Abstracts tagged "Scleredema"

Abstract Number: 1887 • 2016 ACR/ARHP Annual Meeting
Olfactory Impairment Is Associate with Cognitive Dysfunction and Regional Brain Atrophy in Systemic Sclerosis
Mariana Freschi Bombini¹, Fernando A. Peres², Nailu A. Sinicato³, Aline Tamires Lapa², Leticia Rittner⁴, Roberto Souza⁵, Ana Paula del Rio¹, João Francisco Marques-Neto¹ and Simone Appenzeller¹, ¹State University of Campinas, Campinas, Brazil, ²Medicine, State University of Campinas, Campinas, Brazil, ³Pediatrics, State University of Campinas, Campinas, Brazil, ⁴Electrical Engineering, State University of Campinas, Campinas, Brazil, ⁵State University of Campinas, campinas, Brazil
Background/Purpose: Several factors has been described as responsible for the association between olfactory impairment and brain regions. In systemic sclerosis (SSc) the olfactory interaction has…
Abstract Number: 2152 • 2015 ACR/ARHP Annual Meeting
Long Noncoding H19X Is a Key Mediator of Tgf-Beta Induced Pro-Fibrotic Effects in the Pathogenesis of Systemic Sclerosis and Other Fibrotic Diseases
Elena Pachera¹, Shervin Assassi², Gloria Salazar², Mojca Frank Bertoncelj³, Rucsandra Dobrota⁴, Matthias Brock⁵, Serena Vettori⁶, Claus Hellerbrand⁷, Carol A. Feghali-Bostwick⁸, Jeorg HW Distler⁹, Gabriela Kania¹⁰ and Oliver Distler¹¹, ¹Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, Schileren, Switzerland, ²Rheumatology, University of Texas Medical School at Houston, Houston, TX, ³Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland, ⁴Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Department of Pulmonology, University Hospital Zurich, Schileren, Switzerland, ⁶Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁷Department of Internal Medicine I, University of Regensburg, Regensburg, Germany, ⁸Medicine, University of Pittsburgh, Pittsburgh, PA, ⁹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁰Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ¹¹Division of Rheumatology, University Hospital And Eular Scleroderma Trials And Research (EUSTAR) Board, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (LncRNAs) are emerging as a novel class of noncoding transcripts involved in the regulation of gene expression. So far, for only…
Abstract Number: 2153 • 2015 ACR/ARHP Annual Meeting
Nintedanib Ameliorates Fibrotic and Vascular Manifestations in Preclinical Models of Systemic Sclerosis
Jingang Huang¹, Christian Beyer¹, Yun Zhang¹, Katrin Palumbo-Zerr², Clara Dees¹, Oliver Distler³, Georg A. Schett⁴, Stefan Lutz Wollin⁵ and Jorg HW. Distler¹, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Rheumatology, Research of Systemic Autoimmune Diseases, University Hospital Zurich, Zurich, Switzerland, ⁴Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Boehringer-Ingelheim Pharma, Div. Research Germany, Bad Biberach, Germany
Background/Purpose: Nintedanib is a tyrosine kinase inhibitor that inhibits PDGF-, FGFR-, VEGFR-receptors and Src kinases. Nintedanib has recently been approved for the treatment of idiopathic…
Abstract Number: 3131 • 2015 ACR/ARHP Annual Meeting
Interferon Regulatory Factor 7 (IRF7): The Possible Link Between Inflammation and Fibrosis in SSc Pathogenesis
Minghua Wu¹, Gloria Salazar¹, Xiaodong Zhou², Xinjian Guo², John D. Reveille³, Sandeep K. Agarwal⁴, Michael R. Blackburn⁵, Maureen D Mayes¹ and Shervin Assassi¹, ¹Rheumatology, University of Texas Medical School at Houston, Houston, TX, ²Internal Medicine, University of Texas Medical School at Houston, Houston, TX, ³Internal Medicine/Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Internal Med, Rheumatology, Baylor College of Medicine, Houston, TX, ⁵Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX
Background/Purpose: A recent global gene expression profile study in a large early SSc patient samples revealed a type I interferon (IFN) signature. Type I IFN…
Abstract Number: 3132 • 2015 ACR/ARHP Annual Meeting
Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis Via Repressing Pro-Angiogenic Factors
Pei-Suen Tsou^1,2, M. Asif Amin³, Elena Schiopu^2,4, David A. Fox³, Dinesh Khanna^1,2 and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Scleroderma Program, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vascular complications, and excessive deposition of extracellular matrix. Vascular dysfunction represents a disease initiating event…
Abstract Number: 822 • 2015 ACR/ARHP Annual Meeting
Beneficial Effect of Botulinum Toxin-a on Raynaud’s Phenomenon in Japanese Patients with Systemic Sclerosis: A Prospective, Open-Label Trial
Sei-ichiro Motegi¹, Kazuya Yamada¹, Sayaka Toki¹, Akihiko Uchiyama¹, Tetsuya Nakamura² and Osamu Ishikawa¹, ¹Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan, ²Clinical Investigation and Research Unit, Gunma University Graduate School of Medicine, Gunma, Japan
Background/Purpose: Systemic scleroderma (SSc) is a generalized connective tissue disease characterized by fibrosis of the skin and internal organs, vascular dysfunction and immune disorder. Patients…
Abstract Number: 851 • 2015 ACR/ARHP Annual Meeting
Does the Clinical Context Improve the Reliability of Rheumatologists Grading Digital Ulcers in Systemic Sclerosis?
Michael Hughes¹, Chris Roberts², Andrew Tracey¹, Graham Dinsdale¹, Andrea Murray¹ and Ariane L. Herrick¹, ¹Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester, United Kingdom
Background/Purpose: Digital ulcers (DUs) are often a primary end point in SSc clinical trials, although the reliability of rheumatologists grading DUs is poor to moderate…
Abstract Number: 1123 • 2015 ACR/ARHP Annual Meeting
Regulatory B Cells Regulate Skin and Lung Fibrosis and Immunological Abnormalities in a Topoisomerase I and Complete Freund’s Adjuvant-Induced Scleroderma Model Via an Antigen-Specific Manner
Ayumi Yoshizaki¹, Takashi Taniguchi¹, Kouki Nakamura¹, Ryosuke Saigusa¹, Takashi Yamashita¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Yohei Ichimura¹, Yoshihide Asano² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Immune cells play a critical role in systemic sclerosis (SSc). B cells have more functions than producing antibodies, including antigen-presentation, various cytokine production, and…
Abstract Number: 1873 • 2015 ACR/ARHP Annual Meeting
Inter and Intrarater Reliability of the Modified Rodnan Skin Score in Early Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Veronica J. Berrocal², Shervin Assassi³, Elana J. Bernstein⁴, Robyn T. Domsic⁵, Faye N. Hant⁶, Monique E. Hinchcliff⁷, Elena Schiopu⁸, Virginia D. Steen⁹, Tracy M. Frech¹⁰ and Dinesh Khanna¹¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Div of Rheumatology, University of Michigan, Ann Arbor, MI, ³Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁸University of Michigan, Ann Arbor, MI, ⁹Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁰Div of Rheumatology, University of Utah, Salt Lake City, UT, ¹¹Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: The Modified Rodnan Skin Score (MRSS) is a semiquantitative assessment of skin thickness which is a commonly used outcome measure in Systemic Sclerosis (SSc)…
Abstract Number: 3006 • 2014 ACR/ARHP Annual Meeting
Activation of the Thromboxane A2 Receptor By 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma
Pei-Suen Tsou¹, George Zakhem², Beatrix Balogh², M. Asif Amin³, Phillip Campbell⁴, Gautam Edhayan³, Ray A. Ohara³, Elena Schiopu³, Dinesh Khanna¹, Alisa E. Koch^2,5 and David A. Fox³, ¹University of Michigan Scleroderma Program, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vasculopathy, and excessive deposition of extracellular matrix. Various studies have demonstrated a paradoxical increase in…
Abstract Number: 1685 • 2014 ACR/ARHP Annual Meeting
Effects of Mycophenolate Mofetil on Pulmonary Lung Function in Interstitial Lung Disease of Systemic Sclerosis
Michael Pham¹ and W Leroy Griffing², ¹Division of Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ, ²Division of Rheumatology, Mayo Clinic Arizona, Scottsdale, AZ
Background/Purpose: Interstitial lung disease remains a primary driver of morbidity and mortality in patients suffering from systemic sclerosis. Cyclophosphamide currently is the treatment with the…
Abstract Number: 966 • 2014 ACR/ARHP Annual Meeting
Adiponectin Is an Endogenous Anti-Fibrotic and Target in Systemic Sclerosis: Novel Link Between Fibrosis and Metabolism
Feng Fang¹, Roberta G. Marangoni¹, Xingchun Zhou², Wen Hong³, Boping Ye³, Asano Yoshihide⁴, Shinichi Sato⁵, Yuri Masui⁶, Chengning Zhang⁷, Katja Lakota⁸, Jun Wei⁹, Monique E. Hinchcliff⁷, Philipp Scherer¹⁰, Laszlo Otvos¹¹ and John Varga¹², ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²College of Life and Science, China Pharmaceutical University, Nanjing, China, ³China Pharmaceutical University, Nanjing, China, ⁴University of Tokyo, Tokyo, Japan, ⁵Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan, ⁶Department of Dermatology, University of Tokyo, Tokyo, Japan, ⁷Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁸Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ¹⁰University of Texas Southwestern Medical Center, Dallas, TX, ¹¹Temple University, Philadelphia, PA, ¹²Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose :Systemic sclerosis (SSc) skin fibrosis is associated with attenuated cutaneous adipose tissue and adipogenic gene expression. Levels of the adipose-derived cytokine adiponectin (APN) and…
Abstract Number: 762 • 2014 ACR/ARHP Annual Meeting
IQGAP1 Enhances Contractility of Scleroderma Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis
Tanjina Akter¹, Ilia Atanelishvili², Yuichiro Shirai³, Sybil Prince Nelson⁴, Alvaro Garcia-Martos⁵, Thomas A. Morinelli³, Richard M. Silver⁶ and Galina S. Bogatkevich¹, ¹Department of Rheumatology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ²Division of Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ³Medical University of South Carolina,Charleston,USA, chareston, SC, ⁴College of Graduate Studies, Medical University of South Carolina,Charleston,USA, chareston, SC, ⁵Hospital la Zarzuela,Madrid,Spain, Madrid, Spain, ⁶Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC
Background/Purpose Scleroderma associated interstitial lung disease (SSc-ILD) is an irreversible and progressive complication and a leading cause of death among SSc patients. Constitutive overexpression of…
Abstract Number: 155 • 2013 ACR/ARHP Annual Meeting
Exome Sequencing For Identification Of Potential Causal Variants For Diffuse Cutaneous Systemic Sclerosis
Angel CY Mak¹, M Kari Connolly², Tamiko Katsumoto^3,4, Paul Wolters⁵, Clare Cleveland^3,4, Blanca M Herrera¹, Paul LF Tang¹, Simi Mathauda¹, Richard Lao¹, Pui-Yan Kwok^1,2 and Lindsey A. Criswell^3,4, ¹University of California, San Francisco, Institute for Human Genetics, San Francisco, CA, ²University of California, San Francisco, Department of Dermatology, San Francisco, CA, ³University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ⁴University of California, San Francisco, Department of Medicine, San Francisco, CA, ⁵University of California, San Francisco, Department of Medicine, Pulmonary Division, San Francisco, CA
Background/Purpose: Scleroderma is a genetically complex autoimmune disease with substantial phenotypic heterogeneity. Previous genome-wide association studies (GWAS) have identified a large number of gene regions…
Abstract Number: 2918 • 2013 ACR/ARHP Annual Meeting
Survival After Lung Transplantation In Systemic Sclerosis. A Systematic Review
Irfan Y. Khan¹, Lianne G. Singer², Marc de Perrot³, John T. Granton⁴, Shaf Keshavjee³, Cathy Chau⁵, Amie T. Kron⁶ and Sindhu R. Johnson⁷, ¹Medicine, Pulmonary Hypertension Programme, University Health Network, University of Toronto, Toronto, ON, Canada, ²Medicine, Division of Respirology, University of Toronto; and Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada, ³Medicine, Toronto Lung Transplant Program, Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, ON, Canada, ⁴Medicine, Toronto Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, ⁵Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Medicine, Toronto Scleroderma Research Program, Toronto Western Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada, ⁷Medicine, Division of Rheumatology, Toronto Western Hospital, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Lung transplantation is a life-saving option for systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) and interstitial lung disease (SSc-ILD) patients. Yet, there is risk…

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