sex bias Archives - ACR Meeting Abstracts

Abstract Number: 812 • ACR/ARP Annual Meeting 2019
Sex Differences in Autoimmunity and Cardiovascular Risk Could Be Associated with Altered Treg Phenotype and Lipoprotein Metabolism
George Robinson¹, Kirsty Waddington ¹, Anna Radziszewska ¹, Hannah Peckham ¹, David A Isenberg ², Yiannis Ioannou ¹, Coziana Ciurtin ³, Ines Pineda-Torra ¹ and Elizabeth Jury ¹, ¹University College London, London, United Kingdom, ²Centre for Rheumatology, London, United Kingdom, ³Centre for Adolescent Rheumatology, University College London London, UK, Londond, United Kingdom
Background/Purpose: Males and females have altered immune responses resulting in variation in autoimmune risk. Sex differences exist in the frequency and activity of immune-cell subsets…
Abstract Number: 2023 • ACR/ARP Annual Meeting 2019
Gene-Expression Analysis of Male and Female SLE Patients Reveals Candidate Pathogenic Pathways
MIKHAIL OLFERIEV¹, David Fernandez ², Dina Greenman ¹, Mary Peng ¹, Kyriakos Kirou ¹ and Mary Crow ¹, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Mary Kirkland Center for Lupus Research, New York, NY
Background/Purpose: The female predisposition for development of multiple autoimmune diseases is well recognized. The female to male ratio reaches a maximum during the reproductive years…
Abstract Number: 2687 • ACR/ARHP Annual Meeting 2014
Estrogen-Mediated STAT1 Activation By Estrogen Receptor a Induces TLR8 Expression: A Novel Pathogenic Mechanism in Systemic Lupus Erythematosus
Nicholas Young¹, Giancarlo Valiente², Lai-Chu Wu³, Michael Bruss⁴, Stacy Ardoin², Craig Burd⁵ and Wael N. Jarjour⁶, ¹Ohio State University, Columbus, OH, ²Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Molecular & Cellular Biochemistry, The Ohio State University, Columbus, OH, ⁶Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Many autoimmune disorders, including Systemic Lupus Erythematosus (SLE) display female gender predominance. Previous studies have demonstrated significant hormonal contributions to SLE pathogenesis, including estrogen,…
Abstract Number: 2686 • ACR/ARHP Annual Meeting 2014
Gene Array Analysis Reveals Unique Estrogen Signature in Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus Erythematosus
Stephanie Amici¹, Nicholas A. Young², Lai-Chu Wu², Mireia Guerau¹ and Wael N. Jarjour³, ¹Health and Rehab Sciences, The Ohio State University, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder predominately affecting females in the reproductive age range. Estrogen is present at higher levels in this…
Abstract Number: 2014 • ACR/ARHP Annual Meeting 2013
Cigarette Smoking and Male Sex Are Independent Risk Factors For Ocular Sarcoidosis
Adam Janot¹, Dörte Huscher², McCall Walker³, Harmanjot K. Grewal⁴, Mary Yu¹, Matthew R. Lammi^5,6 and Lesley Ann Saketkoo^7,8, ¹Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, ²German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany, ³LSUHSC School of Medicine, New Orleans, LA, ⁴Rheumatology, Lousiana State University Health Sciences Center, New Orleans, LA, ⁵Section of Pulmonary and Critical Care Medicine, LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ⁶Louisiana State University Health Sciences Center, Pulmonary and Critical Medicine, New Orleans, LA, ⁷LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ⁸Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA
Background/Purpose: Sarcoidosis is a multi-organ system granulomatous disease of unknown origin with an incidence of 1-40/100,000. Though pulmonary manifestations are predominant, ocular morbidity is characteristic. …
Abstract Number: 628 • ACR/ARHP Annual Meeting 2013
Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus
Nicholas A. Young¹, Lai-Chu Wu¹, Craig Burd², Alexandra Friedman¹, Benjamin Kaffenberger¹, Murugesan Rajaram³, Larry S. Schlesinger⁴, Hayley James⁵, Margaret Shupnik⁶ and Wael N. Jarjour⁷, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, ³Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Center for Microbial Interface Biology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Asthma, Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, VA, ⁶Endocrinology; Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, ⁷Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Epidemiological data suggests that females of child-bearing age are more resistant to infectious disease. The sex hormone estrogen (E2) is present at elevated levels…

Abstracts tagged "sex bias"

Sex Differences in Autoimmunity and Cardiovascular Risk Could Be Associated with Altered Treg Phenotype and Lipoprotein Metabolism

Gene-Expression Analysis of Male and Female SLE Patients Reveals Candidate Pathogenic Pathways

Estrogen-Mediated STAT1 Activation By Estrogen Receptor a Induces TLR8 Expression: A Novel Pathogenic Mechanism in Systemic Lupus Erythematosus

Gene Array Analysis Reveals Unique Estrogen Signature in Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus Erythematosus

Cigarette Smoking and Male Sex Are Independent Risk Factors For Ocular Sarcoidosis

Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus