ACR Meeting Abstracts

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Abstracts tagged "Sjogren’s syndrome"

  • Abstract Number: 1484 • 2017 ACR/ARHP Annual Meeting

    Association between Primary Sjogren’s Syndrome, Arterial Stiffness and Subclinical Atherosclerosis: A Systematic Review and Meta-Analysis

    Wai Chung Yong, Anawin Sanguankeo and Sikarin Upala, Bassett Medical Center, Cooperstown, NY

    AbstractBackground/Purpose: In rheumatoid arthritis and systemic lupus erythematosus, cardiovascular disease is frequently a major cause of mortality or morbidity. Studies have shown that acute systemic…
  • Abstract Number: 2816 • 2017 ACR/ARHP Annual Meeting

    Prediction of Connective Tissue Disease in an at-Risk Cohort Using a Novel Interferon Stimulated Gene Expression Score

    Md Yuzaiful Md Yusof1,2, Yasser M El-Sherbiny1,3, Antonios Psarras1, Elizabeth M.A. Hensor1,4, Adewonuola Alase1, Alaa Mohamed1, Miriam Wittmann1,4, Paul Emery1,4 and Edward M Vital1,4, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Clinical Pathology dept., School of Medicine, Mansoura University, Mansoura, Egypt, 4NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Prediction of connective tissue disease in an at-risk cohort using a novel interferon stimulated gene expression scoreBackground/Purpose: A period of ANA positivity and other immune…
  • Abstract Number: 573 • 2017 ACR/ARHP Annual Meeting

    Subepithelial Infiltrate of the Vagina in Primary Sjogren’s Syndrome: The Cause of Vaginal Dryness?

    Jolien F. van Nimwegen1, Karin van der Tuuk2, Ellen R. Klinkert2, Erlin A. Haacke3, Frans G.M. Kroese1, Harry Hollema3, Marian J. Mourits2 and Hendrika Bootsma1, 1Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Women with primary Sjögren’s syndrome (pSS) often experience vaginal dryness. The cause of this symptom is unknown. This study compared the vaginal and cervical…
  • Abstract Number: 1485 • 2017 ACR/ARHP Annual Meeting

    Association between Primary Sjogren’s Syndrome, Cardiovascular and Cerebrovascular Events: A Systematic Review and Meta-Analysis

    Wai Chung Yong, Anawin Sanguankeo and Sikarin Upala, Bassett Medical Center, Cooperstown, NY

    AbstractBackground/Purpose: Studies have demonstrated that acute systemic inflammation and chronic systemic vasculitis are associated with endothelial dysfunction and atherosclerotic plaque formation, subsequently leading to cardiovascular…
  • Abstract Number: 2817 • 2017 ACR/ARHP Annual Meeting

    Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero

    Gudny Ella Thorlacius1, Malin Hedlund1, Margarita Ivanchenko1, Vijole Ottosson1, Amina Ossoinak1, Linda Lagnefeldt1, Lars Rönnblom2, Sven-Erik Sonesson3, Maija-Leena Eloranta4 and Marie Wahren-Herlenius1, 1Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 2Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 3Pediatric Cardiology Unit, Department of Women´s and Children´s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 4Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden

    Background/Purpose: Women with Sjögren’s syndrome and autoantibodies against Ro/SSA are at risk for pregnancy complications, including neonatal lupus erythematosus (NLE) and a congenital heart block…
  • Abstract Number: 30 • 2017 ACR/ARHP Annual Meeting

    Specificity of Salivary Gland-Derived Monoclonal Antibodies from Sjogren’s Syndrome Patients Using Human Proteome Arrays

    Sherri Longobardi1, Christina Lawrence2, Kristi A. Koelsch3, Kenneth Smith2, Constantin Georgescu2, Michelle L. Joachims2, Lida Radfar4, Astrid Rasmussen2, Kathy L. Sivils2, Jonathan Wren2, R. Hal Scofield2 and A. Darise Farris2, 1Graduate Program in Biological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, 4Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK

    Background/Purpose: Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by focal lymphocytic infiltrations in the lacrimal and salivary glands, autoantibodies to the ubiquitous Ro…
  • Abstract Number: 574 • 2017 ACR/ARHP Annual Meeting

    Is Elastography a New Tool to Differentiate Sjögren Syndrome to Sicca Syndrome?: Results of the Elsa (elastography of salivary glands) Study

    Sandrine Jousse-Joulin1, luc Bressollette2, thibault depinoy3, guillermo carvajal Alegria3, Divi Cornec4, Thierry Marhadour5, Dewi Guellec6, Valérie Devauchelle-Pensec7 and Alain Saraux8, 1Rheumatology, CHu La cavle Blanche, Brest, France, 2Doppler unit, Cavale Blanche hospital, brest, France, 3rheumatology department, cavale blanche hospital, brest, France, 4CHU Brest, Brest, France, 5Rheumatology, CHU La Cavale Blanche, Brest, France, 6Rheumatology, CHU Brest, Brest, France, 7Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, 8Rheumatology, Brest University Medical School Hospital, Brest, France

    Background/Purpose: Ultrasonography (US) has been developed in salivary glands (SG) and particularly in primary Sjögren syndrome (pSS) for 10 years. However, the training curve is…
  • Abstract Number: 1487 • 2017 ACR/ARHP Annual Meeting

    Salivary Gland Ultrasonography (SGUS) and Subclinical Parotid Involvement: Usefulness of Sgus in the Identification of a Subset of Patients with Sjögren’s Syndrome at Higher Risk for Extraglandular Disease Manifestations

    Chiara Baldini1, Nicoletta Luciano2, Francesco Ferro2, Elena Elefante2, Rosaria Talarico3, Chiara Tani2 and Marta Mosca2, 1Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 2Rheumatology Unit, University of Pisa, Pisa, Italy, 3Rheumatology Unit, University of Pisa, PISA, Italy

    Background/Purpose: Salivary gland ultrasonography (SGUS) has recently appeared as a promising tool for the diagnosis and the early stratification of patients affected by primary Sjögren’s…
  • Abstract Number: 2828 • 2017 ACR/ARHP Annual Meeting

    A Graph-Theoretic-Approach Applied to Modular-Repertoire-Analysis Identifies Shared Gradual Whole Blood Interferon Signatures in Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome Patients and Reveals New Interferon-Related Modules in Disease Progression

    Ilya Korsunski1, Noémie Jourde-Chiche2, Peter Gregersen3, Damien Chaussabel4, Laurent Chiche5 and Naomi I. Maria6, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, 3Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Med Res, Manhasset, NY, 4Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, 5Internal medicine, Hopital europeen, Marseille, France, 6Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: There is significant clinical and molecular heterogeneity among patients suffering from systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and primary Sjögren’s Syndrome…
  • Abstract Number: 46 • 2017 ACR/ARHP Annual Meeting

    Secondary Light Chain Editing and Allelic Inclusion in Antibody Secreting Cells from the Minor Salivary Gland

    Kristi A. Koelsch1, Kenneth Smith2, Astrid Rasmussen3, C. Erick Kaufman4, David M. Lewis5, Lida Radfar6, Christopher J Lessard2, Biji T Kurien2, Judith A. James3, Kathy L. Sivils3, A. Darise Farris7 and R. Hal Scofield8, 1Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, 5Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 6Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 7Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 8Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Heavy and light chain gene usage and mutational analyses of the Ig variable regions (V-regions) enable the identification of gene usage within B cell…
  • Abstract Number: 722 • 2017 ACR/ARHP Annual Meeting

    Differential Diagnosis of Autoimmune Diseases, Outlier Detection Plus Subgrouping in Clinical Trials By High Content Autoantibody Profiling

    Peter Schulz-Knappe, Petra Budde and Hans-Dieter Zucht, Protagen AG, Dortmund, Germany

    Background/Purpose: Early diagnosis as well as initiation of successful treatment are two big challenges in the management of patients with autoimmune diseases (AID). Overlap of…
  • Abstract Number: 1489 • 2017 ACR/ARHP Annual Meeting

    Development and Validation of a Questionnaire to Assess Healthcare Utilization and Access in Cohorts of Patients with Primary Sjögren’s Syndrome

    Chiara Seghieri1, Chiara Baldini2, Luca Quartuccio3, Francesco Ferro4, Saviana Gandolfo5, Salvatore De Vita6 and Stefano Bombardieri4, 1Istituto di Management Scuola Superiore Sant'Anna, Pisa, Italy, 2Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 3Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, Udine, Italy, 4Rheumatology Unit, University of Pisa, Pisa, Italy, 5Rheumatology Clinic, Medical Area Department, University of Udine, Udine, Italy, 6Rheumatology Clinic, Academic Hospital S. M. della Misericordia, Medical Area Department, University of Udine, Italy, Udine, Italy

    Background/Purpose: The geographic variation in healthcare service utilization and quality across and within countries is well documented. Part of this geographic variation is linked to…
  • Abstract Number: 2830 • 2017 ACR/ARHP Annual Meeting

    Epigenetic Cell Counting: A Novel Tool to Quantify Immune Cells in Salivary Glands Detects Robust Correlations of T Follicular Helper Cells with Immunopathology

    Joel A.G. van Roon1, Frederique M. Moret1, Sofie L.M. Blokland1, Aike A. Kruize2, Gerben Bouma3, Andre van Maurik3, Sven Olek4, Ulrich Hoffmueller4 and Timothy R.D.J. Radstake5, 1Rheumatology & Clinical Immunology/ Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 3Immunoinflammation TAU, GlaxoSmithKline, Stevenage, United Kingdom, 4Epiontis GmbH, Berlin, Germany, 5Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Histological analysis of salivary glands for decades has been a valuable tool in the characterization of patients with primary Sjögren’s syndrome (pSS) and non-Sjögren’s…
  • Abstract Number: 552 • 2017 ACR/ARHP Annual Meeting

    Mast Cells Are Involved in the Pathogenesis of Sjögren  Syndrome By Inducing Tissue Fibrosis

    Shinjiro Kaieda1, Kyoko Fujimoto2, Masaki Okamoto3, Masaki Tominaga2, Tomoaki Hoshino4 and Hiroaki Ida5, 1Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, 2Kurume University School of Medicine, Kurume, Japan, 3Medicine, Kurume University School of Medicine, Kurume, Japan, 4Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, 5Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan

    Background/Purpose: Mast cells have been implicated in many immune-inflammatory disorders. They mediate a variety of inflammatory and fibrotic conditions, but their role in sialadenitis and…
  • Abstract Number: 873 • 2017 ACR/ARHP Annual Meeting

    Type I High-IFN Gene Signature in Associated with Higher Essdai at Enrollmment and Follow-up in the Prospective Multicenter Assess Cohort of 395 Patients

    Jacques-Eric Gottenberg1, Pierre-Etienne BOST2, Benno Schwikowski2, Raphaele Seror3, Valérie Devauchelle-Pensec4, Philippe Dieudé5, Jean-Jacques Dubost6, Anne Laure Fauchais7, Vincent Goeb8, Eric Hachulla9, Pierre Yves Hatron10, Claire Larroche11, Véronique Le-Guern12, Jacques Morel13, Aleth Perdriger14, Emmanuelle Dernis15, Stephanie Rist Bouillon16, Alain Saraux17, Damien Sène18, Jean Sibilia19, Olivier Vittecoq20, Gaetane Nocturne21, Sarah TUBIANA22, Philippe Ravaud23 and Xavier Mariette24, 1Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 2Pasteur Institute, System biologique, PARIS, France, 3Department of Rheumatology, Assistance Publique–Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France, 4Department of Rheumatology, Brest University Hospital, Brest, France, 5Rheumatology, Hôpital Bichat, Paris, France, 6Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, 7Rheumatology, Limoges, France, 8Rheumatologie, Rheumatology Department CHU Teaching Hospital Amiens, Amiens, France, 9CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France, 10Internal Medicine, Lille, France, 11Internal Medicine, Paris, France, 12service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 13Rheumatology, CHU Lapeyronie and Montpellier University, Montpellier, France, 14Service de Rhumatologie, CHRU de Rennes, Rennes, France, 15Service de Rhumatologie, CH du Mans, Le Mans, France, 16Rhumatologie, Hopital La Source, La Source, France, 17Rheumatology, Brest University Hospital, Brest, France, 18Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, 19Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 20INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, 21INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 22CRB Bichat, PARIS, France, 23Hôpital Hôtel Dieu, Paris, France, 24Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France

    Background/Purpose: The type I interferon (IFN) signature is a hallmark of the pathogenesis of primary Sjögren’s syndrome (pSS). However, little is known regarding the clinical…
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