ACR Meeting Abstracts

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Abstracts tagged "scleroderma and transforming growth factor"

  • Abstract Number: 1706 • 2017 ACR/ARHP Annual Meeting

    Dipeptidyl-Peptidase-4 (DPP4) Promotes Fibroblast Activation and Is a Potential Molecular Target for Treatment of Fibrosis

    Alina Soare1, Hermina Györfy1, Alexandru Matei1, Clara Dees1, Chih-Wei Chen1, Andreas Ramming2, Georg Schett3 and Jörg Distler1, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 3Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany

    Background/Purpose: Dipeptidyl-peptidase-4 (DPP4) has been reported to identify a dermal fibroblast lineage involved in scaring and its inhibition leads to reduced scar formation. Its role…
  • Abstract Number: 2926 • 2017 ACR/ARHP Annual Meeting

    Fucosyltransferase-1 Mediates Macrophage Driven Myofibroblast Differentiation and TGF-β Signaling in Systemic Sclerosis and Bleomycin-Induced Fibrosis

    W. Alexander Stinson1, Ellen Cealey1, Pei-Suen Tsou1, Ray A. Ohara1, Yuxuan Du2, Jonatan Hervoso1, Nicholas Lepore1, Sarah Arwani1, Dinesh Khanna1, David A. Fox1 and M. Asif Amin1, 1Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, 2Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, MI

    Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by dysregulated fibrosis of the skin. During fibrosis, macrophage release of transforming growth factor (TGF-β)…
  • Abstract Number: 1859 • 2016 ACR/ARHP Annual Meeting

    Fucosyltransferase-1 Mediated Fucosylation of TGF-βR1 Is Critical to TGF-β Signaling in Scleroderma and in Bleomycin-Induced Fibrosis

    W. Alexander Stinson1, Pei-Suen Tsou1,2, Yuxuan Du3, Huadong Cui1, Ellen Cealey3, Nicholas Lepore4, Ray A. Ohara1, Gautam Edhayan1, Sarah Arwani1, Rachel Morgan1, Dinesh Khanna1,2, David A. Fox1 and M. Asif Amin5, 1Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2University of Michigan Scleroderma Program, Ann Arbor, MI, 3Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 4University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 5Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose:  Systemic sclerosis (SSc) is a connective tissue disease characterized by systemic fibrosis. The dysregulation of transforming growth factor-β (TGF-β) signaling causes proliferation of myofibroblasts…
  • Abstract Number: 2289 • 2012 ACR/ARHP Annual Meeting

    Adiponectin Has Potent Anti-Fibrotic Effects Mediated Via AMP Kinase: Novel Target for Fibrosis Therap

    Feng Fang1, Lei Liu2, Yang Yang2, Jun Wei1, Swati Bhattacharyya3, Ross Summer4, Boping Ye2 and John Varga3, 1Rheumatology Division, Northwestern University, Chicago, IL, 2School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, 3Division of Rheumatology, Northwestern University, Chicago, IL, 4Pulmonary Center, Boston University, Boston, MA

    Background/Purpose: Fibrosis in scleroderma is associated with transforming growth factor-β (TGF-β) signaling activation, collagen deposition and myofibroblast accumulation. Peroxisome proliferator activated receptor gamma (PPAR-γ) inhibits…
  • Abstract Number: 2294 • 2012 ACR/ARHP Annual Meeting

    The Histone Deacetylase SIRT1 Is Anti-Fibrotic and Mediates Resveratrol Effects

    Roberta G. Marangoni1, Archit Ghosh1, Jun Wei2 and John Varga3, 1Medicine, Rheumatolgoy, Northwestern University, Feinberg School of Medicine, Chicago, IL, 2Rheumatology Division, Northwestern University, Chicago, IL, 3Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Fibrosis in scleroderma is associated with increased collagen synthesis driven by TGF-β and associated epigenetic modifications. The Class III histone deacetylase SIRT1 has anticancer…
  • Abstract Number: 1517 • 2012 ACR/ARHP Annual Meeting

    TLR9 Signaling in Fibroblasts Promotes Pro-Fibrotic Responses Via TGF-Beta

    Yang Yang1, Feng Fang2, Lei Liu1, Junjie Shangguan3, Boping Ye1 and John Varga3, 1School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, 2Rheumatology Division, Northwestern University, Chicago, IL, 3Division of Rheumatology, Northwestern University, Chicago, IL

    Background/Purpose: Systemic sclerosis (SSc) is associated with progressive fibrosis and transforming growth factor β (TGF-β) is implicated in its pathogenesis. Toll-like receptors (TLR) respond to…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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