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Abstracts tagged "Sjogren’s syndrome and clinical research"

  • Abstract Number: 1784 • 2017 ACR/ARHP Annual Meeting

    The Novel Anti-CD40 Monoclonal Antibody CFZ533 Shows Beneficial Effects in Patients with Primary Sjögren’s Syndrome: A Phase IIa Double-Blind, Placebo-Controlled Randomized Trial

    Benjamin Fisher1, Margit Zeher2, Wan-Fai Ng3, Michele Bombardieri4, Maximilian Posch5, Athena S Papas6, Arwa M Farag6, Thomas Daikeler7, Bettina Bannert8, Alan J. Kivitz9, Steven E. Carsons10, David A. Isenberg11, Francesca Barone12, Simon Bowman13, Pascal Espie14, Grazyna Wieczorek14, Pierre Moulin14, David Floch14, Cyrielle Dupuy14, Xiaohui Ren14, Petra Faerber14, Andrew M Wright15, Hans Ulrich Hockey15, Michael Rotte14, James S. Rush15 and Peter Gergely14, 1Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, 2Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Debrecen, Hungary, 3Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 4Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, UK, London, United Kingdom, 5Charité Research Organisation GmbH, Berlin, Germany, 6Tufts University, Boston, MA, 7Rheumatology, University Hospital Basel, Basel, Switzerland, 8University Hospital Basel, Basel, Switzerland, 9Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, 10NYU Winthrop University Hospital, Department of Medicine, Mineola, NY, 11Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 12Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, 13Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, Birmingham, United Kingdom, 14Novartis Institutes for Biomedical Research, Basel, Switzerland, 15Novartis Pharmaceuticals Corporation, Basel, Switzerland

    Background/Purpose: Primary Sjogren’s syndrome (pSS) is a systemic, progressive autoimmune disease characterized by formation of ectopic germinal centers in exocrine glands and secretory gland dysfunction.…
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