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Abstracts tagged "Scleredema and mouse model"

  • Abstract Number: 755 • ACR/ARHP Annual Meeting 2014

    Increased Degradation of BMPR2 in a TGFβ Dependent Transgenic Mouse Model of Scleroderma with Susceptibility to Pulmonary Arterial Hypertension

    Adrian J Gilbane1, Emma C. Derrett-Smith2, Andrew Pearce3, Christopher P Denton4 and Alan M. Holmes5, 1Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 2Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, 3Respiratory Disease Area, Novartis, London, United Kingdom, 4Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom, 5Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom

    Background/Purpose Scleroderma patients are susceptible to development of pulmonary arterial hypertension (PAH) that has similarities to some forms of heritable PAH.  The basis for this…
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