Abstracts tagged "Sjogren’s syndrome and cytokines"

Abstract Number: 2633 • 2017 ACR/ARHP Annual Meeting
Patients with Secondary Sjögren’s Syndrome to SLE Are Characterized By Typical Autoantibodies and a Pro-Inflammatory State
Marika Kvarnstrom¹, Guillermo Ruacho², Johanna Gustafsson³, Agneta Zickert⁴, Vilija Oke⁵, Johan Rönnelid⁶, Kerstin Elvin⁷, Iva Gunnarsson⁸ and Elisabet Svenungsson⁸, ¹Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Department of Medicine, Unit of Rheumatology,, Stockholm, Sweden, ³Dep. of Medicine, Karolinska Institutet, Karolinska University Hospital, Unit of rheumatology,, Stockholm, Sweden, ⁴Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁵Department of Medicine, Rheumatology Unit, Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁶Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁷Department of Clinical Immunology and Transfusion Medicine,, 4Unit of Clinical Immunology, Stockholm, Sweden, ⁸Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose :Sjögren´s syndrome occurs in isolation (primary Sjögren´s syndrome, pSS), but it is also often secondary (sSS) to, and sometimes difficult to delineate from, other…
Abstract Number: 654 • 2016 ACR/ARHP Annual Meeting
The Level of B-Cell Active Cytokines and Soluble B-Cell Activating Factor/a Proliferation-Inducing Ligand Receptors in Patients with Primary Sjogren’s Syndrome
You Jung Ha¹, Jaehyung Hur¹, Sang Wan Chung¹, Eun Ha Kang², Yeong Wook Song^3,4 and Yun Jong Lee⁵, ¹Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, The Republic of, ³WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Medical Research Institute, WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Medical Research Institute, Seoul National University College of Medicine, Seoul, Korea, The Republic of, ⁴Department of Internal Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea
Background/Purpose: Primary Sjögren`s syndrome (pSS) is an autoimmune diseases characterized by lymphocytic infiltration of exocrine glands and dysregulated proliferation and differentiation of B cells. Two…
Abstract Number: 1504 • 2013 ACR/ARHP Annual Meeting
Anti-Inflammation Effect Of Peroxisome Proliferator-Activated Receptor-ã (PPAR-ã) In Non-Obese Diabetic Mice With Sjogren’s Syndrome
Bei Xu¹ and Xiaomei Li², ¹Department of Rheumatology and Immunology, The third Affiliated Hospital of Anhui Medical University, The First Hospital of Hefei, Hefei, China, ²Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, Anhui, China
Background/Purpose: To investigate the anti-inflammation effect of peroxisome proliferator-activated receptor-γ (PPAR-γ) in non-obese diabetic mice (NOD mice) with sjogren`s syndrome.Methods: Twenty 8-weeks-old female NOD mice were randomly divided into…
Abstract Number: 1494 • 2013 ACR/ARHP Annual Meeting
Increased Expression Of Interleukin 33 In Sera and Salivary Gland From Patients With Sjögren Syndrome
Seung Min Jung¹, Young Sun Suh², Jung Hee Koh², Jae Ho Lee², Jennifer Lee², Soo Young Lee³, Ji Hyeon Ju², Kyung-Su Park², Dae Chul Jeong⁴, Sung Hwan Park² and Seung-Ki Kwok¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ³Department of Pediatrics, School of Medicine, The Catholic University of Korea, Incheon St. Mary's Hospital, Incheon, South Korea, ⁴Division of Rheumatology, Department of Pediatrics, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea
Background/Purpose: Interleukin 33 (IL-33), a member of IL-1 superfamily, exerts pro-inflammatory effect by binding with ST2 expressed on many cell types. Recently, the association of…
Abstract Number: 2196 • 2012 ACR/ARHP Annual Meeting
Decreased Expression of TSLP in Labial Salivary Glands of Patients with pSS Is Associated with Local and Systemic Disease Parameters
M.R. Hillen¹, A. Bikker², A.a. Kruize², M. Wenting-van Wijk², F.P.J.G. Lafeber³, C.E. Hack⁴ and J.A.G. van Roon⁵, ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymic Stromal Lymphopoietin (TSLP) is a potent immunomodulatory cytokine involved in Th2-mediated immune responses and homeostatic T-cell expansion. Reduced TSLP expression by intestinal epithelial…
Abstract Number: 505 • 2012 ACR/ARHP Annual Meeting
Characterization of an in Vitro Model of Human Salivary Gland for Studying Sjögren Syndrome (SS)
M. Jesus Dominguez-Luis¹, M.Teresa Arce-Franco¹, Estefania Armas-Gonzalez¹, Ada Herrera-Garcia¹, Teresa Giraldez², Pablo Miranda², Diego Alvarez de la Rosa³, Jose Garcia-Verdugo⁴, Carlos Martinez-Jimeno⁵ and Federico Diaz-Gonzalez¹, ¹Rheumatology Service. Hospital Universitario de Canarias., La Laguna, Spain, ²Unidad de Investigación of Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain, ³Department of Physiology. Universidad de La Laguna,, La Laguna, Spain, ⁴Cellular Morphology Laboratory, Centro de Investigación Príncipe Felipe., Valencia, Spain, ⁵Maxilofacial Department, Hospital Universitario de Canarias,, La Laguna, Spain
Background/Purpose: Sjögren's syndrome (SS) is an autoimmune exocrinopathy of unknown etiology that is characterized by decreased salivary secretion (xerostomy) and lacrimal (xerophthalmy). Histopathological lesions…

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