ACR Meeting Abstracts

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Abstracts tagged "sex hormones and systemic lupus erythematosus (SLE)"

  • Abstract Number: 5 • 2017 Pediatric Rheumatology Symposium

    Effects of Puberty on Systemic Lupus Erythematosus:  Results of a multi-center prospective longitudinal observational study in children entering puberty with SLE

    Kathleen O'Neil1, Hermine Brunner2, Andrew Zeft3, Anne Stevens4, Suzanne Li5, Tracey Wright6, Emily von Scheven7, B. Anne Eberhard8, C. Egla Rabinovich9 and Deborah M. Levy10, 1Pediatrics, Indiana University, Indianapolis, IN, 2Rheumatology, PRCSG, Cincinnati, OH, 3Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, 4University of Washington, Department of Pediatrics, Seattle, WA, 5Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, 6Pediatrics/Rheumatology, University of TX Southwestern, Dallas, TX, 7Division of Rheumatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, 8Cohen Children's Medical Center of New York, New Hyde Park, NY, 9Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 10Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose:  Lupus often presents during puberty, and when it affects pre-pubertal children, disease activity is thought to increase at puberty. Sex hormones play some role…
  • Abstract Number: 1757 • 2015 ACR/ARHP Annual Meeting

    Absence of Estrogen Receptor Alpha Is Protective Against Nephrotoxic Serum-Induced Nephritis

    Chelsea Corradetti1, Neelakshi Jog2, Michael Madaio3 and Roberto Caricchio4, 1Temple University, Philadelphia, PA, 2Rheumatology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Medicine, Medical College of Georgia, Augusta, GA, 4Medicine, Rheumatology, Temple University, Philadelphia, PA

    Background/Purpose: Glomerulonephritis (GN) is one of the most serious manifestations of systemic lupus erythematous (SLE). Lupus GN is characterized by severe inflammation and necrosis and…
  • Abstract Number: 2687 • 2014 ACR/ARHP Annual Meeting

    Estrogen-Mediated STAT1 Activation By Estrogen Receptor a Induces TLR8 Expression: A Novel Pathogenic Mechanism in Systemic Lupus Erythematosus

    Nicholas Young1, Giancarlo Valiente2, Lai-Chu Wu3, Michael Bruss4, Stacy Ardoin2, Craig Burd5 and Wael N. Jarjour6, 1Ohio State University, Columbus, OH, 2Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 3Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 5Molecular & Cellular Biochemistry, The Ohio State University, Columbus, OH, 6Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Many autoimmune disorders, including Systemic Lupus Erythematosus (SLE) display female gender predominance.  Previous studies have demonstrated significant hormonal contributions to SLE pathogenesis, including estrogen,…
  • Abstract Number: 2686 • 2014 ACR/ARHP Annual Meeting

    Gene Array Analysis Reveals Unique Estrogen Signature in Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus Erythematosus

    Stephanie Amici1, Nicholas A. Young2, Lai-Chu Wu2, Mireia Guerau1 and Wael N. Jarjour3, 1Health and Rehab Sciences, The Ohio State University, Columbus, OH, 2Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 3Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder predominately affecting females in the reproductive age range.  Estrogen is present at higher levels in this…
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