ACR Meeting Abstracts

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Abstracts tagged "Sjogren’s syndrome and autoantibodies"

  • Abstract Number: 564 • 2017 ACR/ARHP Annual Meeting

    Molecular Identification of a Ro-Specific Salivary IgA Repertoire with Unique Clonal Signatures in Primary Sjogren’s Syndrome

    Jing Jing Wang1, Alexander Colella1, Tim Chataway2, R. Hal Scofield3 and Tom Gordon1,4, 1Immunology, Flinders University, Adelaide, Australia, 2Proteomic Facility, Flinders University, Adelaide, Australia, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Immunology, SA Pathology, Adelaide, Australia

    Background/Purpose: Autoantibodies against 60-kD Ro (Ro60)/SSA have been detected in the saliva and serum of patients with primary Sjögren's syndrome (SS) by routine methods that…
  • Abstract Number: 571 • 2017 ACR/ARHP Annual Meeting

    Anti-Modified Protein Antibody Response Pattern in Primary Sjögren’s Syndrome: Clinical and Prognostic Implications

    Alessia Alunno1, Francesco Carubbi2,3, Holger Bang4, Onelia Bistoni1, Paul Studenic5, Günter Steiner5, Elena Bartoloni6, Josef S. Smolen5,7 and Roberto Gerli1, 1Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, 2ASL1 Avezzano L'Aquila Sulmona, L'Aquila, Italy, 3Rheumatology Unit, University of L'Aquila, L'Aquila, Italy, 4Orgentec Diagnostika GmbH, Mainz, Germany, 5Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 6Rheumatology Unit, University of Perugia, Perugia, Italy, 7Hietzing Hospital, Department of Internal Medicine, Vienna, Austria

    Background/Purpose: Over the last decades, several post translationally modified proteins have been identified as auto-antigens in rheumatoid arthritis (RA). No data regarding Abs against acetylated…
  • Abstract Number: 559 • 2017 ACR/ARHP Annual Meeting

    Performance of Multiple Platforms for Autoantibody Testing in Sjogren’s Syndrome

    Astrid Rasmussen1, Kiely Grundahl2, Lida Radfar3, C. Erick Kaufman4, David M. Lewis5, Barbara M. Segal6, Nelson L. Rhodus7, Harini Bagavant1, Umesh Deshmukh8, Christopher J Lessard8, R. Hal Scofield1 and Kathy L. Sivils1, 1Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 3Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 4College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 6Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 7Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, 8Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: The research classification and clinical diagnosis of SjšgrenÕs syndrome (SS) relies heavily on the detection of autoantibodies against Ro/SSA and La/SSB, particularly in the…
  • Abstract Number: 2802 • 2015 ACR/ARHP Annual Meeting

    Co-Occurence of Anti-Ro52/TRIM21 and Anti-TRIM38 Autoantibodies Is Associated with Higher Severity of Dry Eye in Sjögren’s Syndrome

    Nina Wolska1, Paulina Rybakowska1, Arkadiusz Klopocki1, Michael Brown1, Courtney G. Montgomery2, Kiely Grundahl1, Astrid Rasmussen1, Robert Hal Scofield3, Lida Radfar4, Donald U Stone5, Juan-Manuel Anaya6,7, John Ice2, Christopher Lessard3, David M. Lewis8, Nelson L. Rhodus9, Raj Gopalakrishnan10, Andrew Huang11, Pamela J Hughes12, Michael D. Rohrer13, Michael Weismann14, Swamy Venuturupalli15, Joel M. Guthridge3, Judith A. James16, Kathy L. Sivils3, Harini Bagavant17, Umesh S Deshmukh17 and , 1Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Dean McGee Eye Institute, Oklahoma City, OK, 6Rheumatology, Center for Autoimmune Diseases Research (CREA), Rosario University, Bogotá, Colombia, 7Cell Biol and Immunogenetics, CIB-Rosario University, Medellin, Colombia, 8College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 9Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, 10Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota, Minneapolis, MN, 11Washington University,, St Louis, MO, 12Division of Oral and Maxillofacial Surgery, University of Minnesota, Minneapolis, MN, 13Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, 14Cedars-Sinai Medical Center, Los Angeles, CA, 15Cedars-Sinai Medical Center, West Hollywood, CA, 16Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 17Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Autoantibodies reactive with Ro52/TRIM21 are detected in almost 70% of primary Sjögren’s syndrome (pSjS) patients and their presence is associated with higher severity of…
  • Abstract Number: 2542 • 2014 ACR/ARHP Annual Meeting

    La Positive, Ro60 Negative Subset of Primary Sjögren’s Syndrome Is a Reality

    Debashish Danda1, Dat Truong2, Marshall Shaw3, Celia Quang3, Kristi A. Koelsch4, Biji T. Kurien5, Harini Bagavant2, Umesh Deshmukh2 and R. Hal Scofield6, 1Clincial Immunology and Rheumatology, Christian Medical College, Vellore, India, Vellore, India, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, 5U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, 6US Department of Veterans Affairs Medical Center, Oklahoma City, OK

    Background/Purpose Twenty-nine sera from 348 primary Sjögren’s syndrome patients were identified as anti-Ro60 (anti-SSA) negative and anti-La (anti-SSB) positive by immunodiffusion, line immunoassays and multiplex…
  • Abstract Number: 2200 • 2012 ACR/ARHP Annual Meeting

    IgE Autoantibodies Against SSA and SSB in Patients with Sjögren’s Syndrome and Healthy Controls

    Stamatina Danielides1, Barbara Dema2, Juan Rivera2 and Gabor G. Illei3, 1Nidcr, NIH, Bethesda, MD, 2Laboratory of Molecular Immunogenetics, NIAMS, NIH, Bethesda, MD, 3Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD

    Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disorder, presenting as an autoimmune exocrinopathy. Although the pathogenesis of this disease is largely unknown, evidence indicates…
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