Abstracts tagged "scleroderma and therapeutic targeting"

Abstract Number: 132 • 2018 ACR/ARHP Annual Meeting
Novel Therapeutic Peptides Which Target CD206 Inhibit Macrophage Dependent Fibroblast Activation in Scleroderma
Bahja Ahmed Abdi¹, Henry Lopez², George Martin³, Charles Garvin³, Jesse Jaynes³, James Stanway⁴, Christopher P. Denton⁵, David Abraham⁶, Shivanee Vigneswaran⁷, Sian Morris⁷ and Richard J Stratton⁸, ¹Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²Murigenics, Vallejo, CA, ³Riptide Bioscience, Vallejo, CA, ⁴Centre for Rheumatology and Connective Tissue diseases, University College London, London, United Kingdom, ⁵UCL Division of Medicine, Royal Free Campus, London, United Kingdom, ⁶Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁷Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁸Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom
Background/Purpose: Alternatively activated macrophages expressing CD206 are believed to promote fibrosis in a range of disorders including systemic sclerosis (SSc). Novel therapeutic peptides (RP) which…