenter Assess Cohort of 395 Patients
Jacques-Eric Gottenberg¹, Pierre-Etienne BOST², Benno Schwikowski², Raphaele Seror³, Valérie Devauchelle-Pensec⁴, Philippe Dieudé⁵, Jean-Jacques Dubost⁶, Anne Laure Fauchais⁷, Vincent Goeb⁸, Eric Hachulla⁹, Pierre Yves Hatron¹⁰, Claire Larroche¹¹, Véronique Le-Guern¹², Jacques Morel¹³, Aleth Perdriger¹⁴, Emmanuelle Dernis¹⁵, Stephanie Rist Bouillon¹⁶, Alain Saraux¹⁷, Damien Sène¹⁸, Jean Sibilia¹⁹, Olivier Vittecoq²⁰, Gaetane Nocturne²¹, Sarah TUBIANA²², Philippe Ravaud²³ and Xavier Mariette²⁴, ¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Pasteur Institute, System biologique, PARIS, France, ³Department of Rheumatology, Assistance Publique–Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France, ⁴Department of Rheumatology, Brest University Hospital, Brest, France, ⁵Rheumatology, Hôpital Bichat, Paris, France, ⁶Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ⁷Rheumatology, Limoges, France, ⁸Rheumatologie, Rheumatology Department CHU Teaching Hospital Amiens, Amiens, France, ⁹CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France, ¹⁰Internal Medicine, Lille, France, ¹¹Internal Medicine, Paris, France, ¹²service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ¹³Rheumatology, CHU Lapeyronie and Montpellier University, Montpellier, France, ¹⁴Service de Rhumatologie, CHRU de Rennes, Rennes, France, ¹⁵Service de Rhumatologie, CH du Mans, Le Mans, France, ¹⁶Rhumatologie, Hopital La Source, La Source, France, ¹⁷Rheumatology, Brest University Hospital, Brest, France, ¹⁸Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, ¹⁹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²⁰INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, ²¹INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, ²²CRB Bichat, PARIS, France, ²³Hôpital Hôtel Dieu, Paris, France, ²⁴Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France
Background/Purpose: The type I interferon (IFN) signature is a hallmark of the pathogenesis of primary Sjögren’s syndrome (pSS). However, little is known regarding the clinical…

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