Abstracts tagged "sex bias"

Abstract Number: 812 • 2019 ACR/ARP Annual Meeting
Sex Differences in Autoimmunity and Cardiovascular Risk Could Be Associated with Altered Treg Phenotype and Lipoprotein Metabolism
George Robinson¹, Kirsty Waddington ¹, Anna Radziszewska ¹, Hannah Peckham ¹, David A Isenberg ², Yiannis Ioannou ¹, Coziana Ciurtin ³, Ines Pineda-Torra ¹ and Elizabeth Jury ¹, ¹University College London, London, United Kingdom, ²Centre for Rheumatology, London, United Kingdom, ³Centre for Adolescent Rheumatology, University College London London, UK, Londond, United Kingdom
Background/Purpose: Males and females have altered immune responses resulting in variation in autoimmune risk. Sex differences exist in the frequency and activity of immune-cell subsets…
Abstract Number: 2023 • 2019 ACR/ARP Annual Meeting
Gene-Expression Analysis of Male and Female SLE Patients Reveals Candidate Pathogenic Pathways
MIKHAIL OLFERIEV¹, David Fernandez ², Dina Greenman ¹, Mary Peng ¹, Kyriakos Kirou ¹ and Mary Crow ¹, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Mary Kirkland Center for Lupus Research, New York, NY
Background/Purpose: The female predisposition for development of multiple autoimmune diseases is well recognized. The female to male ratio reaches a maximum during the reproductive years…
Abstract Number: 2687 • 2014 ACR/ARHP Annual Meeting
Estrogen-Mediated STAT1 Activation By Estrogen Receptor a Induces TLR8 Expression: A Novel Pathogenic Mechanism in Systemic Lupus Erythematosus
Nicholas Young¹, Giancarlo Valiente², Lai-Chu Wu³, Michael Bruss⁴, Stacy Ardoin², Craig Burd⁵ and Wael N. Jarjour⁶, ¹Ohio State University, Columbus, OH, ²Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Molecular & Cellular Biochemistry, The Ohio State University, Columbus, OH, ⁶Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Many autoimmune disorders, including Systemic Lupus Erythematosus (SLE) display female gender predominance. Previous studies have demonstrated significant hormonal contributions to SLE pathogenesis, including estrogen,…
Abstract Number: 2686 • 2014 ACR/ARHP Annual Meeting
Gene Array Analysis Reveals Unique Estrogen Signature in Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus Erythematosus
Stephanie Amici¹, Nicholas A. Young², Lai-Chu Wu², Mireia Guerau¹ and Wael N. Jarjour³, ¹Health and Rehab Sciences, The Ohio State University, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder predominately affecting females in the reproductive age range. Estrogen is present at higher levels in this…
Abstract Number: 2014 • 2013 ACR/ARHP Annual Meeting
Cigarette Smoking and Male Sex Are Independent Risk Factors For Ocular Sarcoidosis
Adam Janot¹, Dörte Huscher², McCall Walker³, Harmanjot K. Grewal⁴, Mary Yu¹, Matthew R. Lammi^5,6 and Lesley Ann Saketkoo^7,8, ¹Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, ²German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany, ³LSUHSC School of Medicine, New Orleans, LA, ⁴Rheumatology, Lousiana State University Health Sciences Center, New Orleans, LA, ⁵Section of Pulmonary and Critical Care Medicine, LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ⁶Louisiana State University Health Sciences Center, Pulmonary and Critical Medicine, New Orleans, LA, ⁷LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ⁸Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA
Background/Purpose: Sarcoidosis is a multi-organ system granulomatous disease of unknown origin with an incidence of 1-40/100,000. Though pulmonary manifestations are predominant, ocular morbidity is characteristic. …
Abstract Number: 628 • 2013 ACR/ARHP Annual Meeting
Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus
Nicholas A. Young¹, Lai-Chu Wu¹, Craig Burd², Alexandra Friedman¹, Benjamin Kaffenberger¹, Murugesan Rajaram³, Larry S. Schlesinger⁴, Hayley James⁵, Margaret Shupnik⁶ and Wael N. Jarjour⁷, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, ³Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Center for Microbial Interface Biology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Asthma, Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, VA, ⁶Endocrinology; Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, ⁷Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Epidemiological data suggests that females of child-bearing age are more resistant to infectious disease. The sex hormone estrogen (E2) is present at elevated levels…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].