Abstracts tagged "Senescent Cells"

Abstract Number: 1806 • 2019 ACR/ARP Annual Meeting
Inflammatory Arthritis Induced by Immune Checkpoint Inhibitor Therapy: A Distinct Clinical Entity and Immunologic Phenotype
Uma Thanarajasingam¹, Xingxing Zhu ¹, Xian Zhou ¹, Jane Jaquith ¹, Yanfeng Li ¹ and Hu Zeng ¹, ¹Mayo Clinic, Rochester, MN
Background/Purpose: Immune checkpoint inhibitors (ICIs) are being used in the treatment of a variety of malignancies. ICIs target cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell-death…
Abstract Number: 1975 • 2019 ACR/ARP Annual Meeting
Fibrates as Drugs with Senolytic and Autophagic Activity for Osteoarthritis Treatment
Uxia Nogueira-Recalde¹, Irene Lorenzo-Gomez ², Francisco J. Blanco ³, María I. Loza ⁴, Diego Grassi ⁵, Valery Shirinsky ⁶, Ivan Shirinsky ⁶, martin lotz ⁷, Paul D. Robbins ⁸, Eduardo Domínguez ⁴ and Beatriz Carames ², ¹Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruña, Spain, ²Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruna, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁴Biofarma Research Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, Spain, ⁵Institute for Interdisciplinary Neuroscience (IINS), Bordeaux, Nouvelle-Aquitaine, France, Bordeaux, France, ⁶Scientific Research Institute of Clinical immunology, Novosibirsk, Rusia, Novosibirsk, Russia, ⁷Department of Molecular Medicine. Scripps Research, La Jolla, CA, USA, La Jolla, CA, ⁸Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN
Background/Purpose: . Increasing evidence suggest that osteoarthritis (OA) is associated with hallmarks of ageing, including cellular senescence or defective autophagy, that could promote disease onset.…
Abstract Number: 1982 • 2019 ACR/ARP Annual Meeting
Senescent Synoviocytes in Knee Osteoarthritis Correlate with Disease Biomarkers, Synovitis, and Knee Pain
Christopher Yohn ¹, Robert O'Brien ¹, Stephanie Lussier ¹, Casey Berridge ¹, Rathi Ryan ¹, Ali Guermazi ², Mahru An ¹, Remi-Martin Laberge ¹, Benjamin Hsu¹, Carl Millward ¹, Kate Doherty ¹ and Jamie Dananberg ¹, ¹Unity Biotechnology, Brisbane, CA, ²Boston Medical Center, Boston
Background/Purpose: Background/Purpose: Cellular senescence is a natural state in which a cell permanently halts division through upregulation of a set of intracellular proteins including p16INK4A…
Abstract Number: 932 • 2018 ACR/ARHP Annual Meeting
Fibroblasts Senescence Is Observed in Rheumatoid and Osteoarthritic Synovial Tissues and Triggers a Pro-Inflammatory Program Ex Vivo
Manuel J Del Rey¹, Alvaro Valin², Alicia Usategui³, Sandra Ergueta³, Vanessa Miranda³, Jesús Fernández-Felipe³, Juan D. Cañete⁴, Francisco J Blanco⁵, Gabriel Criado³ and Jose L. Pablos^6,7, ¹Grupo de Enfermedades Inflamatorias y Autoinmunes, Servicio de Reumatología,, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoimmunes, Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ³Grupo de Enfermedades Inflamatorias y Autoinmunes, Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁴Rheumatology Department Hospital Clinic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, ⁵Rheumatology Division (INIBIC-CHUAC), Osteoarticular and Aging Research Lab, Proteomics Unit, La Coruna, Spain, ⁶Servicio de Reumatología, Rheumatology Department, Hospital 12 de Octubre, Spain, Madrid, Spain, ⁷Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain
Background/Purpose: Inflammation is an important component of most age-related disorders. Cellular changes associated to aging are tightly connected with pro-inflammatory mechanisms. The purpose of this…
Abstract Number: 1048 • 2018 ACR/ARHP Annual Meeting
Identification of Novel Molecules with Senolytic and Autophagy Activity As Osteoarthritis Therapeutics
Uxia Nogueira-Recalde¹, Francisco J Blanco¹, Maria I. Loza², Diego Grassi³, Paul Robbins³, Eduardo Dominguez⁴ and Beatriz Carames¹, ¹Cartilage Biology Group, Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, ²BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, ³Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, ⁴BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain
Background/Purpose: Disease-modifying treatments for Osteoarthritis (OA) are not available. Aging-related features such as failure of homeostasis mechanisms, including autophagy, cause extracellular matrix damage, chondrocyte senescence…
Abstract Number: 1931 • 2017 ACR/ARHP Annual Meeting
Targeting Cartilage Aging As Osteoarthritis Therapeutics By Drug Repurposing
Beatriz Carames¹, Uxia Nogueira-Recalde², Maria I. Loza³, Francisco J Blanco² and Eduardo Dominguez⁴, ¹Cartilage Biology Group. Rheumatology Division, INIBIC–CHUAC, A Coruña, A Coruña, Spain, ²Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, ³BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, ⁴BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain
Background/Purpose: Background: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause…
Abstract Number: 2945 • 2017 ACR/ARHP Annual Meeting
Incident Hand OA Is Strongly Associated with Reduced Peripheral Blood Leukocyte Telomere Length
Timothy E. McAlindon¹, Mary Roberts², Lena Franziska Schaefer³, Jeffrey B. Driban⁴, Jeffrey Duryea³, Francisco J Blanco⁵, Jose-Luis Fernandez-Garcia⁶ and Charles Eaton⁷, ¹Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, ³Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain, ⁶Genetic Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁷Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI
Background/Purpose: Hand OA (HOA) is a painful, destructive and deforming polyarticular disorder that impairs an individual’s ability to perform manipulative activities of daily life and…
Abstract Number: 1832 • 2016 ACR/ARHP Annual Meeting
Increased Interferon b Expression in Bone Marrow Mediates a Senescent Phenotype and Impaired Production of Immunomodulatory Factors By SLE Mesenchymal Stromal Cells
Lin Gao¹, Jennifer H. Anolik² and R. John Looney², ¹medicine- allergy, immunology and rheumatology, University of Rochester Medical Center, Rochester, NY, ²Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Bone marrow mesenchymal stromal cells (MSCs) are multipotent stem cells that create a special microenvironment for hematopoiesis and immunity. MSCs display robust immunomodulatory properties…
Abstract Number: 2132 • 2016 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Premature Senescence in Aging and Osteoarthritis
Beatriz Carames¹, Paloma Lopez de Figueroa¹, Madalena Ribeiro¹, Valentina Calamia², Fernando Osorio³, Carlos Lopez-Otin³ and Francisco J. Blanco^1,4, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Research Lab. Proteomics Unit - Associated Node to ProteoRed, Rheumatology Division, Proteomics Group-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, ³Degradome Lab, Universidad de Oviedo, Oviedo, Spain, ⁴Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: Previous findings indicated that autophagy is defective in Aging and Osteoarthritis (OA). Autophagy is essential to maintain chondrocyte homeostasis by regulating the intracellular macromolecule…
Abstract Number: 2142 • 2016 ACR/ARHP Annual Meeting
Identification of Novel Molecules Targeting Cartilage Aging As Osteoarthritis Therapeutics
Beatriz Carames¹, Uxia Nogueira-Recalde¹, Eduardo Dominguez², Maria I. Loza³ and Francisco J. Blanco^1,4, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain, ³BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, ⁴Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause extracellular…
Abstract Number: 2839 • 2016 ACR/ARHP Annual Meeting
Circulating CD4+CD28null T-Cells Predict the Occurrence of New Lung Damage in Systemic Lupus Erythematosus (SLE) Patients
Manuel Ugarte-Gil^1,2, César Sánchez-Zúñiga³, Rocio V. Gamboa-Cardenas¹, Madeley Aliaga-Zamudio⁴, Francisco Zevallos¹, Ana Mosqueira-Riveros⁴, Mariela Medina¹, Giannina Tineo-Pozo⁴, Claudia Elera-Fitzcarrald¹, Victor Pimentel-Quiroz¹, Omar Sarmiento-Velasquez¹, Jorge M. Cucho-Venegas¹, Jose Alfaro-Lozano¹, Zoila Rodriguez-Bellido^1,5, Cesar A. Pastor-Asurza^1,5, Graciela S. Alarcón⁶ and Risto Perich-Campos^1,5, ¹Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²Universidad Cientifica del Sur, Lima, Peru, ³Diagnostic Support, Hospital Grau. EsSalud, Lima, Peru, ⁴Molecular Biology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ⁵Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁶Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Peripheral CD4+CD28null T-cells constitute a subset of long-lived cytotoxic CD4+ T-cell with pro-inflammatory functions. This T-cell subpopulation has been reported to be associated with…
Abstract Number: 1606 • 2015 ACR/ARHP Annual Meeting
Telomere Damage in Rheumatoid Arthritis
Yinyin Li¹, Jihang Ju¹, Thomas M. Bush², Mark C. Genovese³, Jorg Goronzy¹ and Cornelia M. Weyand⁴, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Medicine/Rheumatology, Santa Clara Valley Medical Center, San Jose, CA, ³Division of Rheumatology, Stanford University Medical Center, Palo Alto, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Production of anti-CCP autoantibodies, the hallmark of rheumatoid arthritis (RA), is dependent on T cell help, positioning T cells into a pinnacle position in…
Abstract Number: 1941 • 2015 ACR/ARHP Annual Meeting
Senescent T-Cells Expedite RANKL-Dependent Bone Loss in Rheumatoid Arthritis
Johannes Fessler¹, Rusmir Husic², Elisabeth Lerchbaum³, Verena Schwetz³, Claudia Stiegler³, Barbara Obermayer-Pietsch³, Winfried B. Graninger⁴ and Christian Dejaco⁵, ¹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ²Rheumatology, Medical University Graz, Graz, Austria, ³Division of Endocrinology and Metabolism, Medical University Graz, Graz, Austria, ⁴Internal Medicine/Rheumatology, Medical University Graz, Graz, Austria, ⁵Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria
Background/Purpose: To study the influence of senescent CD28-T-cells on systemic osteoporosis in rheumatoid arthritis (RA) and patients with primary osteoporosis. Methods: Prospective, cross-sectional study on…
Abstract Number: 759 • 2015 ACR/ARHP Annual Meeting
Prolactin Level Is Independently Associated with Circulating CD4+CD28null in Systemic Lupus Erythematosus Patients
Manuel Ugarte-Gil^1,2, César Sánchez-Zúñiga³, Rocio V. Gamboa-Cardenas¹, Madeley Aliaga-Zamudio³, Francisco Zevallos¹, Giannina Tineo-Pozo³, Jorge M. Cucho-Venegas¹, Ana Mosqueira-Riveros³, Risto Perich-Campos^1,4, Jose Alfaro-Lozano¹, Mariela Medina¹, Zoila Rodriguez-Bellido^1,4, Graciela S. Alarcon⁵ and Cesar A. Pastor-Asurza^1,4, ¹Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²Universidad Cientifica del Sur, Lima, Peru, ³Molecular Biology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ⁴Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁵Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Peripheral CD4+CD28null T-cells are a subset of long-lived cytotoxic CD4+ T-cells with pro-inflammatory functions, and they are increased in autoimmune and cardiovascular diseases. Prolactin…
Abstract Number: 1737 • 2014 ACR/ARHP Annual Meeting
Altered Phenotype and Function of Senescent Regulatory T Cells in Rheumatoid Arthritis
Johannes Fessler¹, Chrsitine Schwarz¹, Anja C. Ficjan¹, Rusmir Husic², Evelyne Höller³, Angelika Lackner¹, Winfried B. Graninger⁴ and Christian Dejaco^1,5, ¹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ²Rheumatology, Medical University Graz, Graz, Austria, ³Endocrinology, Medical University Graz, Graz, Austria, ⁴Internal medicine/Rheumatology and Immunology, Medical University Graz, Graz, Austria, ⁵Department of Rheumatology and Immunology, Medical University Graz, Graz A-8036, Austria
Background/Purpose Immunosenescence accompanied by accumulation of senescent T cells is a hallmark feature in the pathogenesis of rheumatoid arthritis (RA). Here we characterize a novel senescent…

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