Abstracts tagged "Sjogren’s syndrome and interferons"

Abstract Number: 1073 • 2017 ACR/ARHP Annual Meeting
Aberrant Cell Signaling in Peripheral Blood Mononuclear Cells upon Interferon Alpha Stimulation in Patients with Primary Sjögren’s Syndrome Associates with Type I Interferon Signature
Richard Davies¹, Daniel Hammenfors^1,2, Brith Bergum¹, Petra Vogelsang¹, Sonia Gavasso³, Johan G. Brun^2,4, Roland Jonsson^5,6 and Silke Appel¹, ¹Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ²Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ³Department of Neurology, Haukeland University Hospital, Bergen, Norway, ⁴Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Broegelmann Research laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁶Department of Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a complex heterogeneous systemic autoimmune disease. Biomarkers for patient stratification are scarce. Several single nucleotide polymorphisms within type I…
Abstract Number: 3034 • 2016 ACR/ARHP Annual Meeting
A Selective JAK1 Inhibitor, Filgotinib Suppresses Lymphocytic Infiltration in Salivary Gland of Non Obese Diabetic Mice Via Suppression of BAFF and Chemokine Production of Salivary Gland Epithelial Cells
Jennifer Lee¹, Seo Hwa Kim², Haneul Kim³, Seung-Ki Kwok⁴, Ji Hyeon Ju⁵ and Sung-Hwan Park⁵, ¹Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ²Division of Rheumatology,, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ⁴seungki73@catholic.ac.kr, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Interferon(IFN) signatures are upregulated in patients with primary Sjogren’s syndrome (pSS) and interferons are considered to play a pathogenic role in pSS. Therefore, Janus…
Abstract Number: 1054 • 2015 ACR/ARHP Annual Meeting
A Potential Role of Type III Interferon in the Glandular Involvement of Sjögren’s Syndrome
Tania Mora¹, Felipe Alonso Masso Rojas², Araceli Paez², Mariana Patlan³, Misael Gómez-Mondragón², Alberto Aranda-Frausto⁴, Maya Chacón Pérez⁵ and Luis M. Amezcua-Guerra^6,7, ¹Rheumatology, National Institute of Cardiology, Mexico City, Mexico, ²Department of Cell Physiology, National Institute of Cardiology, Mexico City, Mexico, ³Department of Immunology, National Institute of Cardiology, Mexico City, Mexico, ⁴Department of Pathology, National Institute of Cardiology, Mexico City, Mexico, ⁵National Institute of Cardiology, Mexico City, Mexico, ⁶Immunology, National Institute of Cardiology, Mexico City, Mexico, ⁷Mexican Accreditation Council of Rheumatology, A.C., Mexico City, Mexico
Background/Purpose: Primary Sjögren's syndrome (pSS) is an autoinmune disorder characterized by lymphocytic infiltration of salivary and lachrymal glands. Recently, it has been showed that plasmacytoid…
Abstract Number: 1047 • 2014 ACR/ARHP Annual Meeting
Type I and II Interferon Signatures in Sjogren’s Syndrome: Contributions in Distinct Clinical Phenotypes and Sjogren’s Related Lymphomagenesis
Adrianos Nezos¹, Fotini Gravani², Efstathia K. Kapsogeorgou³, Michael Voulgarelis⁴, Haralampos M. Moutsopoulos⁴, Mary K. Crow⁵ and Clio Mavragani⁶, ¹Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ²Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Athens, Greece, ³Pathophysiology, School of Medicine, National University of Athens, Greece, Athens, Greece, ⁴Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ⁵Department of Medicine, Hospital for Special Surgery, New York, NY, ⁶Department of Physiology, School of Medicine, University of Athens, Athens, Greece
Background/Purpose: Both type I and II interferons (IFNs) have been implicated in the pathogenesis of Sjogren’s syndrome (SS). We aimed to explore the contribution of…