Abstracts tagged "Sjogren’s syndrome and mTor"

Abstract Number: 2872 • 2017 ACR/ARHP Annual Meeting
Elevated mTORC1 Signature in B Cells from Sjögren’s Syndrome Patients: mTOR Inhibition As a Novel Therapeutic Strategy to Halt B Cell Hyperactivity
Sofie L.M. Blokland^1,2, Maarten R. Hillen^3,4, Rina G.K. Kommer-Wichers⁴, Aike A. Kruize², Timothy R.D.J. Radstake^2,5, Jasper C.A. Broen^2,4 and Joel A.G. van Roon^2,4, ¹Rheumatology & Clinical Immunology/ Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ⁵Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: A hallmark feature of primary Sjögren’s syndrome (pSS) is B cell hyperactivity, including presence of autoantibodies, aberrant presence of B cells and plasma cells…

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